Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HMGN2P20
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:24330396-24331936  UCSC
Coordinates (T2T) chr2:24365023-24366563  UCSC
Coordinates (hg19) chr2:24553265-24554805  UCSC
Strand +
Parental Sequence NM_005517.4
Parental seq. overlap 891 bp
Parental seq. overlap (%) 45.9%
Genomic Region Intragenic (ITSN2)
Retrocopy Summary HMGN2P20, located on chr2:24330396-24331936, is a retrocopy of the parental gene HMGN2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HMGN2
Full Name high mobility group nucleosomal binding domain 2
Also known as HMG17
Coordinate chr1:26472440-26476642
Strand +
Gene summary The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HMGN2P6
Bonobo Pan paniscus HMGN2P4
Gorilla Gorilla gorilla HMGN2P6
Orangutan Pongo abelii HMGN2P8
Gibbon Nomascus leucogenys HMGN2P25
Green monkey Chlorocebus sabaeus HMGN2P28
Crab-eating macaque Macaca fascicularis HMGN2P36
Rhesus Macaca mulatta HMGN2P44
Baboon Papio anubis HMGN2P46
Golden snub-nosed monkey Rhinopithecus roxellana HMGN2P54
Marmoset Callithrix jacchus HMGN2P55
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HMGN2P20
ACCACCATGCCCAAGAGAAAGGGTGAAGGGGATGCTAAAGGAGATAAAGCCAAGGTGAAGAACGAACCACAGAGAAGACCCATGAGGTTGTCTGCTAAACCTGCTCCTCCAACGCCAGAGCCCAAGCCTGAAAAGGCCCCTGCAAAGAAGGGAGAGAAGGTACCCAAAGGGAAAAAGGGAAAAGCTTATGCTGGCAAGGAGGGGAATAACCTTGCAGAAAATGGAGATGCTAAAACAGACGGGGCACAGAAAGCTGAAAGTGCTGGAGATGCCAAGTGAAGTGTGTGTATTTTTTATAACTGTGTACTTCTGGTGACAGTAGTTTGAAATACTATTTTTTATCAAGTTTTATAAAAAATGCAGAATTTCAcTACTTTTTTTTTTTTTAAGCTATGTTGTTAGCACACAGAACACTTCATTGTTGTTTTTGGGGGAAGGGCCATATGTCACTAATAGAATGTCTCCGAAGCTGGACTAATGTGGAGGAAACACCTTTCCCTTCTAGTTTTGAGAGAGTTCCTCTTGGCTCCCAGGAGGAGGGATTCCCTGACTTTAACACACATGGCCACCTTGGCACAAAAGCCTTGTGGTATGGAAAACAAATTTGTTTTTATGTCCTCTTCTCCCTTTCCGTCCTTCAGCAGAGACTTAACTCCCTTAAACCCAGACATCTGTTGAGACCTGACCCCCCAATCATTAGTTACCAGTGTGTCAGGCAATCTGGACTTTCCAGTGATGCCACTGAGACGGCACCTGTCAAAAGAGCAGTGGTTCTTCAGATAAATTCTGCCATTTTCATTTCACTTCCTGAAAGTCAGGGTCGGCTGGGAAAAGTTGTTAAACAATATGCTAAATGTGAAATGTCAACCCTCACTCTAAACTTTCCCTGTTCACAGCATCAGATGAAGACTTCATTGGGTTTTAGAGTGGCTTTC
