Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name TRNT1P2
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Plot displaying the genomic locations of a retrocopy (in chr22) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr22:45792420-45793598  UCSC
Coordinates (T2T) chr22:46277125-46278303  UCSC
Coordinates (hg19) chr22:46188300-46189478  UCSC
Strand -
Parental Sequence NM_001367323.1
Parental seq. overlap 1000 bp
Parental seq. overlap (%) 30.4%
Genomic Region Intragenic (ATXN10)
Retrocopy Summary TRNT1P2, located on chr22:45792420-45793598, is a retrocopy of the parental gene TRNT1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TRNT1
Full Name tRNA nucleotidyl transferase 1
Also known as CCA1|CGI-47|MtCCA|RPEM|SIFD
Coordinate chr3:3126940-3153435
Strand +
Gene summary The protein encoded by this gene is a CCA-adding enzyme which belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. This essential enzyme functions by catalyzing the addition of the conserved nucleotide triplet CCA to the 3' terminus of tRNA molecules. Mutations in this gene result in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TRNT1P2
Bonobo Pan paniscus TRNT1P2
Gorilla Gorilla gorilla TRNT1P2
Orangutan Pongo abelii TRNT1P2
Gibbon Nomascus leucogenys TRNT1P1
Green monkey Chlorocebus sabaeus TRNT1P1
Crab-eating macaque Macaca fascicularis TRNT1P2
Rhesus Macaca mulatta TRNT1P2
Baboon Papio anubis TRNT1P2
Golden snub-nosed monkey Rhinopithecus roxellana TRNT1P2
Marmoset Callithrix jacchus TRNT1P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.20.40.6
log10(TPM+1)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

AdiposeBone MarrowBreast Mammary TissueBrain CerebellumColonColon Colonic MucosaEsophagusHeartHeart VentricleKidneyLiverBrain MidbrainOvaryPancreasBrain PonsKidney CortexEye RetinaMuscle SkeletalSkinSmall IntestineBrain Spinal CordSpleenTestisThymusTracheaHeart ValveMuscle Smooth01234
log10(TPM+1)

