Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPL27AP4
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:106304861-106305172  UCSC
Coordinates (T2T) chr2:106765673-106765984  UCSC
Coordinates (hg19) chr2:106921317-106921628  UCSC
Strand +
Parental Sequence NM_000990.5
Parental seq. overlap 259 bp
Parental seq. overlap (%) 5.7%
Genomic Region Intergenic
Retrocopy Summary RPL27AP4, located on chr2:106304861-106305172, is a retrocopy of the parental gene RPL27A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPL27A
Full Name ribosomal protein L27a
Also known as L27A
Coordinate chr11:8682792-8689872
Strand +
Gene summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Gorilla Gorilla gorilla RPL27AP2
Orangutan Pongo abelii RPL27AP2
Green monkey Chlorocebus sabaeus RPL27AP6
Crab-eating macaque Macaca fascicularis RPL27AP7
Rhesus Macaca mulatta RPL27AP8
Baboon Papio anubis RPL27AP6
Mouse lemur Microcebus murinus RPL27AP1
Horse Equus caballus RPL27AP4
Egyptian rousette Rousettus aegyptiacus RPL27AP6
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gibbon Nomascus leucogenys Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPL27AP4
ATGCATCACCACAAGATCAACTTCCACAAATAACACCCAGGTTCCTTTGGGAAAGTTGGTATGCGGCATTACCACTTGAAGTGGAACCAGAGCTTTGCCCGAACGACTGCCCTACTGTAAACTTTGATAAATTGTGGACCTTGGTCAGTGAGCAGACATGGGTAAATGCTGCCAAAACCAAGACAGGAATTGGTCCCATCATTGATGTGGTGTGGCCAGGCTTCTACAAAGTTCCAGGTAAGGGAAAACTGCTAAAGCAGCCTGTCATCATGAAGGTCAAATGCTTCAGCAGAATTGCTGAGGAGAAGATTA
>NM_000990.5
CTTTTTCGTCTGGGCTGCCAACATGCCATCCAGACTGAGGAAGACCCGGAAACTTAGGGGCCACGTGAGCCACGGCCACGGCCGCATAGGCAAGCACCGGAAGCACCCCGGCGGCCGCGGTAATGCTGGTGGTCTGCATCACCACCGGATCAACTTCGACAAATACCACCCAGGCTACTTTGGGAAAGTTGGTATGAAGCATTACCACTTAAAGAGGAACCAGAGCTTCTGCCCAACTGTCAACCTTGACAAATTGTGGACTTTGGTCAGTGAACAGACACGGGTGAATGCTGCTAAAAACAAGACTGGGGCTGCTCCCATCATTGATGTGGTGCGATCGGGCTACTACAAAGTTCTGGGAAAGGGAAAGCTCCCAAAGCAGCCTGTCATCGTGAAGGCCAAATTCTTCAGCAGAAGAGCTGAGGAGAAGATTAAGAGTGTTGGGGGGGCCTGTGTCCTGGTGGCTTGAAGCCACATGGAGGGAGTTTCATTAAATGCTAACTACTTTTTCCTTGTGGTGTGAGTGTAGGTTCTTCAGTGGCACCTCTACATCCTGTGTGCATTGGGAGCCCAGGTTCTAGTACTTAGGGTATGAAGACATGGGGTCCTCTCCTGACTTCCCTCAAATATATGGTAAACGTAAGACCAACACAGACGTTGGCCAGTTAAACATTTCTGTTTATAAAGTCAGAATAATACCTGTTGATCACTGAAAGGCCTGCATGTATTGTACTCTGAATTTTACAGTGAATGAGAGAATGTACCCTAATTGTTCAACAGGGCTCAAAAGGAAAGATTCCATTTTGATGGGTCACATTCTAAAGAGGGGCAGTGTGATAGGAATGAGATGGTCCTTTAGGACTTAAGTTCTCAGCCCAAGGTTTTTCCACGTGGCCCCCTCATCttttttttttttttaaacggagtctctcttgccaggctggagtgcagtggcacgatctcggctcactgcagcctccgcctcccaggttaagcgattctcctgcctcagcttcctgactaactgggattacaggcgcccaccaccatgcccagctaatttttgtattttcagtagagatggggtttcaccatgttggccatgctggtctctaactcctaacctcaagtgatctgcccacatcggcctccaaaagttctgggattatagtgtgagccactgcgcccggccATGGCTCCTTAATCTTGatccaaattattgttacatccagaatgtgatgaatcaaaatctcgagatgggggtccagcaatctgaaatttcagtatgccAGGGCTTTTCTGTATGTCAAAGTGGGTTTGAAATAGTTAATTTTTCTTCTAGTCTGAAATGTATCGGGAAAATTTGGAAATCCTGAAGGCTGGAAATTGAAATAAGTTTTTCTAGGATTTGTGTCTCTTGCTATTGGAAAACTGATGGTGACCAATTCATGTTTACAAATAAGATCCTCATAGATCTCGGTAAATTATAATTTGCTACAGTTTTATGGTTCTTCCTGTGATTTTGAGCTTTTTTTGACCCAAAATAATACAGTCTAAAACTATAGACAAATAAGATGGCACTTAGACTCCTGGGTTTTAGTTAGTGGAGGTTTCCTTAGTGCACTGTGGGGTCATAATAAGCCGAGAACCATGGCTGTCTATGGGACACATCTGTCAGGACAACCTTTAGAGGATGTTGGGGATCAAATAGAAGGCACAGAGAAGCACTGAATTGGCTTACATAAGAATAGGCTAGAATTACAAGTAGTGAAACCTCGATTCAGCTGGACAATTTTAAACAAATGTATCATTTGGCTTGTATCTTCTGTTGTGCTGGAGAAGTTAGAAATAAGGGCTCtccagaccagcctgaccaacctggagaaaccttgtctctactaaatacacaaaattagccaggcgtggtggcacatgcctgtaatcccagctactttggaggctgagccaggagaatctccaggaggcggaggttgctgtgagccgagatcgtgccattgcactccagcttgggcaacaagagtgaaactctgtcCACCCCCCCCAAAAAAAGTAAGGGCTCTCCATTAGGGCCCATAGAGGACTTGTAATATGGAACCTGAATCCAAGGATCCCACAATAAGTGGTCAGTAGTTCATGATGAATTAAAAGACTCAATATTTGGTCTTCACCCAATACCTGTGTGActtttagtcctaatttcctcatctttaaaatttcagtgaaagtgcctacctgaggattgtgtagattaaaatggaaaccgtgcacttaattttttgttttgttttgagacggagtctcgctctgtcgcccaggctggagtgcagtggtgcgatctcagatcactgcaagctccgcctcctaggttcagaccattctcctgcctcagcttcccaagtagctgggactacaggcgcccgccactgcgcccggctaattttttgcatttttagtagagacagggtttcaccgtgttagccaggatggtctcgatctcctgatctgcccgcctcagcctcccaaagtgctgggattacaggcatgagccaccgcgcccggccCAGGCACTTAATTTTTGTGTTTGACTTAGTAACTTAAGTGCAAACTATTACGGGAGCAGATGGAGTCAATTGGCCTTCATGTGATTGTCAGTGGGAAATTGGTCCAAGCAGAGGGAATACTGGTTCAGGAAACTGGTTTGGGAAGGTTAGGCAAACGGGAAGTGCTATGGTGGAGAGAAAGATTACTCTGGCCGGGCTGTAAAGGACGGCTACAATGGGAGGCTGAAGGCAGAACCAAGAAAATGGGAGTGAGTATGGAAAAGGTACGATTCAGACGGCATAATGGACGGGACTTGGAGACTGAATTGTAGTGGGCCGACCACAAAATGATAAGGCATGGAAGGAAGTAGAGTTTGGGGGGAAGGATCCCTAGTCCCTTAATGGCTACCTTCTTCCCCAGGAGTTGTTAGGCCATCCGATCCCCTGGCCTGGGAAAGAAACACTGATTTCGTTGCTGGCTTGTTCACTCACCAGAAGCTACAGCTACTAACAGTTCTAAAAACTGTTTCATGTGATGAGGAACAGACGAAAATAGTTTTGAGCCCTAAGTCCGCCGATTCCAGTGCTTTCTTGAACCCGCATTTACTAAAATATTTTCATGACTGCCAAGCTTTGAATAGCCTGCTGTGTTCATGGAGGCTCATACTGGCGATCTCTAGTGGCTGGCTAAAGCTTGAATTGCAAAAGATCTAATTTCTGGTCTAATGTAtatatgccttaaatatagttgcgttcaaacgtgggagctgcaggtgcaacttgattttatgacaaatggctgccacataatttgcacaagcagtgctcgtcaagggcagctaaatcaggcgagctttcaatcaaaataaatGTACTACTAAACCCTACTTAGCGGCTAACTAGCCCAAGAGCAGACAGCCCACGGACGGACTGCAAGTCGGAAGCGCGGGCGGAAGCTGTGCAGCGCCCACCTGGTGGCTCCATCGGCCGCGTTCATCAGTCAGCACGACCCGACCTCAGTGGCGTCCTCACAACACAGACCGGACCTTGGGTCTTACCCCGGCACCTGAGAACCACTTCCGGTGAGTAGCTTCTACTTCCGGAGACGATGACTCCCCCGCGTCCCAGACCGGAAGAAGCCCGGCGGAGACCGGCCTCGCTCGGCCACTTCCGGCAAGGGCGGAGCCGGCCAGTGGTGCGCGAGCGCAGATAACTCCCCTGGAGAGGCGGGATGTTCAACTCCACCCCTGGTCCTTGGGCGGCCGTGGGTCCCCTTCGAAGCGGAGGAATGGCCAACCTCGCCGCACTTCGAGCCCCTTTAGGGTGCGTTTAAGAACAGTGGGCGTGGCCTTTACGTAAATCTTCGAGATGGGAACCTCCAGAATTTGTCTCAATTGTCTAAAAGGTAATGAGCGTCAGCGACATTCAAGGGCACTTTGGGCTAAAAAAGAAAGTGCTTGTACACGGATGGAAATATTCTAGAAGAACATAAAAGGAATTTCCTCTTAGGAGGTTAGGGAAATGAGCACGAAGTATGTTTTGGTGCAGTTTTTTGTTCAACCCAATGCGTATTTTCATATTGAGAGGCAATATAAATGGAGCGAAAGTATCTTGAGAAAAAAAAAAAAACTACCAGAACTTGCCGTTGCTGAAAAGTAATATTTTCTCTTTCGAGAGTTTTCATGGCCTTTTAAATTACACCCCCACCTCCACAGGCAAATAAATTTGTTTTGGAATGCATACCACATCATCTGGCTCTAGAAACGTATTTTGTGTAGCTCCCCTAGCAAGAATATAGGTTAAAGCGTAAATTTAATTCCTGGCTCTATTTTACATCCCAATTTTTATTTTCCTCTCATTCCCACTTTACGTTGTTTCAAATAACCTAGTTTGTGTATCCCTGTAAGTCATTTTGGTATAAAGTAGGTTATAAGTGTACATGCGAAAAGATGTTTTTAACAAAAATGTAACTGA

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