Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name BNIP3P29
Plot displaying the genomic locations of a retrocopy (in chr19) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr19:22065812-22066216  UCSC
Coordinates (T2T) chr19:22204207-22204611  UCSC
Coordinates (hg19) chr19:22248614-22249018  UCSC
Strand -
Parental Sequence NM_004052.3
Parental seq. overlap 326 bp
Parental seq. overlap (%) 19.9%
Genomic Region Intragenic (ZNF257)
Retrocopy Summary BNIP3P29, located on chr19:22065812-22066216, is a retrocopy of the parental gene BNIP3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name BNIP3
Full Name BCL2 interacting protein 3
Also known as HABON|NIP3
Coordinate chr10:131967683-131982013
Strand -
Gene summary This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes BNIP3P5
Bonobo Pan paniscus BNIP3P6
Gorilla Gorilla gorilla BNIP3P7
Orangutan Pongo abelii BNIP3P3
Gibbon Nomascus leucogenys BNIP3P2
Green monkey Chlorocebus sabaeus BNIP3P2
Crab-eating macaque Macaca fascicularis BNIP3P7
Rhesus Macaca mulatta BNIP3P8
Golden snub-nosed monkey Rhinopithecus roxellana BNIP3P9
Marmoset Callithrix jacchus BNIP3P1
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>BNIP3P29
CTGTGACAGCCCACCTCATTCAAAGACACCACGGGATACGCATAAGGCTTCTAAAACAGACACCCAAAGCATTTGAGAGAAAAACAGCTCTCAAATGAGCAAGATTTTATTGAGAGAAATAAAGAAGTTAAAAGCATCTTAAGAAAAACTCAAATTAGACATAAGATTTATCGAAATAGCCAGAAAATATTCCCCTGAAAAGAATTTCTAAGCATCCAGAGTGCACAGCTACTCTCAGCATGAGAAACATGAGCATTATAAAGAAAGTGTGCATATTTTCAGCAGAATTTCATAAGGTTTCTCTTTCATCTCTGTTGCTCTCTCATCTCCTAGCCATTGAATGGGGGATCTATGTTGAAATACATCTGACAACTTCCACCAGCACTTTTTGATGAAGAATTGGAA
>NM_004052.3
AAGTCGCGGCCAATGGGCGACGCGGCCGCAGATCCGCCCGGCCCCGCCCTGCCCTGTGAGTTCCTCCGGCCGGGCTGCGGGGCTCCGCTCAGTCCGGGAGCGCAGCTGGGCCGCGGCGCTCCGACCTCCGCTTTCCCACCGCCCGCAGCTGAAGCACATCCCGCAGCCCGGCGCGGACTCCGATCGCCGCAGTTGCCCTCTGGCGCCATGTCGCAGAACGGAGCGCCCGGGATGCAGGAGGAGAGCCTGCAGGGCTCCTGGGTAGAACTGCACTTCAGCAATAATGGGAACGGGGGCAGCGTTCCAGCCTCGGTTTCTATTTATAATGGAGACATGGAAAAAATACTGCTGGACGCACAGCATGAGTCTGGACGGAGTAGCTCCAAGAGCTCTCACTGTGACAGCCCACCTCGCTCGCAGACACCACAAGATACCAACAGAGCTTCTGAAACAGATACCCATAGCATTGGAGAGAAAAACAGCTCACAGTCTGAGGAAGATGATATTGAAAGAAGGAAAGAAGTTGAAAGCATCTTGAAGAAAAACTCAGATTGGATATGGGATTGGTCAAGTCGGCCGGAAAATATTCCCCCCAAGGAGTTCCTCTTTAAACACCCGAAGCGCACGGCCACCCTCAGCATGAGGAACACGAGCGTCATGAAGAAAGGGGGCATATTCTCTGCAGAATTTCTGAAAGTTTTCCTTCCATCTCTGCTGCTCTCTCATTTGCTGGCCATCGGATTGGGGATCTATATTGGAAGGCGTCTGACAACCTCCACCAGCACCTTTTGATGAAGAACTGGAGTCTGACTTGGTTCGTTAGTGGATTACTTCTGAGCTTGCAACATAGCTCACTGAAGAGCTGTTAGATCCTGGGGTGGCCACGTCACTTGTGTTTATTTGTTCTGTAAATGCTGCGTTCCTAATTTAGTAAAATAAAAGAATAGACACTAAAATCATGTTGATCTATAATTACACCTATGGGATCAATAAGCATGTCAGACTGATTAATGTCTACTGTGAAAATTTGGTAGTAAATTTTCATTTGATATTAGATATAAATATCTGAATATAAATAATTTTAATATACTAGTCATGATGTGTGTTGTATTTTAAAAATTATCTGCAACCTTAATTCAGCTGAAGTACTTTATATTTCAAAAGAATGAATAACATTGATAATAAAATCGCTACTTTAAGGGGTTTGTCCAAAATAAATATTGTGGCCTTATATATCACACTATTGTAGAAAGTATTATTTAATTTAAATGGATGCAGGTTGTCTACTAAAGAAAGATTATATATAACTATGCTAATTGTTCATAATCAACAGAAACCAAGATAGAGCTACAAACTCAGCTGTACAGTTCGTACACTAAACTCTTCTTGCTTTTGCATTATAAGGAATTAAGTCTCCGATTATTAGGTGATCACCCTGGATGATCAGTTTTCTGCTGAAGGCACCTACTCAGTATCTTTTCCTCTTTATCACTCTGCATTGGTGAATTTAATCCTCTCCTTTGTGTTCAACTTTTGTGTGCTTTTAAAATCAGCTTTATTCTAAGCAAATCTGTGTCTACTTTAAAAAACTGGAAATGGAAAAAAAAATAAATCTTTGCCAAATCCTTCAGAT

Publications

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