Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SNRPEP4
Plot displaying the genomic locations of a retrocopy (in chr19) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr19:5576507-5576951  UCSC
Coordinates (T2T) chr19:5563190-5563634  UCSC
Coordinates (hg19) chr19:5576518-5576962  UCSC
Strand -
Parental Sequence NM_003094.4
Parental seq. overlap 435 bp
Parental seq. overlap (%) 27.9%
Genomic Region Intergenic
Retrocopy Summary SNRPEP4, located on chr19:5576507-5576951, is a retrocopy of the parental gene SNRPE. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SNRPE
Full Name small nuclear ribonucleoprotein polypeptide E
Also known as HYPT11|SME|Sm-E|snRNP-E
Coordinate chr1:203861599-203871152
Strand +
Gene summary The protein encoded by this gene is a core component of U small nuclear ribonucleoproteins, which are key components of the pre-mRNA processing spliceosome. The encoded protein plays a role in the 3' end processing of histone transcripts. This protein is one of the targets in the autoimmune disease systemic lupus erythematosus, and mutations in this gene have been associated with hypotrichosis. Several pseudogenes of this gene have been identified. [provided by RefSeq, Jun 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SNRPEP11
Bonobo Pan paniscus SNRPEP12
Gorilla Gorilla gorilla SNRPEP11
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SNRPEP4
GTGAAATTCCACCATGGCGTACCGTGGCCAGGGCCAGAAAGTGCAGAAGGTTATGGTGCAGCCCATCAGCCTCATCTTCAGATACTTACAAAATAGATCGCGGATTCAGGTGTGGCTCTATGAGCAAGTGAATATGCGGATAGAAGGCTGTATCATTGGTTTTGATGAGTATATGAACCTTGTATTAGATGATGCAGAAGAGATTCATTCTAAAACAAAGTCAAGAAAACAACTGGGTCGGATCATGCTAAAAGGAGGTAATATTACTCTGCTGCAAAGTGTCTCCAACTAGAAATGATCAATGAAGTGAGAAATTGTTGAGAAGGATACAGTTTGTTTTTAGATGTCCTTTGTCCAATGTGAAGATTTATTCATATTGTTTTGATTACCGTTGTGTTACTACAAGATGGCAATAAATACTATGGGATTGTTTGTGTTAAAAa
>NM_003094.4
CTTTATTCCGGAAGTTGCTCTCAGAGGCAGCGTGCGGGTGTGCTCTTTGTGAAATTCCACCATGGCGTACCGTGGCCAGGGTCAGAAAGTGCAGAAGGTTATGGTGCAGCCCATCAACCTCATCTTCAGATACTTACAAAATAGATCGCGGATTCAGGTGTGGCTCTATGAGCAAGTGAATATGCGGATAGAAGGCTGTATCATTGGTTTTGATGAGTATATGAACCTTGTATTAGATGATGCAGAAGAGATTCATTCTAAAACAAAGTCAAGAAAACAACTGGGTCGGATCATGCTAAAAGGAGATAATATTACTCTGCTACAAAGTGTCTCCAACTAGAAATGATCAATGAAGTGAGAAATTGTTGAGAAGGATACAGTTTGTTTTTAGATGTCCTTTGTCCAATGTGAACATTTATTCATATTGTTTTGATTACCCTCGTGTTACTACAAGATGGCAATAAATACTATGGGATTGTTTGTATTAAAAAATTTACATTGCTTCTTACTATTCAGCAGTAGAAACTTTTTACACAGTAACACCATTCGTTGCTGGTATTTAGTTTTCTGAAGGGTCGCAGTTGCCTTGAGCACTTGGTATTCGCAGAGCTTGGACCTGTAGATTTTGAGGCAGATTAGGAATTCTGCCTGATGGGTAAGCTTCCAGTATTGGGAGGTGGAGAAGGGGAGGGTTCAGAAAAATAAATAAGAGTTATTGCACTAACAAAAGTCTTCATCACTTGTAGTTCTGGATGCTGGAATACCAGAGTTTCTAACCTAAATATGTTGGGTACATTATTTAATGGGGTCAGTATTGCTCAACACTCTCATTGAGTCACTGTGAGGTCTTTGTGAATTTTATCGCTAAGATCAGAATGTGAGAAGTATTTGGATATAGGGAAAGAATGAAGTGCCTTTCAAGTACATTAAAAATCAGTTAAGAGTTTACAGGAAAGAGACTGAGATTGGTAATCTGAAAAGGACCACAAGCATAGCTGGTAGGCAAATTGTTAGGCAGAATAATGGTATGTTGGAGAAATACACCTGTCTCTTATTCTTATCTCTTAAGAATTTTGGTTCTTCCCCCAGTGATTGCTGGTTGAATTCTTATATGGACAGGTTTCCCTTCCCCCAGTATCGCACATGGTTCTAGTTAGAATCCTGTTAGATAGTGAGCATCTGCTGTTAGCTAGACACTGTTGAATCAATACAGTGAAACAGACAGGTAAGCAGGTGGTTTTAATGCCTCATTCTAAGTGCTATTTAAATTGGATCTTGAAAGATGAATAAGGCCTGCCTTAAGTTCTGCTAAAGGCCATGTTGTTATTAAGGACGGGTGAGGAAGGACCAAGAAGTCTGGCTCCTGCTTTTCTACATGCCTGTGAAGGAGACTTTTCATGAAACTGAATAAAAGAAATCCTTTCCGAGATAGAGGAGATTTGTAGGTGAATGCAGAAGTGTATCCAGCTTTGAACCATGCATTCCATCTATATTCCTCCTGTCTGAACTCATGCTCTTTTGATTATGTTTTGAAATAAAGGGCTGCATTAGTTCTTTTAA

Publications

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