Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TBPL1P1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:172522227-172522901  UCSC
Coordinates (T2T) chr3:175307298-175307972  UCSC
Coordinates (hg19) chr3:172240017-172240691  UCSC
Strand +
Parental Sequence NM_001253676.2
Parental seq. overlap 640 bp
Parental seq. overlap (%) 14%
Genomic Region Intragenic (TNFSF10)
Retrocopy Summary TBPL1P1, located on chr3:172522227-172522901, is a retrocopy of the parental gene TBPL1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TBPL1
Full Name TATA-box binding protein like 1
Also known as MGC:8389|MGC:9620|STUD|TLF|TLP|TRF2
Coordinate chr6:133952174-133990432
Strand +
Gene summary This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TBPL1P1
Bonobo Pan paniscus TBPL1P1
Gorilla Gorilla gorilla TBPL1P1
Orangutan Pongo abelii TBPL1P1
Gibbon Nomascus leucogenys TBPL1P1
Green monkey Chlorocebus sabaeus TBPL1P1
Crab-eating macaque Macaca fascicularis TBPL1P1
Rhesus Macaca mulatta TBPL1P1
Baboon Papio anubis TBPL1P1
Golden snub-nosed monkey Rhinopithecus roxellana TBPL1P1
Marmoset Callithrix jacchus TBPL1P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TBPL1P1
AGAAATCTGTTTGCCAGAATTCACAAAGAGCAATAGACCTCATGTGAGTTATGAATCTGAACTTCATCCTGCTGTGTGCTATTGGATAAAGACTCTAAGAGCTACATTACAGATTTTTTCGACAGGAAGTATCACAGTAACAAGGCCCTATTTAAAGGCTGTTGCTACTGCTGTGGAACAGATTTACCCATTTGTGTTTGAAAGCAGGAAAGAAATTTTATCATTCACCACTTAATTGGTTAGAATCTCTTACTGTGCACCTTTTAAAACCTGCTGCACATTGGACTCAAAAGGAAAACTGAACCAACGGTAATTGAGGAAATAGACTCTTTTATTTATTCATGGCTACAGTGTAAGCTCCAGTCCCTTTGGATTTTATTCCAAACCTTGTTATAATATAAAAAAGGAAGTTTACAAGACATGTCATTGCTGCTTTTACAAAAGGACATTCTATTTATTTTCGCAGGAATTCTCATGTCCCCATAAGCAGAGCTGTCACAGTGTGCACTACCTTAGGTTGTTTTATTGTTGTCATTGTTATTTTTTTCCATTTTGAGCTAATGTGTTTTATCTGTGAATAGTCTTTTACATTTTTGTATGCTGAAAATGGGCACCAAAGAACCTGTAAAAATTATCTTTTTCAATTGAATGTGCACAAATAAAAGTTTGGAAAAG
>NM_001253676.2
