Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SEPTIN7P8
Plot displaying the genomic locations of a retrocopy (in chr19) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr19:53771493-53773279  UCSC
Coordinates (T2T) chr19:56850968-56852754  UCSC
Coordinates (hg19) chr19:54274747-54276533  UCSC
Strand -
Parental Sequence NM_001788.6
Parental seq. overlap 1362 bp
Parental seq. overlap (%) 31.1%
Genomic Region Intergenic
Retrocopy Summary SEPTIN7P8, located on chr19:53771493-53773279, is a retrocopy of the parental gene SEPTIN7. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SEPTIN7
Full Name septin 7
Also known as CDC10|CDC3|NBLA02942|SEPT7|SEPT7A
Coordinate chr7:35800986-35915763
Strand +
Gene summary This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. [provided by RefSeq, Jul 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SEPT7P6
Bonobo Pan paniscus SEPTIN7P5
Gorilla Gorilla gorilla SEPTIN7P7
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SEPTIN7P8
GAGATTAAGATGCCTCGAATTGTCTAGGGTGTTGTGTACTTAGAAAGTAACAGCTCTAAGTACCTTTCCTACATTTTCTTTTTCTTTTTTTATTAAACAGGTCTCTTCAGTTTAATGCAAGAGAACATTTTACTGTTGTACAGTCATGTTCTGGTGGTTTGATAGTTTACAGGAGATTCCAAAATAAAAGGACTCTGGAAGGTTTTCATTGACGATGAATTGCCATAATATGATGCAAACTGTGCTTCTCTATGATAATTATAATACAAAGGTTCCATTCAATGCAGCATATACAATAATGTAATTTAGTCTAACACAGTTGACCCTATTTTTGACACTTCCATTGTTTAAAAAAAAACACATGAAAAAAAAACCCTATATGCTTACAGTGCACCTAGAGCTTTTTATAATAACCTCTTTTTGTTTGTTTGTTTTGGATTCTTTAAATATATATTATTCTCATTTAGTGCCCTCTTTAGCCAGAATCTCATTACAGCTTCATTTTTGTAATAATATTTAATTTAGATATTTTCCAAATATTGACCCTGCTAAAATAGAATATAGCATCTTCCATATGGTAGGAACCAACAAGGAAACTTTGCTTTAACTCCCTTTTTACGATTTACGGTAGGTAGCAGGGGGGAAAAATGCATTTATAGATCATTTCTAGGCAAAATTGTGAATCTCACAACCAACCTGTATGCGGTCTCTTTATTTTACTAGAAATGGGAATCATGGCCTCTTGAAGAGAAAAAAGTCACCATTCTGCATTTAGCTGTATTCACATATTGCATTTCTGTATTTTTTGTTTGTATAGTAAAAAAATCACGTAATAAACCATGCCGTGATGTTGTTGAGACTTAAACCACTGGATGTTGAGTTTATGAAACATTTGCATGAAAAAGTGAATATCATCCCACTTACTGCCAAAGCAGACACACTCACACCAGAGGAATGTCAACAGTTTACAAAACAGATAATGAAAGAAATCCAAGAACATAAAATTAAAATATATGAATTTCCAGAAACAGATGATGAAGAAGAAAAGAAACGTGTTAAAAAGATAAAGGACCGTTTACCTCTTGCTGTGGTGGGTAGTGATATTATCACTGAAGTTAATGGAAAAAGGGTCAGAGGAAGGCAGTATCCTTGGGGTATATATTGTGCTGTGATTTAGCTCCAGCAGTGCCATGTGCAACTGAAAAAGAATTTGGGAGCACGGCACAAAGAATTAGAGGAGAAACGTCGTCAGTTTGAGGATGAGAAAGCAAACTGGGAAGCTCAACAACGTATTTTAGAGCAACAGAACTCTTTGAGAACCTTGGAAAAGAACAACAAGAAAGGGAAGATCTTTTAAACTCTCTATTGACCACCAGTTGTGTATTAGTTGCCAATATGCCAGCTTGGACATCAGTGTTTGTTGGATTCATTTGACCAAGTTGCACCAGTTTGATCCATAATGATGGATTTAACAACATGACAAAAATGGAACAATCCAAAGTTTTAATCAAAGAAGGTGGTGTTTAGTTGCTGCTCAGGATAGTTGATACCTCAGGATTTGGAGATGCAGTGGATAGTAGTAATTGCTGGCAGCCTGTTATCGATTACATTGATAGTAAATTTGAGGACTACCTAAATGCAGa
