Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name METTL21AP1
Plot displaying the genomic locations of a retrocopy (in chr21) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr21:39235330-39236079  UCSC
Coordinates (T2T) chr21:37619878-37620627  UCSC
Coordinates (hg19) chr21:40607256-40608005  UCSC
Strand -
Parental Sequence XM_011510725.2
Parental seq. overlap 646 bp
Parental seq. overlap (%) 26.6%
Genomic Region Intragenic (BRWD1)
Retrocopy Summary METTL21AP1, located on chr21:39235330-39236079, is a retrocopy of the parental gene METTL21A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name METTL21A
Full Name methyltransferase 21A, HSPA lysine
Also known as FAM119A|HCA557b|HSPA-KMT
Coordinate chr2:207580635-207626053
Strand -
Gene summary Enables ATPase binding activity; Hsp70 protein binding activity; and protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine methylation. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes METTL21AP1
Bonobo Pan paniscus METTL21AP1
Gorilla Gorilla gorilla METTL21AP1
Orangutan Pongo abelii METTL21AP1
Gibbon Nomascus leucogenys METTL21AP2
Green monkey Chlorocebus sabaeus METTL21AP1
Crab-eating macaque Macaca fascicularis METTL21AP1
Rhesus Macaca mulatta METTL21AP1
Baboon Papio anubis METTL21AP1
Golden snub-nosed monkey Rhinopithecus roxellana METTL21AP1
Marmoset Callithrix jacchus METTL21AP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>METTL21AP1
TCAAACCGTTAACATCCAGTCTAAGTGCAGGTCTGGTCAGAGGGCTGGGTGCAGGCAGATTGGCCCTGTTGCCCTATGAGGAGACCGTGGGATTGGGGTTGCAGAAATTCCATAAGCCTCTTGCCACCTTTGTGAACCACATGACACAGATCTGGCAGGACCGGAGACAACTGGGAATTGCCACAGTGGTTTGGGATGTGGCCATGGTTCTCTCCACACATCTGGAGATGGGAGCTGTGGAGCTCTTGGGCTGCCCCGCAGTGAAACTGGGTGCTGGCATAGGGCTGATGGGCATAGTGGCTGCCCTGCTGGGTGCTCATGTGACTGTCATAGATCGAAAAGTAGCATTAGAGTTTTGTAAATCAAATGTTCAAGGCAATTTACCTCCTTGTATCCAACCCAGAGCTTTTGTTAAGGAGCCGACTTGGGGAAAGAATTTGGGGAGTTTTTCTCCTAGAGATTTTGACCTGATACTTGGAGCCGATATCATATATTTAGAAGAAACATTCACAGATCTTCTCCAAACACTGGACCATCTCTGTAGCAATCACTCCATGATTCTTTTACCTTGCTTAATTCACTATGAACGGAGTAACTTTTGAGCAATGCTGGAGAGGCAGTTTACTGTAGGGTTCACTATGATACTGAGAAAGACGTACATACTTACACAGAAGAGAAGCCACAGCAAGGACCTACAGTTGGCTATCATTTATAAGAATGCTGTCATTGAGGGTGTTGATTAAGGTCTTG
>XM_011510725.2
