Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MTHFD2P1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:95654183-95655747  UCSC
Coordinates (T2T) chr3:98356441-98358005  UCSC
Coordinates (hg19) chr3:95373027-95374591  UCSC
Strand -
Parental Sequence XM_006711924.2
Parental seq. overlap 1384 bp
Parental seq. overlap (%) 69.4%
Genomic Region Intergenic
Retrocopy Summary MTHFD2P1, located on chr3:95654183-95655747, is a retrocopy of the parental gene MTHFD2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MTHFD2
Full Name methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Also known as NMDMC
Coordinate chr2:74198591-74217565
Strand +
Gene summary This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MTHFD2P2
Bonobo Pan paniscus MTHFD2P2
Gorilla Gorilla gorilla MTHFD2P2
Orangutan Pongo abelii MTHFD2P2
Gibbon Nomascus leucogenys MTHFD2P4
Green monkey Chlorocebus sabaeus MTHFD2P6
Crab-eating macaque Macaca fascicularis MTHFD2P1
Rhesus Macaca mulatta MTHFD2P1
Baboon Papio anubis MTHFD2P1
Golden snub-nosed monkey Rhinopithecus roxellana MTHFD2P2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MTHFD2P1
CGGCATTTTGGAATCACCAGTGAGACAATTGTGAAACCAGCTTCAATTTCTGAGGAAGAATTGTTGAAGTTAATAAATAAACTGAGTAATGTTGATAATTAGATAATTAGATGGCCACCTTGTTCAGCTGCCTCTTCCAGAGCACACTGATGAGAGAAAGATCTGCAATGCTTTTTCTCCAGACAAGGATGTTGATGGCTTTCCTGTAATGAATGTAGGACGAAAGTGTTTGGACCAATATTCCATGTTACCGGCTACCCCATGGGGTGTGTGGGAAATAATTAAGCGAACTGACATTCCAACCCTAGGGAAGAATGTGGTTGTGACTGGAAGGTCAAAAATTGTTGGAATGCCCATTGTAATGTCACTGCACATACGTGGGGTGCATGAACGTCCCAGAGATGATGCCACCGTTAGAATATCTCATGGATATACTCCCAAAGAGCAGTTGAAGAAACAAAATATTTGCAGATATTGTAACATCCGCTGCACGAATTCTAAACCTGTTCACAATAGATATAATCAAGGAAAGAACAGCAGTTGTTGATGTGGGAATAACTAGAGTTCAAGATCCCGTAACTGCTCAACCCAAATTGGTTGGAGACGTGGGTTTTGAAGGAGTCAGATAAAAAGCCGGTTACATCATGCCACTTCCTGGAGGTGTTGGCCTCATGACGGTGGCGATGCTAATGAAGAATACCATTACTGTTGCAAAAAAGTTCTGAGGCTTGAAGAACAGTAAGTGCTGACGTCTAAAGAGCTTGGAGTAGCCACTAATGAACTATTGTGTCTTCTATGTCACAAACAGCACTCCAAGCCAGCTCAAGAAGCAAAGCAGGCCAATAGAAAGACAATATTTTTTATTTATTCTACTGAAGTGGTTTAAAATGATGCTTTGTATTTATTGAAAGCTTAAATTGGAGGGTGTTTGTGCACAATAGCTCTGCAGTACCTCACCAGGGAGCATTCCACTATGCAGGGGCGTGTATCTAGCTAACAGCAGCCATTAACCCAGTGATGAACCTGGGAGACATTTGTCATATTGAGATGGATATTTAACTCTGTCAAACCACCTCGGTTGAATATTTGCCTTCATTAGGACTGCGTTTCCCAAATGCTATTTCAATAAGAGTTGATACTCATTTTAGGCACCAAAACTTTTGGATTCAACTGATCAAACCAAAGGAAAAGTGTTGCTAGACAAAATTAGGGAAAAGGTGAAAGAGGAAAATATGGTAGTAATCGAGTAGAAAAAAATTCCTCTAATTTATATATGCATTGATTAGTAACCAGATTTATCTAAGTAGGACTGAATTGGCTAGGATAAAAAGAAAAAATACGTATTAATCCTTTTCCTAAGCTGTCTTTTTGAGGCTTAGTCAGTCATTGGGAAAATGTTTAAGATTGTTCCTTGATATTTGTCCTCATTTTATGTATGCTACCCTTCAGTACGTTCTCCCCATTTTAGATTTCTAGGATTGAAAGGCTTACTTTATAAATTAGTCATGTGTATTGTCATATTTGGCTTTGCTATATACTTTAATTTCATTGTTAAAATTTTGTAC
