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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPL7P61
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:163152183-163153317  UCSC
Coordinates (T2T) chr2:163609497-163610631  UCSC
Coordinates (hg19) chr2:164008693-164009827  UCSC
Strand -
Parental Sequence NM_000971.4
Parental seq. overlap 668 bp
Parental seq. overlap (%) 51.1%
Genomic Region Intergenic
Retrocopy Summary RPL7P61, located on chr2:163152183-163153317, is a retrocopy of the parental gene RPL7. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPL7
Full Name ribosomal protein L7
Also known as L7|humL7-1
Coordinate chr8:73290242-73294466
Strand -
Gene summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RPL7P7
Bonobo Pan paniscus RPL7P7
Gorilla Gorilla gorilla RPL7P8
Orangutan Pongo abelii RPL7P7
Green monkey Chlorocebus sabaeus RPL7P10
Crab-eating macaque Macaca fascicularis RPL7P38
Rhesus Macaca mulatta RPL7P37
Baboon Papio anubis RPL7P33
Golden snub-nosed monkey Rhinopithecus roxellana RPL7P54
Gibbon Nomascus leucogenys Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPL7P61
GGTGGCAACTTCTATGTACCTGCATGCAGAACCCAAAACGATGTTTGTCATCAGGATCGGAGGTATCAGTGATGTGAGCCCAAAGATCCGAAAGGTGTTGCAGCTTCTTCACCTTCATCAAATCTTCAGTGGAACCTTTATGAAGCTCAACAAGGCTTCGTTTAACATTCTGAGGATTGTAGGACCATATATTACATGGGGGTACCCAAATCTGAAGTCAGTAAATGAACTTATCTACAAGGATGGTTATTGCAAAATCAATAAGAAGCAAATTGCTTTGACAGGTAACACTGATTGCTCGATCTCTTGGCATCATCTTCATGGAGGATCTGATTCATGAGATCTATACTGTTGGAAAATGCTTTAAGAAGCAGACAACTTCCTGTGGCCCTTCAAATTATCCTCTCCATGAGGTGGAATGAAAAAAAAAAAAAAGACAGCTTATTTAGTAGAAAGTGATGATCCTGGCAACAGGGAGGAACAGATCAACAGGCTTATCAGAAGAATGAACTAAGGTGTCTACCACGATTATTTTTCTAATCTGGTGAGTTAATAAAACAGTACCTGCTCTCAGATTGAAAAGGCTGAAACCATGGAGGGTGTCAAAGAGAAGGAGGAGGTTCCTGCTGTGCCAGAAACCCTTAAGAAAAAGCAATGGGATTTCGTAGAGCTGAAGATCAAGCACCTGAGAAAGAATTTTGCCCAAAAGATGCTTCAAAAGGCAAGGAGGAAGCTTATTTGTGAAAAAAGAGAAGCACTATTACAAGGAATATAGACAGATGTACAGCACAGAAATTCGATAGGTAGGATGGCAAGAAAAGGTGGCAACTTCTCg
>NM_000971.4
CCTCTTTTTCCGGCTGGAACCATGGAGGGTGTAGAAGAGAAGAAGAAGGAGGTTCCTGCTGTGCCAGAAACCCTTAAGAAAAAGCGAAGGAATTTCGCAGAGCTGAAGATCAAGCGCCTGAGAAAGAAGTTTGCCCAAAAGATGCTTCGAAAGGCAAGGAGGAAGCTTATCTATGAAAAAGCAAAGCACTATCACAAGGAATATAGGCAGATGTACAGAACTGAAATTCGAATGGCGAGGATGGCAAGAAAAGCTGGCAACTTCTATGTACCTGCAGAACCCAAATTGGCGTTTGTCATCAGAATCAGAGGTATCAATGGAGTGAGCCCAAAGGTTCGAAAGGTGTTGCAGCTTCTTCGCCTTCGTCAAATCTTCAATGGAACCTTTGTGAAGCTCAACAAGGCTTCGATTAACATGCTGAGGATTGTAGAGCCATATATTGCATGGGGGTACCCCAATCTGAAGTCAGTAAATGAACTAATCTACAAGCGTGGTTATGGCAAAATCAATAAGAAGCGAATTGCTTTGACAGATAACGCTTTGATTGCTCGATCTCTTGGTAAATACGGCATCATCTGCATGGAGGATTTGATTCATGAGATCTATACTGTTGGAAAACGCTTCAAAGAGGCAAATAACTTCCTGTGGCCCTTCAAATTGTCTTCTCCACGAGGTGGAATGAAGAAAAAGACCACCCATTTTGTAGAAGGTGGAGATGCTGGCAACAGGGAGGACCAGATCAACAGGCTTATTAGAAGAATGAACTAAGGTGTCTACCATGATTATTTTTCTAAGCTGGTTGGTTAATAAACAGTACCTGCTCTCAAATTGAAATATAttgttgtatttgtgatttgttgttgttgttgttAGCCTGCCTCTGTCTTCCCTTAACTACTGTGGCAAGTGTGGTGTGTGATAAAATTAAGCCAAATCAACAGCCCATTTCGTGCAAAATCAGGGTCGAGTCTGTGTGAAAGACATCTCTTGGGTTTTTAAAAGGCTTTTCTATACAAAAGATTTTAATTTTTTGTTTTTTAACTGTGCTGAGTGATTCGAAATGGGTTTATTCTAAGAAAGCCTGTTTCACAAGCATTTGTACATGATTTGTCGGTAAGGTAATCCAACTTTGGTTTATGGAAAAAATTGAATTTAGTTGCTAAAATTTATTTCTCGGGCCTTCGCTTGTTTATAAACTGCCATGTAAATGTGTTGTTTTCCTTTTGCATTCCA

Publications

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