Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name IDI1P1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:138307417-138309111  UCSC
Coordinates (T2T) chr2:138753130-138754824  UCSC
Coordinates (hg19) chr2:139064987-139066681  UCSC
Strand +
Parental Sequence NM_004508.4
Parental seq. overlap 1400 bp
Parental seq. overlap (%) 51%
Genomic Region Intergenic
Retrocopy Summary IDI1P1, located on chr2:138307417-138309111, is a retrocopy of the parental gene IDI1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name IDI1
Full Name isopentenyl-diphosphate delta isomerase 1
Also known as IPP1|IPPI1
Coordinate chr10:1039152-1056704
Strand -
Gene summary IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes IDI1P1
Bonobo Pan paniscus IDI1P1
Gorilla Gorilla gorilla IDI1P1
Orangutan Pongo abelii IDI1P2
Gibbon Nomascus leucogenys IDI1P3
Green monkey Chlorocebus sabaeus IDI1P2
Crab-eating macaque Macaca fascicularis IDI1P3
Rhesus Macaca mulatta IDI1P3
Baboon Papio anubis IDI1P2
Golden snub-nosed monkey Rhinopithecus roxellana IDI1P4
Marmoset Callithrix jacchus IDI1P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>IDI1P1
TGAGAACATTGAGAAAGGGTTATTGCATTGAGCTTTTAGTGTCTTCTTATTCAACACTGAAAATAAGCTTCTGCTACAGCAAAGATCAGATGCTAAGATTACCTTTCCAAGTTGTTTTACTAATACTTGTTGTAGTTATCTATTAAGTAAACCAGGTGAACTTGAGGAAAATGATGGCCTTGGAGTGAGGAGAGCAGCACAGAGGCAGCTGAAAGCTGAGCTAGGAATTCCCTTGGAAGAGGTTCCTCCAGAAGAAATTAATTATTTAACACTAATTCACTACAAAGCTCAGTCGGATGGTATCTGAGGTGAACATGAAATTGATTACATTTTGTTTGTGAGGAAGAATGTAACTTTGAATCCAGATCCCAGTGAGATTAAAAGCTATTGTTATGTGTCAAAAGAAGAACTAAAAGAACTTGGGGAAAAAAGCAGCCAATTGTGAAATTAAGATAACGTCATGGTTTCAAATTATTGCAGAGGCTTTTCTCTTTAAATGGTGGGATAACTTAAATCATTTGAATCAGTTTGTTGACCATGAGAAAATATACAGAATGTGAATATGTAGGTGAATGATTACTGAAAAATTTCTCTACTTAACAAATTTAGAATGACTTTTTTCATTTAAATTTAGTTTACTATCATCAATGTATTATATACACTGATACTTTACAACTTGTGTGGAAAAAAATAACTTATAATTTTGTATCACACACCTTGTATATGTGTTCTGCTTCTAAACGACATTTATGAGAGATTATTGTGAAATGAGTGAGAGCAAATAAAAATTTAACCTGTGCAGACACACATGCTTATGGCAAATTTGAACAAATGAGTGAAGCCCCGTGTTTTTAGTAAGCTGTGATAAACATTTCCGGAGCACTCGCAGAGCACTGTTATTTTCCAGGTGCTTTATGTATCGTTAAATTTTTATCATAGTTCAGAAAAATGTGCAAAGGAAACTATTGCTTAGCTCCTTCAAAACAGTCCTAATTAACTTCATATTAACAGATTAAACTAGCATAGCAGGTTCAAGGGAAATTAAATGATATGGACCCTAATTTGTATCATTCTGAGTTGATGGTGTGGTTTATCCATTCTGGAAATATGTTGATACTTCAAGTCAGCCATTGCTTTTGATAAGAGATATTGATTAGGTTAAACCTTCTTTTAAGTAGTATTTGCCAATTAGCACAGTCTGTTTTCAGAATTAAAGTGGGCACAGAGGTGTTCATAAAATGGGAATTGAGTCTCACTCGACAAGAGTTGCTTAACCgTCCTACAGAGCAGGCAATATTGCAGGGAGAAAAAAATAACAATGACAAAGGCCAGTGTTCATGTTAAATGGATTGAGATTATGGAATGTGTATATTAATGTTAAAAATTATATCTTGATCAATGTACTTTTATAAACTTGCCATAGATATCTCAAATTTGAAATCTCATAATGGCTTTATTATTCTTAAATGCTGTATGATAATGAAAAAAATAAAAATTTACTTCTTACAAAGTTAAA
>NM_004508.4
