Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RAB6D
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:131360857-131364156  UCSC
Coordinates (hg19) chr2:132118430-132121729  UCSC
Strand -
Parental Sequence NM_002869.5
Parental seq. overlap 3130 bp
Parental seq. overlap (%) 93.9%
Genomic Region Intergenic
Retrocopy Summary RAB6D, located on chr2:131360857-131364156, is a retrocopy of the parental gene RAB6A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RAB6A
Full Name RAB6A, member RAS oncogene family
Also known as RAB6
Coordinate chr11:73675638-73761074
Strand -
Gene summary This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RAB6AP2
Bonobo Pan paniscus RAB6AP1
Gorilla Gorilla gorilla RAB6AP1
Orangutan Pongo abelii RAB6AP2
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RAB6D
ACTCAGCAGGTTGGGCTGCGGCGGCGGCGGCTGGGGAAGCCGAAGCGCCGCGCGTGAGAGATCCCAGATACGTCTGCGGTTCCGGCTCCGCCACCCTCCGCCTTTCTCCCGCAGGTCTTGGAGCCGGGTGAGGAAGAAGGGAACGGCCCTAGCCTTGGGAAGCCAAAGCACACCCCTGGCTCCTGCCGACACCGCCCTCCTTCCCTTCCCAGCCGCGGGCCTCGCTCGGTGCTCGGCTACTCTGCCGGGAGGCGGCGGCGGCTGCCAGTCTGTGGAGAGTCCTGCTGCCCTCCAGCCGGGCTCCTCCACCGGCCCTTGCAGGGGCGCAGAGAGCTCGGCGCCCGCCCTTCCGCTCGCCTTTTTCGTCAGCCGGCTGGAGCAGCATCGGTCCGGGAGGTCTCTGGGCTGAGGCGGCGACAGCTCCTCTAGTTCCACCATGTCCGCGGGCGGAGACTTCGGGAATCCGCTGAGGAAATTCAAGCTGGTGTTCCTGGGGGAGCAAAGCGTTGCAAAGACATCTTTGATCACCAGATTCAGGTATGACAGTTTTGACAACACCTATCAGGCAATAATTGGCATTGACTTTTTATCAAAAACTATGTACTTGGAGGATGGAACAATCGGGCTTCGGCTGTGGGATACGGCGGGTCAGGAACGTCTCCGTAGCCTCATTCCCAGGTACATCCGTGATTCTGCTGCAGCTGTAGTAGTTTACGATATCACAAATGTTAACTCATTCCAGCAAACTACAAAGTGGATTGATGATGTCAGAACAGAAGGAGGAAGTGATGTTATCATCACGCTAGTAGGAAATAAAACAGATCTTGCTGACAAGAGGCAAGTGTCAATTGAGGAGGGAGAGAGGAAAGCCAAAGGGCTGAATGTTACGTTTATTGAAACTAGGGCAAAAGCTGGATACAATGTAAAGCAGCTCTTTCGACGTGTAGCAGCAGCTTTGCCGGGAATGGAAAGCACACAGGACGGAAGCAGAGAAGACATGAGTGACATAAAACTGGAAAAGCCTCAGGAGCAAACAGTCAGCGAAGGGGGTTGTTCCTGCTACTCTCCCATGTCATCTTCAACCCTTCCTCAGAAGCCCCCTTACTCTTTCATTGACTGCAGTGTGAATATTGGCTTGAACCTTTTCCCTTCATTAATAACGTTTTGCAATTCATCATTGCTGCCTGTCTCGTGGAGATGATCTATTAGCTTGACAAGCACAAAAAAAGTCAGCGTCTTCATTATTTATATTTTACAAAAAGCCAAACTATTTCAGCGTATTCCAGTGATAACTTTAAAAATTAGATACATTTTCTTAACATTTTTTTTCTTTTTTAATGTTATGATAATGTACTTCAAAATGATGGAAATCTCAACAGTATGAGTATGGCTTGGTTAACGAGCAGTATGTTCACAGCCTGCTTTATCTCTCCTTGCTCTTCTCACCTCTCCCTTACCCCGTTCCCTATTTCCGTGTTCTTACCTAGCCTCCCCCCACTTCCTCAAAACAAACAAGAGATGGCAAAGCAGCAGTCCGACCAAGCCCACTGGAATTATCCTTTAATTTTACAGATACCACTTGCTGTAGGCTGTGGACCAAGATGTCCAGAATTATTCTTGAGCACTGATATAAATTACTTAGATCCTCTTTGAGGTCAGAATTCAGCGATCACGGTAGGCAGTGCTTGAATGAGAAAAGCCTCCTGGTGCATCTTCAAAATGAGTCCTAAAGAACATACTGAGTACTTATAAGTAGCAGAACATAAAATGTATTTCTGACTAAAACAAATGGTCCTTTCACATGTGCTTTATTAGACTCTGGGAGAGAAAATTAACCAAGTGCTTCAGAACAGGTTTTTAGTATTTAATTCTTCATGGTAAGATAATGACGTTCTAATGAACTATTTCTCCCAAGGTTTTAAAATTGTCAAGAGTTATTCTGTTTGTTTAAAAAATAAGAAACCTCTTTAAGCAATAGATTTTGCTTGGGTTTTCTTTTTTTAAAAAATAATACTATGCAGGCAAGACACCATAAAAGTTTAATTCCTTACAGAAGAACCAGTGGAAGAATTTAAATTTGGCACTACGATCAAAACTACTGAATTAGCAGAAATAACGATATCTAAAGCTTACCAACAAAAGAACCCTCAGCAGAAGAGCAAAAACTTTGCTCAGGACATTTGAGGTCAAATTGAAGATGGAAACCGGAAACCATTTTCTTGTAAGCCCCTAGAGGCAGATCAGGTAAAGCATACATAGTAGAGGGAAAGGAGAGAATGGAAATAAAACTGAATATTATGCAGATTTATGCCTTATTTTTTAGCATTTTTTTAAGGTTGGGTCTTTCAGGCTGGTTTTCGTTTGTATGAGATCTGTATAGTTTAATTAACTAATGATTTAGTTTTATATTTAAGCTACGATTAATCTTTTTTCTTTGGTGATATTTCTTTGCTTTTTTTTTAACAACTTTCAATTTTTAGATGTTTCGTTGAATCTATTTAGAGCTTCACCATGGCAATATGTATTTCCCTTGAAACACTGCAAACAAATATACTAGGAGTGTGCCCTTTTAATCTTCACTAGTTATTGTGAGATTGCTGTGTAAGCTAATAAACACATTTGTAAATACATTGTTTGCAGGAAGAAAACTTCGAGTTATAGGTCAGGAAAAGCCTGCTGAATTTATGTTGTAAACGTTACTTAACACAGTATAAAGATGAAAAGACAACAAAAATATCTTCATACTTCCTCATCCCCTCATTGCAACAAAACCTTAAACTGGGAGAACCTTAGTCCCCTCTCTTTCCTCTTCCTCCTCCACTTCCCACTTATTGTCACCTTGTAATATTCAGAGAGCACTTGGATTATGGATCTGAATAGAGAAATGCTTACAGATAATCATTAGCCCACATACCAGTAACTTACACTTAAAGATGGGATGGAGTTATAAAGTGCTTTTATAATACAATATAATTGCTAAAGGCAAGGGTTGACTCTGTTTTATTTTGACATGGCATGTCCTGAAATAAATATTGATTCACTGTGGCAGATGGGTCATACTCTTTATTTGGAAGAAGTTGTGACTTCTGACATGGGGGTGATTGCCTTCCTACACTGTTGCATTTGATTCTTTTTATGTATTTTTTAAAAAGTAAGCAGTTATACTGCTTTTAATATTGATTGGTCTTTTTATTTGGCTTGGAGTTCTTCAAAGCAGTGAAGTGTGTTCATAGTCCAGATTTTTTTTTAGTAAACACAATTTTGCTGCCa
>NM_002869.5
ACTCAGCAGGTTGGGCTGCGGCGGCGGCGGCAGCTGTGGAAGCTCAGGCGCTGCGCGTGAGAGGTCCCAGATACGTCTGCGGTTCCGGCTCCGCCACCCTCAGCTTCTCTTCCCCAGGTCTGGGAGCCGAGTGCGGAAGGAGGGAACGGCCCTAGCTTTGGGAAGCCAGAGGACACCCCTGGCTCCTGCCGACACCGCCCTCCTTCCCTTCCCAGCCGCGGGCCTCGCTCGGTGCTAGGCTACTCTGCCGGGAGGCGGCGGCGGCTGCCAGTCTGTGGAGAGTCCTGCTGCCCTCCAGCCGGGCTCCTCCACCGGGCCTTGCAGGGGCCGAGAGAGCTCGGTGCCCGCCCTTCCGCTCGCCTTTTTCGTCAGCTGGCTGGAGCAGCATCGGTCCGGGAGGTCTCTAGGCTGAGGCGGCGGCCGCTCCTCTAGTTCCACAATGTCCACGGGCGGAGACTTCGGGAATCCGCTGAGGAAATTCAAGCTGGTGTTCCTGGGGGAGCAAAGCGTTGGAAAGACATCTTTGATCACCAGATTCATGTATGACAGTTTTGACAACACCTATCAGGCAACAATTGGCATTGACTTTTTATCAAAAACTATGTACTTGGAGGATCGAACAATCAGGCTTCAGCTGTGGGATACTGCGGGTCAGGAACGTTTCCGTAGCCTCATTCCCAGTTACATCCGTGATTCTGCTGCAGCTGTAGTAGTTTACGATATCACAAATGTTAACTCATTCCAGCAAACTACAAAGTGGATTGATGATGTCAGAACAGAAAGAGGAAGTGATGTTATCATCATGCTAGTAGGAAATAAAACAGATCTTGCTGACAAGAGGCAAGTGTCAATTGAGGAGGGAGAGAGGAAAGCCAAAGAGCTGAATGTTATGTTTATTGAAACTAGTGCAAAAGCTGGATACAATGTAAAGCAGCTCTTTCGACGTGTAGCAGCAGCTTTGCCGGGAATGGAAAGCACACAGGACAGAAGCAGAGAAGATATGATTGACATAAAACTGGAAAAGCCTCAGGAGCAACCAGTCAGTGAAGGAGGCTGTTCCTGCTAATCTCCCATGTCATCTTCAACCTTCTTCAGAAGCTCACTGCTTTGGCCCCCTTACTCTTTCATTGACTGCAGTGTGAATATTGGCTTGAACCTTTTCCCTTCAGTAATAACGTATTGCAATTCATCATTGCTGCCTGTCTCGTGGAGATGATCTATTAGCTTCACAAGCACAACAAAAGTCAGTGTCTTCATTATTTATATTTTACAAAAAGCCAAAATATTTCAGCATATTCCAGTGATAACTTTAAAAATTAGATACATTTTCTTAACATTTTTTTCTTTTTTAATGTTATGATAATGTACTTCAAAATGATGGAAATCTCAACAGTATGAGTATGGCTTGGTTAACGAGCGGTATGTTCACAGCCTACTTTATCTCTCCTTGCTTTTCTCACCTCTCACTTACCCCCATTCCCTATTACCCTATTCTTACCTAGCCTCCCCCGACTTCCTCAAAACAAACAAGAGATGGCAAAGCAGCAGTTCTACCAAGCCCATTGGAATTATCCTTTAATTTTACAGATACCACTTGCTGTAGGCTACGGACCAAGATGTCCAAAATTATTCTTGAGCACTGATATAAATTACGGTCTTCTTTGAGGTCAAAATTCAGCCATCATGGTAGGCAGTGCTTGAATGAGAAAAGGCTCCTGGTGCATCTTCAAAATGAGTCCTAAAGAACATACTGAGTACTTAGAAGTAGAAGAACATAAGATGTATTTCTGACTAAAACAAATGGCTCTTTCACATGTGCTTTATTAGACTCTGGGAGAGAAAATTAACCAAGTGCTTCAGAACAGGTTTTTAGTATTTAATTCTTCACGGTAAGAAAATGAAGTTCTAATGAACTGTTTCTCCCAAGGTTTTAAAATTGTCAAGAGTTATTCTGTTTGTTTAAAAAATAAGAAACCTCTTTAAGCAATAGATTTTGCTTGGGTTTTCTTTTTTAAAAACATAATACTGTGCAGGCAAGGCACTGTAAAAGTTTTAATTCCTTCCAGAAGAACCAGTGGAAGAATTTAAATTTGGCGCTACGATCAAAACTACTGAATTAGTAGAAATAATGATGTCTAAAGCTTACCAACAAAAGAACCCTCAGCAGAATAACAAAAACTTTGCTCAGGACATTTGAGGTCAAATTGAAGACGGAAACCGGAAACCGTTTTCTTGTAAGCCCCTAGAGGCAGATCAGGTAAAGCATACATAGTAGAGGGAAAGGAGAGAATGGAAATAAAACTCAATATTATGCAGATTTATGCCTTATTTTTTAGCATTTTTTAAGGTTGGGTCTTTCAGGCTGGTTTTGGTTTGTATTAGATCTGTATAGTTTAATTAACTGGTGATTTAGTTTTATATTTAAGCTACAATTAATCTTTTTTCTTTGGTGATATTTATTTCTTTGCCTTTTTTTTTTTTAACAACTTTCAATCTTCAGATGTTTCGTTGAATCTATTTAGAGCTTCACCATGGCAATATGTATTTCCCTTAAAACACTGCAAACAAATATACTAGGAGTGTGCCCTTTTAATCTTTACTAGTTATTGTGAGATTGCTGTGTAAGCTAATAAACACATTTGTAAATACATTGTTTGCAGGACGAAAACTTCTGAGTTACAGCTCAGGAAAAGCCTGCTGAATTTATGTTGTAAGCATTACTTAACACAGTATAAAGATGAAAAGACAACAAAAATATCTTCATACTTCCTCATCCCCTCATTGGAACAAAACCTTAAACTGGGAGAACCTTAGTCCCCTCTCTTTCCTCTTCCTCCTCCACTTCCCACTTATTGTCACCTTGTAATATTCAGAGAGCACTTGGATTATGGATCTGAATAGAGAAATGCTTACAGATAATCATTAGCCCACATACCAGTAACTTATACTTAAAGATGGGATGGAGTTGTAAAGTGCTTTTATAATACAATATAATTGTTAAAGGCAAGGGTTGACTCTTTGTTTTATTTTGACATGGCATGTCCTGAAATAAATATTGATTCAATATGGCAGATGGGTCATATTCTTTATTTGGAAGAAGTTGTGACTTCTGACATGGGTGTGATTGTCTTCCTACACTGTTGCATTTGATTCTTTTTATGTATTTTTAAGAAAGTAACCAGTTATACTGCTTTTAATATTGATTGGTCTTTTTATTTGGCTTGGAGTTCTTCAAAGCATTGAAGTGTGTTCATAGTCCAGGTTTTTTTTTTAATAAACACAATTTTGCTGCCAAAAATATATAAATAAAACACGAAAGAAAACAA

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