>NM_001788.6
agtcgagcgagagcCTGTGGAGGAGTCCGCCTGCTGTAGCGTGCGTAAGCAAGGCAGCTACGCCGGGCGGCTACGCTGCGGAATCGGCGTAGGCGCCTTTGGAGAATCGGCGGGCTGCGCTCCGCTGGGGCTGGTCGCGGAGGGGGGGAGGGGATGTCGGTCAGTGCGAGATCCGCTGCTGCTGAGGAGAGGAGCGTCAACAGCAGCACCATGGTAGCTCAACAGAAGAACCTTGAAGGCTATGTGGGATTTGCCAATCTCCCAAATCAAGTATACAGAAAATCGGTGAAGAGAGGTTTTGAATTCACGCTTATGGTAGTGGGTGAATCTGGATTGGGAAAGTCGACATTAATCAACTCATTATTCCTCACAGATTTGTATTCTCCAGAGTATCCAGGTCCTTCTCATAGAATTAAAAAGACTGTACAGGTGGAACAATCCAAAGTTTTAATCAAAGAAGGTGGTGTTCAGTTGCTGCTCACAATAGTTGATACCCCAGGATTTGGAGATGCAGTGGATAATAGTAATTGCTGGCAGCCTGTTATCGACTACATTGATAGTAAATTTGAGGACTACCTAAATGCAGAATCACGAGTGAACAGACGTCAGATGCCTGATAACAGGGTGCAGTGTTGTTTATACTTCATTGCTCCTTCAGGACATGGACTTAAACCATTGGATATTGAGTTTATGAAGCGTTTGCATGAAAAAGTGAATATCATCCCACTTATTGCCAAAGCAGACACACTCACACCAGAGGAATGCCAACAGTTTAAAAAACAGATAATGAAAGAAATCCAAGAACATAAAATTAAAATATACGAATTTCCAGAAACAGATGATGAAGAAGAAAATAAACTTGTTAAAAAGATAAAGGACCGTTTACCTCTTGCTGTGGTAGGTAGTAATACTATCATTGAAGTTAATGGCAAAAGGGTCAGAGGAAGGCAGTATCCTTGGGGTGTTGCTGAAGTTGAAAATGGTGAACATTGTGATTTTACAATCCTAAGAAATATGTTGATAAGAACACACATGCAGGACTTGAAAGATGTTACTAATAATGTCCACTATGAGAACTACAGAAGCAGAAAACTTGCAGCTGTGACTTATAATGGAGTTGATAACAACAAGAATAAAGGGCAGCTGACTAAGAGCCCTCTGGCACAAATGGAAGAAGAAAGAAGGGAGCATGTAGCTAAAATGAAGAagatggagatggagatggagcaggtgtttgagatgaagGTCAAAGAAAAAGTTCAAAAACTGAAGGACTCTGAAGCTGAGCTCCAGCGGCGCCATGAGCAAATGAAAAAGAATTTGGAAGCACAGCACAAAGAATTGGAGGAAAAACGTCGTCAGTTCGAGGATGAGAAAGCAAACTGGGAAGCTCAACAACGTATTTTAGAACAACAGAACTCTTCAAGAACCTTGGAAAAGAACAAGAAGAAAGGGAAGATCTTTTAAACTCTCTATTGACCACCAGTTAACGTATTAGTTGCCAATATGCCAGCTTGGACATCAGTGTTTGTTGGATCCGTTTGACCAATTTGCACCAGTTTTATCCATAATGATGGATTTAACAGCATGACAAAAATTATTTTTTTTTTTGTTCTTGATGGAGATTAAGATGCCTTGAATTGTCTAGGGTGTTCTGTACTTAGAAAGTAAGAGCTCTAAGTACCTTTCCTACATTTTCTTTTTTTATTAAACAGATATCTTCAGTTTAATGCAAGAGAACATTTTACTGTTGTACAATCATGTTCTGGTGGTTTGATTGTTTACAGGATATTCCAAAATAAAAGGACTCTGGAAGATTTTCATTGAGGATAAATTGCCATAATATGATGCAAACTGTGCTTCTCTATGATAATTACAATACAAAGGTTCCATTCAGTGCAGCATATACAATAATGTAATTTAGTCTAACACAGTTGACCCTATTTTTTGACACTTCCATTGTTTAAAAATACACATGGAAAAAAAAAAAACCCTATATGCTTACTGTGCACCTAGAGCTTTTTTATAACAACGTCTTTTTGTTTGTTTGTTTTGGATTCTTTAAATATATATTATTCTCATTTAGTGCCCTCTTTAGCCAGAATCTCATTACTGCTTCATTTTTGTAATAACATTTAATTTAGATATTTTCCATATATTGGCACTGCTAAAATAGAATATAGCATCTTTCATATGGTAGGAACCAACAAGGAAACTTTCCTTTAACTCCCTTTTTACACTTTATGGTAAGTAGCAGGGGGGGAAATGCATTTATAGATCATTTCTAGGCAAAATTGTGAAGCTAATGACCAACCTGTTTCTACCTATATGCAGTCTCTTTATTTTACTAGAAATGGGAATCATGGCCTCTTGAAGAGAAAAAAGTCACCATTCTGCATTTAGCTGTATTCATATATTGCATTTCTGTATTTTTTGTTTGTATTGTAAAAAATTCACATAATAAACGATGTTGTGATGTAATATTGTGTGAGGTCTTAAATATCCTACAGTCGATGTACAAGAGTAGAGTATGTTTGGGAAGAAACTTTTCAGCTTAAGTTTGCCTCCTCTACAATGACATCTTTTATATGCTTGTCTCATTTAGAATGCATATGTGCTGATTTTCTAATTTAAGAGATACCATATCTCTCTATTCATTTCTATCTCTCATTTGTATGCTTATTTTTCTGAGAACAttttttttttcccccagacagggtcttgcttcattgcccaggctggagtgcggtggcacaaacacgacttgactgcagcctcaaccctctgggctcaagcagtcctcctgcctcagccccctgagtatctgggattgcaggcgtgcaccaccacgcctggctaatttttgtattttttgcagcctcccaaagttctgggattacaggcatgagccgtcatgcctggccTCTGAGAACAGTTTCTGACTCATTCAGATTAGGTATACTCTCAAGTCCCTGGAAACTGAAATTTTTTTTAACTGTAAAGAGGGTAGTGTCATTTCTTTTCTTAAGGTCAAGTGACATAGATTTTAATGTAATGCATAATTTAGGTAAGAAATTAATTAATGTAGCCTAGTTTATTATCTTGAAATGTTTTACCCTATTTACTTTTTAAAATTAATGACCTAAGCGGAGGGAATAATTATAAGTCAATAGCAGAGAGATTGTTGTTTGGGTGTTTATTTTTTTCAGTTTTTGTTTTGAGAGATTGGGTTAACACCTCTAGCCAAAATTGTTTGGTTTTAGGGAGGCTAACAATAACCTACTGAATTTGGAAAATGCAAAGGTAAAAAATGTATATAGACTGCCTGCTGAACTGGTTAAGTACTACTGCTTCTGGGAAATACTATTTCAAAATTCTATGTATTATAATAATAAATTTGTAAGACATTCATTATTCTACCATCCTAATGAAAACTTTCAGAAGTCTTTCTTTATCCATGGCATGCCCAGGGTTTTACCTGAATCTGATACAGGATCTATATAACTTTACTAGGACTTTTGATTGTTGACTCCAGGCTTAGGTATATCAGAAGGTTCTTTTTGCCATTTGGCCTGTGGATGTCTGAGAAGATCATTCACAATACATGTAAAATTCAGGTAGGCCTAAGGAAAGGCCAGCCTGTAGAAAGCAAAATGGCAGTGTCTGTTCTCCACTGTTGGAGGCATTATGTAATTTAAGTATCCTGTTAGCCACTGTCTTTCTGCTAATTAAGTGGGGCTGAACAAGTAAGCACTAATAATACCAGTGAACCACTTGGGCACCTTGTGGGTAGAGTTTTGCTGCCACCTAGTGGAATGGGATATCATTGCTTCCATATCAGGTTCACAAGCAAGTTAAGTGGGCACAGTTTATTTCTGTGTAGCTCAGGCTGTAATCTTGAAAGCTGAGGAGATACCCATGCCTCTCAGACTCATTAGCTGGGTGTCACATTACCACCTGCACATTCTGACCCACCGCATCTTAATATGTTTTGTCCTCTTGGAGAAACTAGGAGTAGAAGTCAGGATATGGTAGGTAAGGGGGAAAAAGGAAAGACGGCTTGATAGCTATGAATGCATGAGGAGCGAAATGTTGACTCAGTTATCTAGATCATGGTCTCCAAACCTGATGCTATTTCCTTACAAAAATATTTGTTGAGCATGTGTCCATAATTATATGTATTGAACAATGAAAATATGTGTCAACAAATGTACTGCTACACTAATGTGAACATTATGGAACAAAATTTGAAAGAGTGAAATAAAAGGTTTACACTTTCCCCAA

Publications

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