RCPedia: Rtcs

Summary

Retrocopy Name	ZNF669P1	Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr2:203061790-203062403 UCSC
Coordinates (T2T)	chr2:203543300-203543913 UCSC
Coordinates (hg19)	chr2:203926513-203927126 UCSC
Strand	-
Parental Sequence	NM_001142572.2
Parental seq. overlap	482 bp
Parental seq. overlap (%)	27.9%
Genomic Region	Intragenic (NBEAL1)
Retrocopy Summary	ZNF669P1, located on chr2:203061790-203062403, is a retrocopy of the parental gene ZNF669. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	ZNF669
Full Name	zinc finger protein 669
Also known as	-
Coordinate	chr1:247099962-247104356
Strand	-
Gene summary	Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	ZNF670P1
Bonobo	Pan paniscus	ZNF670P1
Gorilla	Gorilla gorilla	ZNF669P1
Orangutan	Pongo abelii	ZNF670P1
Gibbon	Nomascus leucogenys	ZNF670P1
Green monkey	Chlorocebus sabaeus	ZNF670P1
Crab-eating macaque	Macaca fascicularis	ZNF670P1
Rhesus	Macaca mulatta	ZNF670P1
Baboon	Papio anubis	ZNF669P1
Golden snub-nosed monkey	Rhinopithecus roxellana	ZNF670P2
Marmoset	Callithrix jacchus	ZNF669P1
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>ZNF669P1
ATGGACTCAGTGACTTTTGAGGATGTGGCTGTAACCTTCACCCCTCAGGAGTGGGCGTTGCTGGATTTTTCCCAGAAGAAACTCTTATAGAGATGTGACGCAGGAAACCTTCAGGAATTTGGCTTCTACAGAAAACAAATGGGAAGACCAGAATGTTGACGATCAAGTCAGAAAATATGGGAGAAATGTAAGTCATATGGTAGAGAGACTGTGTGAAGGTAAACAAAATAGTCAAGGTGGAGAAACCTTCAGCCAGAATTCAAATCTTAATCTGAACAAGAAAGTTTCTACTAAAGTAAAACCATGTGTATGCAGAATGTGTGGAAAAGTCTTCATATGTCATGCATCTCTTCACAGGTATATTATATCTCACTCTGGACACAAACTATTTGAGTGTGAGGACTGTGAAATGAAGCCATATAAATGTAAACAATGTGGGAAAGCCTTTAATTCTCTCACAGGTGTTTGAAGACACATGGTAATGCACAGTGATAATGGATTTTATAAATGTACAGTATGTGGGGAAAACTTTATTTTCCCCAGTTTATTTCAAATGCACCAGAAAACTCACACTGGAGAAAACAACCCTATAAATGTAAACATTGTGGTAAAGA

>NM_001142572.2
GTCTCTCCTTCGCCGGAGCCGGCTCTTCCTGTTAGTCTCCGCTGCTAGTTCTTGGCTCTGGGAGGCCCAGGTGGCTCTGCAGCAGCCTCTGCCACCCTGTGACCTGCGAGTATTGGGACATCCCTAGCTGACGCCAGGACACCCGGGAAGCCGAGGAATGGACTCGGTGGCTTTTGAGGATGTGGCTGTGAACTTTACCCAGGAGGAATGGGCTTTGCTAGATTCTTCTCAGAAGAATCTCTACAGAGAAGTGATGCAGGAAACCTGCAGGAACCTGGCTTCTGTAGGAAGCCAATGGAAAGACCAGAATATTGAAGATCACTTCGAAAAACCTGGGAAAGATATAAGAAATCATATCGTACAGAGACTGTGTGAAAGTAAAGAAGATGGTCAGTATGGAGAAGTTGTCAGCCAAATTCCAAATCTTGATCTGAACGAGAACATTTCTACTGGATTAAAACCATGTGAATGCAGTATTTGTGGAAAAGTCTTTGTACGTCATTCCCTCCTTAATAGGCATATCCTAGCTCACTCAGGATACAAACCATATGGAGAGAAGCAATATAAATGTGAACAGTGTGGGAAATTCTTCGTTTCTGTTCCAGGTGTTAGAAGACACATGATAATGCACAGTGGAAATCCAGCTTATAAATGTACGATATGTGGGAAAGCTTTTTATTTTCTCAATTCAGTTGAAAGACATCAGAGAACTCACACAGGAGAAAAACCCTATAAATGTAAACAATGTGGTAAAGCATTCACTGTTTCCGGTTCTTGTCTAATACATGAACGAACTCACACTGGAGAGAAACCCTACGAATGTAAGGAATGTGGGAAAACATTCAGATTTTCTTGTTCTTTTAAGACGCATGAAAGGACTCACACTGGAGAAAGACCCTATAAATGTACCAAATGTGATAAAGCCTTCAGCTGTTCCACTTCCCTTCGTTACCATGGAAGCATTCATACTGGAGAGAGACCCTATGAGTGTAAACAATGTGGCAAAGCCTTTAGTCGTTTGAGTTCCCTTTGTAACCATAGAAGTACTCATACCGGAGAGAAACCCTATGAATGTAAACAATGTGATCAAGCCTTCAGTCGCCTCAGTTCCCTTCACCTCCACGAAAGAATTCATACTGGAGAAAAACCCTATGAATGTAAGAAATGCGGTAAAGCCTACACTCGTTCCAGTCACCTTACTCGCCATGAAAGAAGTCATGATATAGAggctgggtgtagtgactcagcctataatcccagcactttgggaggccaaggcgtgtggattgcttgagcccaggagttcataaccagcctggattaaaacaatgtgaaacaacctgggcaacatggtgaaaccctgtctttacaaaaaataaaataatgccgggcacggtggcttacgcctgtaatcccagcactttgggaggccgaggcgggtggatcacgaggtcaggagatcgagaccatcctggccaacacggtgaaaccccgtctctactaaaaatacaaaaaattagctgggcgtggtggcagacgcctgtggtcccagttactcgggaggctgaggcaggagaatggcatgaacccgggaggcggaacttgcagtgagccgagatcgcaccactgcacttcagcctgggtgacagagtgagactctgtctcaaaaaataagataaaataaaataaaaaaataattagctggg

