Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name MSL3P1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:233865442-233868323  UCSC
Coordinates (T2T) chr2:234354245-234357127  UCSC
Coordinates (hg19) chr2:234774088-234776969  UCSC
Strand -
Parental Sequence NM_001193270.2
Parental seq. overlap 1834 bp
Parental seq. overlap (%) 70.5%
Genomic Region Intergenic
Retrocopy Summary MSL3P1, located on chr2:233865442-233868323, is a retrocopy of the parental gene MSL3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MSL3
Full Name MSL complex subunit 3
Also known as MRSXBA|MRXS36|MRXSBA|MSL3L1
Coordinate chrX:11758159-11775772
Strand +
Gene summary This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MSL3P1
Bonobo Pan paniscus MSL3P1
Gorilla Gorilla gorilla MSL3P1
Orangutan Pongo abelii MSL3P1
Gibbon Nomascus leucogenys MSL3P3
Green monkey Chlorocebus sabaeus MSL3P2
Crab-eating macaque Macaca fascicularis MSL3P3
Rhesus Macaca mulatta MSL3P3
Baboon Papio anubis MSL3P2
Golden snub-nosed monkey Rhinopithecus roxellana MSL3P4
Marmoset Callithrix jacchus MSL3P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MSL3P1
TTCGTAGATTACAGCATAAATTGGCAAGAAATGCTGTAGCTCACCTGAGGAGCAAGAGAGAAAGAAGCAGCCGCTCCAGGTTGCTTGGTGCTGACTCTGTCTTTTTTTAAAAGGCCTCTCCATCGAAGAAAAAAATGAAAATGATGAAAACTCATTAAGCAGTTCCTCTGACAGTAGTGAAGACAAGGATGAAAAAATAAGTGAAGAATGTGATATTGAAGAAAAGACTGAAGTGAAAGAAGAACCGGAGCTTCAAACAAAAAGGGAAATGGAAGAAAGAACAGTAACTCTAGAAATCCCTGAAGTTCTGAAGAGGCAGCTGGAGGATGATTGTTACTACATTAATCGGAGGAAACGGTTAGTGCAACTTCCATGCCACACCAACATCATAACGATTTTGGAATCCTATGTGAAGCATTTTGCTATCAGTGCAGCCTTTTCAGCCAATGAGAGGCCTCGTCACCATCACGCTATGCCACATGCCAGCATGAACGTGCCTTATATCCCAGCAGAAAAGAATATTGACCTTTGTAAGGAGATGGTGGATGGATTAAGAATAACCTTTGATTACACTCTCCCGTTGGTTTTACTCTATCCCTATGAACAAGCTCAGTATAAAAAGGTGACTGCATCTAAGGTTTTTCTTGCAATTAAGGAAAGTGCCACAAATACTAATAGGAGCCAGGAGAAGCTCTCTCCCAGCTTACGTTTGTTGAATCCATCCAGGCCGCAGTCTACAGAGAGTCAGTCGACCAGCGGTGAACCAGCCACCCCTAAAAGGCGCAAAGCCGAGCCGCAAGCAGTGCAGTCTCTGAGGCGGTCCTCGCCCCACACCGCCAACTGTGACAGGCTTTCTAAGAGCAGCACCTCACCTCAGCCCAAGCGCTGGCAGCAGGACATGTCCACCAGTGTGCCCAAGCTGTTCCTGCACCTGGAAAAGAAGACACCTGTGCATAGCAGATCATCTTCACCTACTCTGACTCCTAGCCAGGAAGGGAGTCCTGTGTTTGCTGGCTTTGAAGGGAGAAGAACTAATGAAATAAATGAGGTCCTCTCCTGGAAGCTCGTACCTGACAATTACCCACCAGGTGACCAGCCACCTCCACCCTCTTACATTTACGGGGCGCAACATTTGCTGCGATTGTTTGTCAAACTTCCAGAAATTCTTGGAAAAATGTCCTTTACTGAGAAGAATCTGAAGGCTTTATTGAAGCACTTTGATCTCTTTGTGAGGTTTTTAGCAGAATACCACGATGACTTCTTCCCAGAGTCAGCTTACGTCGCTGCCTCTGAGGTGCATTACAGCACCAGGAACCCCCAGGCAGTCAATAAGTGTTGATGGTTCTGTAAGAACAACTGCTCCATCTAGCATGGTGTTCTGAGTTCCAGGTAAAAAATTAACAAGGTGGTGGGTTTTTATCCAGAGCACAAAACAAAGTGCCCACCAGGGGGCTTTGACAGAGGTGTGCCCTGTTGTTTGAGTTCCCCATGTACTGTAGTTACTCTGTTTAGAATTATTTCCTAGGTGCCTGAAAGTGTTCTGACATGACACTTGCTACTTTGTAGGCCATCTGTGATGGCAGGTAAAAAGCAACTGTTCACAGTGAAATGTTCATGGAAGTGTACATAGGTTAGGCCATTTCAGCAGACATTGCAGTTAGTCAGCAAGAACCACATTGTTTCGTTATTTGTTAGCATTAAACAAAATTTTTTTTGCAAATTGGTTTCATTCTCTTGATGAAGCTGAGCAACTGTCCAACAAGGTTTAGTTTGTACTTGAAAACTGCAAAGTAGTCTCAAAGTATTTTAGAGGGAATCCATATTGATGGCAAAAGAAAATTTGCAGCTATAATTTGCTTCTGACGGTTCCTTCTCTGTGAAACATTATTTTTGGTGATCTAAAGAAAGCATTGCCTTTCTTGTTTGCAATTTTACAGCTATACTTTTTTGTGTAATGTTACGGTTCCCTTTCTGTAAAATGTTCTTTTTGGTGATCTAAATAAAGCCTCTCTTGTTTGAAAAGGTTTCTCTCTTCGCGTTAAATCTCCCCTGCCGTGCAGCCTGGTGCCGCGTAGGCTCCCGTGGGACGCTCCCGTCGGACGCCGTCCGACCTAGATTGTTAATGTTATTGTTGGGAAAGGCGAAAAAGGCAGAAAGATCCCAGAATAGCTGATCCGTTGTAACGGTTGGAACTGAAGCTGGGATAGATGGGTAGCCGAAGATCATGTGCTTCGTGAGCCCAGTGAAAATCGTAGATTg
>NM_001193270.2
GCACGCGCGGTTGGGAGCCTCGCCCATGCTTTGTCGCGTTACCGGGGCTACCGTTTGCGCCCCCGACTGCAACGGTGGCCGCTGAGGGAGGAGGCTTCTCGAATACGGTTTCTGTCTTCGCGTTAAATGTCTCCTTCTGTGCGGCCTGGTGCCGGGTGGGCTCCTGTGGGACGCCCTGGCCGTCCGATCCAGATTGTTGATGTTATTGTTGGGAAAGACGAAAAAGGCAGAAAGATCCCAGAATATCTGATCCATTTTAATGGTTGGAACAGAAGCTGGGATAGATGGGCAGCAGAAGATCATGTGCTTCGTGATACCGATGAAAATCGTAGATTACAGCGTAAATTGGCAAGAAAAGCTGTAGCTCGCCTGAGGAGCACAGGAAGAAAGAAGAAGCGCTGCAGGTTGCCTGGTGTGGACTCTGTCTTAAAAGGCCTCCCCACTGAAGAAAAAGATGAAAATGATGAAAACTCATTAAGCAGTTCCTCTGACTGTAGTGAAAACAAGGATGAAGAAATAAGTGAAGAAAGTGATATTGAAGAAAAGACTGAAGTGAAAGAAGAACCAGAGCTTCAAACAAGAAGGGAAATGGAAGAAAGAACAATAACTATAGAAATCCCTGAAGTTCTGAAGAAGCAGCTGGAGGATGATTGTTACTACATTAACAGGAGGAAACGGTTAGTGAAACTTCCATGCCAGACCAACATCATAACGATTTTGGAATCCTATGTGAAGCATTTTGCTATCAATGCAGCCTTTTCAGCCAATGAGAGGCCTCGTCACCATCACGTTATGCCACATGCCAACATGAACGTGCATTATATCCCAGCAGAAAAGAATGTTGACCTTTGTAAGGAGATGGTGGATGGATTAAGAATAACCTTTGATTACACTCTCCCGTTGGTTTTACTCTATCCATATGAACAAGCTCAGTATAAAAAGGTGACTTCGTCTAAATTTTTTCTTCCAATTAAGGAAAGTGCCACAAGCACTAACAGGAGCCAGGAGGAACTCTCTCCCAGTCCGCCTTTGTTGAATCCATCCACGCCACAGTCCACAGAGAGTCAGCCGACCACCGGTGAACCAGCCACCCCCAAAAGGCGCAAAGCTGAGCCAGAAGCATTGCAGTCTCTGAGGCGGTCCACGCGCCACAGTGCCAACTGTGACAGGCTTTCTGAGAGCAGCGCTTCACCTCAGCCCAAGCGCCGGCAGCAGGACACATCCGCCAGCATGCCCAAGCTCTTCCTGCACCTGGAAAAGAAGACACCTGTGCATAGCAGATCATCTTCACCTATTCCTCTGACTCCTAGCAAGGAAGGGAGTGCTGTGTTTGCTGGCTTTGAAGGGAGAAGAACTAATGAAATAAACGAGGTCCTCTCCTGGAAGCTTGTGCCTGACAATTACCCCCCAGGTGACCAGCCGCCTCCACCCTCTTACATTTATGGGGCACAACATTTGCTGCGATTGTTTGTGAAACTTCCAGAAATCCTTGGAAAGATGTCCTTTTCTGAGAAGAATCTGAAGGCTTTATTGAAGCACTTTGATCTCTTTTTGAGGTTTTTAGCAGAATACCACGATGACTTCTTCCCAGAGTCGGCTTATGTCGCTGCCTGTGAGGCACATTACAGCACCAAGAACCCCCGGGCAATTTATTAAAATGTTGTTGGTTCTGTAAGAGCAACTGCTCTGTCTAGTTTGGCGCTCTGGGTTCCAGGTGAATAACTAACAAGGTGGTGGGTCTTTACCCACAGCGCAAACACAATGCCCACCTTGGGGCTCTGTTGTTTGAGTTGCCCACATACTGCAGTTATTCTGTTAGGAATGATTCCCTGGGTGCCTGAAAGTGCTCTGACACGACACTTGTTACTTTGCAGGCCATCTGTGATGGCAAGGAAAAAGCAACTATGTTCACAGTGAAATATTCGTGGAATAGGTTAGGCCATTTCAGTAGACATTGCAGTTAGTTAGCAAGAACCACATTGTCTCTTTATTTGTTAGCATTAAACAAATTTTTTTTTGCAAATTGGTTTTATTTTTTTGATGAAGCCGAGCAACTCTGTCCAAAAAGGTTTAGTTTGTACTCGGAAACCACAAAGTAGTCTCAAAGTATTTTAGAGGGAATCGATATTGATGGCAAAAGAAAATTTGCAGCTATGCATTTGCTTCTAACGGTTCCCTCTCTGTGAAACATTATTTTTGGTGATCTAAAGAAAGCATTGCCTTTCTTATTTGAGATTTTACAGCTATACTTTGTTGTGTAATGTTATGGTTCCCTTTCTGTAAAATGTTATTTTTGGTGATCTAAATAAAGCCTGTCTTGTTTGAAAGAA

Publications

PMID - Link Title