Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name AK4P6
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Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:151027089-151027877  UCSC
Coordinates (T2T) chr4:154350980-154351768  UCSC
Coordinates (hg19) chr4:151948241-151949029  UCSC
Strand +
Parental Sequence NM_013410.4
Parental seq. overlap 752 bp
Parental seq. overlap (%) 11%
Genomic Region Intergenic
Retrocopy Summary AK4P6, located on chr4:151027089-151027877, is a retrocopy of the parental gene AK4. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name AK4
Full Name adenylate kinase 4
Also known as AK 4|AK3|AK3L1|AK3L2
Coordinate chr1:65147342-65232145
Strand +
Gene summary This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes AK4P1
Bonobo Pan paniscus AK4P1
Gorilla Gorilla gorilla AK4P1
Orangutan Pongo abelii AK4P1
Gibbon Nomascus leucogenys AK4P2
Green monkey Chlorocebus sabaeus AK4P2
Crab-eating macaque Macaca fascicularis AK4P3
Rhesus Macaca mulatta AK4P3
Baboon Papio anubis AK4P1
Golden snub-nosed monkey Rhinopithecus roxellana AK4P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.10.2
log10(TPM+1)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

Related Sequence

>AK4P6
GAGCACAGAAGTTGGTGAGATGGCAAAGCAGTATATAGAGAAAAGTCTTTTGGTTCCAGACCATGTGATCACATACCTAATGATGTCTGAGTTGGAGAATAGGTGTGGCCAGCACTGGCTCCTCGATGGTTTTCCTAGGACATTAGGACAAGCCGAAGCCCTGGACAAAATCTGTGAAGTGGATCTAGTGATCAGTTTGAACATTCCATTTGAAACACTTAAAAGATCGTCTCAGCCGCCGTTGGATTCACCCTCCTAGCGGAAGGGTATATAACCTGGACTTCAATCCACCTCATGTTCATGGTATTGATGTACTGGTGAACCATTAGTCCAGCAGGAGGATGATAAACCTGAAGCAGTTGCTGCCAGGCTAAGACAGTACAAAGACATGGCAAAGCCAGTCATTGAATTATACAAAAGCCAAGGAGTGCTCCACCAATTTTCTGGGATGGAGACGAACAAAATCTGACCCTACATTTACACACTTTTCTCGAACAAGATCACACCTATTCAGTCCAAAGAAGCATATCGACCCTGCCCAGTGGGAGAACCAGGAAGAGGTGGTCATTCATTCAATTGTGTGTGTAGTATTGGTGATGTGTCCAAATTAGAAGCTAGCTGAGGTAGCTTGCAGCATCTTTTCTAGCTGAAATGGCGAACTGATAGGAAAACAAATGAGTAGAAAGAGTTCACAAAGAGGCCCTCCTCTGCCTTTCAAAAGGAAGGTCACCTACACATTTAAGGTGTCTCTGCACATGTCTCAAGCCCTTCACAAGAAAGCAAGTACA
>NM_013410.4