CAGGTTCCCGGTGCTTCGCGCGTCTGCCGTTGTCACAGGCCAGGGAGGTGGCACCACCAGGCGAAGCTTGGCGAGATTGTGTCGTCAAGCGCGTACGGGCGCCAATTGGCCGGGCGATGtggcgtggactggcgctggcgcgagcgattggctgcgcggcccgggggcgggGCCAGTGGGCGGTGCGCGCCGCAGACTGTGCTCAAAGCGGGCGCCATCCGGGACCGGCGGTTGTCTGTGGCCGGAGGCTGATCAGTGTTCTAGAACAGATCAGACATTTTGTAATGATGCCTGAAATAAACACTAACCACCTCGACAAGCAACAGGTTCAACTCCTGGCAGAGATGTGTATCCTTATTGATGAAAATGACAATAAAATTGGAGCTGAGACCAAGAAGAATTGTCACCTGAACGAGAACATTGAGAAAGGATTATTGCATCGAGCTTTTAGTGTCTTCTTATTCAACACCGAAAATAAGCTTCTGCTACAGCAAAGATCAGATGCTAAGATTACCTTTCCAGGTTGTTTTACGAATACGTGTTGTAGTCATCCATTAAGCAATCCAGCCGAGCTTGAGGAAAGTGACGCCCTTGGAGTGAGGCGAGCAGCACAGAGACGGCTGAAAGCTGAGCTAGGAATTCCCTTGGAAGAGGTTCCTCCAGAAGAAATTAATTATTTAACACGAATTCACTACAAAGCTCAGTCTGATGGTATCTGGGGTGAACATGAAATTGATTACATTTTGTTGGTGAGGAAGAATGTAACTTTGAATCCAGATCCCAATGAGATTAAAAGCTATTGTTATGTGTCAAAGGAAGAACTAAAAGAACTTCTGAAAAAAGCAGCCAGTGGTGAAATTAAGATAACGCCATGGTTTAAAATTATTGCAGCGACTTTTCTCTTTAAATGGTGGGATAACTTAAATCATTTGAATCAGTTTGTTGACCATGAGAAAATATACAGAATGTGAATATGTAGGTAAATGATTACAGAAAAATTTATCTGCTTAACAAACTTAGAATGACTTTTTCCTTTTAAATTTAGTTCTATCATTAATTTATCATTAAATTTAGTTCTATCATTTGGTACTATCATTAATGTATTATATACACTGATACTTTAAAACTTGTGTGGAAAAAACTAACTTATAATTTTGTATCACACACCCTGGATATGTGTTCTGTTTCTAAGCGACATTTGTGAGAGATTATTGTAAAATGAGAGCGAGCAAATAAAACTTAATTTAATCTTTGCAGATACATACTTATGGGAAATTTGAACAAATGAGTGAAACTCTGTTTTTAGTAGGCTGTGATAAACATTTCCGGAGCACTTGCAGAGGACTTGCTATTTGCCAGGTGCTTTATGTATCATTAAATTTTTCTCATAGTTCAGAAAAATGTGCAAAGGAAACTATTGTCTCGCTCCTTCAAAACAGTCTTAATTAACTTTCATATTAGCAGATTAAACTAGCAGAGCAGGTTCAAGGGAAATTAAATGATATGGACCCTAATTTGTATCATTCTGAGTTGATTGTGTGGTTTATTCATTCTGGAAACATGTTGATACTTACAGTCAGCCACTGCTTTTGATAAGTGATATTGATTAGGTTGAATCTTCTTGTAAATAGTATTTACCAGTTAGCAAAGTCTGTGTTTTCAGAATTACAGTGAGCACAGAGGTGTTCATAAAATGGGAATTGAGTCCCACTCGGTAagagttgcttaaacttgacactgttgacatttgggctggataaaacccctgtggtggggtctgtgctgtgcattgcaggatggtgagcagcgtccctctcatgtgacacccacagttatgccggatgttgccagatgcccctaggggacagagtcaacccccaactgaggaccactgTCCTACAGAGTCAGGAAATATTGTAGGGAGAAAAAAATAACAACAACAAAGGCCTGTGTTAATGTTAAATAGATGAGATTATGGAATGTGTATATTAATGTTAAAAATTGTACCTTGATCAATGTACTTTTTATAAACTTGCCATAGATATCTCAGATTTGAAACCTCAAGACAGATTTATTATTCTTAAATGCTGTATGATAATGAAGAAAAATAAAAATTTATTTCTTGCAAAGTTAAATGTTTGTTAAATTCAATAGAATGACTCATTTATGGTTAACTTTGGGCAATTTATAATTTCAGACAAGACTGTTTAGCAAGTATTTTATTGAAAAGTAAAAAAAATTGCAATTTAATACTGTGTTTAGTTTGTTAAAATTTTGATACACTAATAGGATATTGCCTGTATAGTTTCCGTTGCATTTATAATATTGTTTCTAATTTTTTTAGTTTTATTTTCTAGGAAGTTTTAGGCTGAAAGCCACATATAATTAGTTATGTGATAACTATGAGTTGCCATGGCTACTGAATTGGACATGGGACCCTTAGACTGCTACCCAGCACCTTGTTAAGTACTTAGCAAGAGTTAGATACTACTGTTGTAATATTACTAGGATGCCATCCAGAAAATGTAAGGAATGtcttttgacctgataaactccttagaactccttcatcttttataaagaggagtatccctctcctagatatagctgcttctgaccccaaaggcagatgtgttggttttCAACTAGAAAGCTAAATGGTACCTATAAATTTTTTTTTTCTTAAACTGTTTTAAACTCTTAATCTTCAAAATATATACTTCTTTGATTCTGGTCAAA

Publications

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