>NM_005517.4
GAAATCCGGTTCTAACCGGTCCGGGGCTCCCAGCGCTATAAAAACTTTATAAACCCCCCGGAGCCCGAGCAGTGTGAAGAAGAGGCGAGAACGACCCCCGGACCGACCAAAGCCCGCGCGCCGCTGCATCCCGCGTCCAGCACCTACGTCCCGCTGCCGTCGCCGCCGCCACCATGCCCAAGAGAAAGGCTGAAGGGGATGCTAAGGGAGATAAAGCAAAGGTGAAGGACGAACCACAGAGAAGATCCGCGAGGTTGTCTGCTAAACCTGCTCCTCCAAAGCCAGAGCCCAAGCCTAAAAAGGCCCCTGCAAAGAAGGGAGAGAAGGTACCCAAAGGGAAAAAGGGAAAAGCTGATGCTGGCAAGGAGGGGAATAACCCTGCAGAAAATGGAGATGCCAAAACAGACCAGGCACAGAAAGCTGAAGGTGCTGGAGATGCCAAGTGAAGTGTGTGCATTTTTGATAACTGTGTACTTCTGGTGACTGTACAGTTTGAAATACTATTTTTTATCAAGTTTTATAAAAATGCAGAAttttgttttactttttttttttttttAAAAGCTATGTTGTTAGCACACAGAACACTTCATTGTTGTTTTTGGGGGAAGGGGCATATGTCACTAATAGAATGTCTCCAAAGCTGGATTGATGTGGAGAAAACACCTTTCCCTTCTAGTTTTGAGAGACTTCCTCTTGGCTCCCAGGAGGAGGGATTCCCTGACTTTGACACACATGGCCACCTTGGCACAAAAGCCTTGTGGTATAGAAAAACAAATTTGTTTTTATGTCCTCTTCTCCCTTTCCATCGTTCAGCATAGACTTAACTCCCTTAAGCCCAGACATCTGTTGAGACCTGACCCCTAGTCATTGGTTACCAGTGTGTCAGGCAATCTGGACTTTCCAGTGATGCCACTGAGATGGCACCTGTCAAAAGAGCAGTGGTTCCATTTCTAGATTGTGGATCTTCAGATAAATTCTGCCATTTTCATTTCACTTCCTGAAAGTCAGGGTCGGCTTGTGAAAAGTTGTTAAACAACATGCTAAATGTGAAATGTCAACCCTCACTCTAAACTTTCCCTGTTCAGAGCATCAGATGAAGACTTCATTGGGTTTTATAGTGGCTTTCTGATTTTTGGTAGTCCATTGAAGAAGGGAGTTTGAAAGTTGTTGTATACTGTTAACGATTGTCTGCCCATGTCCTGCCTGAAATACCATGATTGTTTATGGAAAGTATCTTTAATAAAGCTGGATACAGTTTGGCTTGGAATGCTGCCTCTGATCTTTTCCCACAAGTGGGGTAACCTGGTTTATCCAAGTCTCTTGGAACAGGGTACGTTCTGCTTTGAGGTACTCCATGTACAGTCTAATGATGATCTTTCACTGATTTATAGTCAGCTTCCAAAACACACAGTGCTAGGTGCAGTTAGGAAGGATTCCAGGAGTAGACTTAGCTGATGGTGAAAGGCTGGGAGTATGGAGTGATTTCTGTACTTGGTTATGCAGCATTCCCTGCAGTGTTTGTTTTTTGCATGACTCCGAATACATGAAGTGTATTAAATGCAGATTTTTGGTAGATCTGCGGTTTTGGCTGGGTAGCTGACAGGAGCCTCTCTACTTCCATCTGCATTTGCAACTTCTATAAAATTAGCAAATTAATAGACTCATGTCAGAGAGTGTCTCTGTGAATGTGTACACAGTTGTCCATTTGTAAGGTAGATGACACTTTGCTCCTAAGTAGACCTGCAAACAAAGACAATGGGGTCTTTCCTGATTCCTTTAGTTTGGAGATGCAGAGAACCCCACGTTTCTCTAAGTGAAATGGCAAGAAGTTATTTGTTAGAATATGGAACTGGTAACAAATTCATGTTTGCACCTTGAATTTGCTTTCACAGACCTGGCTGTATTGTTGGACAGGAATAAAGTAAATTGGAGACTAA

Publications

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