Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name YBX1P12
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:174172497-174172688  UCSC
Coordinates (T2T) chr2:174661240-174661431  UCSC
Coordinates (hg19) chr2:175037225-175037416  UCSC
Strand +
Parental Sequence NM_004559.5
Parental seq. overlap 162 bp
Parental seq. overlap (%) 5.4%
Genomic Region Intragenic (OLA1)
Retrocopy Summary YBX1P12, located on chr2:174172497-174172688, is a retrocopy of the parental gene YBX1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name YBX1
Full Name Y-box binding protein 1
Also known as BP-8|CBF-A|CSDA2|CSDB|DBPB|EFI-A|MDR-NF1|NSEP-1|NSEP1|YB-1|YB1
Coordinate chr1:42682418-42703805
Strand +
Gene summary This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes YBX1P5
Bonobo Pan paniscus YBX1P3
Gorilla Gorilla gorilla YBX1P3
Orangutan Pongo abelii YBX1P5
Gibbon Nomascus leucogenys YBX1P12
Green monkey Chlorocebus sabaeus YBX1P4
Crab-eating macaque Macaca fascicularis YBX1P9
Rhesus Macaca mulatta YBX1P10
Baboon Papio anubis YBX1P8
Golden snub-nosed monkey Rhinopithecus roxellana YBX1P14
Marmoset Callithrix jacchus YBX1P6
Pale spear-nosed bat Phyllostomus discolor YBX1P13
Greater mouse-eared bat Myotis myotis YBX1P4
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>YBX1P12
GGGGAGAAGTGCTGGAGGGTACCCACAACCAGTGGGCAAGGGAACAAGGCAGACCAGTGGGGCGGAGTAGGTATCGGGGATACAGACCATGATTCTGCAGGGACCCTCTGCCAAAGGTAGTCTAGAGAGGACAGAAATGAAGAGGATAGGGAAAAATCAAGGAGATGATATCCAAGGTCAGCAGCCACCTCA
>NM_004559.5
ATTCTCGCTAGTTCGATCGGTAGCGGGAGCGGAGAGCGGACCCCAGAGAGCCCTGAGCAGCCCCACCGCCGCCGCCGGCCTAGTTACCATCACACCCCGGGAGGAGCCGCAGCTGCCGCAGCCGGCCCCAGTCACCATCACCGCAACCATGAGCAGCGAGGCCGAGACCCAgcagccgcccgccgccccccccgccgcccccgccctcagcgccgccgACACCAAGCCCGGCACTACGGGCAGCGGCGCAGGGAGCGGTGGCCCGGGCGGCCTCACATCGGCGGCGCCTGCCGGCGGGGACAAGAAGGTCATCGCAACGAAGGTTTTGGGAACAGTAAAATGGTTCAATGTAAGGAACGGATATGGTTTCATCAACAGGAATGACACCAAGGAAGATGTATTTGTACACCAGACTGCCATAAAGAAGAATAACCCCAGGAAGTACCTTCGCAGTGTAGGAGATGGAGAGACTGTGGAGTTTGATGTTGTTGAAGGAGAAAAGGGTGCGGAGGCAGCAAATGTTACAGGTCCTGGTGGTGTTCCAGTTCAAGGCAGTAAATATGCAGCAGACCGTAACCATTATAGACGCTATCCACGTCGTAGGGGTCCTCCACGCAATTACCAGCAAAATTACCAGAATAGTGAGAGTGGGGAAAAGAACGAGGGATCGGAGAGTGCTCCCGAAGGCCAGGCCCAACAACGCCGGCCCTACCGCAGGCGAAGGTTCCCACCTTACTACATGCGGAGACCCTATGGGCGTCGACCACAGTATTCCAACCCTCCTGTGCAGGGAGAAGTGATGGAGGGTGCTGACAACCAGGGTGCAGGAGAACAAGGTAGACCAGTGAGGCAGAATATGTATCGGGGATATAGACCACGATTCCGCAGGGGCCCTCCTCGCCAAAGACAGCCTAGAGAGGACGGCAATGAAGAAGATAAAGAAAATCAAGGAGATGAGACCCAAGGTCAGCAGCCACCTCAACGTCGGTACCGCCGCAACTTCAATTACCGACGCAGACGCCCAGAAAACCCTAAACCACAAGATGGCAAAGAGACAAAAGCAGCCGATCCACCAGCTGAGAATTCGTCCGCTCCCGAGGCTGAGCAGGGCGGGGCTGAGTAAATGCCGGCTTACCATCTCTACCATCATCCGGTTTAGTCATCCAACaagaagaaatatgaaattccagcaataagaaatgaacaaaAGATTGGAGCTGAAGACCTAAAGTGCTTGCTTTTTGCCCGTTGACCAGATAAATAGAACTATCTGCATTATCTATGCAGCATGGGGTTTTTATTATTTTTACCTAAAGACGTCTCTTTTTGGTAATAACAAACGTGTTTTTTAAAAAAGCCTGGTTTTTCTCAATACGCCTTTAAAGGTTTTTAAATTGTTTCATATCTGGTCAAGTTGAGATTTTTAAGAACTTCATTTTTAATTTGTAATAAAAGTTTACAACTTGATTTTTTCAAAAAAGTCAACAAACTGCAAGCACCTGTTAATAAAGGTCTTAAATAATTGTCTTTGTGTAAATTTGTCTAGTTTTGCTTTAGTTTGTAAGTATTTAGCTATTTATAGGACCCTTAGCTTGACCCAGTCTACAAATAGATGATGCTCACTGGTAATTCCCTCAGGTAAAATGTCTCAAAATCTCTAATCCTTTAAGTGGCATGCCTGTGGGCCCATACTAAAAATTAGAAAATACATACTCTGATAACCTGGCCATTTTTCATTGAAGGATTTAGCTCATTTGTAAGAAAGACTTGAGTGTAGATTTTGGGTGGGTCCCTTTGGCTGTGAGGCATTGTTTAAAAGGGCATTGCTCTAGCCTAGACCGACCAGACTCTCATCCTGCTCCACTTAGTTTTGTCACCTTGGGAGAATTTGTTTCAGTGTGTCAATTGAAGATGCCAATTGAAGTGTTAGGACAACCTGTCACACTGCCTGGTGTGGTCATCAAATATTGGTTCAGCTCCTTATGTCCTAGAGATGGAAACAAGTAATATAAAACCCATGGGAAAGCTGCTTAGGAACATGGAGGTTGGTGAGCTTGTAATTATGTGGTTCTCAACACCTTAAATCCTAAGCCTAGTCTGGCTGATCttttctctttttgagacggagtcttgttctgtcatcaggctggagtacagtggcacaatcttggctcactgcaacctccacctctaggtttaagcgattctcctgcctcggccaccttagtagctgggagtacaggtgcgtgccaccacacccagctaatttttgtatttttaatagagatggggttgcactgtgttagccaggatggtcttgatctcttgaccttgtgatccgcccgcctcagcctcccaaagtgctgggattacaggtgtgagccaccgcacctggccTCTCTGGCTTTTGTTTTCTAATGTTTTGTTAGATGTTCTTTGGCTTGCTTTGTGAAATAGTCATGTAGTTGATAGTGACTGCTGCCCCGAAACACTCCAGATCATCCTGGCCAGCTATCAGGGCCCAGGGGAAGCAGACAGTAGGGGTCGGGAGTAGGCCAGAGTGGCACATCAGGAATCCTGCAGTGCTGTGGAAGTCATCTCCTGCTTGGGACTAACTCTTTGCAGAGGACTTGATAAGAGACTACTCAAAAAAAATTTTTTTAACCCTACTTAGTGTAAATATCTGTACTGCAGAAGTGAGTTAGCCTATTTCTTGCTGGTGTTCATGAAAATACTGTGTTGGCAAGAGTGCAGTGGACCTGAAACTTCAACTGTTGGTAGCATCTAAACTGTTACTTACAACTGCAGACGCACACAGTCCCTGACTTAAACAGTGGTTTGACTTAGGGGCTTTTAGTGGGGTtacggtttctactgaatcaacattgttttcatggcatcacagagttgaaaaatcataaatgaaaccattgtaagttgACTGCAGTGTTGCCAACattaaatgcagtttcaacttaa

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