RCPedia: Rtcs

Summary

Retrocopy Name	HSBP1P2	Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr4:110251631-110252113 UCSC
Coordinates (T2T)	chr4:113553927-113554409 UCSC
Coordinates (hg19)	chr4:111172787-111173269 UCSC
Strand	-
Parental Sequence	NM_001537.4
Parental seq. overlap	438 bp
Parental seq. overlap (%)	5.1%
Genomic Region	Intergenic
Retrocopy Summary	HSBP1P2, located on chr4:110251631-110252113, is a retrocopy of the parental gene HSBP1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	HSBP1
Full Name	heat shock factor binding protein 1
Also known as	NPC-A-13
Coordinate	chr16:83807978-83819737
Strand	+
Gene summary	The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	HSBP1P1
Bonobo	Pan paniscus	HSBP1P1
Gorilla	Gorilla gorilla	HSBP1P1
Orangutan	Pongo abelii	HSBP1P1
Gibbon	Nomascus leucogenys	HSBP1P2
Green monkey	Chlorocebus sabaeus	HSBP1P1
Crab-eating macaque	Macaca fascicularis	HSBP1P1
Rhesus	Macaca mulatta	HSBP1P1
Baboon	Papio anubis	HSBP1P2
Golden snub-nosed monkey	Rhinopithecus roxellana	HSBP1P1
Marmoset	Callithrix jacchus	HSBP1P1
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>HSBP1P2
TGGGCACCAGGGATATAGCCGAGACTGACCCCAAGAATGAGCAGGAACTCACCTCAGTGGTGCAGAAACTCCTGCAGCAGATCCAAGATAAATTTCAGACCATGTCTGACCAGATCATTGGGAGAACTGATGATATGAGTAGTTGCACTGATGATCTGGAAAAGAACATCGCAGATCTCATGACACAGGCTGGGGTGGAAGAACTGGAAAGTAAAAACAAGATACCTGCCACACAAGAGGTGAAGGTTGCTAATAATTTATACTGAAATCTGGAACACCATTTTTCCAAGCCAAGAGAAGATTGAATGGGTTTTTGCAGCTAACTACTATGTGTATACAGGTTTTATAAAAAGTGTGCATTCTTATCACATACTATATAGTTAGTCTATAGAGTGATTTACCCCCCAGTTTCTTAAACATAGTATCTTCACATCTTGGACCTTGGTCAATTTTGCTATTAACGATTAAACATTAAAACTTTGC

>NM_001537.4
AGTCTCGTCGCGAGAAGCAGCGGCCCGGGGCGACTGAGCGGACAAACGGAAGTGTAGGTTACGGTCTGAGACATCACCGCCAAGCTGGGCATCGGGGAGATGGCCGAGACTGACCCCAAGACCGTGCAGGACCTCACCTCGGTGGTGCAGACACTCCTGCAGCAGATGCAAGATAAATTTCAGACCATGTCTGACCAGATCATTGGGAGAATTGATGATATGAGTAGTCGCATTGATGATCTGGAAAAGAATATCGCGGACCTCATGACACAGGCTGGGGTGGAAGAACTGGAAAGTGAAAACAAGATACCTGCCACGCAAAAGAGTTGAAGGTTGCTAATAATTTATACTGGAATCTGGCATTTTTCCAAGCCAAGAGAAGATCGAATGGCTTTTTGCAGCTAACTACTATGTGTAGACAGGTTTTATATTATAAAGTATGCATTCTTATCACCTAGTATATAGTTAGTTTGTAGAGTGATttccccccagtttcttgaacatggtatcttcacatcttggaccttggtcagttgtgctattcattattaaacaCTAAAACTTTGGCGGTTCTTGCATAACATTGTCAGATTTTTTAGTGTATTTCTGTGAAGTCATTTTTTTTCTTGTCATTCCTTTTGTAGTAGTTGCTGTTTGGATAAAAGTTGATGTGTGATTTTTTATTAAACAAATAGTAAACCCTTCAATTATAGTTAGTCTTGGTGAAGTAAGATGTTTGTAGACTTTAGAGTTCTTTAATTCTTGGCACAACGTGACTGTTGAGCTAACACCAAATAGTGTGTTGGCAATACTTTTCAAATGGCTGAAAACACCTAAAAATTGTTCATTCAGAAATATCTGTCACTGCTCTGTTGCCAAAACTCAGAATAGAACTTAGACGTATGTCTGAGTCCCTGAGATCACATGCTAAAGTCGATGAAAAGTAACCACTGCCACTGTCTTGTGTCAGAACTTTTACAGTACAGAAAATAACAGAATAGCCTTCTGTAATGAGGCGTTTGTTAGAGTTTTGCATGAGATTCTAATACTTCAGTAGGACCCTACCTACGTGGTTCATCTACAATGGTTACCATAAAAAATCTGGCAGGATTTTAAAACTCAATCAGTCTTTCCTTTGAGCTAGTGACTTGAAAAGAAAGAGAGAAGGAAAAGAGACCATATTAAGTCCATGCCAGTTGCTTGGCTAGAATATGATCAACGACTTGTAGTAGACTCAAGTTTTTAAAAAACACTATTTTACTTAAACTGTTTCTTATCTAAATTCTTGCAGAGTGTCAATGTTATCATTGATTATAGAAGACAGGGATAATACCTTTATCTCTGGCCACTCAAAAATGCAGTGCCAGGAGTGCTAAACCTAGAGGCCAATACTGATGACCTGGAAGGTGATCCATATGATTGTCACCACAAAGTGCTTTTACACAAAAACTTGAAAATTTGAAAAACATGATTTTTTTAAGTTTCTCATCTCACCAGTCTTGGTGTTTATATTGCAAATCTATCAAAGTAAGAAATAATTTGTGCTGTATACAAATTACATGGGGAACATAAAGGAGTGAGATCCTTCTGTGATAAAATGAATTCACCACTCTGGTTACCCAACTACAGAACCTCCTTTGATCAGGCCAGTAGGTTGTGATGCAGGCTGGAGCCCCCGAATGCCCCACACACACTGCAGCATTGACCAGACCATCCGAAACCTGCGTCCCTGGTGATGTTCTCAAGCCTCGGAAGTGGCAAATGGAAATGATATGGCCGGTTGCGGTTGTAGGAGAGTTGTGACTtaggcaggagtcgacctcctcaagtaatggaacgatttcaaaggcaggctgccctgaccaaaaatatctgccatgaataaaggtgcctgaaatcctgctatgaagcttcctttgtgtcaaaaatctgtttggttttcagatggaaatgcagaaatcacattagagtatcaactaaaacctctggacggattaagtacaagtagcccaaggcaaagcAGGAGAGGGGGTGTTGGGGGAGGTTGCCTGCTGGAAGGGGAAGCTGAGGAGCGGGAGGAGGGCTTGCCAAGACTGGCATTGCAGGAGACTTGTCTCaggtgtgttcccagaactcttgcccctggagatgctgcaggaaggaaggggttatggtcacttgggtttagacgacattctgtgaacctcatgaagaaattagcatattaaagactctgaaagtagagcagagaactcagctttaacctGCTCACCTGCTAGTTTTCGAggtctcgctctgttgcccaggctggagtgcagtggcacagtcatagctcacttggagcctgaagctcctgggctcaggcagtcctcctgcctcagcctcccaagtagctaatattacaggttcgtgccaccgcacctgggtcttgctgtgttgcccaggctggtctagaactcctaggctcaagcagtcctgtctcagcctcccaaagtgctgggattacaggctggagccaccatgcctgtccAAGGGTCTTTTTTATACTATATGAAGTATTCCTTCTCCAGCTATTCTTGTTCGTTTACCAGCCAGTGAAGATTCTCTTGAGGGCTGAACAATACAGATGAGTATGGGGGCCCTCGCACCAAGGAAAACAGCGTTACATTTAATTAAGTGCCCTGTCTCAAACCCCAAGGCCCCACAGcttcttcatttggcccctagttcatcctgctttcctttgagccacaggattttaaaatatttcaatcttattttcatatcaattttttctttgtttcactacaagtacagtcattgtttaaccctatcaggactaacacaatatttcacgtaactaagagttaatttgcccttgtgagtccttggaatttaagccccacacacacacacttagagcactgttgctatgggaacatagagtcctccaaacaaaagtgaactttttcaacatgctgtttgtaaatggaagccttccCAAGCAGACACTGTGTTCCTCTTTTATTTTGTATTTTGCACATTATATATTTTGATTAGATTAAAATGGAGGAATTTGCAGGATGTGTTGTCATATCTAGCCCTGAAAGTTAACTGGTTACAGTTACCAAATGTTCACagctagcgccattgaaagcattgactgtaaaccgctgtactgtgctaagccttttgtttgcactgtttggcttaatcctcacaacaacactgagaggttttcatttgatgagtcatatttaaagaaaaggaacccaagacggggagtcaggggcacaaggtcacagctggtaaTGATGACCCTGGAATGTCCTCACAGCTGCACACCTGCACCGCTCACAAACACAGCTGACCGTCTCACAGCTGCACACCTGCACCGCTCACGAGCACAGCTGACCGTCTCACAGCTGCACACCTGCACTGCTCACGAACACAGCTGATCGTCTGCCTCTTCGTGTGAGCTGAGCTCCGAATCTCAGCTGTCCAGGCTGTCTGGAAATCATCAGCCCCACTGGCTGGATCTCAAAATTTACTTTCAAAAGGCTGATGGAGTGTTTTCAATTAAACATGACCTAAAATTAAGTAATAAACACACTGGATGTGAGTTTTTATTTGGAATTTAAACTATTCAGAGCTGGTAGAAAATGTGTGCTCCTGGATCAGTGCCTTTTTTCTCCTAAATCAGTTGAGAACAACAACAGAAACAAATGACATTCCTCAAACATTTGCCCAGAGCACAACCACGGGGAATATGAACCACAGGTTTTCACATTGGTTTTCCATGCCTATACCTGTCCTGTCTCCCACAAAAATTATTGCTTGAGGCCCAACCCGGGGGATAAAAAGACACCCCCCCGCCACTCCGTGACCTATTAGCTTACCATCCTATTGGATTTCACTGTTTTTTGTTTTGTGGTGTTTTTTTTTTATTGCAACGAAGACTTTTAAATGGACTCATGAAGAAGCCATCACCTGGAATCTTAATCTTGCATTAATTTTAAGTGTCTGATTTTAGCTGCAGCCACTTGAGAACTTTTCAATGAATGAAAATGAGGGAGGGGAGATGCAAGTCACTGCCCAAAAACAAAACCAGAGGAATTGTGATTGAACATTGCACTTATCAACCCTACAAATTAATATGGAAATAGGAAAAGGGTTTGTTTCAACAAGTCAGGATGACAGTATTTTAAAAAAGAAAAAAaggccagcctgggcaatatactgagactccatctctacaaaaaagtagaaaaattagcccagagtgtggtggcacacatctgtgctcccagctactcaggaggctgaggtgggaggatcatttgagcccaggaagtcgaggttgcagtgagctgtgatcggacgactccactccagccggggtgacagagcaagaccctgtctcaaaaaaaaaaaaaaaGGGCGGATCCTAACGCTTGGTCCTCACACCTGAGGCTCTCACTAAGAGGTGGCTGGAAGCTCCTCAGACCGCTGCCTAGGGTTCGAGTGATCCTGAAAGCTGTACAACATCAGCCTCTGTGGGATCCCTGAGAATGATGAAATGTAATATGTGGCTGTCTCATCAACAGAGCTTCATTTTACCAAAGCATATGTAGACACCACATACATGAACTACATACCTATCGTGTAGATGCTGCCCTGCCTCATAAGAACACTCTTGACTGTCCTGCTTCACAATAATAATCTTCGCAATAATGATCTAATAATGGTCAAATTCTGTGTCTCTACCGTAGAAAACAGAATTTGACCATTTAGTCACGTTGGTCTTGCAAAATGTCCACCTTCCAAAAGAGAACAGTATTGCTTCCCAATAATTAAGAATAGTCTGGATTCAGGATCCAGCAGCttagaagcgtttagctaccaatagcaaaaatcagcccttttaacaatggtgggatgtattatttcacatggcaagaagtcccaagggagggcagctctggggcgagtaaattctgcacctcaGTAAAACTAAGAGCAAGACCCggccgggcgcagtggctcatgcctgtaatcccagcactttgggaggccgaggtgggtggatcacctgaggtcaggagttctaaaccagcctggccaacatggcgaaacccccgtctctactaaaaatacaaaaattagccaggcgtggtggtgggcgcttgtaatcccagttgctcgggaggctgagggaggaggatcgcttgaactcaggaggtggaagttgcagtgagccgagatcgtgccactgcactccagcctgggtaacagagcgagactccatctcaaaaaataaaaaacaaaaaaataaataaaaAATAAAAAGACCCAACCCCAGATTTGTTCCACCTGGGTGCATCCGGTCAGAGAATGCCTTTCTTCTTCCCTTTTGTCTCCTAAGAGTGAAGAAAATGTTTCTTTGAAGGTGTTTCCACCCCACTCCTGTGCCTAAAATGATCCTGGCAAACAGGACCCGCATGATAGGTTGAGCCATGTGGTTCTTGTttttttgttgtcacaactcaggttgggggtgttactggcatcaagagtgtagaaaccagggatgctgcgtcaacaccctaccatgcacaggacaaccctcaccccaaagagtggcacagccccaagtgtcaacagtgctgaggttgaggaatccCAGCTTAACCCATTCATGAGACCACCTGAGCCTGGTGTAACGGTTCTGCTGATAGTTTCCGGACCCTCAGAGGTGGAGACATAAGAgaacaataccagggttccatcagaaaggaaatcagaatggctatcgggtggacaacctacagtgtttgctacaGACCTTCTAGATGTAACTTCTAGATTATAAACACTGGTAACACTGGAGATGGTTAAATCGGAATTAGCtgactgtcaaccttggtggcacattagaatcacctggggagcagttcaaaggcccaaaactgggcagcaccacagaaccctcacatcagaatccccatgggtgggcccagacagcagtgttcatcttagactccagtgtgcagtcgaggtcgagaacTGCATTCAAGAAGGCCTGTCTACTGCGAACCGTCCGATGATGTAATTCACCAAGTTCCATGGGATTCCGCCACGCCCGTGTCAACCCAGCTGACACGTCCAACTTGGACAATCAGGGCTTTGACCCCCGTTACCTGGCATTCAATTCAATCCATGTGTCACGCATGCCCCAACAATTTGTGTCCCAACTGTTTGAATCAAAGGATTTCTGATTCCCTGATGGGTGATGACTCAGTAACCGGATTCAGCTTCAGATCTGCCTGACATTTTTCCTGCCTGTCCtgggccaggtatggcgctagctgctttcacctgtatcatctcattcactgctcaGAGGCTCTCGAAAGCTGTTGACATTATCAAAAAGTTTTCCAGCTGGAATTCATCTCCCTCTAATCAGCCTTCAAAACCTCCATTTGTAAACCATTGCTGTAGTTTTATtacctcttaccttggtctttacaagttgctgtcaaaacccagtaagtgtttacagaaagaaactttacatattaaatatcttaaaggtcttttatgcagaatatgcagttaattttgatgggctatggataatcatcagaagagccatttctggaaatgtaaataatatggctgtttcttttaacagtgcattctcctgaaaacataagaccatttgactgattctgctccagaatcttattgaggcaaaggactggaccgaattattcatggaacagaagcctaggactggtaagtccaggaaatgctgcaaaacaatgccctcaaaagaaatcagcctttccctttgataggtatctctcctgcaagccaggctcaggtgcgcctcaattagaacctgtgttcgctggggccataattaagaatcttaaagggaaagaatgttttgaaagccatctgtcaaaagtacgcAGTCTTGCTTGTAGAATTTTAGAGGTTCATGGTTACCGTGGGTCGGCACTGGGTCTGTGAGCCCTCATCCCCAGggctcggtttcctatcagaatccttgtctggaaggttgattatatcagatgcgcattttgccagcatcctcagaaggagatgcgaggaagattcttttcctgggccactctcattttctcaaacttggacaagtcttaacaataatctgtgacccaactttgtcttccccatgatgaaaaacagaccccatagaaactctctggcacaAAAACTCTGGAATCACTGACCCCAGACATTGTTCCCTGCCATCCACTCTGCCAGACATTTCTTGGATTTATTCAAGCTGACTTGTATTCCAGAACAATTGTGGACAAGATTTGCTAGTAATGCTTCCAACAAGTTACCGTTTAGCAAGTTCAGAACTTGAAGAATCCCTTTTATCCTAACGCTGACTAATAAACTGGTGAGAACTGTTTGAAATACCCATAAGTCAATGGAGGTCGTAATTTGCTTTTATGCTGTATTAAACACCACTGAGATGTTAAGGTCTTTCTTGGGAACCACCGTGATGTTCTCTTCTGGACTCTTCGTAACCCCTTCAGCAGACGACCCTGTATCTGGTCTTGGTTCTGAAAGGTTTGCAGCGGCACCTAAGTCACTGAAGTTCTGGCAGAATTCATTCTCCTGCTCTCTACTGGGACTTGTTTTCCATAATTGGTCTGAGAACAACAGATTTTTTTCTTTTTTGCCTCGGATTTCAACAAAACATACATGGAAAGAATATTTTCTTCCTTGGAGACATTTCCCATAGGGcagtggttcttaaaatacgttcctgaaccggcagcatcagaatcccctgggaacgtgctggaaatgtagatccccaggccctacctagccctactgaatcagagaccctgggagggaggtccagcagcctgggttttaacacatcctccaggcgattctgaGAGTGAGAGAGCCAGGGCCTTCGGGCATCAACCTTGGGGCGAGGGTGTTGGGTTGCCCAACACCCTTTAGTCTAATGGCTTTAGGGTCAAATATGTCTAAACCAagaagccccatggggcactgattagcatgcaggtccccaggccccctttttgtagatcctgattcagaatatctgggacgggggctggagattcatatttttaataaattcccTCATTTATTATTTTTGTGTCTTATTTCCCATACACAAAAACACTGCGTAGAGAAATGGGAGTGTGGGCGATGCTCCCATGCTGGGAGTCTCAGGCCTGGGCTAGTCCTAAAATAATTGAAAAGGAATTGATTCTTAATTACCCAGAACGTCCACGCTCTAGGACCTAGTGTGACCTCTTCTGCCTTCTGAACCGAGGAGTCCACCCCTAAGCCCGAGGAACTGAGCGTGAAGAGCCCTGACGCCATGAAGACTTGAATCACTTTAAAGCAATTTGCTTCTTATTAAAATGTACTTCAGTAAAAAATCATTTCAACTCTTAAGCCACAAAAGGATATCCAATCATTTAAAGCTTCCTGAGTGTTTCGGTTGATTAAAAAGCTTTTAAAGAGCATAGTAAATATTTTACCAGAAGGATAAGTTATTCAGTATGGAGATTATTTATTAAAAACTAGTAATTTATT

>NM_001537.4 

AGTCTCGTCGCGAGAAGCAGCGGCCCGGGGCGACTGAGCGGACAAACGGAAGTGTAGGTTACGGTCTGAGACATCACCGCCAAGCTGGGCATCGGGGAGATGGCCGAGACTGACCCCAAGACCGTGCAGGACCTCACCTCGGTGGTGCAGACACTCCTGCAGCAGATGCAAGATAAATTTCAGACCATGTCTGACCAGATCATTGGGAGAATTGATGATATGAGTAGTCGCATTGATGATCTGGAAAAGAATATCGCGGACCTCATGACACAGGCTGGGGTGGAAGAACTGGAAAGTGAAAACAAGATACCTGCCACGCAAAAGAGTTGAAGGTTGCTAATAATTTATACTGGAATCTGGCATTTTTCCAAGCCAAGAGAAGATCGAATGGCTTTTTGCAGCTAACTACTATGTGTAGACAGGTTTTATATTATAAAGTATGCATTCTTATCACCTAGTATATAGTTAGTTTGTAGAGTGATttccccccagtttcttgaacatggtatcttcacatcttggaccttggtcagttgtgctattcattattaaacaCTAAAACTTTGGCGGTTCTTGCATAACATTGTCAGATTTTTTAGTGTATTTCTGTGAAGTCATTTTTTTTCTTGTCATTCCTTTTGTAGTAGTTGCTGTTTGGATAAAAGTTGATGTGTGATTTTTTATTAAACAAATAGTAAACCCTTCAATTATAGTTAGTCTTGGTGAAGTAAGATGTTTGTAGACTTTAGAGTTCTTTAATTCTTGGCACAACGTGACTGTTGAGCTAACACCAAATAGTGTGTTGGCAATACTTTTCAAATGGCTGAAAACACCTAAAAATTGTTCATTCAGAAATATCTGTCACTGCTCTGTTGCCAAAACTCAGAATAGAACTTAGACGTATGTCTGAGTCCCTGAGATCACATGCTAAAGTCGATGAAAAGTAACCACTGCCACTGTCTTGTGTCAGAACTTTTACAGTACAGAAAATAACAGAATAGCCTTCTGTAATGAGGCGTTTGTTAGAGTTTTGCATGAGATTCTAATACTTCAGTAGGACCCTACCTACGTGGTTCATCTACAATGGTTACCATAAAAAATCTGGCAGGATTTTAAAACTCAATCAGTCTTTCCTTTGAGCTAGTGACTTGAAAAGAAAGAGAGAAGGAAAAGAGACCATATTAAGTCCATGCCAGTTGCTTGGCTAGAATATGATCAACGACTTGTAGTAGACTCAAGTTTTTAAAAAACACTATTTTACTTAAACTGTTTCTTATCTAAATTCTTGCAGAGTGTCAATGTTATCATTGATTATAGAAGACAGGGATAATACCTTTATCTCTGGCCACTCAAAAATGCAGTGCCAGGAGTGCTAAACCTAGAGGCCAATACTGATGACCTGGAAGGTGATCCATATGATTGTCACCACAAAGTGCTTTTACACAAAAACTTGAAAATTTGAAAAACATGATTTTTTTAAGTTTCTCATCTCACCAGTCTTGGTGTTTATATTGCAAATCTATCAAAGTAAGAAATAATTTGTGCTGTATACAAATTACATGGGGAACATAAAGGAGTGAGATCCTTCTGTGATAAAATGAATTCACCACTCTGGTTACCCAACTACAGAACCTCCTTTGATCAGGCCAGTAGGTTGTGATGCAGGCTGGAGCCCCCGAATGCCCCACACACACTGCAGCATTGACCAGACCATCCGAAACCTGCGTCCCTGGTGATGTTCTCAAGCCTCGGAAGTGGCAAATGGAAATGATATGGCCGGTTGCGGTTGTAGGAGAGTTGTGACTtaggcaggagtcgacctcctcaagtaatggaacgatttcaaaggcaggctgccctgaccaaaaatatctgccatgaataaaggtgcctgaaatcctgctatgaagcttcctttgtgtcaaaaatctgtttggttttcagatggaaatgcagaaatcacattagagtatcaactaaaacctctggacggattaagtacaagtagcccaaggcaaagcAGGAGAGGGGGTGTTGGGGGAGGTTGCCTGCTGGAAGGGGAAGCTGAGGAGCGGGAGGAGGGCTTGCCAAGACTGGCATTGCAGGAGACTTGTCTCaggtgtgttcccagaactcttgcccctggagatgctgcaggaaggaaggggttatggtcacttgggtttagacgacattctgtgaacctcatgaagaaattagcatattaaagactctgaaagtagagcagagaactcagctttaacctGCTCACCTGCTAGTTTTCGAggtctcgctctgttgcccaggctggagtgcagtggcacagtcatagctcacttggagcctgaagctcctgggctcaggcagtcctcctgcctcagcctcccaagtagctaatattacaggttcgtgccaccgcacctgggtcttgctgtgttgcccaggctggtctagaactcctaggctcaagcagtcctgtctcagcctcccaaagtgctgggattacaggctggagccaccatgcctgtccAAGGGTCTTTTTTATACTATATGAAGTATTCCTTCTCCAGCTATTCTTGTTCGTTTACCAGCCAGTGAAGATTCTCTTGAGGGCTGAACAATACAGATGAGTATGGGGGCCCTCGCACCAAGGAAAACAGCGTTACATTTAATTAAGTGCCCTGTCTCAAACCCCAAGGCCCCACAGcttcttcatttggcccctagttcatcctgctttcctttgagccacaggattttaaaatatttcaatcttattttcatatcaattttttctttgtttcactacaagtacagtcattgtttaaccctatcaggactaacacaatatttcacgtaactaagagttaatttgcccttgtgagtccttggaatttaagccccacacacacacacttagagcactgttgctatgggaacatagagtcctccaaacaaaagtgaactttttcaacatgctgtttgtaaatggaagccttccCAAGCAGACACTGTGTTCCTCTTTTATTTTGTATTTTGCACATTATATATTTTGATTAGATTAAAATGGAGGAATTTGCAGGATGTGTTGTCATATCTAGCCCTGAAAGTTAACTGGTTACAGTTACCAAATGTTCACagctagcgccattgaaagcattgactgtaaaccgctgtactgtgctaagccttttgtttgcactgtttggcttaatcctcacaacaacactgagaggttttcatttgatgagtcatatttaaagaaaaggaacccaagacggggagtcaggggcacaaggtcacagctggtaaTGATGACCCTGGAATGTCCTCACAGCTGCACACCTGCACCGCTCACAAACACAGCTGACCGTCTCACAGCTGCACACCTGCACCGCTCACGAGCACAGCTGACCGTCTCACAGCTGCACACCTGCACTGCTCACGAACACAGCTGATCGTCTGCCTCTTCGTGTGAGCTGAGCTCCGAATCTCAGCTGTCCAGGCTGTCTGGAAATCATCAGCCCCACTGGCTGGATCTCAAAATTTACTTTCAAAAGGCTGATGGAGTGTTTTCAATTAAACATGACCTAAAATTAAGTAATAAACACACTGGATGTGAGTTTTTATTTGGAATTTAAACTATTCAGAGCTGGTAGAAAATGTGTGCTCCTGGATCAGTGCCTTTTTTCTCCTAAATCAGTTGAGAACAACAACAGAAACAAATGACATTCCTCAAACATTTGCCCAGAGCACAACCACGGGGAATATGAACCACAGGTTTTCACATTGGTTTTCCATGCCTATACCTGTCCTGTCTCCCACAAAAATTATTGCTTGAGGCCCAACCCGGGGGATAAAAAGACACCCCCCCGCCACTCCGTGACCTATTAGCTTACCATCCTATTGGATTTCACTGTTTTTTGTTTTGTGGTGTTTTTTTTTTATTGCAACGAAGACTTTTAAATGGACTCATGAAGAAGCCATCACCTGGAATCTTAATCTTGCATTAATTTTAAGTGTCTGATTTTAGCTGCAGCCACTTGAGAACTTTTCAATGAATGAAAATGAGGGAGGGGAGATGCAAGTCACTGCCCAAAAACAAAACCAGAGGAATTGTGATTGAACATTGCACTTATCAACCCTACAAATTAATATGGAAATAGGAAAAGGGTTTGTTTCAACAAGTCAGGATGACAGTATTTTAAAAAAGAAAAAAaggccagcctgggcaatatactgagactccatctctacaaaaaagtagaaaaattagcccagagtgtggtggcacacatctgtgctcccagctactcaggaggctgaggtgggaggatcatttgagcccaggaagtcgaggttgcagtgagctgtgatcggacgactccactccagccggggtgacagagcaagaccctgtctcaaaaaaaaaaaaaaaGGGCGGATCCTAACGCTTGGTCCTCACACCTGAGGCTCTCACTAAGAGGTGGCTGGAAGCTCCTCAGACCGCTGCCTAGGGTTCGAGTGATCCTGAAAGCTGTACAACATCAGCCTCTGTGGGATCCCTGAGAATGATGAAATGTAATATGTGGCTGTCTCATCAACAGAGCTTCATTTTACCAAAGCATATGTAGACACCACATACATGAACTACATACCTATCGTGTAGATGCTGCCCTGCCTCATAAGAACACTCTTGACTGTCCTGCTTCACAATAATAATCTTCGCAATAATGATCTAATAATGGTCAAATTCTGTGTCTCTACCGTAGAAAACAGAATTTGACCATTTAGTCACGTTGGTCTTGCAAAATGTCCACCTTCCAAAAGAGAACAGTATTGCTTCCCAATAATTAAGAATAGTCTGGATTCAGGATCCAGCAGCttagaagcgtttagctaccaatagcaaaaatcagcccttttaacaatggtgggatgtattatttcacatggcaagaagtcccaagggagggcagctctggggcgagtaaattctgcacctcaGTAAAACTAAGAGCAAGACCCggccgggcgcagtggctcatgcctgtaatcccagcactttgggaggccgaggtgggtggatcacctgaggtcaggagttctaaaccagcctggccaacatggcgaaacccccgtctctactaaaaatacaaaaattagccaggcgtggtggtgggcgcttgtaatcccagttgctcgggaggctgagggaggaggatcgcttgaactcaggaggtggaagttgcagtgagccgagatcgtgccactgcactccagcctgggtaacagagcgagactccatctcaaaaaataaaaaacaaaaaaataaataaaaAATAAAAAGACCCAACCCCAGATTTGTTCCACCTGGGTGCATCCGGTCAGAGAATGCCTTTCTTCTTCCCTTTTGTCTCCTAAGAGTGAAGAAAATGTTTCTTTGAAGGTGTTTCCACCCCACTCCTGTGCCTAAAATGATCCTGGCAAACAGGACCCGCATGATAGGTTGAGCCATGTGGTTCTTGTttttttgttgtcacaactcaggttgggggtgttactggcatcaagagtgtagaaaccagggatgctgcgtcaacaccctaccatgcacaggacaaccctcaccccaaagagtggcacagccccaagtgtcaacagtgctgaggttgaggaatccCAGCTTAACCCATTCATGAGACCACCTGAGCCTGGTGTAACGGTTCTGCTGATAGTTTCCGGACCCTCAGAGGTGGAGACATAAGAgaacaataccagggttccatcagaaaggaaatcagaatggctatcgggtggacaacctacagtgtttgctacaGACCTTCTAGATGTAACTTCTAGATTATAAACACTGGTAACACTGGAGATGGTTAAATCGGAATTAGCtgactgtcaaccttggtggcacattagaatcacctggggagcagttcaaaggcccaaaactgggcagcaccacagaaccctcacatcagaatccccatgggtgggcccagacagcagtgttcatcttagactccagtgtgcagtcgaggtcgagaacTGCATTCAAGAAGGCCTGTCTACTGCGAACCGTCCGATGATGTAATTCACCAAGTTCCATGGGATTCCGCCACGCCCGTGTCAACCCAGCTGACACGTCCAACTTGGACAATCAGGGCTTTGACCCCCGTTACCTGGCATTCAATTCAATCCATGTGTCACGCATGCCCCAACAATTTGTGTCCCAACTGTTTGAATCAAAGGATTTCTGATTCCCTGATGGGTGATGACTCAGTAACCGGATTCAGCTTCAGATCTGCCTGACATTTTTCCTGCCTGTCCtgggccaggtatggcgctagctgctttcacctgtatcatctcattcactgctcaGAGGCTCTCGAAAGCTGTTGACATTATCAAAAAGTTTTCCAGCTGGAATTCATCTCCCTCTAATCAGCCTTCAAAACCTCCATTTGTAAACCATTGCTGTAGTTTTATtacctcttaccttggtctttacaagttgctgtcaaaacccagtaagtgtttacagaaagaaactttacatattaaatatcttaaaggtcttttatgcagaatatgcagttaattttgatgggctatggataatcatcagaagagccatttctggaaatgtaaataatatggctgtttcttttaacagtgcattctcctgaaaacataagaccatttgactgattctgctccagaatcttattgaggcaaaggactggaccgaattattcatggaacagaagcctaggactggtaagtccaggaaatgctgcaaaacaatgccctcaaaagaaatcagcctttccctttgataggtatctctcctgcaagccaggctcaggtgcgcctcaattagaacctgtgttcgctggggccataattaagaatcttaaagggaaagaatgttttgaaagccatctgtcaaaagtacgcAGTCTTGCTTGTAGAATTTTAGAGGTTCATGGTTACCGTGGGTCGGCACTGGGTCTGTGAGCCCTCATCCCCAGggctcggtttcctatcagaatccttgtctggaaggttgattatatcagatgcgcattttgccagcatcctcagaaggagatgcgaggaagattcttttcctgggccactctcattttctcaaacttggacaagtcttaacaataatctgtgacccaactttgtcttccccatgatgaaaaacagaccccatagaaactctctggcacaAAAACTCTGGAATCACTGACCCCAGACATTGTTCCCTGCCATCCACTCTGCCAGACATTTCTTGGATTTATTCAAGCTGACTTGTATTCCAGAACAATTGTGGACAAGATTTGCTAGTAATGCTTCCAACAAGTTACCGTTTAGCAAGTTCAGAACTTGAAGAATCCCTTTTATCCTAACGCTGACTAATAAACTGGTGAGAACTGTTTGAAATACCCATAAGTCAATGGAGGTCGTAATTTGCTTTTATGCTGTATTAAACACCACTGAGATGTTAAGGTCTTTCTTGGGAACCACCGTGATGTTCTCTTCTGGACTCTTCGTAACCCCTTCAGCAGACGACCCTGTATCTGGTCTTGGTTCTGAAAGGTTTGCAGCGGCACCTAAGTCACTGAAGTTCTGGCAGAATTCATTCTCCTGCTCTCTACTGGGACTTGTTTTCCATAATTGGTCTGAGAACAACAGATTTTTTTCTTTTTTGCCTCGGATTTCAACAAAACATACATGGAAAGAATATTTTCTTCCTTGGAGACATTTCCCATAGGGcagtggttcttaaaatacgttcctgaaccggcagcatcagaatcccctgggaacgtgctggaaatgtagatccccaggccctacctagccctactgaatcagagaccctgggagggaggtccagcagcctgggttttaacacatcctccaggcgattctgaGAGTGAGAGAGCCAGGGCCTTCGGGCATCAACCTTGGGGCGAGGGTGTTGGGTTGCCCAACACCCTTTAGTCTAATGGCTTTAGGGTCAAATATGTCTAAACCAagaagccccatggggcactgattagcatgcaggtccccaggccccctttttgtagatcctgattcagaatatctgggacgggggctggagattcatatttttaataaattcccTCATTTATTATTTTTGTGTCTTATTTCCCATACACAAAAACACTGCGTAGAGAAATGGGAGTGTGGGCGATGCTCCCATGCTGGGAGTCTCAGGCCTGGGCTAGTCCTAAAATAATTGAAAAGGAATTGATTCTTAATTACCCAGAACGTCCACGCTCTAGGACCTAGTGTGACCTCTTCTGCCTTCTGAACCGAGGAGTCCACCCCTAAGCCCGAGGAACTGAGCGTGAAGAGCCCTGACGCCATGAAGACTTGAATCACTTTAAAGCAATTTGCTTCTTATTAAAATGTACTTCAGTAAAAAATCATTTCAACTCTTAAGCCACAAAAGGATATCCAATCATTTAAAGCTTCCTGAGTGTTTCGGTTGATTAAAAAGCTTTTAAAGAGCATAGTAAATATTTTACCAGAAGGATAAGTTATTCAGTATGGAGATTATTTATTAAAAACTAGTAATTTATT

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