Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name VPS26AP1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:113919151-113920504  UCSC
Coordinates (T2T) chr3:116640409-116641762  UCSC
Coordinates (hg19) chr3:113637998-113639351  UCSC
Strand +
Parental Sequence NM_004896.5
Parental seq. overlap 1242 bp
Parental seq. overlap (%) 29.4%
Genomic Region Intragenic (GRAMD1C)
Retrocopy Summary VPS26AP1, located on chr3:113919151-113920504, is a retrocopy of the parental gene VPS26A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name VPS26A
Full Name VPS26 retromer complex component A
Also known as HB58|Hbeta58|PEP8A|VPS26
Coordinate chr10:69124178-69174412
Strand +
Gene summary This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes VPS26AP1
Bonobo Pan paniscus VPS26AP1
Gorilla Gorilla gorilla VPS26AP1
Orangutan Pongo abelii VPS26AP1
Gibbon Nomascus leucogenys VPS26AP1
Green monkey Chlorocebus sabaeus VPS26AP1
Rhesus Macaca mulatta VPS26AP2
Baboon Papio anubis VPS26AP1
Golden snub-nosed monkey Rhinopithecus roxellana VPS26AP2
Marmoset Callithrix jacchus VPS26AP2
Crab-eating macaque Macaca fascicularis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>VPS26AP1
AGGAGCTGGGGCTGACAGTTCTCCTGAGTGAAAAGGAGTAAAGTAGCGGGGATGTGGTGGCCGTGCTGACAATGAGTTTTCTTGAAGGCTTTTTTGGTCCAGTTTGTGAGATTGATATGTCTTTAATGATGGAGAAGCCAGGAAAATGACAGAAATGAAAACTGAAGATGGCAAAGTAGAAAAACACCATCTCTTTATAATGGAGAATCTGTTTCAGGGAAGGTAAATGTAGCCTTTAAGCAACCTGGATAGAGGCTAGAGCACCAAGGAATTAGAATTGAATTTATAGGTCAAATGGAACTTTACAATGACAAGAGTAATGCTCATGAATTTATAAACCTAATGAAAGAACTAGCCTTACCTGGAGAACTGACTCAGAGAAGAAGTTATGATTTTGAGTTTATGCAAGTTAAAAAGCCATATGCATCTGACATCGGTGCCAGTGTTCACTTGAGGTATTTTCTTAAAGTGACAATAGTGAGAAGACTGACAGATTTAGTAAAAGAATGTGATCTTATTGTTCACCAGCTTGCCACCTGTCCTGATGTTAACAACTGTATTAAGATAGAAGTGGGCATTGAAGATTGTCTACATATATAATTTGAATATAGTAAGTCAAAGTATCATTTAAAGCATGTAATTGTTGGAAAAATTTACTTCTTAGTAGTAAGAATAAAAATACAACATATGGAGTTACAACTGATCAAAAAAGAGATCACAGGAATTGGACCCAGTACCACAGCAGAAACAGAAACATCACCAAATATGAAATAATGGATGGTGCACCAGTAAAAGGTGAATCAATTCCAATGAGACTGTTTTTAGTGGGATATGACCCTACTCCAACAATCAGATGTGAACCAAAAAGTTTCAGTAAGGTACTTTTTGAATTTAGTGTTTGTTGATGAGGAAGACTGAAGGTACTTCAAACAGCAGGAGATCATTTTATGAAGAAAAGCTCCTGAAAAACTGAGGAAACAGAGAAAAAACTTTCACCAGTGATTTGAATCTCCAGAATCACAGGCATCTGCTCAACAGCCTGAAATGTGAACTGAATAGGAGACCAAAAAAAAAAAGCAACAAATTCCTGTAACCATTGAGTTAAGTTCAGCAGGTTGAAGATGGTTGCAGCTGTAGAGGGGAGAAAGAGCAAAACTCCATATATATTAGTCTTCCTTTATCTTACAGTGCTGCATTTATTTTACGGTATAATGAAATGTTCTCCATGTATATACATTTTAAAAAATGCTCTCTTTGAAACACTGGAACTTTCTTAAACTGCCTTTTTTGTTTTTACTTCACACTTTGATGATAAGCACTCAGATGTGCATCAGCATAAACATTAAAAATTTTC
