Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CIR1P2
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:114713441-114714945  UCSC
Coordinates (T2T) chr4:118016461-118017965  UCSC
Coordinates (hg19) chr4:115634597-115636101  UCSC
Strand -
Parental Sequence NM_004882.4
Parental seq. overlap 757 bp
Parental seq. overlap (%) 29.9%
Genomic Region Intergenic
Retrocopy Summary CIR1P2, located on chr4:114713441-114714945, is a retrocopy of the parental gene CIR1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CIR1
Full Name corepressor interacting with RBPJ, CIR1
Also known as CIR
Coordinate chr2:174348022-174395712
Strand -
Gene summary Enables histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nuclear speck. Part of protein-containing complex. Colocalizes with centrosome. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CIR1P1
Bonobo Pan paniscus CIR1P1
Gorilla Gorilla gorilla CIR1P1
Gibbon Nomascus leucogenys CIR1P2
Green monkey Chlorocebus sabaeus CIR1P1
Crab-eating macaque Macaca fascicularis CIR1P1
Rhesus Macaca mulatta CIR1P1
Baboon Papio anubis CIR1P1
Golden snub-nosed monkey Rhinopithecus roxellana CIR1P1
Marmoset Callithrix jacchus CIR1P1
Orangutan Pongo abelii Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CIR1P2
GAAACTTCAGAAAGCAGTAGAGTGAGAGCGACATTAAAGGAAAAAATATATTGAAAAGAAGAAAAGAAAGAAATGCAAGAGCTCAGGGCATAACAACAGTGATTCTGAAGAGAAGGACAAGCCTAAAAAGAGAAAACTTTATAAAGAACTTTCTAAAAGTTACCCTAAACTGGAAAAAAGCCAAGGAAAGGCCTGAGTTCTTAAAACACAAGAGTTCTAGGGAGAATGGCAAATGGAGCCATTCCGATTCTGACAAAAAGTCCAGAAGCCATAATCATAGCCCAGAGAAAAGAGTCTCTGAAAGAAAGGAGGGGAGCTGCAGAAGCCATGGCAGAGAAGATAGGATCTGGGGAAGCCAAAGCAGTTCTGTAGCTATAAACAAAGAGAGATAAGAAAACAGCCACAGCCAAGTCCCAGTGAAGAGTGTAGTAGAAGAAATGACACCAGAAGCCATGGCACAGATGTATACAGAGAAGAAAAAAATGTACAGAGTACCCAGGAGATACGCATAATAAAGTGACACAAAGAGAATGAAGCAGAATGAGAGACTAAAGAGAGACTCTATGTGATGATTATCTGGGAATAAAAATATCTCCACTTTTTAATGAATACCTTTATCATGGGCTAAATGATGTACTATTGTCTTTCTAATTAATAAAGCTCTATTTACTGCTTTCCCCAGCTCCAGCTCCAAGATGGGGAAATCCTTCACCAACTTCATGTGCAAGAAGGACTTTCATCCCACCTCTAAATCTAATGTCAAAAAAATATGGAGGGAGGAATAGAAAATATTACATGGTAAGAAGAAATAAGAAGAATTAATGCAACAATATCTTTAAGAACAAGAATCGTATGATAATAGCTTGGTTATGGGATATGAATCTGTAAAGAATGGTCTTAATTTCATGTATGAAGCCCCACCAGAAGCTTAAAAAGTAGACAAAGAGAAAGAAGAAATAGAGGAGAGACTGAATACAAATTTGAATGGCAGAAAGGAGCCCTACAAGAAAAATATGCCAAAGATGACATGAACATCAGAGATCAGCCCTTTGGTATTCAGGTTTGAAATGTGAGGGGCATTAAATGTCACAAATGGGGTCATGTCAACAGAGATCAAGAATACACTTTGTTGGGTCTTTCTGGAATCAATGCAAGTTCAGTTCCCAGTGATGGCTCAGGGCCATCAATGCACCCCTCAGAGCCAATAGAGGAAATGAGAAACAGTGGATTTGCCCTGCAATGTAATGTACTGCAGAGAAACTTGACCACAAATGATCCATCACAGGAGTTTGCTGTAAGTGACACTGAAGAAGATCCAGAAGTTGAATTTTTAAAGTTATTAACAACCAAACAAAAACAGAAACTTCTCAGGAAATTAGATAAACTGGAGGAGAAACAAAGAAAAAGAGATAGAAAAAAAGAAAAAGTTTCAGAAGATCTGAAGTACACACAAAAAACATAAAAACAAAt
>NM_004882.4
GCTGCTGGAAACGCAGTTCCGGTTAGGCGGCTGAGTTTGTTTACGTTGCTAACAGATCTAGCCCCTGCTTTCCCTAGTTCCAGTTCCAAGATGGGGAAATCCTTCGCCAACTTCATGTGCAAGAAAGACTTTCATCCTGCCTCCAAATCCAATATCAAAAAAGTATGGATGGCAGAACAGAAAATATCATATGATAAGAAGAAACAAGAAGAATTGATGCAGCAATATCTTAAAGAACAAGAATCATATGATAATAGATTGCTTATGGGAGATGAACGTGTAAAGAATGGCCTTAATTTCATGTATGAAGCCCCACCAGGAGCTAAAAAAGAAAACAAAGAGAAAGAAGAAACAGAAGGAGAGACCGAATACAAATTTGAATGGCAGAAAGGAGCCCCACGAGAAAAATATGCCAAAGATGACATGAACATCAGAGATCAGCCCTTTGGTATTCAGGTTCGAAATGTGAGGTGCATTAAATGTCACAAATGGGGTCATGTCAACACAGATCGAGAATGTCCTTTGTTTGGTCTTTCTGGAATCAATGCAAGTTCGGTTCCCACTGATGGCTCAGGGCCATCGATGCACCCCTCGGAGCTAATAGCGGAGATGAGAAACAGTGGGTTTGCACTGAAACGAAATGTACTGGGGAGAAACTTGACCGCAAATGATCCATCACAGGAGTATGTTGCAAGTGAGGGTGAAGAAGATCCAGAAGTTGAATTTTTAAAGTCACTAACAACCAAACAAAAACAGAAACTTCTCAGGAAATTAGATCGACTGGagaagaaaaaaaagaaaaaagatagaaaaaagaaaaaGTTTCAGAAGAGCAGAAGTAAACACAAAAAACATAAGtcctcttcttcctcatcttcctcctcctcctcctcttcctcTACTGAGACTTCAGAAAGCAGTAGTGAGAGTGAGAGTaacaataaagaaaaaaaaatacaaaggaagaaaagaaagaaaaacaaGTGTTCAGGGCATAACAACAGTGATTCTGAAGAGAAGGACAAGTCTAAGAAGAGAAAGCTTCATGAAGAACTTTCTAGCAGTCACCATAACCGGGAAAAAGCCAAGGAAAAGCCCAGGTTCTTAAAACACGAGAGTTCTAGGGAGGACAGCAAATGGAGCCATTCTGATTCTGACAAAAAGTCCAGAACCCATAAACATAGCCCAGAGAAGAGAGGCTCTGAAAGAAAGGAGGGGAGCAGCAGAAGCCACGGCAGGGAGGAAAGGAGCCGGAGAAGCCGGAGCAGAAGTCCTGGTAGTTACAAGCAAAGGGAGACAAGGAAACGGGCACAGCGAAATCCTGGTGAAGAGCAAAGCAGAAGAAATGACAGCAGAAGCCATGGCACAGACTTGTATAGAGGAGAAAAAATGTACAGAGAGCACCCAGGAGGTACACATACTAAAGTGACACAAAGAGAATGAAGCAGAAGTAGAGAAGAAAGACTGTATGTGACAATTACCTGGGAATAAAAATATCTCCACTTTTTTATTGAATACCTTTAGCAAGGGGTAAATTATGTACTGTTGTCTTTCTAATAAAAAAGCTCAATTTTAATTTTTCATCTCTAGACTGTCAATTCAAGTACAAAACTACATGAGTACTATAAGAATGAATTTTGCAAATATTTGTAAGTAAGCTATTTTGGGGCTGTGGAAATATTTTCTGTTGGTAACTGTTTCTTGTTCCCCATACCAGATAAAAACCGCATATAACTCTGTGACATTTTCTTTGTTCTGAAACATCATTAAAAGAATGACAGTACATTGAATGGGTATAATTTACTTTTTTCAATTCAAATTTGTTATTCTAGGATTTGAATTTGCTTGAAGTGAATTGTAATAATTATTCAAATTCATTAGTATAAATTAAGGATTAATAAATCTTTAAGACTTTTAA

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