Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PGAM1P6
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:23872267-23873030  UCSC
Coordinates (T2T) chr2:23906959-23907722  UCSC
Coordinates (hg19) chr2:24095137-24095900  UCSC
Strand -
Parental Sequence NM_002629.4
Parental seq. overlap 649 bp
Parental seq. overlap (%) 35.9%
Genomic Region Intragenic (ATAD2B)
Retrocopy Summary PGAM1P6, located on chr2:23872267-23873030, is a retrocopy of the parental gene PGAM1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PGAM1
Full Name phosphoglycerate mutase 1
Also known as HEL-S-35|PGAM-B|PGAMA
Coordinate chr10:97426191-97433444
Strand +
Gene summary The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PGAM1P1
Bonobo Pan paniscus PGAM1P1
Gorilla Gorilla gorilla PGAM1P1
Orangutan Pongo abelii PGAM1P1
Gibbon Nomascus leucogenys PGAM1P10
Green monkey Chlorocebus sabaeus LOC103216807P6
Crab-eating macaque Macaca fascicularis PGAM1P13
Rhesus Macaca mulatta PGAM1P12
Baboon Papio anubis PGAM1P12
Golden snub-nosed monkey Rhinopithecus roxellana PGAM1P16
Marmoset Callithrix jacchus PGAM1P15
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PGAM1P6
TCCCCAGCCCGCTGCCATGGCCACCTACAAACTGGTGTTGATCTGGCCCAGTGAGAGCACCTGGAACCTGGAGAACTGCTTCAGCGACTGGTACAATGCCAATGTGAGCCCGGCGGGCCATAAGGAGATGAAGAGTGGCAGGCAGGCAGGCACTGTGAGATGGCTGGCTATGAGTTTGACATCTGCTTCACCTCAGTGCAGAAGAGAGCAATCTGGACCCTCTGGACAGTGCTAGATGCCATTGATCAGATGTGGTTGCCTGTAGTGAGGACTTGGTGCCTCAGTGAGCAGCACTATGGGGGTCTGACTGATCTCAGTAAAGCAGAAACTGCTGCAAAGCATGGTGAGGCCCAGGTGAAGATCTGGAGGCTCTCCTATGATGTTCCACCACCTCCGATGGAGCCTGACCATCCTTTCTACAGCAACATTAGTAAGGATCGCAGGCATGCAGACCTCACGGAGGATCAGCTACCCTCCTGTGAGAGTCTGAAGGACTCTCAAAGCCAGAGCTCTGCCGTTTTGGAATGAAGAAATAGCTCACCTGGTAAAAGAGGGGAAATGGGTGCTGATTGCAGTGCATGGCAACAGCCTCTGGGGCATTGTGAAACATTTGGATGGTCTCTCTGAAGAGGCTGTCATGGAGCTGAACCTGCCGACTAGTATTCCCATTGTCTATGAATTTGACAAGAACTTGAAGACCATCAGGTGCATGCAGTTCCTGGGGGATGa
>NM_002629.4
GAGAACTTGCGCGGGAGCCGGACTGAGCGGTGCGAGCGCGCAGGCGCGGCCGACGGGGCGGGCTGCTACTCCGGAATCTGCTAATCCCAGTCGGTGCCGCATCCCCAGCCCGCCGCCATGGCCGCCTACAAACTGGTGCTGATCCGGCACGGCGAGAGCGCATGGAACCTGGAGAACCGCTTCAGCGGCTGGTACGACGCCGACCTGAGCCCGGCGGGCCACGAGGAGGCGAAGCGCGGCGGGCAGGCGCTACGAGATGCTGGCTATGAGTTTGACATCTGCTTCACCTCAGTGCAGAAGAGAGCGATCCGGACCCTCTGGACAGTGCTAGATGCCATTGATCAGATGTGGCTGCCAGTGGTGAGGACTTGGCGCCTCAATGAGCGGCACTATGGGGGTCTAACCGGTCTCAATAAAGCAGAAACTGCTGCAAAGCATGGTGAGGCCCAGGTGAAGATCTGGAGGCGCTCCTATGATGTCCCACCACCTCCGATGGAGCCCGACCATCCTTTCTACAGCAACATCAGTAAGGATCGCAGGTATGCAGACCTCACAGAAGATCAGCTACCCTCCTGTGAGAGTCTGAAGGATACTATTGCCAGAGCTCTGCCCTTCTGGAATGAAGAAATAGTTCCCCAGATCAAGGAGGGGAAACGTGTACTGATTGCAGCCCATGGCAACAGCCTCCGGGGCATTGTCAAGCATCTGGAGGGTCTCTCTGAAGAGGCTATCATGGAGCTGAACCTGCCGACTGGTATTCCCATTGTCTATGAATTGGACAAGAACTTGAAGCCTATCAAGCCCATGCAGTTTCTGGGGGATGAAGAGACGGTGCGCAAAGCCATGGAAGCTGTGGCTGCCCAGGGCAAGGCCAAGAAGTGAAGGCCGGCGGGGAGGATACTGTCCCCAGGAGCACCCTCCCTGCCCGTCTTGTCCCTCTGCCCCTCCCACCTGCACATGTCACACTGACCACATCTGTAGACATCTTGAGTTGTAGCTGCAGACGGGGACCAGTGGCTCCCATTTTCATTTTAGCCATTTTGTCGCCTGCACCCACTCCCTTCATACAATCTAGTCAGAATAGCAGTTCTAGAGCACAGGTTCTCAGTCTAAGCTATGGAAAAGCTCCCCTTATCCAACAGAGTTTAAAAGTAGTGACTTGGGTTTTTGCGAGTGCTTTGTTTACTAAGGACTTTGGGGAGGAACCATGCTAAGCCATGACCAGTGAGGAGAAGCAACAGAGCCTGTCTGTCCCCATGAGCGGAGTCTGTCCTCTGCTCTTCTGCAGTCAGGTCACTGCCTACTGCCTGGGGGCTCTAGTCATTCCAGTGGAAGACGAATGTAACCTGCGTGGTGATGTGACAACTGTTTCCTCCCTGACCCCAGAGGATCTGGCTCTAGGTTGGGATCAATCCTGAATTTCGTTATGTGTTAATTTACTTTTATTAAAAAAGTATAGTATATATAATACAAAACAATAACCCTTCTGGGGTTTCTTGTGGCGGTTGAAATAGTCCCACATGTGGTCATCAGAAAATAAGCCATTCCTCATACCAATATAGGATCAGCTCCTTGACCTCTGAGGGGCAGGAGTGCTTCCTGGTGTGTGTATTAGAATCCCTTCCTGCCTTGTTTCATGGCAGTGAAATGCCTCTTGGTCCTGTCCAAGTGTATCTTTCACTGATTTCTGAATCATGTTCTAGTTGCTTGACCCTGCCACATGGGTCCAGTGTTCATCTGAGCATAACTGTACTAAATCCTTTTTCCATATCAGTATAATAAAGGAGTGATGTGCAATAGCT

Publications

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