>NM_004896.5
GAGGTCACGTGACGGAGCGCCGGAGCGGAGGGAGCCGGGGCTGGGAGTTCTCCTGAGGGAAGAGGAGTGGAGTAGGGGGGACGCGGCGGCGGCGTTGACAATGAGTTTTCTTGGAGGCTTTTTTGGTCCAATTTGTGAGATCGATATTGTTCTTAATGATGGGGAAACCAGGAAAATGGCAGAAATGAAAACTGAAGATGGCAAAGTAGAAAAACACTATCTCTTCTATGACGGAGAATCCGTTTCAGGAAAGGTAAACCTAGCCTTTAAGCAACCTGGAAAGAGGCTAGAACACCAAGGAATTAGAATTGAATTTGTAGGTCAAATTGAACTTTTCAATGACAAGAGTAATACTCATGAATTTGTAAACCTAGTGAAAGAACTAGCCTTACCTGGAGAACTGACTCAGAGCAGAAGTTATGATTTTGAATTTATGCAAGTTGAAAAGCCATATGAATCTTACATCGGTGCCAATGTCCGCTTGAGGTATTTTCTTAAAGTGACAATAGTGAGAAGACTGACAGATTTGGTAAAAGAGTATGATCTTATTGTTCACCAGCTTGCCACCTATCCTGATGTTAACAACTCTATTAAGATGGAAGTGGGCATTGAAGATTGTCTACATATAGAATTTGAATATAATAAATCAAAGTATCATTTAAAGGATGTGATTGTTGGAAAAATTTACTTCTTATTAGTAAGAATAAAAATACAACATATGGAGTTACAGCTGATCAAAAAAGAGATCACAGGAATTGGACCCAGTACCACAACAGAAACAGAAACAATCGCCAAATATGAAATAATGGATGGTGCACCAGTAAAAGGTGAATCAATTCCAATAAGGCTATTTTTAGCAGGATATGACCCAACTCCAACAATGAGAGATGTGAACAAAAAATTTTCAGTAAGGTACTTTTTGAATTTAGTGCTTGTTGATGAGGAAGACCGGAGGTACTTCAAACAGCAGGAGATAATTTTATGGAGAAAAGCTCCTGAAAAACTGAGGAAACAGAGAACAAACTTTCACCAGCGATTTGAATCTCCAGAATCACAGGCATCTGCCGAACAGCCTGAAATGTGAACTGAACAGGAGAAAAAAAGAAAAGCAAAAAACTCCTGTAACCCTTGAGATTAAGTTCAGCAGGTTAAAGATGGTTGCAGCTGGAGGGGGCGGAAAAAGGCCAAAACTCCATATATGTTAGTCTTCCTTTATCTTACAGCGCAGCATTTATTTTATGATATAATGAAATGTTCGTTCATGTATATACATTTTTAAAAGTGCTTTCTTTGAAACACTGGAACTTTGTTAAGCTGCCTTTTTTTTTTTAACTTCCTACTTTGATGATAAGCACTCAGATATATATCAGCGTAAACATGAAAAATTTTCATGTGAGTAGGCTGGTATTTGTAATTTTGCTTTCTTTCTGCATAATGTTGATTATAAATCCTCTCTTTTCAGGCTAATGATTACCTCTTATTCTCTACATGCAAAAAATTAAATATTTTGTGTTCAAATAAAATTAGAAAACCTGAGTGGCCTCTTGTGTCCTGCAGAGATTTAAAACATGGCATCTCAATATTTTTGAGAACTACATTTGTTTTTAACATATGTGTTTGAGAAAAGCATATGGAGTGTTTCACCGCAGGCACTTCTGAGTACCATTCCATGGCTTCCAGAATTTTATCCTCTTTGAGGTCTTCTGTGCTATGAATATTAGATTTCTTTCCCCAAGGGATTATGTGGCAGGTCATTATGGCCTTCTTTTTTTTGGCCATATTAAGTAACAGTTTTGCTATATTCCAGTAGTACCGTTGTGTGTTTTCTGCAATGTGGAGTTGACTTAGCTTGGCATTTTAGATTTGTTAAAACTATTTTTTCCATAAATACTTTGAAACATATTTATATATTTCAATTTAAGGAATCTTTTTGCCATGTGTATGCAAATATTATTTTCTTCATACATTCATTTTCTTTTCAGGGGAAAATTTTGGGATGGGGGACTCAGGAGGACCTGTGAAGCATGTAGTTATCTAGATCTGGGTAATTTCATGTTTATTAAACTCGAACTTTGGCTAGTTAAACTCATATTGAAACTTCATCTAGTCTCTTAATTTTTTAACACTAAATTCAAGTCATTTGTTTTAAGTCTCTAAAAAAGAAGATTGCAGTCATCCATTCATATGCATGGGGTCTGATCGCAAATACACTAAATGTGGAGTGTAGGAACCAAAATGAAACCTGCTGTATGGAAACTACTTTCACTTATGGTTCATTGGTTTTTGTACCAATATTTTTTATGCACTTCAGTGCAAGTCTTGTCAGTTAACCTTACTTTATGAGTAAGCTAAATAACCCAAATTACATTTCTTTAAACCTGTTTTACTACTATGGCACTTTGATAAAATGGTCAGGAACCAACTTTACTGGCAAAAGGGTCCATGTACCACCATGTGCTGGAGCATCTGTTCTACATGTGGATATCTATGAATGGTAATGTTTTCCTTCATGTAAGTGCCTATTCAGAGTTTCAGAATTTTAAAATGCCAAATATTTTCATGGTCATTTGCATGTAGTAAGCCAGAAAATATTCAAAGAGATTTTGAAAACCAATTGTATTTAACCAGCCTCAAATTGTGCAACCATGATGTATAATAAAGAATTTGAAACAGAAACTGAGCTTGCTGTTTGCATGATTAAAATAGCTCTGTTCTCAAATCTCTTCTCATTGTTAGATTTATTGTCGAGGATAGGATTGTTCAATAGTTTAGGAAGCTGTAACTGTGATAATGAATTTTTATAAATATTACTGGTTTCAATTTTAAATAGATATATAATGCTTTTAATAGGCTGGCTTAAAACTGTCATATACAGGATGCCTATCCGTTTTGCTCAAGACTTTTTGTAGCATAACCAATTTGAAAAAAATTCAAATTTAATATTTGGTGATTTCAGTCAAAAGTCAGCCAGCTAATTAGAAGTCATAAACTGAAAAAGAAATTTGTGTCTTTAATGAAGAGTTACAATGTCTAATCcattggttctcaaccctggctgcatatcagaatcaccttagaagcttttaaaataaccaggcccgggtcctactctgaccaataaaataagaatctcagagactgggccataagcattaAAAACAAAACAACCTCAAAAAAATAcctgtcatctcagccacttcaggagtctgaggcggaaggatcacctggaattcgagaccagcctggccaacaaaaatgagaccctatctctacaaaaaaattaacaatgagctgggcatggtggcatgcacctgtatttccagctatttaggaagctgagacaggaagatccctttgagaggtgaagccagctggacttctgagttgcgtggggacttggagaacttttctgtcttacaaggggattgtagaatgcaccaatcaacactctagctaggattgtaaaacgcactctggctagctggaggtttgtaaaatgtaccaatcagtgcttgtgaaaacgcaccaatcaggctgggcacagtggctcacgcctgtaatcccagcactttgggaggctgaggcgggcagatcacctgagttccaggagttcgagaccagcctgaccaacgtggagaaactccatctctaccaaaaatgcattagtcgggcgtggtggcacatgcctgtaatcccagctactagggaggctgaggcagaattgcttgaacccgggaggcagaggttgcagtgagccgagatcacaccaatgcactccagcctggctagaagtttgtaaaatggaccaaccagtgttctgtagaatggaccaatcagcaggacgtgggcggggacaaataagagaataaaagctggccaccccccagccagcagcggcaaccggctcgggtccccctccatactgtggaagctctgttctttcactcttcacgatacatcttgctgctgctcactctgggcctgtgccacatttaagagctgtaacactcaaggcgaaggtccacggctccgttaagtcagcgagaccgcaaacccactggaaggaaccaactctggacacaccttgagtacacgaatttgaaattacactgaggtgatcatgccactgcactgtagcttgggtgacagagacaccatgtctcaaaaaTCTACCCAGAGTTGGGAACCACTGATCTAAACCATTAAAATTTTTATTTCTGTCACTAA

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