Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HMGN1P8
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr21). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:167693258-167694660  UCSC
Coordinates (T2T) chr3:170477153-170478555  UCSC
Coordinates (hg19) chr3:167411046-167412448  UCSC
Strand -
Parental Sequence NM_004965.7
Parental seq. overlap 663 bp
Parental seq. overlap (%) 40.7%
Genomic Region Intragenic (PDCD10)
Retrocopy Summary HMGN1P8, located on chr3:167693258-167694660, is a retrocopy of the parental gene HMGN1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HMGN1
Full Name high mobility group nucleosome binding domain 1
Also known as HMG14
Coordinate chr21:39342315-39349088
Strand -
Gene summary The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HMGN1P5
Bonobo Pan paniscus HMGN1P5
Gorilla Gorilla gorilla HMGN1P6
Orangutan Pongo abelii HMGN1P5
Gibbon Nomascus leucogenys HMGN1P22
Crab-eating macaque Macaca fascicularis HMGN1P7
Rhesus Macaca mulatta HMGN1P8
Baboon Papio anubis HMGN1P3
Golden snub-nosed monkey Rhinopithecus roxellana HMGN1P1
Marmoset Callithrix jacchus HMGN1P24
Green monkey Chlorocebus sabaeus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HMGN1P8
TTAAATTACTTCTACTCTTCATGTTGTTTTTTAGTGGAATTGTTTCCTTGGGCAAACCACTCCTTGAGCCTGGCTCTACCTATCAGAATTGTGTGCACTCTGTAACATCTTTGGTCATGGTAGTCCTGTTTTTCTAATAACTTTGTTAATGTGCTGTGAAAGATTAAAGTATATAGTGTATATGCTATTAAATTGTGAATTGGTGGGACGTATGTGACAGCTTATCAACATTTGAAGGTACTGGTACTTGATAGCCTTTTAAGGTAATTTTGCCTCAGTTGTAAGCTGGAAAGTCACTGGAATAACTTTAGAGAATAATAATGATACGTGGCTTTTTAGATTTTGCAGTACATATGTTCAGAATTATGTACAAGTTGAAATGTCTGTGTACTGATCCTCAACAGCGCCTTCCCCACTTCCAGGATGCCCAAGAGGACGGTCAGCTCAGCTGATGGGACAGTGAGGGAAGATCCCAAAAGGAGATTGATGTGGTTGTCAGCTAAACCTGCTCTTTCAGTAGTGGAAATTGAAGCCCCAAAAGGTAGCAGGAAAAGATAAATCTTCAGGCAAAAAAGTGCAAACAAAAGAGAAAAGAGTAGGAAAGTGAAAACAAGCCAAAGTAGCTAAGAATAAAGATTTACCTGCAGAAAACAGAAAAACTAAAACTGAAGAGAGTCCAGCCTCTGAAGCAGGAGAGAAAGAAGCCCAGTCTGATTAATATCGCATACCATGTCTTATCAGTGGTTCCCCGTCTCTCTTCTTACATAATCCAGGAGAATATTTTTATCAACTATGTTGTAAATGCATGTTTTTTAGTAGCTCTAATGTTTTTTAATAGCTCTAGAAACATTTAAGGAGGGAATTCCACTGCATTCCATTTTTTAAGTGTAAATGCTTTTTTTTTTAAAGAGGTGAAATAATTTAATTTGCTGGTTATTTTTTGGTACAATGGGAAAATAATGTTGGATATTGAATTATGGGAAGCCTTGACTGTTATGGGTGTCAGCTTAACATTCCATAGATGGGTGGTTAGTTTTTATATCCCATAATATAAAGCATACTAAATGGCAAAGTGGAGTCGCAGTCCTGCATTTCATGTCTTGAACATTTTTAATTACTt
>NM_004965.7
ATCCGGTTCTCCCACCGCCCCCGCTGTGGGTCTCAGCAGCTCGGGCGGCGGGAGGAGTGGCAGCGGCAAGGCAGCCCAGTTTCGCGAAGGCTGTCGGCGCGCCGCGGCCCGCAGGCACCCGGCACGCGCCTTCCCCGCAGGCACCCGGCACGCGCCTTCCCCGCCGCCACGATGCCCAAGAGGAAGGTCAGCTCCGCCGAAGGCGCCGCCAAGGAAGAGCCCAAGAGGAGATCGGCGCGGTTGTCAGCTAAACCTCCTGCAAAAGTGGAAGCGAAGCCGAAAAAGGCAGCAGCGAAGGATAAATCTTCAGACAAAAAAGTGCAAACAAAAGGGAAAAGGGGAGCAAAGGGAAAACAGGCCGAAGTGGCTAACCAAGAAACTAAAGAAGACTTACCTGCGGAAAACGGGGAAACGAAGACTGAGGAGAGTCCAGCCTCTGATGAAGCAGGAGAGAAAGAAGCCAAGTCTGATTAATAACCATATACCATGTCTTATCAGTGGTCCCTGTCTCCCTTCTTGTACAATCCAGAGGAATATTTTTATCAACTATTTTGTAAATGCAAGTTTTTTAGTAGCTCTAGAAACATTTTTAAGAAGGAGGGAATCCCACCTCATCCCATTTTTTAAGTGTAAATGCTTTTTTTTAAGAGGTGAAATCATTTGCTGGTTGTTTATTTTTTGGTACAACCAGAAAATAGTGTGGGATATTGAATTATGGGAGGCTCTGACTGTCTCGGGTGTCAGCTTAACATTCCACAGATGGGGGGTTAGTTTTTATATCCTATAATACAAAGCATATTAAATGGCAATATGGAGTCAGTCCTGCATTTAATGTCTTGAACATTTTAAATTACTTCTATTACCATGTTGTTTTTTAGTAGAATTGTTTCCTAAAGAAAACCACTCTTTGATCATGGCTCTCTCTGCCAGAATTGTGTGCACTCTGTAACATCTTTGTGGTAGTCCTGTTTTCCTAATAACTTTGTTACTGTGCTGTGAAAGATTACAGATTTGAACATGTAGTGTACGTGCTGTTGAGTTGTGAACTGGTGGGCCGTATGTAACAGCTGACCAACGTGAAGATACTGGTACTTGATAGCCTCTTAAGGAAAATTTGCTTCCAAATTTTAAGCTGGAAAGTCACTGGAATAACTTTAAAAAAGAATTACAATACATGGCTTTTTAGAATTTCGTTACGTATGTTAAGATTTGTGTACAAATTGAAATGTCTGTACTGATCCTCAACCAATAAAATCTCAGTTATGAAAATA

Publications

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