AGTCCGCCTGCTACTCGGTCCCGGCGCTGGGCTGAGGGGAGGGGTTGTCTTAAAAGTCTCTCCTTCCCCCTGTAGGGGCGGCCGGCGAGTCCCAGTGAGAGCGGAGGGTGCCAGAGGTAGGGGGCCGAGAAACAAAGTTCCCGGGGCTTCCTCCGGGGCCGCGGTCGGGGCTGCGCGTTTGACCGCCCCCCTCCTCGCGAAGGCAATGGCTTCCAAACTCCTGCGCGCGGTCATCCTCGGGCCGCCCGGCTCGGGCAAGGGCACCGTGTGCCAGAGGATCGCCCAGAACTTTGGTCTCCAGCATCTCTCCAGCGGCCACTTCTTGCGGGAGAACATCAAGGCCAGCACCGAAGTTGGTGAGATGGCAAAGCAGTATATAGAGAAAAGTCTTTTGGTTCCAGACCATGTGATCACACGCCTAATGATGTCCGAGTTGGAGAACAGGCGTGGCCAGCACTGGCTCCTTGATGGTTTTCCTAGGACATTAGGACAAGCCGAAGCCCTGGACAAAATCTGTGAAGTGGATCTAGTGATCAGTTTGAATATTCCATTTGAAACACTTAAAGATCGTCTCAGCCGCCGTTGGATTCACCCTCCTAGCGGAAGGGTATATAACCTGGACTTCAATCCACCTCATGTACATGGTATTGATGACGTCACTGGTGAACCGTTAGTCCAGCAGGAGGATGATAAACCCGAAGCAGTTGCTGCCAGGCTAAGACAGTACAAAGACGTGGCAAAGCCAGTCATTGAATTATACAAGAGCCGAGGAGTGCTCCACCAATTTTCCGGAACGGAGACGAACAAAATCTGGCCCTACGTTTACACACTTTTCTCAAACAAGATCACACCTATTCAGTCCAAAGAAGCATATTGACCCTGCCCAATGGAAGAACCAGGAAGATGTGGTCATTCATTCAATAGTGTGTGTAGTATTGGTGCTGTGTCCAAATTAGAAGCTAGCTGAGGTAGCTTGCAGCATCTTTTCTAGTTGAAATGGTGAACTGATAGGAAAACAAATGAGTAGAAAGAGTTCATGAAGAGGCCCTCCTCTGCCTTTCAAAAGGCTGGTCACCTACACATGTTTAAGGTGTCTCTGCACATGTCTCAAGCCCATCACAAGAAAGCAAGTACAGTGTGGATTTCAAATGGTGTGTAACTTCAGCTCCAGCTGGTTTTTGACAGCTGTTGCTGTGGTAATATTTTTGACATGTGATGGTGATAGTCTCTGGTTCTCCCCATCCCCACAAAGGCTGTTGAACCACAGCACCAGGAAGCCTGAGAATGAATCCTGAGGGCTCTAGCCCAGGCTTTGTCCCAGGCTTTCTGGTGTGTGCCCTCCTGGTAACAGTGAAATTGAAGCTACTTACTCATAGTGGTTGTTTCTCTGGTCTTGAGTGACTGTGTCCACAGTTCATTTTTTTCCGGTAGGAATAACTCCTTTTCTACATCCACGCTCCATAGAGTCTCTCCTTTTCAGACATCCTGGGATGAAAGAATTTGGCttttttttttctttttttttttGGACATCTGTTTTCACTCTTAGGCTTTTAAACAATAGTTATTGCTTTTATCCCTCTCAGATTCTAATAACTGAGAGCGATGGGGCTATATTGAATCTCTGTATGCACTGAGAACTGAGCTATGAAGAGGATCTTATTAAACTGCTGGTCTGACTTTATGGATTGACACTGTTCCTTTCTTTTATTGTGAAAAAAAAAAAAAACCCTGAAAGTCTTGGGAACCCCCTAAAGTCTTTTGGGAATCCTCAAAAAGCATGGGAAGTTAAGTATTTAGCTACATAAATGTTGTAAGATCATATCTTATGTATAGAAGTAATAAGACCATTTGGAATTACTGGACTAATTGAATAGTTAAGGTTTCTATTCGGGACAATAAAATGTATTTTGAAAGTGCTGCTAACTATTGATGCTGACAGTGTTTCACTCCTATGAGTGACCCAAACATATTATAAATATGTGGTAAAGGGAATGGAGCCTGTGGGGTTGAGCAGAATGTTGTACTAGCTGTGCCTGGACTGAGTATAACAGCTTTATGATTATGAGAAAACAAATTCTTTATTTTTTTTTTCTGTTCCAAAGATTCATCCTATGGGGTGGCCATAAAGTCTAGAATTAGATACTAATATTTTGTCATTCATTATAACATATCAATAAACCATTTGTTAAAAGATTTGCCTGGTTTCCAGACTTGGTGGCCACCTTGAATAATTCTTGCTGTCTTCTGGGAAGGATGATGAAATTTATTCCTGCTGCCTTAAAAATATGTATCCCTTCTTCACCCATCATGACTGTCCCCAGTGAGTGTCCTTTACTATTCTTGGGAGTGACTCCTGTCTAACTTTTCATACTGGCGAGAAGAAAAGAAGCCTATTTTAACACTTTAGTGGTGTTGAAACACATTACTTACTTTCTGAAGATGTCCCAGTGAATCCTCTGTCAATTCACTGCCATATGTAATCTATATGATAAGGAATGCATCTTCCTTCTAAGTACTGCCCAAACTCTTGCCAGCTCCTCTCCCATTGTCCCTTCATGTGAATATTTCTTGGCTACCTTAGTGGAAATATAGATCAGTTTTCTCCCCATCCATCCTCTCAAACATAATGAGATTGTTTACTTTTTAGATTTATGCAGTGAAAATGCCCAGTCAGGTCTGAATCGTCAGTGCATTATATTGACTCTGAGCACTTTAGAATTTAGAGTTGCAATTGAATGCCAGCTGTGGAGATGGGGTGCATATCAGATATATAAATAAAGCTCAGGTTTGCTAGGGAACCAGGTATAGAGAAAAATAAGTCTGATATGAGGAAAATTGCACAATTTAGAGTAGTTATGCCGTAGAGAAAATTTCCACAAACTAGGAAATGTAGAGAGTTATTCTATAGAATACTCAAAAGAGGAAAGTATGTGATTTTTGGAAACAGGAAAATCTTCAAACTTCTTTCTTCACTTCCCTTTGTGTTTAGCTGACCCTCCAATGTGATCATTGCCTTTGGAGTTTGGGAGAGGTACGGGAAGTGGCCTGAtccctgcttccatacttcactcctccatccatccttccctccctcttcccctccAGCTAAATGGACAATTCTAGCCAACATTGAGTCACTCAATAAGTCTCAACAGTGGGTGTGTTTGCTGAGATTGTCCAGCGGTTGAGCAGTTTGGTCTCACCTCCCTCGCTAGTTGAGACCAAAAAGAGACAAATAACTTTTTCATGGTCTTTGAAACATAATGCTTATTTCGTGGTCAATGGCTTTAAAAAAATCTGTTTCTTGTTTTCTTCAACAAACTCACTAGTTTTCCCTTAAATGATATTGTAAAAATTAAAGTAATCTTGAAAATGTTTTGACAAAAGTAAAATTAAAGGGACATCttttcttgttttgttttttttttttCTATTGCCACACATGACCgttccttcacctttaagcaaagagagtggttcagatggtttctaagatgccaacctgacctcgcattctgtcattctaCCCAGCTCTTAATTCAATTTGCTTCCATTATCCTAACAGGCTTCTTTCTTACTTAGAACTTGGAAAGGCTGCTGTATTTAATACCCTCCAACACTAACGCAGACTtaagataggtactgtttattgaaaacctactgagtgaaatgtgcggttttaggaccttcataaacatctcatttaatctttctagcatcctgtgaaacagccatgatttcacgttgataaacaaagaagacaggggtcccagggatgtgaagcatcttgcccaggcttctgctgctggtgaccagtgtagccaggactccagcccaggttttcctgactcagaagactgagctttttccTGGATGTTATTAATAGCTAATTGTGTCCAAGCAACCAAGGGCCTTGAGTCTGCTTGGTTCTGCTTATGGCCTCACATCAAGAAATGGAGCTAGTCcatgtctgtagtcccaatgctttgggaagccatgatgggaaggttgtcggaggccaaaagttcaagaccaggctgggcaatatcacaagactccatctctacggaaaagtaaaaaattagccagtcatggtggtgtacacttatggtcctagttactcaggagacttaggcaggaggattgcttgatcctaggaattcgaggctgcagtgagctatgattgcacctctgcacccaagcctgggcgacacagcgagaccctctctcttaaaaaaaaaaaaTAGCAGAGCTCACCAAAGTGATGTTCACCTTTTTATGACATTCCTTTTTCTTAGCTTAAGAAAAGAAAGCTGCTAGATGAGAGTCTTAGTTTTCCTGCATAAGACCTCCTTTATGAATAGAATAAAAGACTGTCAAAGTAGGCTGGGCTTGGGCCCAGGCTAATCTATGAAGGAAGCAAGCTCGTGTTCCTTACCTATCCTTTTGGTGTCCATTGGATTGTGCCCCGAAGTGGCCTTTACCCTTGAGCCGTCCCCAGCCATGGTGCTCACACATAGGCTTTTGAGCTCCTTGGAGCTATCCAGATCCTGCTCACTTTTCCTTCCTGAGATCAGAACAAATCACCCCCTTACTCCCACTCCAAACAAGGCCTTGATGATAAACTAATCCTTCCTAAAATGCTGGTAGGTAAACAAGCAATGATGAAGCATTGAACACAGGTTAACTCCTGACTTTTGTACCATTGTCTATTCCATTACACATTAACATGACTCTGAATGCCAGATCCAAACCTTTGCCCACCATCTGCTTGTCGTGCAACAGTTGAGGCAGTAACCAGGGGAGATTCACTTCCTGTCTTGTCCTTCCCCAGGGATCACCCCCCTGCTGCCCTCTAGCAGCCAAACTCAGATGAGTTCCATTGTTACCCTAGGTGTGCCCATCTCTTTGGTAGGGAAGGAGAAAGGTAAGAATAGCCATCAGTGAGGAAGGATTCTTGGAGCGAGGAGCCACTGTGGTTTTTCCTGCTATTTAAGATGTTGAGACCGGATAACTTTAGAAAGATACCTGCACAAACCCATAAATAGTGCTTTTATAAAGTTTAGTTCACCGGAACCTGAGTTCAGTATTTGACATTAGCTTTTTGTCCAAAGAGTTGAAGCCTGCTGGAGGTCTTTGCTCAAATAATAAATACCACATATTTCCAAGTGTGTTCAGGTATAGGCACTAGGtactgtctgtttacttcatgttaggcacattacatgcattggctaatcaaatcctcaTCAATTACATATGTAATAATCTAAACTTGCCTCCTTGTATTATAAATGGAAATAATCCTGTTTATTTAAACGGGTTTTCATGTACCTGTAGGGATTAGGAAACTCAAATGGCCTTTTTAATACCTTTCCCTAGTTTGAGCTCCCTGTTCTCTTTAACAGATAAAACAACATATTTGCTTCAGCCTGGAATCTGTTTTTGGTGCTTTGGTGCAGAGACAGGAAATGGGCACTCAGAGTCACACTGGTAGTTGCACACTGTATCTACAGAGGGCGTGTCTCATCTGTACTCTGCTGGGTTACAGGATTTCAGTAGGTATTTGTGTCCACCTGAGAATTCTGTTTATTACCTTTCATTTGACAGTGTCTTTCCTTTCTGCAGTTGATTTTGCTAGAGAGGCAATTCATAAGGTGAGGTCCTGTTCATAGTATGACTTGCTTTCTCAATATCTCCTTCAATTTTTAGTAACTCTTGGTCTATTTGGTGTCTTTAAAAAAAATAACCTAGTAATAAAGACTTCTTTTAATGTGGAAATGTGGTCTGGTAGTAAGTTATTTCTTTCCACATGTAACTGACCCAATCTGGTTTCCAAATGAGAAGTGTGCAGGCCCCAGAGGTTGAGAAGCCATATTTCAACTGTGAAAAAAATCTGCTTCCTGCATCTGTTGAAATATAGTTGTTCATACTTGCCATCCCTTATCTTTCTTGTAACAATTTGCACAGTTCTTGCCAGAATAAATGCCATTATCTGTATGTTTCAGGGAGTTCCCCAATTTGATCATTTTtgtgtgtgtgtggtgtgtgtgtgAGAGAGAGAGATACTGCAGTAAAACATTTCTAAAGGATGAAAGCTCTTGTATGGCATAGATATGAATTCCTTCCTCTGGTAATAATTAGGTTATTCCCAGAAGCACAGTGTCATTCTTTAAATAAAAGCTTTCCTGTTTAAAGCTTTTCAAAGGAGCAGACCACCTTGAAGATTCCCCCTAGGGTTGATATGTGTCTAATTCATTTTATAAAAATTATTCTTGTCTTCATTTTAAAGCTTTGGCTATATAGTCAGAAATGTCCTAAATAACAAACTATTTTGTATTTAATTTAGGGAAGACTAAAGGGAAGAAAAATGAAAACTCAGTCTTTATGTAAGCTCCAAGGATATTAGGGCTTAAAGGGCTTTTCTAGTTTTATGAGAATTTGTACTACTGATTTTTATATATTCCTGTTTTTGAGATGAACAGATCTCTGGGGAAATTGTTGAGTTACAATGGCATTTCACTGTGATCCCTCTCAAGCTCAGATCAGTTCTATAACCCAATGACAACCTGTCTCTTTGGTTTACTGTCCTGTGAAATGTCAGCTCAAGTTTCCCAGAAGTCGTGTGTTTATGATGAGTCAGAGTGCTTTTCCTCGGTGGGACAGTTGCTGGCCCTCTTAATTTTGGTGTATGTGCTTCCAAGTATCTAAACCTCCAGTCTGATCTGTATATGCTATCCTAACTGTTAATTGTATTATTGATTATGTTGATTATCTTGCTTGAAGGTTCATACTTTTCAATTTGATAGAAATAAAGTTTTTTTCTGCTTATAGCTAGCGAA

Publications

PMID - Link Title
No publications available for this retrocopy