Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PSMD10P1
Plot displaying the genomic locations of a retrocopy (in chr20) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr20:50913733-50915155  UCSC
Coordinates (T2T) chr20:52684331-52685753  UCSC
Coordinates (hg19) chr20:49530270-49531692  UCSC
Strand +
Parental Sequence NM_002814.4
Parental seq. overlap 1260 bp
Parental seq. overlap (%) 85.1%
Genomic Region Intragenic (ADNP)
Retrocopy Summary PSMD10P1, located on chr20:50913733-50915155, is a retrocopy of the parental gene PSMD10. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PSMD10
Full Name proteasome 26S subunit, non-ATPase 10
Also known as dJ889N15.2|p28|p28(GANK)
Coordinate chrX:108084207-108091542
Strand -
Gene summary This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PSMD10P3
Bonobo Pan paniscus PSMD10P3
Gorilla Gorilla gorilla PSMD10P3
Orangutan Pongo abelii PSMD10P3
Gibbon Nomascus leucogenys PSMD10P2
Green monkey Chlorocebus sabaeus PSMD10P1
Crab-eating macaque Macaca fascicularis PSMD10P2
Rhesus Macaca mulatta PSMD10P2
Baboon Papio anubis PSMD10P3
Golden snub-nosed monkey Rhinopithecus roxellana PSMD10P3
Marmoset Callithrix jacchus PSMD10P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PSMD10P1
CGGGTGTGTGTCTAAACTTATGGTCTGCAACTTGGCCTACAGAGGGAAGCTGGAGGAGGTGAAGGAGAGGATTCTGGCCAATAAACCCCTGGCTATGAGAACTGACCAGGACAGAAGTGCATTGCATTGGGCATGCTCAGCCATACATACATAAATTATTGAATTTTTGTTTCAACTTGGAGTGCCAGTGAATGATAAAGACTATGCGAGATTGGTCTCCTCTTCAGACTGCTGTTTGTGCTGGCCAGAATGAGACTGTAAAAGCCCTTCTGGGAAAAGGTGCTCAAGTGAATGCTGTCAATCAAAATGGCTCTACTCCCCTACATCATGCAGCTTCCAAAAACAGGCATGAGATTGCTCTCATGTTACTAGAAGGTGGGGCTAATCCAGATGGTAAGGATCATTATGAGGCTACAGCAAAGCACCAGGCCACAGCCAAGGGTAACTTCAAGATGATTCATATCCTTCTGTACTACAAAGCATCCACAATCATCCAAGACACTGAGGGTAACACTCCTCCACACTTAGTCTGTGATAAGAGTGGAAGAAGCAAAACTGCTGGTGTCCCAAGGAGCAATATTTACATAGAGAATAAAGAAGAAAAGAAACCCCACAAGTGGCCAAAGGTGCCCTGGGTTTAGTACTCAAGAGAATGGTAGAAGGTTAAACAGCTTGGATTTCTTCTTACTTTCTATGTTGTGATGCTGTCCCCAGTGTCCTGGAAACTAACATACTTGGGCACAGGACATCATCTACAAATGTTTTCTCACCTTCAAAGTCTTATAAACATGTTGACTATTGTTCCTGCTGAGGTTCTTATTCTAAACTTACGGCTTGCTTTCTGGGCACTGAGTAACTGCTGACTGTTCTACTGTTGTCACATATTCTTGTATACTGAATTTCGGCTAATTCTGAGTAAGTGATTCCGTGGCTGTTGTTAATCTTCAGCAACCTCCGAGCATGCACCTTGTATCAGTCTCTGAAATAGAATAGCTCCAATAGCAACAGGCTAGTCGTTCTGCTAGATGGTTCTAGGTGGACTCCGTGATGTTCCTCCATACAGTTAAACATCCTAACTTGTTTCTCAAGCTCACTCAGGCCTATGCCAGACAGTTGTTTTTTTCCCCAACCATGAGATTTTATTTTTGTGATAGGAGGAATATTTACGTATTTCAGTGGACCAAATTTTAAGTTGGGGGTTGTGCTAGAAAATAATGAAAAACAACTTCCCATGTACACGTGTATTTTTTTTTTGATGAGCTATTTGCCAAGATAAAACGTATGGTTTTTTAAAAAGGAAGTTTTAAAGTACCTATATCGAGTCAGCTTACATTGAAAAAATGTCAAGCTTGTTAAAATGATTATGTAACAAAATGTATTCTGATTTGTATTTCAGAAACTAAAAAATAAAATGTTGAAAGAA
>NM_002814.4
AAGTAGTTGCTGGGACAGCGAAATGGAGGGGTGTGTGTCTAACCTAATGGTCTGCAACCTGGCCTACAGCGGGAAGCTGGAAGAGTTGAAGGAGAGTATTCTGGCCGATAAATCCCTGGCTACTAGAACTGACCAGGACAGCAGAACTGCATTGCACTGGGCATGCTCAGCTGGACATACAGAAATTGTTGAATTTTTGTTGCAACTTGGAGTGCCAGTGAATGATAAAGACGATGCAGGTTGGTCTCCTCTTCATATTGCGGCTTCTGCTGGCCGGGATGAGATTGTAAAAGCCCTTCTGGGAAAAGGTGCTCAAGTGAATGCTGTCAATCAAAATGGCTGTACTCCCTTACATTATGCAGCTTCGAAAAACAGGCATGAGATCGCTGTCATGTTACTGGAAGGCGGGGCTAATCCAGATGCTAAGGACCATTATGAGGCTACAGCAATGCACCGGGCAGCAGCCAAGGGTAACTTGAAGATGATTCATATCCTTCTGTACTACAAAGCATCCACAAACATCCAAGACACTGAGGGTAACACTCCTCTACACTTAGCCTGTGATGAGGAGAGAGTGGAAGAAGCAAAACTGCTGGTGTCCCAAGGAGCAAGTATTTACATTGAGAATAAAGAAGAAAAGACACCCCTGCAAGTGGCCAAAGGTGGCCTGGGTTTAATACTCAAGAGAATGGTGGAAGGTTAAACAGCTTGGATTTATTCTTACTTTGTATGTTGTGTTGTTGTCCCCAGTGTCCTACAAACTAATGTATTTGTGCACAAGACATCATCTATGAATGATGAAGTTTTCTCACCTTCAAAGTCTTATAAACATGTTGACTCTTGTTCCTGCTGAGTTACTTGTTCGAAGCTTACAGCTTGTTTTCCAGGCATCGAATAACTGTTGAGATTGTTCTACTGTTGTCGTATATTCTTCTATATTGAATTCTGGTTAATTTGGAGTAACTAATTCTGTGGCTGTTGTGAGTCTTCAGCACCCTCCCATGTACCTTATATCCCTCTCTGAAACAGAACAGCTCCAATAGCAACAAGCTAGTTGTTCTGCCAGATGTTTCTATGTGGATTCTGTAATGTTCCTCCATACAGTTAAAACATCCTAACTTGTTTTTCAAGCTCACTCAGGCCTACGCCAAACGTTTCTGTTTTTTTTAACCATGAGGTTTAATTTATTTTTGTGATAGGAGGGATATTTACATATTTTAGTGGACCACATTTTAAGTTGGATGGTGTGCTCTAAAATACTGAAAAACAATAGCCCATATACCTATGTATTTGTTTTTGATGGGTTGTTTACTCTGAAATAAAATGTATGGTTTTCTTAAAAGGAAGTTTTAAAGTACCTATTTTGTGTCATCCTGTATTGAAAAGAATGTCAAGCTTGTTAAAATGACATGTAACAAAAATGTATTTTGATTTGTATTTCAGAAACTAAAAAATAAAATGTTGAAAGAA

Publications

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