>NM_001142572.2 

GTCTCTCCTTCGCCGGAGCCGGCTCTTCCTGTTAGTCTCCGCTGCTAGTTCTTGGCTCTGGGAGGCCCAGGTGGCTCTGCAGCAGCCTCTGCCACCCTGTGACCTGCGAGTATTGGGACATCCCTAGCTGACGCCAGGACACCCGGGAAGCCGAGGAATGGACTCGGTGGCTTTTGAGGATGTGGCTGTGAACTTTACCCAGGAGGAATGGGCTTTGCTAGATTCTTCTCAGAAGAATCTCTACAGAGAAGTGATGCAGGAAACCTGCAGGAACCTGGCTTCTGTAGGAAGCCAATGGAAAGACCAGAATATTGAAGATCACTTCGAAAAACCTGGGAAAGATATAAGAAATCATATCGTACAGAGACTGTGTGAAAGTAAAGAAGATGGTCAGTATGGAGAAGTTGTCAGCCAAATTCCAAATCTTGATCTGAACGAGAACATTTCTACTGGATTAAAACCATGTGAATGCAGTATTTGTGGAAAAGTCTTTGTACGTCATTCCCTCCTTAATAGGCATATCCTAGCTCACTCAGGATACAAACCATATGGAGAGAAGCAATATAAATGTGAACAGTGTGGGAAATTCTTCGTTTCTGTTCCAGGTGTTAGAAGACACATGATAATGCACAGTGGAAATCCAGCTTATAAATGTACGATATGTGGGAAAGCTTTTTATTTTCTCAATTCAGTTGAAAGACATCAGAGAACTCACACAGGAGAAAAACCCTATAAATGTAAACAATGTGGTAAAGCATTCACTGTTTCCGGTTCTTGTCTAATACATGAACGAACTCACACTGGAGAGAAACCCTACGAATGTAAGGAATGTGGGAAAACATTCAGATTTTCTTGTTCTTTTAAGACGCATGAAAGGACTCACACTGGAGAAAGACCCTATAAATGTACCAAATGTGATAAAGCCTTCAGCTGTTCCACTTCCCTTCGTTACCATGGAAGCATTCATACTGGAGAGAGACCCTATGAGTGTAAACAATGTGGCAAAGCCTTTAGTCGTTTGAGTTCCCTTTGTAACCATAGAAGTACTCATACCGGAGAGAAACCCTATGAATGTAAACAATGTGATCAAGCCTTCAGTCGCCTCAGTTCCCTTCACCTCCACGAAAGAATTCATACTGGAGAAAAACCCTATGAATGTAAGAAATGCGGTAAAGCCTACACTCGTTCCAGTCACCTTACTCGCCATGAAAGAAGTCATGATATAGAggctgggtgtagtgactcagcctataatcccagcactttgggaggccaaggcgtgtggattgcttgagcccaggagttcataaccagcctggattaaaacaatgtgaaacaacctgggcaacatggtgaaaccctgtctttacaaaaaataaaataatgccgggcacggtggcttacgcctgtaatcccagcactttgggaggccgaggcgggtggatcacgaggtcaggagatcgagaccatcctggccaacacggtgaaaccccgtctctactaaaaatacaaaaaattagctgggcgtggtggcagacgcctgtggtcccagttactcgggaggctgaggcaggagaatggcatgaacccgggaggcggaacttgcagtgagccgagatcgcaccactgcacttcagcctgggtgacagagtgagactctgtctcaaaaaataagataaaataaaataaaaaaataattagctggg

Publications

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