Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SVIPP1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:97490535-97491058  UCSC
Coordinates (T2T) chr1:97338392-97338917  UCSC
Coordinates (hg19) chr1:97956091-97956614  UCSC
Strand +
Parental Sequence NM_001320340.1
Parental seq. overlap 420 bp
Parental seq. overlap (%) 12.6%
Genomic Region Intragenic (DPYD)
Retrocopy Summary SVIPP1, located on chr1:97490535-97491058, is a retrocopy of the parental gene SVIP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SVIP
Full Name small VCP interacting protein
Also known as -
Coordinate chr11:22812429-22829865
Strand -
Gene summary Endoplasmic reticulum-associated degradation (ERAD) is the pathway by which misfolded proteins in the endoplasmic reticulum are targeted to the proteasome for degradation. Multiple specialized proteins interact with one another during ERAD to complete this process. The protein encoded by this gene is an inhibitor of ERAD, functioning to disrupt the interaction of these protein components. This downregulation of ERAD may be needed to protect the cell from overactive protein degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SVIPP1
Bonobo Pan paniscus SVIPP1
Gorilla Gorilla gorilla SVIPP1
Orangutan Pongo abelii SVIPP1
Gibbon Nomascus leucogenys SVIPP1
Green monkey Chlorocebus sabaeus SVIPP1
Crab-eating macaque Macaca fascicularis SVIPP1
Rhesus Macaca mulatta SVIPP1
Baboon Papio anubis SVIPP1
Golden snub-nosed monkey Rhinopithecus roxellana SVIPP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SVIPP1
GAGGCTGCAGAGAGAAGGCAAAAAGAGGATGCATCTCAGGGAATGTTGGATGTTTAATCTCTAGAATaTTGGTACATCTGGGCCCCCACCAGAAGGTGAACTTAGGTGTACAGTTTCAAGAAGCATAACATGAGTGGACAAGTCTACTGCCAACAACTGGTTAATATCTGCAATCAGGTGGAATTCCTCAACTTAATTTCTTCTCTGAATAAATTAAGATTCAGACTTTGTAATACTATTGCCCTGAAATGTAATGCTAAAAAAAAAAACCAAAAAACTGATTTTCAAGCTTAGAAGATGGCTACACCTTTCACTAAATACTTATTTTACTACATTTGCTCTTCTGCAGTAAGCTACTGATTTGCTATTTTTCTTAGTATTTAAAAGATGTAACTAAATAGTGAATATATACATTGCATATAAAATTCTGCATATACTTCTAAGATTAAAATTTGCAATTGTATTTCCATCTCTCATAAAATGATCTAA
>NM_001320340.1
GCGAGGACGGGTGGACGCGTCAGGAGGGTCGTTGGGTCCTGTCAGAGCGACCTAGGCCGTCGCCTCCGTGTAGATCTCCACTTTTGTAACAAAAAGTTGTCGAAAGGCGGCTGTGGCGTCTTTCTACCTTCCACTGACTTTAGCTGCGCCGGATCTTCATAGGGCGCCGGCGCACGCAGAGGGCGTTACGCGTGGGACATTCCGGGGGATGTGGTAGATGGAATTCGGCGCGAAAAGACATTGCTTTCTCCGGGAGCTCTTTAGTCGTCTAGGAGATGAAGAGAAAAGAGCAAAGCTTGCAGAGGCTGCAGAGAGAAGACAAAAAGAGGCTGCATCTCGGGGAATTTTAGATGTTCAATCTGTGCaagaaaagagaaagaaaaaggaaaaaatagaaaaacaaaTTGCTACATCCGGGCCCCCACCAGAAGGTGGACTTAGGTGGACAGTTTCATAAAGCATAACATGAGTAGAAGAATCTACTGCCAATAACTGTTTATTATCTGCAATCAAGTGGGCTTCATCAATTTAATTTCTTCTCTTTGAGTAAATGAAGATTCAGACTTTGTAATATTATTGCCCTTAAGTGCAATGCTAAAAAAACGTTGATTTTCAAGCTTAGAGAATGGCTAGACTTTTCATTAAATACTGATTTTCCTACATTTGCTCTTCTGCAGTTAGTGGGTGATTTGCTATTTTTCTTAGTAGTTAAAAAATGGAACTAAATAGTGAATATACATACACTGCATGTAAACATTCTGCATATACCTCTAAGATTAAAATTCGCAGTTGTCTTTTCATCCTTTATAAAATGATCTAACTACTTATATTTGTGCTGCATCGCGTTACATCTGTTTTTATTTCACTATGAAGATGTTTGATTAAACTTATGGACTTAGTGCCTTTAAACTGATCATCAGGGAGAATCTTGAAAAAATCATTTGAAGGGCTGATGTGAAGGAGCACTGTAAATTTTTATAACTTAGTAATGAGTATTCTTAGGCAGATGTAAAATTTTTTCCAATTTATTTTTATTTATGTAGCTTATAAAATTAACATACCCTGTTTTACTTTATGATAAAGGATTTTTTGTTTGCTGAATTTAAAATTATATATTAGTGATACCATCAGAGGGCAGTGATGTTCTATTGTATATTAAATTCAGCTCTGTAAGGATCTTTGTAGTAATTGAATGAGTTAAACTAATAATCTGGATGGGTTATAATGAGTAGTAATATATTTGTCCATATTTCATAAGTAGTGTTAATCTTGTGTACTTATTAGAGAACGATCATAAGATTTATACAGATGTGAAACTGCGAAGGCAAGTATGAATGTATGAAAAAAACATGTAGGTACTGTACTTACAAAAGGTCTACTTCAGATATAAAAATATTAGGTAATTCTATACAATGCATAGTCATAAACCTTAACATTTTTGTTCATTAGAAACATGAATTTTATAGCATTTTTTGTTTCTCCTATATAATACACTGAAATAAAAGAATTTGTGTTAGCTATTAAGGCTGATAGCTCTTTTAAATGGCAAGGCCACATGTTGAGCCCTAAATTAAAATTTGCAGATATTAAGTGCTAATAGAAATTTTAAGTTAAATCGACCAAGTTCACTTGCTTTACACAAAGGAAACTGAGCCACTATCTTCATCTACCCCTCCAACAAAAATTATGTTATACTGCAGTGTATTGTACATGTTAATTTTTAAAAGTTTGAACTATTATATAATACAGGTCTCTTGACTTCTCATGGAAAAATTATTTTTTCTATTATGGTGTGAAATATTGTGTGAATATCTAGGCAAAACATAACAATTTGGCTCAATTTTCTTCTTTAGAGGATTCGTGCTGTTTTTGTTCATAAAGGGTAGTGAAATCATTGAACTATATTTTAGAATGAAAATTTTTGATTTTATTAAAATGATTTTTTCAAGGCAGAAAGTAAAAGGAATGATTGATAGCGGAGTGCATATAGAGCTAGAGCATATCATCCTTGAACTCTGCAAATCCTTTCTTCCATTTTAATATAGCAAGAACAATTTTGTCTTTACTACATCTTAAAGAATTAGAACTTGGGTTGGTGTAAGTGACTTACTTCCAGGGAATCATGCCCTATTTCTACCAGCAGGTCATACCCAAATGTCACACTATCTATTGTTAACCATGAATGATATTCAGATCTATTACTTTTCGTGAAAAGTGGAACATGTTACTTCCAACCATGGCCTGTCACCGTGAGTGTGATCAGCTTTCTCCAAAACCACATGGGTCGCAGGAGCTAAGGGGTGGTACCCAAATGTTAGGAACAGTGTTAGGAAAGGGCAAGGGAAAAGAAGTGACTGGATGTCTTATGAGAAACCGGTAAATGACTAAAAAAAAAAGCAAATGACTAAAAACATGACTAAAAAATtatatatatatataatatatatattatatatgtgtgtatatatataCACATAATATCTGCAAATTCTAATTTATATATGTGTGTGTATATacacacacacacatgcacatacacacatacGTCCAGACATCTCCCTCATAAAATAACCATCAGTTTCTATGAAAACCTTAAGTGGAAGCCAATTTCCCATAGTAAATAATTTAGGAGAAAATTATAATGCTTAAAATGTTGCTCAAACCCCTGACCTATTACTAAACTATAATTGGAACAGTAAAATGCATATATGTAACTATCATATCATGATTTAAAATTGCTTAAACCATTGCTGCTTAATACTAATCAAACTTAACGGCTGCTAACAAAAGTTGTGAATTATTACACGGCCTCTTTGTAACGTGCTGCATGTTTTTTAAAACATCTCTGTGTTTCTGTTTGTTCCACTGCTGGTATTTGGAATGTAATTTAACAGTTCTCACACATGGTTTGGTTATAAATTCTGTATTGCCTTTTAGGGATATAAATATACATTTTTTTCTATGTAAAAATTAGCTTTAGCTGTCTCTTTAACAAAATTTTATCTTTACTACATCCTAAATACTTAGAACCTGAGTTGGTGGTTAGGGAAACCTCAGGAACATTTTAATCACATTGGGATTCAGAAGAGCAACAGAACCAAAGGTTGTTTGGTGTGTTCATACAATCCCTGGATTTATAGGTGGATTTTCTATAAAGGAAAAATGATGTAATTAGTATCCTGTTTTTTCCTAAAGAAATAATACTATCATAAAAATTCTGTCTATCCTTTGTACCCCAGGAAAATGGACATGAACTTTGAATTTTCCCTTTCTCCAAATGTTTGACTTTTTATTTTCACTGATAAGCATTATG

Publications

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