GTTACGCGATTTTCGCTCCCGCGGGCAGCGCCTCTCAGGCCACTCCCGAGGGACCCCGAGGACGCACTCGGGCCCCAGGGCGACGGTTCAAACGGGCCATTGTGCGCCCCCGGGGTCCCCCGGCCCCTGCAGGGCTACTTGGGCGCAGAGCCGCGGAGGGTCTCCGTTCCTAGAGGTCCTCCTATCCCGGGCTGCCTGAGTCCTCGCCAGCATCCGCCCTCTCCCACTCCCATCCTTCCTGGATCCGCCTCTCGGTTCCCGAGGGACAGTCCCGACCGCAAACCCACGTAGAGTAAGGAATGTGGGACAGGCGACAGAAGTGGCATACGGTCCTGCGTTATCCCTCCGTCTCGCCACACCTTGTGTCTCCATCTCTCCCCACTTCCTTCCCTCCGTCTGTCATCTGTCATCCCCGGTCGCTCTAAGACCAGGATTCCAATTCGCCTAGTGAGGAATCTCACTAGGGGAATTTATCGCGACATCATAAattaacgggttcattttgactgaaaaagcgaaggacttttttcaggcagaaaacaagtctcgtctggacgGATGTGATCTTCGTGGTGGAAAGCTAAATTTTAAAACCACCCCAATGGATGCAGACAGTGATGTTGCATTGGACATTCTAATTACAAATGTAGTCTGTGTTTTTAGAACAAGATGTCATTTAAACTTAAGGAAGATTGCTTTGGAAGGAGCAAATGTAATTTATAAACGTGATGTTGGAAAAGTATTAATGAAGCTTAGAAAACCTAGAATTACAGCTACAATTTGGTCCTCAGGAAAAATTATTTGCACTGGAGCAACAAGTGAAGAAGAAGCTAAATTTGGTGCCAGACGCTTAGCCCGTAGTCTGCAGAAACTAGGTTTTCAGGTAATATTTACAGATTTTAAGGTTGTTAACGTTCTGGCAGTGTGTAACATGCCATTTGAAATCCGTTTGCCAGAATTCACAAAGAACAATAGACCTCATGCCAGTTACGAACCTGAACTTCATCCTGCTGTGTGCTATCGGATAAAATCTCTAAGAGCTACATTACAGATTTTTTCAACAGGAAGTATCACAGTAACAGGGCCCAATGTAAAGGCTGTTGCTACTGCTGTGGAACAGATTTACCCATTTGTGTTTGAAAGCAGGAAAGAAATTTTATAATTCACCACTTAATTGGTTAGAATCTCTAACTGAGCACCTTTTAAACCTGCTGCACATTGGACTCAAAAGGAAAACTGGACCAACAATAATTGAGGAAATAGACTCTTTTATTCATTCACGGCTACAGTGTAAGCTCCAGTCCCTTTGGATTTTATTCCAAACCTTGCTGTAATATAAAAGGAAGTTTACAAGACATGATATTGCTGCTTTTACAAAAGGACATTCTATTTATTTTCGCAGTAATTCTCATGTCCCCATAAGCAGAGCTGTCACAGTGTGCACTACCTTAGATTGTTTTATTGTCGTCATTGTTATTTTTTTCCATTTTGAGCTAATGTGTTTTATTTGTGAATAGTCTTTTACATTTTTGTATGCTGAATATGGGCACCAAAGAACCTGTAAAAGTTATCTTTTTCAATTGAATGTGCACAAATAAAAGTTTGGAAAAGATCTCTCTTCATTCTATAACTTTTATTCCCCATTTTCTATTTTAACAAAAATTGTATTCATACTTCTTTTTTTTAAAATCTATGCAAGCTTAAGACTTTGGCTAAAGTGTGTTGGCTTCTTTTTGAAGTGTATTTtgtgtgtgtgtgtgtgtgtgtgtgtatatatatatatatatatGCACCACATGTGTATAGTATCTTTTAATGCTCTGTTACCAAATAACAAATAGGAATTTTTTTTCTTGCAGATTAGAAATAAAAACGTGTATATAAACTCTAGGGAACCAGACTAGAAGTTTATAGATAAAGGATAATGTTTTATGTTGCTAATTTAATATGATAGAAAATGTTAAATAACTTGTAAAGGTTAAGAAATTGTAGTTTTAAGAAGAGAAACCTCTTACCCACTAGATGGAAATGAGAAAGAAGCTGTGATGAATGGTGCCTCATTTGGACCTTTGTTTTTCTGGAAAGACTCAACACCTGTAGTTGTAGAGAAGTGATTGAGGTTCTTGACTTTAATCTTGGGTTGATGCCCAAGCCTATACTAAGAGTCTTGTCAGAAGTTGGTAACATGGAGATGTTTTAACAAGAAGTGCCCATAAGCTGCCTCTGTGCCACAGTGTAATTATCAAATAGCCCCACTTGAATTTGAAAGCCATTTTGTGTGATACTGTCCTTCCCCTTGCTGTATCTTATTTAATGGAGTTAAAGAGTGACTATTCAGTATATGAGATTGCTACTCTTAAAGTTATAATAAATATGCATTTATGAAACAGTGTCTCTGGCTCACCCAGGAGCCCTGATGTGGTAATACAGGATCAAGCTGTAGTTGTGCCCTGTCATTTAGGTTTAGGAGTTTAGTGTAACCAACAGTGATTATACCTAGAAATAAAGCTGAGTGGAGAGTCCAATTAGCTTCTCAGGAGAAACTTAATGGGGACAATATTCCAACACAATGTTCCACAAAAACTTGTATTTCCAAAATGTTTTTAAACCTTTGTGGAAAAATTGCAACATCCTAATCTCCATATATAGTACATTTTCCTTACTGTATTATAAAATCTTGAAAACCTAGCTTAGGCACTGCACTGAACAACACATATTATTTTTATCTTTTTTCTTCTCAATGCCTTCCCTAACCTCCTGCTTATTCCAAAGTGGAAAGCAAAGGCTAACTTACATTTTTCCTTCTTGTGAAATATTTCATTGAGATTTTTAGACTTGTATTTTTCCTTTTTTTTAAAAAAAAAGTGTTTATTTCCTTTATTTTAAGATTCAGTAGGATAGCCAAATTCATAGAGAATAAAATTACATGAAAGAGTTACAAGCTCACTGTTTTAAAGACTTGACATTTTTCATTTAGTTTTAATTAACAGTAATAAGTCACCTCCTGTTTTTCAATGTTCACCAAAAAAAGAAACATAGAATAGGGGGAAAACATGCTTATATAGCCAAGGTACAGATCCAGATGATGTAACCTTTTTAGTATTCGCATGACTTGAAAACTGGGCAGATCAATAGATAATCGAAGTGCTTTATCTGAAGGGAGAGGGTAAAGACAGTGTGACCAGGTTTGTTTTCAGGGCTGCCGAATGAGCCTCACCTAACAGTGTCCATGGGTAATTCGCTAACCTTAACAAAGATGGGAAGAAGTGAGTGCTCTGATGTCTTCTGCTGGCTCTCCATAAGTACTGTAAATTTTTTTTATAAATAAAAACTGTGAATATATATGTACAAGTTGTAAGTATTTCCCCCTTTTTATTTTTGAAAATCAAGAAGCTTGATTTGGTGTGGTGCAATGGATATTGGATAAAAATTTGAAGACAAAATTGTTTAGTTACAGACTCAGGATAATAAAAGAAAAATATAAAAGAATGCTCAAGATACTGAAGTCAAGGTCACTAGTAATAAACTGGCTAGGTTGATAAACAATTTCCTGCCCATTTATAATGAAGGGCTAAACAAAAAATACCTGAAGTATATATAGAGTTTGAACTATAAACACGGAAGGAAACATGGGGCAGAACACACTTCCCTTCTCTTTCCAAAAACAAAAAACAATGCATGCTCTGATTTGCGTATGAAATACACCATGATAGAATTGAGATCTCCAATCTCCTTTCCTTTTAGCTTCCCCCTGCCAATTTTTATACAGATAATACACTGCAGATCCAGGCCTTTTAGTCAGTCTCCTGAGTCTCTGATATAGTTTTACTACTTACATAGGTTTATAGTCTCTCCACATTGTTATAAAGGAATGTAATAGATCATGTTTCCTTATATGACATTGGGACAGTTTGTTAGGAACCAATAGGAAAATTCCAAGCTAAATAAAAAGGAGCTTTGGCTCTTAGGATTCTCTTTTCTTCAGGTTAATCATATTTTAAAATTCTTTTTCAAGTTAGGTTGTTCGTGCTTTTAAGTTTTTTGTGTGTCTTCCATCACTTAAATATTAGTAATTTAATATGTTATTTGGTTCAAGATTTGATTGTGGATTTTCTATCATACCCAAATTTTATTAGTAAGACCTCTTAACAAGTCTTTAAAATCAACTGGAGAAGTAAGAGAACAGTTCATCGTTGTGTGGGTGAAACCCACGTTGCTGGTACAGGTGGCCATCATAGAAAAGAACATGAGGGAATTGTCCTGATGTCTGAATGTCATTTATTGTGTCTTCAGTTATCTGAACATCATCATCAATTATAGCCTGTGTACCGTAACCTGAGGTAGTGATATTCCTGAGGAGTGTGAAGAATTGGACACTGTGGATTACTATACATTGTCATGAAAGCCTTACAAGGAGGCAGCTTTTCTAGGCTTGACTTAATAACTTCAACCTAATTGCTTAGAGATTTGGATAAATAACCTAATGGCCTGACTCCTTTTCTAATGTTTTACTAACAGCTACTTCTAAATAAATATGGTCCCAGGATTTTAAAA

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