AGCCGCTTGGAGGCCCCCAGTGTCGCTCACTTCCAGGGTCGGGGAGACGGAACTGCGGCGACCATGTATTTCTGGTTTATCAAACCGCTAACACCCAGTCTAAGGGCAGGTCTGAGCAGAGGGCGGGGTGCAGGCGGAATGGCCCTCGTGCCCTATGAGGAGACCACGGAATTTGGGTTGCAGAAATTCCACAAGCCTCTTGCAACTTTTTCCTTTGCAAACCACACGATCCAGATCCGGCAGGACTGGAGACACCTGGGAGTCGCAGCGGTGGTTTGGGATGCGGCCATCGTTCTTTCCACATACCTGGAGATGGGAGCTGTGGAGCTCAGGGGCCGCTCTGCCGTGGAGCTGGGTGCTGGCACGGGGCTGGTGGGCATAGTGGCTGCCCTGCTGGGTGCTCATGTGACTATCACGGATCGAAAAGTAGCATTAGAATTTCTTAAATCAAACGTTCAAGCCAACTTACCTCCTCATATCCAAACTAAAACTGTTGTTAAGGAGCTGACTTGGGGACAAAATTTGGGGAGTTTTTCTCCTGGAGAATTTGACCTGATACTTGGTGCTGATATCATATATTTAGAAGAAACATTCACAGATCTTCTTCAGACACTGGAACATCTCTGTAGCAATCACTCTGTGATTCTTTTAGCATGCCGAATTCGCTATGAACGGGATAACAACTTCTTAGCAATGCTGGAGAGGCAATTTACTGTGAGAAAGGTTCACTACGATCCTGAAAAAGATGTACATATTTACGAAGCACAGAAGAGAAACCAGAAGGAGGACTTATAATTGGCTATAATTTATAAGAATGTTGTCATTGAGTGTGTCACTTAAGGTCTTAGACTGCAAATCTAACCATATTTAATGAAATGTCTTACTGTACAAAAAGTCTAAGCCAAAGGTTCTCAGGGGAGAAAGCACATGTGCAGTTTTAAAACAAAGCAGTGCTTTGTCCCATTGCTGTGATTTTTAGTCAGACTTTACTCAGTCTGAAATGCAATTAACATTAAAGGATTAAGTGTGAGATTTCGATTTATGCTATTTGTGTATCCCATACTCCTCCCTTTTAATAAACAGTTTCCACTGATGATATGAAGGGCCGGTATAAAGAAGTCTTTAAATGAGTAAGCTTTCTTGGTAAGATTAAATCTTACAAATTATTTTTAAAACCTTGTGATATATACAATGTTTAGCTGAGTTTTCTAATTTTCTGGATGTAAAACAAAAGGTTTAACCTATACATTCCTTGAGCTGTTAGTGCTATTTAAATCTTTTGCCCTGTTTAGGTCCTAAACACTTTTAGTTGAGTAGGATATGAGCTTTTTTGGGTCTCATATCATGCTTTTTGCCTTAATTTCAGGtatatatatatatataaataaaggaattaagtaaaaataaaATTTCAGTTACTTTTTAAAAGCACCTGAAATCTggccggatgcggtggctcatgcctgtaatcccaccactttgggaggccgaggcgggcagatcacctgaggtcaggagttcaagaccagcctggccaacatggtgaaaccccatctctactaaaaatacaaaaattagccgggcgtggtgtcaggcgcctgtaatcccagctactcaggaggctgaggcaggagaatcgcttgaacctgggaggcagaggttgcagtgagctgagattgcaccattgtactccagcctgggggacaagagcgagactccatctcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaGCACCTGAAATCTTGAATAGGTTTTCTATTTCAAGTCAAGAGCTGAGGTTTTCCCCTTCTGTTTTACCCTTGCTCAAATGTCTTAATGCAGTTCTTTCCCAAGCTTTCCCTGCTTCCTTAACAACGCATAGGATGACATTAAAAGTTTTAAATCTCATCCCTGCCTGAGAGGTTAGCTTCCTACATATAAGCTCCTTTTGTATTGGACttgtaattgctcattcagtggtagtattgccctgtagagtgtaagctccttgagggccaagaatgcttctgcctcttccattgttgcttccccagtacctTCTGTATATTTCATAACCAAATAATGAAAAAGATACATTCCATTTAAAGGGCATTGACTTTGGGTTAAATGATTGTTATATTGTTTTAGGATTATCTATGATACACTTTGACATCTCACACACACACATGAACTTTTCTTTTTACAATGCAAAAGTTTAAACAATAGCTTAAATTTAGACTGCAAGAATATTATAATCTCAATATGGTATTTGGTACTAGAGATAGATTTCTTTTATAAAATCTTAAAAACAGGACGTTCTCTTCCTTTTGAACCTTTATCCCAGAGGTGAAAATATCCAATATGTTGTTTTCTGCATATATTGAAGTAGTAGTTTCACTTTAATAAAGATGGATTAAAAGTTGT

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