Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PDLIM1P4
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:98782294-98783542  UCSC
Coordinates (T2T) chr3:101490567-101491809  UCSC
Coordinates (hg19) chr3:98501138-98502386  UCSC
Strand +
Parental Sequence NM_020992.4
Parental seq. overlap 1009 bp
Parental seq. overlap (%) 67.4%
Genomic Region Intergenic
Retrocopy Summary PDLIM1P4, located on chr3:98782294-98783542, is a retrocopy of the parental gene PDLIM1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PDLIM1
Full Name PDZ and LIM domain 1
Also known as CLIM1|CLP-36|CLP36|HEL-S-112|hCLIM1
Coordinate chr10:95237569-95291006
Strand -
Gene summary This gene encodes a member of the enigma protein family. The protein contains two protein interacting domains, a PDZ domain at the amino terminal end and one to three LIM domains at the carboxyl terminal. It is a cytoplasmic protein associated with the cytoskeleton. The protein may function as an adapter to bring other LIM-interacting proteins to the cytoskeleton. Pseudogenes associated with this gene are located on chromosomes 3, 14 and 17. [provided by RefSeq, Oct 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PDLIM1P1
Bonobo Pan paniscus PDLIM1P1
Gorilla Gorilla gorilla PDLIM1P1
Orangutan Pongo abelii PDLIM1P1
Gibbon Nomascus leucogenys PDLIM1P2
Green monkey Chlorocebus sabaeus PDLIM1P1
Crab-eating macaque Macaca fascicularis PDLIM1P1
Rhesus Macaca mulatta PDLIM1P1
Baboon Papio anubis PDLIM1P1
Golden snub-nosed monkey Rhinopithecus roxellana PDLIM1P1
Marmoset Callithrix jacchus PDLIM1P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PDLIM1P4
AGAAGCAAGGCTGCTATAGCTAATTGATGTATGCAAGATGTAATTACAGCCATTGATAGGGAAAATATCAGCAATATGATGCCCTTGGAAGCTCAGAAAAAAGTCAAAAGGCTGTACCATGACTCTCACAATAGCCAGATCTGAATATAAAATCTAGTCTCTTCTGGTGATGGAGAAAAGGAAGTGTCATCCATACAAGATGAATTTACACTCTGAACCCCAGGAGGTCCTGCACGTAGGAAGTGCCTACAATCCAAGTACCATGCTCTTTACTGCCTCTCCTGCTTCCAGCACTGTCCCTGGGGTCATCCAAACCAGTACAGTAACCCAGCTGGCCTCTCTTCTGAAAACATCTCCAACTTCAACAATACTTTGAGATACCATATTGCTGGTATTTCAAAAACTGCTGCCAGCAGGGAGGAGGCCAATGGCGTGTCCATAGATCATGTTCAGCCTCCAAGTGGTCTCATAATCAACAAAGAATCTGAAGTTTACAAGATGCTTCAGGAGAAACAGGAGTTGAATGAACCCCTGAAACAGTCTACCTCTTTCCTGATTTTGCAGGAAATCCTGGAGTCTGAGATAAAAGGGGATCTCAACAACCCTCAGGATTCAGAAGTGTTACTCAGCTCAGTCTATTACTCAGTGGCTGCATCAATTGGAAATGCTCAGAAGGTGCCCATGTGTGACAAATGTGGTCCTGGCATTGTAGGCATGTTTGTAAAGCTGCGGGGACCATCATCCCCTCCCTGAATGTTACGTGTGCACTGATTGTGACACTCACCCGAAAGAGAAGGGCtCCATCAAATCTACTGTGAAGAGCATGCCCAGGAGCAAGTCACACCACTTGAGGGTACGATGTGGTCATCATGTTCCCCAAGTGATCCAGCAGACCTGCACTGACCACCGTTCTCCAGCCAGCCTCTGCTGCAGCTAGTTCTCTAAATGTTCTGGCCTTGTCTCTTGAAAGTTCTGTACTTATTCCCCCACCCCACAACCCGCTTACCTTGGTTTTATCCCTGCTCATTGAACCTTGAGTCCCTTGTCTTGGTTAACTGACTCACACTGACTGTGTGGTGCCCGCCCACTTTTACAATGAATGGCAAACTGTTTTTGTTCAGTGTCCCCTTGCCGGCAACACTGTGTACCTTCCTCCCCTCAGTTCTTCTCTGCTGCAAATGGACATCAGCCACATTTGAACCAAATCAAATATAATATGTCTGACATTGATTT
>NM_020992.4
CTCCGACAGCCGCCGGGGGTGCCCTGCAAGCTGTTCCGCGCGTCCTGCCCGTCTGTCCCCGCGGGTCGTCGCCCGCCACAGCCGCGCCATGACCACCCAGCAGATAGACCTCCAGGGCCCGGGGCCGTGGGGCTTCCGCCTCGTGGGCGGCAAGGACTTCGAGCAGCCTCTCGCCATTTCCCGGGTCACTCCTGGAAGCAAGGCGGCTCTAGCTAATTTATGTATTGGAGATGTAATCACAGCCATTGATGGGGAAAATACTAGCAATATGACACACTTGGAAGCTCAGAACAGAATCAAAGGCTGCACAGACAACTTGACTCTCACTGTAGCCAGATCTGAACATAAAGTCTGGTCTCCTCTGGTGACGGAGGAAGGGAAGCGTCATCCATACAAGATGAATTTAGCCTCTGAACCCCAGGAGGTCCTGCACATAGGAAGCGCCCACAACCGAAGTGCCATGCCCTTTACCGCCTCGCCTGCCTCCAGCACTACTGCCAGGGTCATCACAAACCAGTACAACAACCCAGCTGGCCTCTACTCTTCTGAAAATATCTCCAACTTCAACAATGCCCTGGAGTCAAAGACTGCTGCCAGCGGGGTGGAGGCGAACAGCAGACCCTTAGACCATGCTCAGCCTCCAAGCAGCCTTGTCATCGACAAAGAATCTGAAGTTTACAAGATGCTTCAGGAGAAACAGGAGTTGAATGAGCCCCCGAAACAGTCCACGTCTTTCTTGGTTTTGCAGGAAATCCTGGAGTCTGAAGAAAAAGGGGATCCCAACAAGCCCTCAGGATTCAGAAGTGTTAAAGCTCCTGTCACTAAAGTGGCTGCGTCGATTGGAAATGCTCAGAAGTTGCCTATGTGTGACAAATGTGGCACTGGGATTGTTGGTGTGTTTGTGAAGCTGCGGGACCGTCACCGCCACCCTGAGTGTTATGTGTGCACTGACTGTGGCACCAACCTGAAACAGAAGGGCCATTTCTTTGTGGAGGATCAAATCTACTGTGAGAAGCATGCCCGGGAGCGAGTCACACCACCTGAGGGTTATGAAGTGGTCACTGTGTTCCCCAAGTGAGCCAGCAGATCTGACCACTGTTCTCCAGCAGGCCTCTGCTGCAGCTTTTTCTCTCAGTGTTCTGGCCCTCTCCTCTCTTGAAAGTTCTCTGCTTACTTTGGTTTTCCCTCTGCTTGTAAAACATTGAGTCCCCTCCCTGCCTTGGTTAATTGACTCACACCAGCTGTGCGATGCCCGCTTTTACAATTAAAGGAAAACTGTTTTGTTCAGTGTCACCTTGTCAGCAACACTGTGTCCCTTCGCCCCACCGTTCTTCTCTGCTGCATTTGGACATCAGCCAAATTTGAACCCAATCAAATATAACGTGTCTGACACTGATTTTGTTTTTACTCAATAAATGTATAGACTACAAA

Publications

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