Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TMED10P2
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:128538027-128539239  UCSC
Coordinates (T2T) chr3:131279593-131280805  UCSC
Coordinates (hg19) chr3:128256870-128258082  UCSC
Strand +
Parental Sequence NM_006827.6
Parental seq. overlap 1061 bp
Parental seq. overlap (%) 25.7%
Genomic Region Intergenic
Retrocopy Summary TMED10P2, located on chr3:128538027-128539239, is a retrocopy of the parental gene TMED10. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TMED10
Full Name transmembrane p24 trafficking protein 10
Also known as P24(DELTA)|S31I125|S31III125|TMP21|Tmp-21-I|p23|p24d1
Coordinate chr14:75131469-75176612
Strand -
Gene summary This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TMED10P1
Bonobo Pan paniscus TMED10P1
Gorilla Gorilla gorilla TMED10P1
Orangutan Pongo abelii TMED10P1
Gibbon Nomascus leucogenys TMED10P1
Green monkey Chlorocebus sabaeus TMED10P2
Crab-eating macaque Macaca fascicularis TMED10P1
Rhesus Macaca mulatta TMED10P1
Baboon Papio anubis TMED10P1
Golden snub-nosed monkey Rhinopithecus roxellana TMED10P1
Marmoset Callithrix jacchus TMED10P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TMED10P2
GGCTGTTTTTGTTTCTGCTCAGCCCCAGCCTGGTCCTCACCATCTCCTTCCACCTGCCCATTAACTCCTGAAAGTTCCTCCATGAGGAGATCCACAAGGACCTGCTAGTGATGGGTGCGTACGAGATCTCCAACAAGTCTGGGGGTGCTGGCAGCCTGCACAGCCACCTCAAGGTCACAGATTCTGCTGGCCACATTCTCTACTCCAAAGAGGATGCAACCAAAGGGAAATTTGCCTTTATCCTGGAAGATTATGACATGTTTGAAGTGTGATTTGAGAGCAAGGAAACAGGGTGGATACCTGATCAATTCGTAATCCTAGACATGAAGCATGGAGTAGAGGCAGAAAAGAAATTACAAGGAGATTACAAAAGTCGAGAAGCTTAAACCGTTATAGATGGAGCTGCAATGCCTAGAAGACCTGTCAGAATCTATTGTTAATGATTTTGCTACGTGAAGAAGAGAGAGATGTGTAGTACTAATGAATCAACAAACACTTGAGCCCTGTACTTCAGTGTCTCTTTAATGTTCTGCTTCATTGGACTAGCCACCTGGCAGGTTTTCTACCTGTGTTGCTTCTTCAAGGCCAAGATGTCGATTGAGTAATGAACGAAGTGCACTCTCCTCCCACCTTGTATCTCAGGCAGCAGAACATCACTGGGCATCCTACCAAAAGCACCATCAAAATGCACTGGAGCCCTCTTGCCAGAACTGATCTCTTGGTGGGGGAGGACATGGGTACCACCTACCCAACAAGTCAATGAGAGATTTCTTTTTAGCTGGTAGTATTTGGACTTGTTTTGCAACAATAGGACCAGTATTAGAGTCACCTATGACCAAAAATAAGGGTTACCAAATAATGCCAAAGCCAGGATTTGTGCTGGGTTTCCTTGTGCGATCTGTTTGAACCAAGTTTTCTTTCCTTCTCCCGCTTTCTCGGCAGCTTGAATTTCCACTCTAGTTCTTTTACCCAGATTGGTATGGCCATGTTGAACTTGTTTCCTTCTGGTTGTCTTCTTTGGGTTTCCTTGTGAAAACACCCTTAACTTTCCTTTTGCCTTTAGCTGAAATGTTTACATAGCTTCTGGTGATATCTTCTCATAATTTTATGTCTCTTAAAAGGTTGACGGATGTGACACTTCAAAAAGTGAGCTTTGAACTGAAGATAACTCTTAAAGAAAATATCATTTTAGACAATTAAAATATTTATGCTC