Related Sequence

>TRNT1P2
AATGAAGGTGCAGGCTCCAGAATTCTAGTCATTTGTCACAGAAAGATTGAAGAGCTTGACAGAATTATTTGTTAAAGAGAATCGTGAATTCAGAATAGCAGAAGGAGCAGTGAGAGATTTATTAAATGGAATAAGACCTCAAGATGTGGACTCTGCTACCATTGTTACCCTTATTGAAATGCAGTAGATGTTTCCGTCAGCTGGTATTTGGATGATGGACAGCAGAAAAGCACAGAACAATTACTGCCAGGCTTCGTGAAGACAATTTTTAAATTACTACACTCTGGACTGATGTTGTCACTGATGGAAGACATGCTGAGGACAAATTCACAACTGACTAGGAGATGCTGAACACAAAGCTCTCTAGCAAACAATTCTATGTCTTTGGGTTTTGATGGTACTTTATCTAATTTAATGGTTATGGAGATTTTTTAAAATAAGAAAAGTCTGTTGGACATCAACAGAGTACAATACAATTGTTTTTGAATTTTAAGATATGTCAGGTTTTGTGGGAGAACTGTAGACAAACCTGGTGACCACGGTCCTGAGAAGCAACTGCAGAGCCTGCAAAAGGCCTGGCTGGGCTATTAGGAGAAAGCATTTGGGTGGAACTAAAAAAGCTCTTGTCAGTAAACATGTAAATCATTTGATTCACCTTATCTATGATCTTCATGTGGCTCCCTATGTAGGTATAACAGCCAATGCAAGTTTAGAAGAATTTAACAAAGTCAGTAAAAATGTCGAAGGTTTTTCACCAAAGCCAATGACTCTTTTGGCCTCATTATTCAAAGTACAGAATGATGTCACAAAATTGGATTGGAGGTTGACGATTTCAAAAGAAGAGAAAAACCTTGGCTTGTTTATAGTTAAAAATAAAAAAGACTGAATTAAAGCAATAGATAGTTCAGAGCCACTGAAACCCTACCAAGACTTTCTCAGGGACTTTAGGGAACTTGCCGTGACTTCTCACATACGTGAACTACTGAAGAGCCAAGGAGAGCACCATCCCCTAAAGGAAAGGCAGCTGTGGTCCCTTCCTACAGTTCCTGTTCAGTGGGCATGACACCAGAAAAGGGGACATTTCTTGGGGGAAAAGAAACCAGGGCTCTATTACAACAACTACAAGAACGGTGGAGAAAAAGTGGTTACCAAGGGGGAAAAGATAAACTTCTAAGTTAT
>NM_001367323.1
AGCCCGGAAGTGCGCGTggcggcggtggcggctgcggcaacagcggggccggTAAGCGGGCGCGCGCCGCTCAGAGGGGCAGAGTTGGTGGCGTGAGTTGCTGCCCCTTCCTTCCTGCTGTGGGCCAGAGGCGCCACCGCGCCCGGTCCTCGAGGAAGACGGGAGCGGGACGTGGCGAGAGGCCTCCTCAGCAGTGGGCAAAATAGCCCCGACGCGGAGGTCGTGTCCCCGCCACGTTTCCGGCGACCGCAGGCGCGGATTCCTTGGCTTCCCTCAGCACTTTCCCCTCCGCGCGGACGGCCCCGAGACGCTTTTTCACTGGGCCTTGTCGCCAGCACCCGGCGTGGGGGGTGAGACGCGCCTTTTCAGGGCTGGGGTTCCCCAGAGCGTTTTCCTAAGTCGAGGCGGAGGTGCGAGGAAACTGAGTGGGTCTTTCCGCCCCACGTGGCCTGCCGGGAAGCGCGGCTCCTCCACCCGCTTCCGTGGAATGGAATGGTTTTTCTCTGCAGGTTTACACCGGGGTCACTCGAGAGCTGCTGCGGCCTCCTTATGGGCAGGACCCCCGTATGGGGAGAACGAGGATGTGATATGTAGAAGGGAAGGCCGCGGTGTGCCAGAAATCAGAGGAGATTGCAAGATGGCAGGAAAAGAATCAGGAAAATGGGGGCAGCAAAACTAAATTCATGGGAAAATACAATGTCTAGGAGCTATCCCAGGGTCGTGAATCCTCGAGTGCAGGTGGGGAAGTAGGGTGATACCCACCTGTGACCATGACAAGTTTTGGAGACCAGAAACTCGGTTAGAGTTTCTAGAACCCCGCATCCCTCTCATACTGCCTGAAGCCCTGCTCTGGGGAGAGTGTCATCACAGTACCATGTGGCATGCGAGTGTCGTGGTAATGCTCCCCGACCAAACCaccaaaccgagggttgggctgcttattctcgctgcccaataatgagatgcagataaactaggaaagaaaggagtttatttctgtaaccaggtacggggcgaaggcgtggaaaatatcccagaccgactcagaattacagagctttccagagcttatataccttATGTGTAGTTGGTGACTGCCTCTCCAGATGCTGAGGTGCCTGTATCATTGGCACAGGCCAGTGCTGAACCGTAGGTGGAGTAGGCTGTGCCTTCCGAAGCAGTATCTATTCACAATGAAGTTGCAGTCTCCCGAATTCCAGTCACTTTTCACAGAAGGACTGAAGAGTCTGACAGAATTATTTGTCAAAGAGAATCACGAATTAAGAATAGCAGGAGGAGCAGTGAGGGATTTATTAAATGGAGTAAAGCCTCAGGATATAGATTTTGCCACCACTGCTACCCCTACTCAAATGAAGGAGATGTTTCAGTCGGCTGGGATTCGGATGATAAACAACAGAGGAGAAAAGCACGGAACAATTACTGCCAGGCTTCATGAAGAAAATTTTGAGATTACTACACTACGGATTGATGTCACCACTGATGGAAGACATGCTGAGGTAGAATTTACAACTGACTGGCAGAAAGATGCGGAACGCAGAGATCTCACTATAAATTCTATGTTTTTAGGTTTTGATGGCACTTTATTTGACTACTTTAATGGTTATGAAGATTTAAAAAATAAGAAAGTTAGATTTGTTGGACATGCTAAACAGAGAATACAAGAGGATTATCTTAGAATTTTAAGATACTTCAGGTTTTATGGGAGAATTGTAGACAAACCTGGTGACCATGATCCTGAGACTTTGGAAGCAATTGCAGAAAATGCAAAAGGCTTGGCTGGAATATCAGGAGAAAGGATTTGGGTGGAACTGAAAAAAATTCTTGTTGGTAACCATGTAAATCATTTGATTCACCTTATCTATGATCTTGATGTGGCTCCTTATATAGGTTTACCTGCTAATGCAAGTTTAGAAGAATTTGACAAAGTCAGTAAAAATGTTGATGGTTTTTCACCAAAGCCAGTGACTCTTTTGGCCTCATTATTCAAAGTACAAGATGATGTCACAAAATTGGATTTGAGGTTGAAGATCGCAAAAGAGGAGAAAAACCTTGGCTTATTTATAGTTAAAAATAGGAAAGATTTAATTAAAGCAACAGATAGTTCAGACCCATTGAAACCCTATCAAGACTTCATTATAGATTCTAGGGAACCTGATGCAACTACTCGTGTATGTGAACTACTGAAGTACCAAGGAGAGCACTGTCTCCTAAAGGAAATGCAGCAGTGGTCCATTCCTCCATTTCCTGTAAGTGGCCATGACATCAGAAAAGTGGGCATTTCTTCAGGAAAAGAAATTGGGGCTCTATTACAACAGTTGCGAGAACAGTGGAAAAAAAGTGGTTACCAAATGGAAAAAGATGAACTTCTGAGTTACATAAAGAAGACCTAAAACTGATGGCTACTAAAAAGCAGAGCATTTCTGGTAAGACTAAATTTTCTCCCCTCCCTCTTAATGAGGTTTTAGAGACTACACCAGAATAAAAGACAGTTTAGGGGACCTCTGTAGAACAACAAGGGTCTTATTTTGTGAATTATATATTTCAAGAACTAAACAGAGATCCACCTTTCTGGATCTGATTTATATCACTGAAATGTACAGTTCTTTTGGAATAGTTTCACCTGAGAAAACATAGTTGGCTATTATCTATCTTAACCTGTTCAGGCTTTTAAAAAAAACTGTTTTTGCATAGGGTAGTACTAAGATCTTAAAAAGTGGTAACTGTCTTGAAGAAAAAACGTTTATTGTTTGTTTGCAATTGAAATAACAGGGTTACCTTAACAATGACTGTCTATGATGTGTCAGTTCTTATCTGAATTCCAAAATAAACCTGTGCTTAAAAAAGAAATAATTGACCAAGTAAGTTTGCATAAAATGTGAATACTAAATGTGTCCCCAGTTGCTGGCATTCATATGTACAGGATTTGTTCTAGCAAGCTATGCTTCAGTATGTGGTTGATATTTTTCTGTCACAATGATTTCTTTATGCATGCAGAGCCTGGGGAAGTCATGGGATTAACTTGAGGGTCACTATTGAGCCTATTAATTAATTATTGTTTTAATAAAACAAACATTGGTATTGGAAGATAAATATGTTTATGTGGTATCTGACAATGTGTATTAGGTGTCATATACAATGGTAATATGCCTGTCTTTAAAGTGTTATTTTATTAATTAAAAGGATATGGCTATTATTATATATTCTCTAAAGATTTGAGTCCTAAATGCTTTCATCAGGTAAATAAAATGTATAATACAAA

Publications

PMID - Link Title
No publications available for this retrocopy