Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name FRA10AC1P1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:162402796-162403052  UCSC
Coordinates (T2T) chr3:165177608-165177864  UCSC
Coordinates (hg19) chr3:162120584-162120840  UCSC
Strand -
Parental Sequence NM_001347713.2
Parental seq. overlap 205 bp
Parental seq. overlap (%) 6.3%
Genomic Region Intergenic
Retrocopy Summary FRA10AC1P1, located on chr3:162402796-162403052, is a retrocopy of the parental gene FRA10AC1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name FRA10AC1
Full Name FRA10A associated CGG repeat 1
Also known as C10orf4|F26C11.1-like|FRA10A|NEDGFC
Coordinate chr10:93667883-93702959
Strand -
Gene summary The protein encoded by this gene is a nuclear phosphoprotein of unknown function. This gene contains a tandem CGG repeat region within a CpG island that normally consists of 8-14 repeats but can expand to over 200 repeats. The repeat region is within the 5' UTR of some transcript variants, but is intronic to another variant. The expanded repeat allele is a fragile site and becomes hypermethylated, causing a reduction in gene expression. A disease phenotype has not been associated with expanded alleles. This gene is found within the rare FRA10A folate-sensitive fragile site. [provided by RefSeq, Dec 2016]

Homology

Species Scientific Name Retrocopy
Golden snub-nosed monkey Rhinopithecus roxellana LOC104658026P1
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>FRA10AC1P1
AAAAAAGACTGTGAAGATTCATCACATATAGAATTCAGATTATTATCTGAATTATCTGAGAGACCTCCAAGAAAAATAATAAACTACATTTTTCTCCAAAGAAATCAAAATATTATGTAAATAAAAACTCTGATAAGAAAGCACTTCAGAATCTGAACTTTAGAAAATCCAACTATCAAAAACAGAAGAAAAACCTCAGGAAGAGGAATTTGATGAATACCTTCAATATTTGTTTCTGTGAAATGGGAGAGAGAAGA
>NM_001347713.2
GGAAGTGGTGCCCAGTCGGGACCCGTAGGGAGAGGCGGGTTGCGggcggcggcggcggcggcggcggcggTGGTGGTTGTGGCGAGGCTGTGCGGCAGGGCGCACGGGACCTGTGCTGCAGCGGCTCTCTCAGGCCGTGGGTCGTCGCTGCAGCTGCCGGGAAAGAAGGAAACGACGACTCCGGGGGCGAACTTGGCACACAGGGAGGAAGGGAAAGGCTGTCCCCCATCAAGATGTAAAGAACGTGAGGACATAGGACAAAGAGTGAGAGGACAATATGGCTTGAACAGATGTGGTAAGACAGCTGGAGTTGACCTAAAAAAGGGTGTAAAATCCAGATGCATGGTCATGGAGGCTATGATTCTGATTTTAGTGATGATGAACGCTGTGGAGAATCCAGCAAAAGGAAAAAAAGGACAGTTGAAGATGACTTACTGCTCCAAAAACCATTTCAGAAAGAAAAACATGGAAAGGTGGCCCATAAACAAGTTGCAGCAGAATTGCTGGATAGGGAAGAAGCAAGAAATAGAAGGTTTCATCTCATAGCTATGGATGCTTATCAAAGACATACAAAGTTCGTAAATGACTATATTTTATACTATGGTGGCAAAAAAGAAGACTTCAAGCGTTTGGGGGAAAATGACAAGACAGACTTGGATGTTATACGAGAAAATCATAGATTCCTATGGAATGAGGAGGACGAAATGGACATGACTTGGGAGAAGAGACTTGCTAAGAAATACTATGATAAATTATTTAAGGAATACTGCATAGCAGATCTCAGTAAATATAAAGAAAATAAGTTTGGATTTAGGTGGCGAGTAGAAAAAGAAGTAATTTCAGGAAAAGGTCAATTTTTCTGTGGAAATAAATATTGTGATAAAAAAGAAGGCTTAAAGAGTTGGGAAGTTAATTTTGGTTATATTGAGCATGGTGAGAAGAGAAATGCACTTGTTAAATTAAGGTTATGCCAAGAATGTTCCATTAAATTAAATTTCCATCACAGGagaaaagaaatcaagtcaaaaaaaagaaaagataaaaccaaaaaagaCTGTGAAGAGTCATCACATAAAAAATCCAGATTATCTTCTGCAGAAGAGGCCTCCAAGAAAAAAGATAAAGGACATTCATCTTCAAAGAAATCTGAAGATTCTCTACTTAGAAACTCTGATGAGGAAGAAAGTGCTTCAGAATCTGAACTTTGGAAGGGTCCACTACCAGAGACAGATGAAAAATCACAGGAAGAAGAATTTGATGAGTATTTTCAGGATTTGTTTCTATGAGACGAGAGAGAGAAGCCTCCGCTCCTTAATGTGAAACTTCATGAAGTTTTAAACTTCATGCAATTTGAAATTCCATATAAGTTTTTATCTGCAAGTTACAGCTTGTGTGGTTTGTCTTTGGAAATAAAAATCCAGGTTCTCTCAGAATGTCAGAGGCTTTGGAAGTTCATTAGTTCAATTAAAGACTTTCCTGTCCTTTAAATATCTTTTCAATTGCTTATCTACAATTCTGTTTTATTTGTAGCTCCTAGAGGATAGAGCTGGACAGATTCCATTGTTCCTACATTTTGTAGGTTTTTTTTCACTGCCTTCATTATGTATCTTCTCTTGCCTTCAttattttattttattatttcttctttttctcttttttAGAGCCACCAATACTGGATTTGTTTGTTTTTCATTTTTTTCttttgtggaaacggagtcctcctgtgttgcccaggctggtattcaaactcctggccttatgcattcctcccaccctggcctcccagagtgctgggattacaggtgtgagccaccatgctctgccAATTATTTTAAATTACTAGGATTAAAGTATATTATGTATGTCTTTAACTTCTTTCTTTCCCATTGATAAACTGGCACCCTTCTTTTAAGTACCTGCTCTCCCATTACCACCTATTTCCAGCTGCTTTTTGAGGTTTTTTGCTTGCCTGTCTCTTGCTTCCTTCTTAACCTCTACCACTTAAGAGAGTTTGTTATAATCAAATTTGACTTCCTAGCCTGTGGATAATTTACTATTAAGTAAATTATTACCACAGGGAGCCAGTGAGGTCCCAGTAGTCTAAAACAGTTCATGTGTTCACAAAAATTGCCTCCCCGGCAGAGATTATGCAGTAAGATAATTTAACTGAATAATACTATGTGCATGTATCTTGCCTCAGATATACTCATGCAAATATGAATATACCTCtgatatggtttggctctgtgtccccacccaaatctcatcttgaatgtgtactcccataattcccacattttataggagggatccagtgagagataatttgaatcaagggggcggtttcccccatattgttcttgtggtagtgaataagtctcacaagatctgatggttttatcaggggcttctgcttttgcatccttctcattttcttttgctgctgccatgtaagaagtgccttttgcctcccaccatgattctgaggctttcccagccatgtggaactgtaagtccaattaaacctctttttcttccccagtctctggtatgtctttatcagcagtgtgaaaatggactaataGAACTTCTATGCAGAAATATAAAATGTAACTTCTTAACATAAGGTCCTAGTCGCAAgggtctatggaggtgcttcaggagatccaagcctttttagaatctgtgcaaacttctgtgtatgttttttggaggaaaagtccataaatttcaaattttcaaaaatcagattttcaaaaggatTTATTGATTTCTGAAAACTAGCAAAGATCTGCTTTTATAAAGAGCAAATAGATGGATAGATATAGGAGAAGATGCTTGACTTGATGAATAAGAGAAAGGACATATAGAAAATGAACTGAACATAAGCAAGTATTTTATTGAAGATATACTATTTTAAATAACATTTAAACACGGAATGATTGGCAATAAACTGCAAAATGAGTAATTTGGTATCATTTTAAAATGGTTATTATCAGAGATTTTCCTTTTATTAAACAGTTattcattaattccacaaatatttatcaggcttctattatatgtgaggcactgagctgggcATGGCTGTAAAGGAACCATCTAGGAAGTAATTATGCAATCATTTCTGAACCTGTTTCAGAAAAGTAAATCAGTGTTGGGTTTATCAGTGTTTAACATTGTTTGATAGTCCCCTCACTTCTTGAATAAATTGTTTTTTTTCACCTCA

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