Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name AIMP1P1
Plot displaying the genomic locations of a retrocopy (in chr20) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr20:14127397-14128338  UCSC
Coordinates (T2T) chr20:14176653-14177594  UCSC
Coordinates (hg19) chr20:14108043-14108984  UCSC
Strand +
Parental Sequence NM_001142416.2
Parental seq. overlap 779 bp
Parental seq. overlap (%) 28.1%
Genomic Region Intragenic (MACROD2)
Retrocopy Summary AIMP1P1, located on chr20:14127397-14128338, is a retrocopy of the parental gene AIMP1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name AIMP1
Full Name aminoacyl tRNA synthetase complex interacting multifunctional protein 1
Also known as EMAP2|EMAPII|HLD3|SCYE1|p43
Coordinate chr4:106315544-106349456
Strand +
Gene summary The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes AIMP1P2
Bonobo Pan paniscus AIMP1P2
Gorilla Gorilla gorilla AIMP1P2
Orangutan Pongo abelii AIMP1P2
Gibbon Nomascus leucogenys AIMP1P1
Green monkey Chlorocebus sabaeus AIMP1P1
Rhesus Macaca mulatta AIMP1P2
Baboon Papio anubis AIMP1P2
Golden snub-nosed monkey Rhinopithecus roxellana AIMP1P2
Marmoset Callithrix jacchus AIMP1P1
Crab-eating macaque Macaca fascicularis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>AIMP1P1
TGCTTCATGATTTTCTGTTGTCTCTTGGCAAAAATGGCAAATAATGATGCTGTTCTGAAGAGGCTGGAGCAGAAGGAGGCAGAGGTGGGTCAAATCATTGAATATCTTAAGCAGCAAGTTGCTCTACTTAAGGAGAAAGCCATTTTTGCAGGCAATTTTGAGGGAAGAGAAGAAACTTTGAGTAGGAAACTGAAGGAAGAAGTTGAATTGAAACAAGAGCTAATTCAGACAGAAATTCAAAACAGAATGAAGCAAATACCATTTCCATCTGGTATTCCACTGCATGCTAATTATGTGGTTTCTGAACGTGATACAATCTACACCAGTAACAACCACATCTTCTGGTATCAAaAACAGCAATCAATAGCAGGAAGCACCAACTCTAAGCCAATAAATGTTTCCCAACTAGATCTTTGAATTGGTTGCATCATAAATGTCAGAAAACACCCTGATGCAGATTCTTTGTATGTAGAAGACGTAGTTGTTGGGGAAATAGTCCCAAGAACAGTTGTCAGTGGTCTGGAGAATCATGTTCCTTTTGAACAGATGCAAAATCAGATGGTGATTTTACTTTGTAACCTGAAACCTACAATGATGAGGGGAGTATTATCTCAAGCAGTGGTCATGTGTGCTTGTTCACCAGAGAAGGTTGAAATCTTGGCCCTTCCTAATGGAGACAATTACTTTTGATGCTTTCCCTGGAGAGCCCAACAAGGAACCAAATCCTAAGAAGATTTGGGAGCAGATCCCACCTCATTTTTATACTATGATGAGTATGTGGCTATATACAAAGGAGCTCCCTTTGAGATGAAAGGGAAGGGAGGGTGTAGGGTTCAAACTATGAACAACAGTGGAATAAAATAAAA
>NM_001142416.2
