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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPL27P8
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:206040496-206040871  UCSC
Coordinates (T2T) chr2:206522433-206522808  UCSC
Coordinates (hg19) chr2:206905220-206905595  UCSC
Strand +
Parental Sequence NM_001349922.2
Parental seq. overlap 324 bp
Parental seq. overlap (%) 41.4%
Genomic Region Intragenic (INO80D)
Retrocopy Summary RPL27P8, located on chr2:206040496-206040871, is a retrocopy of the parental gene RPL27. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPL27
Full Name ribosomal protein L27
Also known as DBA16|L27
Coordinate chr17:42998273-43002959
Strand +
Gene summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L27e family of ribosomal proteins and a component of the 60S subunit. A splice site mutation in this gene has been identified in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RPL27P7
Bonobo Pan paniscus RPL27P7
Gorilla Gorilla gorilla RPL27P7
Orangutan Pongo abelii RPL27P7
Gibbon Nomascus leucogenys RPL27P12
Green monkey Chlorocebus sabaeus RPL27P5
Crab-eating macaque Macaca fascicularis RPL27P10
Rhesus Macaca mulatta RPL27P10
Baboon Papio anubis RPL27P15
Golden snub-nosed monkey Rhinopithecus roxellana RPL27P14
Marmoset Callithrix jacchus RPL27P7
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPL27P8
ACAAAGCTGTCATCGTAAAGAACATTAATGATGGCACCTCAGACTGCCCCTACATCCAAGCTCTCGTGGTTGGAATTGATCGCTATCCCTGCAAAGTGACAGCTGCCATGGGCAAAAAGAAGATTACCAGGAGGTCAAAGATCGAGTCTTTTGTGAAGGTTTATAACTACAATCATCTTACGCCTACAGTGCACTCTGTGGATATCCTCTTACACAAAACTGTCATCCACAAGGATGTCTTCAGAGATCCTGCTCTTAAACACAAGTCCCAATGGGAGGCCAAGGTCAAGCTCAAAGAGAGATACAAAACGGGCAAGAACAAGCAGTTCTTCCAGAAGCTACAGTTTTAGATGTTTTGTTTCCATCTTAAAAATTA
>NM_001349922.2
AGCGGAAGTGTCCTTCTTTCCTTTTTGCTGGTAGGGCCGGGTGGTTGCTGCCGGTAAGTAGAAGCTTGGGTTGAATCTTTCAATCCGCTGCCATCCGCGGCTTGGGGGTCGAAGGTCCGGGCGGCGCCGGGTGCATTCCTTCCCTAGGTCTCTGGCGGCTACGTATCCGATCCTGTCCTGCGAGCAGGGCCCTCGGGCGGCCTTGACCAAGGCGACAGTGAACACAGTCTGAAGTTCCGGCCCAAGACCTGGGCTTGCTGGCAGGAGTCAGCTCTGGGCATCTTTGGCTTTACGGATTTTTAAGTGGCCCTTTCTCCTTGCTCTCTGCAGAAATGGGCAAGTTCATGAAACCTGGGAAGGTGGTGCTTGTCCTGGCTGGACGCTACTCCGGACGCAAAGCTGTCATCGTGAAGAACATTGATGATGGCACCTCAGATCGCCCCTACAGCCATGCTCTGGTGGCTGGAATTGACCGCTACCCCCGCAAAGTGACAGCTGCCATGGGCAAGAAGAAGATCGCCAAGAGATCAAAGATAAAATCTTTTGTGAAAGTGTATAACTACAATCACCTAATGCCCACAAGGTACTCTGTGGATATCCCCTTGGACAAAACTGTCGTCAATAAGGATGTCTTCAGAGATCCTGCTCTTAAACGCAAGGCCCGACGGGAGGCCAAGGTCAAGTTTGAAGAGAGATACAAGACAGGCAAGAACAAGTGGTTCTTCCAGAAACTGCGGTTTTAGATGCTTTGTTTTGATCATTAAAAATTATAAAGAAAAAAA

Publications

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