>XM_006711924.2
CGCGTGGCCCGCGCGCGCGCTTCCCTCCCGGCGCAGTCACCGGCGCGGTCTATGGCTGCGACTTCTCTAATGTCTGCTTTGGCTGCCCGGCTGCTGCAGCCCGCGCACAGCTGCTCCCTTCGCCTTCGCCCTTTCCACCTCGCGGCAGTTCGGAATCAACAGTGAGACAATTATGAAACCAGCTTCAATTTCAGAGGAAGAATTGTTGAATTTAATCAATAAACTGAATAATGATGATAATGTAGATGGCCTCCTTGTTCAGTTGCCTCTTCCAGAGCATATTGATGAGAGAAGGATCTGCAATGCTGTTTCTCCAGACAAGGATGTTGATGGCTTTCATGTAATTAATGTAGGACGAATGTGTTTGGATCAGTATTCCATGTTACCGGCTACTCCATGGGGTGTGTGGGAAATAATCAAGCGAACTGGCATTCCAACCCTAGGGAAGAATGTGGTTGTGGCTGGAAGGTCAAAAAACGTTGGAATGCCCATTGCAATGTTACTGCACACAGATGGGGCGCATGAACGTCCCGGAGGTGATGCCACTGTTACAATATCTCATCGATATACTCCCAAAGAGCAGTTGAAGAAACATACAATTCTTGCAGATATTGTAATATCTGCTGCAGGTATTCCAAATCTGATCACAGCAGATATGATCAAGGAAGGAGCAGCAGTCATTGATGTGGGAATAAATAGAGTTCACGATCCTGTAACTGCCAAACCCAAGTTGGTTGGAGATGTGGATTTTGAAGGAGTCAGACAAAAAGCTGGGTATATCACTCCAGTTCCTGGAGGTGTTGGCCCCATGACAGTGGCAATGCTAATGAAGAATACCATTATTGCTGCAAAAAAGGTGCTGAGGCTTGAAGAGCGAGAAGTGCTGAAGTCTAAAGAGCTTGGGGTAGCCACTAATTAACTACTGTGTCTTCTGTGTCACAAACAGCACTCCAGGCCAGCTCAAGAAGCAAAGCAGGCCAATAGAAATGCAATATTTTTAATTTATTCTACTGAAATGGTTTAAAATGATGCCTTGTATTTATTGAAAGCTTAAATGGGTGGGTGTTTCTGCACATACCTCTGCAGTACCTCACCAGGGAGCATTCCAGTATCATGCAGGGTCCTGTGATCTAGCCAGGAGCAGCCATTAACCTAGTGATTAATATGGGAGACATTACCATATGGAGGATGGATGCTTCACTTTGTCAAGCACCTCAGTTACACATTCGCCTTTTCTAGGATTGCATTTCCCAAGTGCTATTGCAATAACAGTTGATACTCATTTTAGGTACCAAACCTTTTGAGTTCAACTGATCAAACCAAAGGAAAAGTGTTGCTAGAGAAAATTAGGGAAAAGGTGAAAAAGAAAAAATGGTAGTAATTGAGCAGAAAAAAATTAATTTATATATGTATTGATTGGCAACCAGATTTATCTAAGTAGAACTGAATTGGCTAGGAAAAAAGAAAAACTGCATGTTAATCATTTTCCTAAGCTGTCCTTTTGAGGCTTAGTCAGTTTATTGGGAAAATGTTTAGGATTATTCCTTGCTATTAGTACTCATTTTATGTATGTTACCCTTCAGTAAGTTCTCCCCATTTTAGTTTTCTAGGACTGAAAGGATTCTTTTCTACATTATACATGTGTGTTGTCATATTTGGCTTTTGCTATATACTTTAACTTCATTGTTAAATTTTTGTATTGTATAGTTTCTTTGGTGTATCTTAAAACCTATTTTTGAAAAACAAACTTGGCTTGATAATCATTTGGGCAGCTTGGGTAAGTACGCAACTTACTTTTCCACCAAAGAACTGTCAGCAGCTGCCTGCTTTTCTGTGATGTATGTATCCTGTTGACTTTTCCAGAAATTTTTTAAGAGTTTGAGTTACTATTGAATTTAATCAGACTTTCTGATTAAAGGGTTTTCTTTCTTTTTTAATAAAACACATCTGTCTGGTATGGTATGAATTTCTGAAA

Publications

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