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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PLA2G10P1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:182691936-182692330  UCSC
Coordinates (T2T) chr3:185496818-185497212  UCSC
Coordinates (hg19) chr3:182409724-182410118  UCSC
Strand +
Parental Sequence NM_003561.3_2
Parental seq. overlap 315 bp
Parental seq. overlap (%) 49.3%
Genomic Region Intergenic
Retrocopy Summary PLA2G10P1, located on chr3:182691936-182692330, is a retrocopy of the parental gene PLA2G10. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PLA2G10
Full Name phospholipase A2 group X
Also known as GXPLA2|GXSPLA2|SPLA2|sPLA2-X
Coordinate chr16:14672548-14694662
Strand -
Gene summary This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes LOC112205828P1
Bonobo Pan paniscus PLA2G10P1
Gorilla Gorilla gorilla PLA2G10P1
Orangutan Pongo abelii PLA2G10P1
Gibbon Nomascus leucogenys PLA2G10P1
Green monkey Chlorocebus sabaeus LOC103228738P1
Crab-eating macaque Macaca fascicularis PLA2G10P1
Rhesus Macaca mulatta LOC717517P1
Baboon Papio anubis PLA2G10P1
Golden snub-nosed monkey Rhinopithecus roxellana PLA2G10P1
Marmoset Callithrix jacchus PLA2G10P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PLA2G10P1
gGGATCTGGCCCTGGGTCCCGCCAGGCCTCCAAGAGGTCACACGTGCACCGACGTGGGATCCTGGAACTGGCAGGAACTGTGGGTTGTATTGACTCCTGAACCCCACTTACCTATATGAAATACAGTTGCTACTGTGGCCTGGGAGGCCATGGCCAGCACCGGGATGCCATTGACTGGACCAGCAGAGAACAAATGCCAAAAGCTCTTGTGCAAGTGTGACCAGGAGATTGCTAACTGCTTAGCCCGAACTGAGTACAACTGAAAGTACCTCTTCTACCCCCAGTTTCTGTGAAAGCAGGACTCGCCCAAGTGCGACTGGCTAGCTTGACTTGAAGTGCTCCTTTGCACAAAGAAATAAAGC
>NM_003561.3_2
GTGACAGCCGGGGTGTGTGTCCGCCGGGCTTGGTGCCTCCGGTGGCCCTGCAGCACCGTCCCACCTCTGCCACCCTCCGATGGGGCCGCTACCTGTGTGCCTGCCAATCAtgctgctcctgctactgccgtcgctgctgctgctgctgcttctACCTGGCCCCGGGTCCGGCGAGGCCTCCAGGATATTACGTGTGCACCGGCGTGGGATCCTGGAACTGGCAGGAACTGTGGGTTGTGTTGGTCCCCGAACCCCCATCGCCTATATGAAATATGGTTGCTTTTGTGGCTTGGGAGGCCATGGCCAGCCCCGCGATGCCATTGACTGGTGCTGCCATGGCCACGACTGTTGTTACACTCGAGCTGAGGAGGCCGGCTGCAGCCCCAAGACAGAGCGCTACTCCTGGCAGTGCGTCAATCAGAGCGTCCTGTGCGGACCGGCAGAGAACAAATGCCAAGAACTGTTGTGCAAGTGTGACCAGGAGATTGCTAACTGCTTAGCCCAAACTGAGTACAACTTAAAGTACCTCTTCTACCCCCAGTTCCTATGTGAGCCGGACTCGCCCAAGTGTGACTGACTACCTTGACTTGAAATGCTCTTTTGCACAAGGAAATAAAGCGTCCTCTCAGTAATGAA

Publications

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