Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name UBTFL8
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:5080780-5081272  UCSC
Coordinates (T2T) chr3:5074727-5075219  UCSC
Coordinates (hg19) chr3:5122465-5122957  UCSC
Strand -
Parental Sequence NM_014233.4
Parental seq. overlap 423 bp
Parental seq. overlap (%) 8.8%
Genomic Region Intergenic
Retrocopy Summary UBTFL8, located on chr3:5080780-5081272, is a retrocopy of the parental gene UBTF. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name UBTF
Full Name upstream binding transcription factor
Also known as CONDBA|NOR-90|UBF|UBF-1|UBF1|UBF2
Coordinate chr17:44205036-44221304
Strand -
Gene summary This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes UBTFP1
Bonobo Pan paniscus UBTFP1
Gorilla Gorilla gorilla UBTFP1
Orangutan Pongo abelii UBTFP1
Green monkey Chlorocebus sabaeus UBTFP1
Crab-eating macaque Macaca fascicularis UBTFP1
Rhesus Macaca mulatta UBTFP1
Baboon Papio anubis UBTFP1
Golden snub-nosed monkey Rhinopithecus roxellana UBTFP1
Gibbon Nomascus leucogenys Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>UBTFL8
AGATCTGGCAACAGAGCATCATCAGCAACTACCTGGCCTGCTTCAAGAACGACCGGGTGAAGGCCTCGAAAGCCATGGATGTGACCTGGAATCCCAAGGAGGAGAACCTGATGTGAATTGAGAAGACAGCCAAAGACCAAAAGTGATGAGAGAGAGCTGAGTGCGATGTGGGCACTTCCAGCTGCTACAGAGTCTTCCAAGATGATGAAATTCCAGGGAGGAAGCAAGAAGCCTTGTGAACCGGTATCAGAAATTCTTCCAGGAACTGCTGTGCAATGGGAGCTGAAACACCTGCCACAGACAGAGCGCATGGTGGGTGGAAATTGGCAGCCATCTCCTGGAGTCAGAAGGAGCACTACAAAAAGCTGGCCAATGAGCAGCGAAAGTATACAAGGTGCACCTGGACACCTGGGTTAATGGTCTCTGTCCCCAGGACCGCAGAGCCTAGAAAGAGTATATCTCTGATAAATGTAAGAGCATGACCAAGCTGCGG
>NM_014233.4
GTGCTTTTCGCCGCGAGGAGCAGCAGgcagcagccacagccgccgccgccgccgccgccgccacagcagcagcagccgccgccccagcgccgccgcctcgcccggaggaggagccgctgccgccgcGGGAGGGAGCTGCGGCTGTGCCCGGCCGAGCGGGGGAGGGCGCCGCCACTCAGAGCCAGGGAGGGAGCCGCTGGAGCGGGAAGCCCGGAGGCCGCGCTGCGCCGGGGTGAGGTGGCTTTGACCCCGGGTTGCCCGGCCAGCACGACCGAGGAGGTGGCTGGACAGCTGGAGGATGAACGGAGAAGCCGACTGCCCCACAGACCTGGAAATGGCCGCCCCCAAAGGCCAAGACCGTTGGTCCCAGGAAGACATGCTGACTTTGCTGGAATGCATGAAGAACAACCTTCCATCCAATGACAGCTCCAAGTTCAAAACCACCGAATCACACATGGACTGGGAAAAAGTAGCATTTAAAGACTTTTCTGGAGACATGTGCAAGCTCAAATGGGTGGAGATTTCTAATGAGGTGAGGAAGTTCCGTACATTGACAGAATTGATCCTCGATGCTCAGGAACATGTTAAAAATCCTTACAAAGGCAAAAAACTCAAGAAACACCCAGACTTCCCAAAGAAGCCCCTGACCCCTTATTTCCGCTTCTTCATGGAGAAGCGGGCCAAGTATGCGAAACTCCACCCTGAGATGAGCAACCTGGACCTAACCAAGATTCTGTCCAAGAAATACAAGGAGCTTCCGGAGAAGAAGAAGATGAAATATATTCAGGACTTCCAGAGAGAGAAACAGGAGTTCGAGCGAAACCTGGCCCGATTCAGGGAGGATCACCCCGACCTAATCCAGAATGCCAAGAAATCGGACATCCCAGAGAAGCCCAAAACCCCCCAGCAGCTGTGGTACACCCACGAGAAGAAGGTGTATCTCAAAGTGCGGCCAGATGCCACTACGAAGGAGGTGAAGGACTCCCTGGGGAAGCAGTGGTCTCAGCTCTCGGACAAAAAGAGGCTGAAATGGATTCATAAGGCCCTGGAGCAGCGGAAGGAGTACGAGGAGATCATGAGAGACTATATCCAGAAGCACCCAGAGCTGAACATCAGTGAGGAGGGTATCACCAAGTCCACCCTCACCAAGGCCGAACGCCAGCTCAAGGACAAGTTTGACGGGCGACCCACCAAGCCACCTCCGAACAGCTACTCGCTGTACTGCGCAGAGCTCATGGCCAACATGAAGGACGTGCCCAGCACAGAGCGCATGGTGCTGTGCAGCCAGCAGTGGAAGCTGCTGTCCCAGAAGGAGAAGGACGCCTATCACAAGAAGTGTGATCAGAAAAAGAAAGATTACGAGGTGGAGCTGCTCCGTTTCCTCGAGAGCCTGCCTGAGGAGGAGCAGCAGCGGGTCTTGGGGGAAGAGAAGATGCTGAACATCAACAAGAAGCAGGCCACCAGCCCCGCCTCCAAGAAGCCAGCCCAGGAAGGGGGCAAGGGCGGCTCCGAGAAGCCCAAGCGGCCCGTGTCGGCCATGTTCATCTTCTCGGAGGAGAAACGGCGGCAGCTGCAGGAGGAGCGGCCTGAGCTCTCCGAGAGCGAGCTGACCCGCCTGCTGGCCCGAATGTGGAACGACCTGTCTGAGAAGAAGAAGGCCAAGTACAAGGCCCGAGAGGCGGCGCTCAAGGCTCAGTCGGAGAGGAAGCCCGGCGGGGAGCGCGAGGAACGGGGCAAGCTGCCCGAGTCCCCCAAAAGAGCTGAGGAGATCTGGCAACAGAGCGTTATCGGCGACTACCTGGCCCGCTTCAAGAATGACCGGGTGAAGGCCTTGAAAGCCATGGAAATGACCTGGAATAACATGGAAAAGAAGGAGAAACTGATGTGGATTAAGAAGGCAGCCGAAGACCAAAAGCGATATGAGAGAGAGCTGAGTGAGATGCGGGCACCTCCAGCTGCTACAAATTCTTCCAAGAAGATGAAATTCCAGGGAGAACCCAAGAAGCCTCCCATGAACGGTTACCAGAAGTTCTCCCAGGAGCTGCTGTCCAATGGGGAGCTGAACCACCTGCCGCTGAAGGAGCGCATGGTGGAGATCGGCAGTCGCTGGCAGCGCATCTCCCAGAGCCAGAAGGAGCACTACAAAAAGCTGGCCGAGGAGCAGCAAAAGCAGTACAAGGTGCACCTGGACCTCTGGGTTAAGAGCCTGTCTCCCCAGGACCGTGCAGCATATAAAGAGTACATCTCCAATAAACGTAAGAGCATGACCAAGCTGCGAGGCCCAAACCCCAAATCCAGCCGGACTACTCTGCAGTCCAAGTCGGAGTCCgaggaggatgatgaagaggatgaggatgacgaggacgaggatgaagaagaggaagatgatgagaatggggaCTCCTCTGAAGATGGCGGCGACTCCTCTGAGTCCAGCAGCGAGGACGAGAGCGAGGATGGGGATGAGaatgaagaggatgacgaggacgaagacgacgacgaggatgacgatgaggatgaagatAATGAGTCCGAGGGCAGCAGCTCCAGCTCCTCCTCCTCAGGGGACTCCTCAGACTCTGACTCCAACTGAGGCTCAGCCCCACCCCAGGGCAGCCAGGGAGAGCCCAGGAGCTCCCCTCCCCAACTGACCACCTTTGTTTCTCCCCCATGTTCTGTCCCTTGCCCCCCTGGCCTCCCCCACTTTCTTTCTTTCTTTAAAAAAAAAAAAAAATACGGTGGGGGTAGGGGGCTGGAGGAGCCCAGGCCAGGACTCTGCAGCCTCAGAGACATCAGCCCTTGGGGGTCCTCCTCCAGGGACAGCAACTATCAGACTAAGCCAGCACCGGACCAGCCTGGCCCACCCCACCCACTTCTGCACTTGCGGTTCCGGCATGGACAATGGACCGGAGAGTGGGGGTGGGGGGTCCCAAAGAGTTTGATGAGGCCCTCCACACCTGCGGCCCAATCCAAGGTGGGGTGGAAGCTTGGGGAAGACCCATTCCTTCCCAGAGGGGCCTGCCACCTGGACCCCTGCATTGGAACTGGAGGCAGGGAACATGGGGAGGAGGAGGGTCGGTGCCTTCAAGAAAACAGGCACTGCCCTGGTGGCCCTCTCCCCTGCCCCCTGCAGGAAGGAGCTGCCTGGACCCGTTCATGGGGGAGGGGGCAGAAGTGTTTTTTATATATGTGTATATATTTTTTTTTAAGCTCTGAGCTGTCAACGAGACGTTTCCTACCGATCTCGGCTGCCGTCTCTGTTGTCATTTCTGGGAGAGGGAGGGTTTAGGGGTAGATTTGGAACCTTTTAAAAATGGTCTTGATGTATGTGGAAGAGAGTATGTGTATGTGTGTTCCTGTACATAGCATGGGTGCAGCTGTGGATGTGTGCAAAAGAgtgtgagtgtgtgtgtgtgtgtgtAAAGGGGTCTGTCCTAGAGCCCACATCAGTTTGTTGTGAATCTGGAAAAAGGGTCGGTGAGGGCCGGGAGATGTTGACCCTGGTGGGAGCAGGCTGAGGCTGCCCCGTTCTCCACATCCTCTGTTTTGCCCAGTCTCTGATTCCATTAGGGGGAGTGTGCTGAAGCCATTCTCGGATGCTTCCCAGACCAGGCTCCCTCTGCCAGAGTCACATGCATCCGAGCTGCTGGTCTCCATTGTCCAGCAGGAAGGCGGAAAGGCAGGCAAGATGGTGTGAAGCTTAAAGCTTGTATTTGATGGAAAAGGTCTCCCCTGTTCATCTGAGAGGCCAAGCCTGGCCACCCCAGGCTCAGAACCTGGGCTTCAAGAAATGTGCTGGGAGCTCCTAACTTACACATCCCTCCAGCCTTCCTTGAATCCTCCCACCACCCCCTATTTCCTTTAATTTCTCAGGTCTGCTCCCTCCTCCCCCAACCCCACAGCTGGGCAAGAAGTCTGCAAAAGCTGCATCTGCAGCTGTCTCTAACTCTTCCCAGCCATCTCCCGTATTTTTTGGTACCTTGATTCCTTGACTCTTAATAAGCCAAGCCACCTTATCTCTGTAGTTCTTATTTTTTTGTTGACTAAATTTGGGGGGTTCTTTTTTATGGTCATGTCACTGACCTATTAAATTGGGGCTTGGTGCTTTTCCACCTTCCCCCTCTGAATGAAAGCCAAGGAATGGGGGAAGAGCGGGAACTCTGCCGCGGAGGTGGAGCAAGAACGGTGAAGGGCCCTGGTCCCAGAGAGGCTGGTGGGTCCCTCTCCCAAAGGAAGGCAGACAGTCTCTGCTTTGCCTTGGACCTTGGTGCTGGGGGTGGGGAGGCCTGGGGGGGACACTCCCCACTCCCATTCCCCTTCCTTTGTCCTAATCCTGGAATTAAGTACAGGGGTTTATAGGTTCTATTTCTTCCCAAGAGCCCTGCAAAGAACCCCAGTTTCCTATTTGGATGCCCCTACACTGTTGTGTTTCAGTGGAATGTATTTTCATTTAAAAACAACTTTGAATGGGGCACTTTTTCTTTCCTGTTTTAAAAATTGAAAAATTCTTACAGTACAAACAGGACTGTCAGGGTGGGGGTGTTGGTGCTGTAAGAGGTCACTCTTGAGTGCATTTTGGCACTGGGATGGGATGGCTGGGGTGGGAAGACCCCCATCCCCACCCCCAACTTCTTTTCTAATATTTAAGGAGTGTTTTGTAGGATTCAACAACCACCACAACTTGAATTTGTATCATGGGAGGTGGGAGGGAGTGGCTTAGAGGTGTCTGCCTATGCTTAAAGCCAACTGTGGAAGTTTTGTTTTCCCTTTTTTGTATAATAAAGTGAAAAACAAA

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