GCTTCCTGCTGTGGCTGTCTCGGAACCCGTGGTCCTCCGCTTCATGATTTTCTGCCGTCTCTTGGCAAAAATGGCAAATAATGATGCTGTTCTGAAGAGACTGGAGCAGAAGGGTGCAGAGGCAGATCAAATCATTGAATATCTTAAGCAGCAAGTTTCTCTACTTAAGGAGAAAGCAATTTTGCAGGCAACTTTGAGGGAAGAGAAGAAACTTCGAGTTGAAAATGCTAAACTGAAGAAAGAAATTGAAGAACTGAAACAAGAGCTAATTCAGGCAGAAATTCAAAATGGAGTGAAGCAAATACCATTTCCATCTGGTACTCCACTGCACGCTAATTCTATGGTTTCTGAAAATGTGATACAGTCTACAGCAGTAACAACCGTATCTTCTGGTACCaaagaacagataaaaggaggaacaggagacgaaaagaaagcgaaagagaaaattgaaaagaaagGAGAGAAGAAGGAGAAAAAACAGCAATCAATAGCTGGAAGTGCCGACTCTAAGCCAATAGATGTTTCCCGTCTGGATCTTCGAATTGGTTGCATCATAACTGCTAGAAAACACCCTGATGCAGATTCTTTGTATGTGGAAGAAGTAGATGTCGGAGAAATAGCCCCAAGGACAGTTGTCAGTGGCCTGGTGAATCATGTTCCTCTTGAACAGATGCAAAATCGGATGGTGATTTTACTTTGTAACCTGAAACCTGCAAAGATGAGGGGAGTATTATCTCAAGCAATGGTCATGTGTGCTAGTTCACCAGAGAAAATTGAAATCTTGGCTCCTCCAAATGGGTCTGTTCCTGGAGACAGAATTACTTTTGATGCTTTCCCAGGAGAGCCTGACAAGGAGCTGAATCCTAAGAAGAAGATTTGGGAGCAGATCCAGCCTGATCTTCACACTAATGATGAGTGTGTGGCTACATACAAAGGAGTTCCCTTTGAGGTGAAAGGGAAGGGAGTATGTAGGGCTCAAACCATGAGCAACAGTGGAATCAAATAAAATGCTTCCACTACCAAAAGACATTAGAGAAAACCTTAAAAGTAATAAAGAGAAATATATTTGTCACTTATACCTAAAATATGAGTGGCTCATTTTTGCATTACTCTCTTCTAGACTTGACTAGTCATTTACTTGGTATATATTGTTTTCATTGATTGGGGAAACACTAGATTTTTACCTCGGTTTTTGATCATTTATAATGGAGAGAGGAAGTTGCCTATGTTTTGTAATAATTTATTTTTTAGCAGGAATATTGATTAGCAGCTTTTTTTTCTTTATACACATAGATAACTAACTAGATTAATGTTTAGTTTCTTATTTGTAGGCACAGGATGCATGAAATTTCAAGCTCTGGGATTTTTTGTATATTGTGTATCTGTATCAAAAATATCCTCTCCTTTTCAAAAATGACAGGTTGGAAAATGTTTGTCAGACTTATTAACTGGTCATATTATAATAATACTGATAATGACCAACTGCTCATTCTGAAAGCCAAACATAAAAGCTAGGAGAAGTGGCATCTGAACATTTTTGCTTTGCTGCCAGAGTAACCCTGACTAATAATACAATAACAGCAATTTTTTTAAAAAACTGAGATTTCCTACTGGCTTGAAGTTTTTCTATTTAGCAAAATAATTAGTAATAAGTTTTGACTAGGTCTAAAGAATGAACACATTGTAAACAGTTGCCACAGTAGTTTCTAATAAATTGATCATAAAAGCAGCTATCCTTTTTTTTTTTAATTCTAGCTTCTTTTTAAAGATTATTTGGGTACCTAATAAAGGATAATTTATATCTTATTACAGACTGATATTTTGCTTTTTCATGTGTCATCATACTGTCAGTATATTAAAAGAAATTACAGCCTAAAACTTAACATATACCATACATATATATTAAGGTGTCAAATAGCTATTCTCACTCATCTTACAAATATTGTAAGAGCAATAAAAATTAATTGAGGAATTATAAGCCTACAGGTCATCAGCCTTGAGGTGATTACTGATGATTTGGGCTTACACACATGTCAGCAAGATAGggagtgtggataggggagggctggtagctaacaaggggcctcacagagaaatattagtgactttaaccaggtttcagaatctgggccttacctttacaggttcaACAAAAGAATGGCATCAATAGAGGCAGAAGTATAGACATTGTTTTAAAAATACACACATGCACACACACACAAAACATTTTAGCATTATAGCTGTCTGAATCCTTCAATAAGAAGGAGAGGcacacacaaatacacacactcacacaaaactcaacaaccataaaacaaCCCTGCATGTTATAAAAGGCAGAATTAAATTTTATTTATTTAAATCCATGGAACTCTGGTAGGCCAGGATATATTATAGTACCATTATCAATGTGATATTCTGAAAATATGAACTGAGCGTCATTAACAATTGTTGGTACCTAAACACAAAATGAATTTCAAAAGTTACTTTGTTCTCAAGATATGTCATTCTTTTGGGAATAAATACTTCTGGTGACAAAGTCTTTTGTGAGTTTTTTGCTCTAATTTTTCTCaattatattaaatttctttaatataatttaaataatattTCAACTACCTAGGTAGTTGAAATTTTCCCAACTAAATGTTGAAATACTGTACCCCAGATCAAATTATCTAATGTTTTGTTAGTGAAACCTAAACTGATGATTAAATCGTTCATCAAACCTAGAGATAATAAAAACTATTGGTCTTTTGTTAAAAGCCCA

Publications

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