>NM_006827.6
GAGGCCTTCGGTGGTGAACGAGTCTCCAGCACCATGTCTGGTTTGTCTGGCCCACCAGCCCGGCGCGGCCCTTTTCCGTTAGCGTTGCTGCTTTTGTTCCTGCTCGGCCCCAGATTGGTCCTTGCCATCTCCTTCCATCTGCCCATTAACTCTCGCAAGTGCCTCCGTGAGGAGATTCACAAGGACCTGCTAGTGACTGGCGCGTACGAGATCTCCGACCAGTCTGGGGGCGCTGGCGGCCTGCGCAGCCACCTCAAGATCACAGATTCTGCTGGCCATATTCTCTACTCCAAAGAGGATGCAACCAAGGGGAAATTTGCCTTTACCACTGAAGATTATGACATGTTTGAAGTGTGTTTTGAGAGCAAGGGAACAGGGCGGATACCTGACCAACTCGTGATCCTAGACATGAAGCATGGAGTGGAGGCGAAAAATTACGAAGAGATTGCAAAAGTTGAGAAGCTCAAACCATTAGAGGTAGAGCTGCGACGCCTAGAAGACCTTTCAGAATCTATTGTTAATGATTTTGCCTACATGAAGAAGAGAGAAGAGGAGATGCGTGATACCAACGAGTCAACAAACACTCGGGTCCTATACTTCAGCATCTTTTCAATGTTCTGTCTCATTGGACTAGCTACCTGGCAGGTCTTCTACCTGCGACGCTTCTTCAAGGCCAAGAAATTGATTGAGTAATGAATGAGGCATATTCTCCTCCCACCTTGTACCTCAGCCAGCAGAACATCGCTGGGACGTGCCTGGCCTAAGGCATCCTACCAACAGCACCATCAAGGCACGTTGGAGCTTTCTTGCCAGAACTGATCTCTTTTGGTGTGGGAGGACATGGGGTACCACCTACACCCAACAAGTCAATGAGGGACTTCTTTTTAATTTGGTAGGATTTTGACTGGTTTTGCAACAATAGGTCTATTATTAGAGTCACCTATGACAAAAAATAGGGGTTACCTAGATAATGCCAAAGTCAGCATTTGTCCTGGGTTCCCTTGTGTGATCTGTTTGGACTATGTTTTCTTTTCTTCTCCCACTTGCTCAGCAGCTTGGGCTTCCATTCTAGTTCTTTTACCAAGATTTTTGTGTGACCATGTTGACTTCATTTGGATTGCCCTCTTTCAATTTCCTTGTGAAAACACCCTTAACTTTCTCTTTACCCTTAGCTGAAATGTTTACATAGCTTCTGGTGATATCTTTTCATGATTTTATATCTCTTAAAATGGTGATGGATGTGACACCTCATAAAAGTGAGCTTTGAACTGTAGATAACTCTTAAAGAAAATGTCATTTTAGACAATTAAAATATTTGTGCTCAACTGCTTGAacttttttcgtgtatgtgtatttaattctatgcaatattatcacatgtgtagattcatgtgaccaccatcacaagagacagaacagttctgtcacatggatcccttgcactgcccttttacagccgcagccacatccctttcttataccctcaccccaacctgtggctaccactgttctgtcctccatctctgtaattttgtcatttcaagaatgttgtatgaatggaatcatacagaatgtaatcttacgaggctgatcttttttcattcagcataattcccttgaaatccatccaagttgttgcatgtatgaatagtttcttcctttttttcttttaaaaatgttttatatatttagggggtataagtacagatttcttacatgcatatattgcatcgtggtgaagtgggggcagttccttttgattgctgagtagtattccatggtatggatgtaccacagtttgcttaaccattcacccactaaaggacataagagttgttttcagttttttgccctaataaagctgctgtgaacattcatgtacaggtttttatgtgaacatacattttcattttctgggataaatgctcaaaagggcaactgttgggttgtatggtaaacacatatatttttgtaagaaactaccctactctttttccagagtggctctactttttacatacagccactcatacaattcagacagcaatgtatgattgatccagtttcttcacatcctcaccagcatttggtattactactattttttatcttaaccattcacatagatgtgtgtaatgataccacatgtggttttaatttgcatttccaatggctaatgatgttgagtatctttttgtgtgctaatttgccatctatgtatcctcttcggtgaaatgtcttcatgtcttttgtctattttctatttaggtcatttgttctttttactattgagttttgagaggttttttatatatcctagataaaattcctctgttagatatgtggttGCTTGAATTTTTAACATAACTTCTACCAAGGAAAAATAAGTAAAATTTCCAACCCTTGCATGGCCAGTCACTTACTTAATTCCTGTCCTTCAGTGTTCCATCTAGAGAATTAAGAGATATGATGTATAAAATAGACATCGAGGGCCATTAAGAGAGTAAATACTTAAAAATACATGTTATGAAAGCAAAGCCAATAATCACTGTAGGAGTATGAGTTGCCTAAGGGCCAAAACTAATGTAAATAAGAGAAAGTGTGGATATAAATGACCATTGTTTATAAACAGTTATGAAAAATGCTGTGACTTGAAATCTTTCCCACATCTCCCAAGAAAGTAGGTAGGAGTTTATCCTTTCCGTAATCTCTTTTTAACCCTGCTGACTATTACAGGGCTTGTTTAATCACAGTGGCAAGAATTACATGTATCTTACAGTAAAGAAACAGAATACTGGAATCGTTAGAGAACCCTGATGTGTTGACCTGGATAAAGTACAAAGGTGGAAGAGGGAATGAGTTATGCTGTTAAAATCTCAGGCTATTCTGTTAATGTTCCTGCTACTATGAACCCAAACTTTTTTTTTCCCCCTTTTGACTCCTTGTGTCTTCCTCTCCTGTGGCATAAAAGTAGTTCTGTCGTTAACTTGTACAACATTGCCATCTGCTGTTGAGAATTGGTAGGTACTGCTTCTGAGAACCTGGCTGCAGATCCTTAGCATAGGCAGCAAATGTTGAGAAAGTCTATCTGTAGTATTACATATACTAAGTTACAGAGGATGCATCCAAGTAGAGAAAATAATATGTGGGTTAAGATACATCCTTAAACttttttttttttggggggggggggacggagtcttgctgcaacgcccaggctggagtgcaatggcactatctcagctcgctgcaaccttcacctcctgggttcaagcaattctcctgcctcagcctcctgagtagctgggaatataggtgcacaccaccatgcctggctaatttttgtattttcagtagaagcagagtttcaccatattggccaggttggtctcgaactcctgacctcaagtgatctgcctgcctcagcctcccaaagtgctgggattacacgcgtgagccaccacacccagccTCCATCTTTAAACTTTTAAATGTGAAATTTCTATCATGTACCGTTAGCCTAACAAGATTTTCTTTCCTATTTCTGACTGGTGCCTTTCCCCTTTTTAGGAGCAACGAAAGCTACTCTCTTAGTTATGTTCTTGTGATGTGACAAAATGTCAAGAAGATAGGAGAAGAGAATATTTTATTTCGTTGATGCTTTTGTTCCCAAGTGTGACCCTAAACTTAAGCTTTGTAGGAGTTGACATTCTTTCATGTCCCTTCCCTTTACTCATGCCGAAACTATCAACTGGGACATTTTGTGCTTTTGGTTTAAAAGTTAATTGATATTATACTTTGGTTTTATCTAAAAAGTAAATGTATTTGCCTTTGACAAAAGACTGACACAAGAGCAAATAAGCTTTAAAATCGGGTGTTATGTGCTTTCCTCCATTTTTGAGCATATTATCCAAAATGGTCTGTATAATATAAATGAGAATGATGCAGTTTAAGTAAGCCTTGTTATACCATTGTCATGGACCCCTGTCATAAAGCCATTTCTTGGTTTGTTTGGGAAAGAGGCATATGGGATTTATACAGATTCACTTGTAAATGTTGGATTGGGGATTTTTGTGTAAATTTTCTCAAATAAAGGCTAGCAGAAACCA

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