Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPL22P25
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:152539223-152539381  UCSC
Coordinates (T2T) chr2:152991654-152991812  UCSC
Coordinates (hg19) chr2:153395737-153395895  UCSC
Strand -
Parental Sequence NM_000983.4
Parental seq. overlap 142 bp
Parental seq. overlap (%) 6.9%
Genomic Region Intragenic (FMNL2)
Retrocopy Summary RPL22P25, located on chr2:152539223-152539381, is a retrocopy of the parental gene RPL22. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPL22
Full Name ribosomal protein L22
Also known as EAP|HBP15|HBP15/L22|L22
Coordinate chr1:6185020-6199595
Strand -
Gene summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RPL22P7
Bonobo Pan paniscus RPL22P7
Gorilla Gorilla gorilla RPL22P7
Orangutan Pongo abelii RPL22P7
Gibbon Nomascus leucogenys RPL22P7
Green monkey Chlorocebus sabaeus RPL22P7
Golden snub-nosed monkey Rhinopithecus roxellana RPL22P17
Marmoset Callithrix jacchus RPL22P6
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPL22P25
AAAAAGAAGGTTCTGAAGTTCACTCTTGATTCCACCCACCCTCTAGAAGATGGAGTCATGGAAGCTGCCAATTTTGAGTGCTTTTTGCAAGAGGATCAAAATGAACAGAAAAGCTGGGAATCTCAATGGAGGGGTGGTAACTATCAAAAGGAGCAAGAT
>NM_000983.4
CCTTTCTAACTCCGCTGCCGCCATGGCTCCTGTGAAAAAGCTTGTGGTGAAGGGGGGCAAAAAAAAGAAGCAAGTTCTGAAGTTCACTCTTGATTGCACCCACCCTGTAGAAGATGGAATCATGGATGCTGCCAATTTTGAGCAGTTTTTGCAAGAAAGGATCAAAGTGAACGGAAAAGCTGGGAACCTTGGTGGAGGGGTGGTGACCATCGAAAGGAGCAAGAGCAAGATCACCGTGACATCCGAGGTGCCTTTCTCCAAAAGGTATTTGAAATATCTCACCAAAAAATATTTGAAGAAGAATAATCTACGTGACTGGTTGCGCGTAGTTGCTAACAGCAAAGAGAGTTACGAATTACGTTACTTCCAGATTAACCAGGACGAAGAAGAGGAGGAAGACGAGGATTAAATTTCATTTATCTGGAAAATTTTGTATGAGTTCTTGAATAAAACTTGGGAACCAAAATGGTGGTTTATCCTTGTATCTCTGCAGTGTGGATTGAACAGAAAATTGGAAATCATAGTCAAAGGGCTTCCCTTGGTTCGCCACTCATTTATTTGTAACTTGACTTCTTTTTTTTTCTGCTTAAAAATTTCAATTCTCGTGGTAATACCAGAGTAGAAGGAGAGGGTGACTTTACCGAACTGACAGCCATTGGGGAGGCAGATGCGGGTGTGGAGGTGTGGGCTGAAGGTAGTGACTGTTTGATTTTAAAAAGTGTGACTGTCAGTTGTATCTGTTGCTTTTCTCAATGATTCAGGGATACAAATGGGCTTCTCTCATTCATTAAAAGAAAACGCGACATCTTTCTAAGATTCTCTGTGGGAAAATGACTGTCAATAAAATGCGGGTTTCTGGGCCATTCGTCTTACTTTCATTTTTTGATTACAAATTTCTCTTGACGCACACAATTATGTCTGCTAATCCTCTTCTTCCTAGAGAGAGAAACTGTGCTCCTTCAGTGTTGCTGCCATAAAGGGGTTTGGGGAATCGATTGTAAAAGTCCCAGGTTCTAAATTAACTAAATGTGTACAGAAATGAACGTGTAAGTAATGTTTCTACAGGTCTTTGCAACAAACTGTCACTTTCGTCTCCAGCAGAGGGAGCTGTAGGAATAGTGCTTCCAGATGTGGTCTCCCGTGTGGGGCCCAGCAATGGGGGCCCCTGATGCCAAGAGCTCTGGAGGTTCTTGAAAGAGGGGACACGAAGGAGGAGTGACTGGGAAGCCTCCCATGCCAAGGAGGTGGGAGGTGCCCTGGAAATAGCTGCCTCATGCCACTTAGGCCATGACTGGATTTAATGTCAGTGGTGTGCCACAGTGCAGAGGCTAGACAACTGAAAGGGGCTACCAAGGCTGGGAAAAAAATGCAATTGTTGCTGTGAGTGACTTTGAAAGACTCTGGTGCCTTGTGGTGCCCTTCTGAAATTCAAACAGTAATGCAAAAGTGTCTGCATTAGAATTTACGGTGTCTAAAATTCATGTTTTTAAAAGAGCTTGCCTACAGATGGTTTCCACACTTGAAATTGTGCCCTGCGAGTTGCATAGCTGGAAGTTCAATGCTCAGTCCTACCTTGGCTCCCATTAAACATTTGGTGCTCTGTGGATTGAGTTGAACGTGTTGAGGCTTTGCAATTTCACTTGTGTTAAAGGCTCTGGCATTTTTCCATTTCTATGCAAATTTCTTTGAAGCAGAATTGCTTGCATATTTCTTCTCTGCCGTCACAGAAAGCAGAGTTTCTTTCAAACTTCACTGAGGCATCAGTTGCTCTTTGGCAATGTCCCTTAACCATGATTATTAACTAAGTTTGTGGCTTGAGTTTACAAATTCTACTTGTTGCATTGATGTTCCCATGTAGTAAGTCATTTTTAGTTTGGTTGTGAAAAAACCCTGGGCTGAAGTTGGCATTTCAGTTAAAAGAAAAAAAGAAACTAGTCCCAGATTTGAAAACTTGTAATAAAATTGAAACTCACTGGTTTTCTATGTCTTTTTGAACTCTTGTAATCGAGTTTTGATCATATTTTCTATTAAAGTGGCTAACACCTGGCTACTCTTACTGTA

Publications

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