Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name EMP2P1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:26141086-26141367  UCSC
Coordinates (T2T) chr2:26176376-26176657  UCSC
Coordinates (hg19) chr2:26363955-26364236  UCSC
Strand -
Parental Sequence NM_001424.6
Parental seq. overlap 261 bp
Parental seq. overlap (%) 5.1%
Genomic Region Intergenic
Retrocopy Summary EMP2P1, located on chr2:26141086-26141367, is a retrocopy of the parental gene EMP2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name EMP2
Full Name epithelial membrane protein 2
Also known as XMP
Coordinate chr16:10528422-10580598
Strand -
Gene summary This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10). [provided by RefSeq, Mar 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes EMP2P1
Bonobo Pan paniscus EMP2P1
Gorilla Gorilla gorilla EMP2P1
Orangutan Pongo abelii EMP2P1
Gibbon Nomascus leucogenys EMP2P1
Green monkey Chlorocebus sabaeus EMP2P2
Crab-eating macaque Macaca fascicularis EMP2P1
Rhesus Macaca mulatta EMP2P1
Baboon Papio anubis EMP2P1
Golden snub-nosed monkey Rhinopithecus roxellana EMP2P2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>EMP2P1
CCCCAGCCGGTCCATCGGTCCAGCAGCCTGCGTAGCGGCCAGCGCCGGCACATCCCGCTCTGGGCTTTAAACGTGACCCCTCGCCTCGCCCTGCCCTATGAAAATGTTGGTGCTTCTTACTTTCACCGTCGCCTTCCACATCACCTCTGCGGCCTTGCTGTTCATCGCCACCATCGACAATGCCTGGTGGGTAGGAAATGAGTTTTTTGCAGATGTCTGGAGAATATGTACCAAAAACACGAAGTGTACAGTAATCAATGACAGCTTTAAAGAGTACTCCAT
>NM_001424.6
ACCCccagccagtccgtcgatccagctgccagcgcagccgccagcGCCGGCACATCCCGCTCTGGGCTTTAAACGTGACCCCTCGCCTCGACTCGCCCTGCCCTGTGAAAATGTTGGTGCTTCTTGCTTTCATCATCGCCTTCCACATCACCTCTGCAGCCTTGCTGTTCATTGCCACCGTCGACAATGCCTGGTGGGTAGGAGATGAGTTTTTTGCAGATGTCTGGAGAATATGTACCAACAACACGAATTGCACAGTCATCAATGACAGCTTTCAAGAGTACTCCACGCTGCAGGCGGTCCAGGCCACCATGATCCTCTCCACCATTCTCTGCTGCATCGCCTTCTTCATCTTCGTGCTCCAGCTCTTCCGCCTGAAGCAGGGAGAGAGGTTTGTCCTAACCTCCATCATCCAGCTAATGTCATGTCTGTGTGTCATGATTGCGGCCTCCATTTATACAGACAGGCGTGAAGACATTCACGACAAAAACGCGAAATTCTATCCCGTGACCAGAGAAGGCAGCTACGGCTACTCCTACATCCTGGCGTGGGTGGCCTTCGCCTGCACCTTCATCAGCGGCATGATGTACCTGATACTGAGGAAGCGCAAATAGAGTTCCGGAGCTGGGTTGCTTCTGCTGCAGTACAGAATCCACATTCAGATAACCATTTTGTATATAATCATTATTTTTTGAGGTTTTTCTAGCAAACGTATTGTTTCCTTTAAAAGCCaaaaaaaaaaaaaaaaaaaaaaaaaaaagaaaaaagaaaaaaaaaaTCCAAAAGAGAGAAGAGTTTTTGCATTCTTGAGATCAGAGAATAGACTATGAAGGCTGGTATTCAGAACTGCTGCCCACTCAAAAGTCTCAACAAGACACAAGCAAAAATCCAGCAATGCTCAAATCCAAAAGCACTCGGCAGGACATTTCTTAACCATGGGGCTGTGATGGGAGGAGAGGAGAGGCTGGGAAAGCCGGGTCTCTGGGGACGTGCTTCCTATGGGTTTCAGCTGGCCCAAGCCCCTCCCGAATCTCTCTGCTAGTGGTGGGTGGAAGAGGGTGAGGTGGGGTATAGGAGAAGAATGACAGCTTCCTGAGAGGTTTCACCCAAGTTCCAAGTGAGAAGCAGGTGTAGTCCCTGGCATTCTGTCTGTATCCAAACCAGAGCCCAGCCATCCCTCCGGTATCGGGGTGGGTCAGAAAAAGTCTCACCTCAATTTGCCGACAGTGTCACCTGCTTGCCTTAGGAATGGTCATCCTTAACCTGCGTGCCAGATTTAGACTCGTCTTTAGGCAAAACCTACAGCGCCCCCCCcctcaccccagacctacagaatcagagtcttcaagggatggggccagggaatctgcatttctaacgcgctccctgggcaacgcttcagatgcgttgaagttggggaccacGGTGCCTGGGCCAGGTCAGCAGAGCTGCCTCGTAAATGCTGGGGTATCGTCATGTGGAGATGGGGAGGTGAATGCAACCCCCACAGCAGGCCAAAACCTTGGCCTCCATCGCCACAGCTGTCTACATCTAGGGCCCCAAAACTCCATTCCTGAGCCATGTGAACTCATAGACACCTTCAGGGTGTGGGGTACAGCCTCCTTCCCATCTTATCCCAGAAGGCCTCTCCCTTCTTGTCCAGCCCTTCATGCTACACCTGGCTGGCCTCTCACCCCTATTTCTAGAGCCTCAGAGGACCCATCCACcattcattcattcattcattcattcattcattcattcattcatCAACATAAATCATAACTTGCATGCatgtgccaggcacaggggataccctctagagacaatctcctcctagggctcatggcctagtggaggagacagaTTAAAACTTAATTAGAAAAACTggctgggtacagtggctcatgcttgtaatcccagcactttgggaggctgaggcgggtggatcacctgaggtcaggagttcaagaccagcctggccaaaatggtaaaacctgtctctactaaaaatacaaaaatgagctgggcgtggtggtgcatgcctgtaatcccagctatcaggtggctgaggcaggagaatcacttgaaatgggaggtggaggttgcagtgagccgagaccgtgccactgcactccagcctgggtgacagagtgagactccatctcaaaaaaagaaaaaaaagaaaagaaaCTAATTACACACTGTGATGGAGGCTGCAAAGAACACCACTAAGAATTCAAAATCAgctgggtgcggtggctcacacctgtaatcccagcactttgggaggctgaggcaggtggatcacaaggtcaggagttcaagaccagcctggccaacatggtgaaaccccgtctctaccgaaaatacaacaaaattagcccggtgtggtggcaggtgcctgtaatcccagctacttaggaggctgaggcaggagaatcgcttgaaactgggaggcggaggtcgcagtgagccgagattcaccactgcactccagcccaggcgacagtctgagactccgtctcaaaaataaaaCGATTCAAAATCGAGGCCTGTGGCATGGTAGGGAGGCTGCTTTACGCGTGCCTATTATTAAATGCTCCTGGAGGCATTTAGGTATTTAGATCAGTCTAAATATAGCTCCATTCAGTTCGTGCAGATGACAGTTATTGGGCAGTACCTGTCTGTGTAACACCCAGAAAACATGTCTGTGGAGGGGCCCATGGTCCCGACAGTAAATGCGGTGAGAGGGTCCCATAGAGCTGGAGTTTTCAAGCTTTAGGGGTTCCCGTGCTGCTTGGGACAGGCTGATTCAGAGGGTCTGGGTGAATGATTTCCAGGTGATTTTAAGACTGTGCTGAGAAATAGGGCTTTTGGGGCCTTGTCCTTCAGGATCAAAGCATGATGCTGTGTGGCAATGCAGACCACCCAGGAACCATCCCAGGAGATAAGCTCTTTGCACCTCATTGTCTTTTTCTGCTTATGTTGGAGCAGGATGCTGGGGGCTGTCCTGGGATGGGGTGTGGGACCTCGTGCTATTTAAATACTTTTGCACTTGACCTTCTGCTGAGTGGAGTGGTGGTTTGCCATCAGCTCAGTTCCAGTGGAGCTGAAGAGACATCTGGTTTGAGTAGTTTTAGGGCCACCATGGATATCTCTTCAATGCAGGATTGGCTCTTTCCATCTGCTCTTTCattcatttgtttttgacagatagtattaaatgtttaccatgttccaggcactgtgtgaggctctgaaaatacaggggtgagcaaatccagatatcctccctgccatcatgaagtttggagtctatgagataggacCCCCTCCCTATGGAGAAGCCACCAATGCAGTACAGGGTGACCTGGGGCCAGAGACAGGACAAATGTCACCTCCTGCCTCCATGAGATACTCTCACTAGTCATATTGTGGGCAAGAATGTGGCTTACACCCCTAGGGTTAACAGGATGCTACCCAAGCTCATGGAGGAAGTTGAATCTTAAGTTCCCTTGAAACTTTCTACCTTGGTGGCTTTTCTATAATTTTCTtttttctttttcttttttttttttttttttgagactgagttttgctcttgttgcccaggctggagtgcagtggcaccatcttggctcaccgcaacctctgcctcctgggttcaagtgattctcctgcctcagcctcccgagtagctgggattacaggcatgtcccaccatgcccagctaatttttgtatttttagtagagatggggtttctccatgttggtcaggctggtttcgaactcccaacctcaggtgatccgcccacctcagccttccaaagtgctgggattacaggcatgagccactgcgtctggccTTCTATAATTTTCTGGTAGTCACGATGGAAACAAACAAAACACCTTAGAACCAGAGATCGACCCCCTCAAGCAATACATCAATTCCCTTCACAAGAAACGTCGGGGCTACATGAGTATCTGTGTTGAATGCGGTCTGAAATGATCCTATGGATTTTCCCGGCTGGTTGCCACTGCTGTACAACATTCAGTGCCCACATCCACCTGTGCCATTAAGCTTTTTTGAGACATGAGAGATGCCTCTTCCCTGCTGTATGACATGCATTTGGGAAGTTGGAAAGAAATGACAAAATCAGGGAGAAAACATCCAAGCTTCTTACCTGTAGATAGAATCAGCCCTCACTTGGTGCTTATTACCAGTTATTCAAGAACAATAACAACAACAAAATTAGTAGACATCCAAGAAGCACATATTAGGACCAAAGATAGCATCAACTGTATTTGAAGGAACTGTAGTTTGCGCATTTTATGACATTTTTATAAAGTACTGTAATTCTTTCATTGAGGGGCTATGTGATGGAGACAGACTAACTCATTTTGTTATTTGCATTAAAATTATTTTGGGTCTCTGTTCAAATGAGTTTGGAGAATGCTTGACTTGTTGGTCTGTGTGAATGTGTATATATATATACCTGAATACAGGAACATCGGAGACCTATTCACTCCCACACACTCTGCTATAGTTTGCGTGCTTTTGTGGACACCCCTCATGAACAGGCTGGCGCTCTAGGACGCTCTGTGTTCACTGATGATGAAGAAACCTAGAACTCCAAGCCTGTTTGTAAACACACTAAACACAGTGGCCTAGATAGAAACTGTATCGTAGTTTAAAATCTGCCTCGCGGGATGTTACTAAACTCGCTAATAGTTTAAAGGTTACTTACAATAGAGCAAGTTGGACAATTTTGTGGTGTTGGGGAAATGTTAGGGCAAGGCCTAGAGGTTCATTTTGAATCTTGGTTTGTGACTTTAGGGTAGTTAGAAACTTTCTACTTAATGTACCTTTAAAATAGTCCATTTTCTATGTTTTGTATAATCTGAAACTGTACATGGAAAATAAAGTTTAAAACCAGATTGCCCAGAGCAAGACTCTAATGTTCCCAACGGTGATGACATCTAGGGCAGAATGCTGCCATTTTGAGGGGCAGGGGGTCAGCTGATTTCTCATCAAGATAATAATGTATGGTTTTTACACTAAGCAACTGATAAATGGACAATTTATCACTGGA

Publications

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