RCPedia: Rtcs

Summary

Retrocopy Name	TRIM38P1	Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr4:165664349-165665735 UCSC
Coordinates (T2T)	chr4:169011025-169012411 UCSC
Coordinates (hg19)	chr4:166585501-166586887 UCSC
Strand	+
Parental Sequence	NM_006355.5
Parental seq. overlap	1021 bp
Parental seq. overlap (%)	10.8%
Genomic Region	Intergenic
Retrocopy Summary	TRIM38P1, located on chr4:165664349-165665735, is a retrocopy of the parental gene TRIM38. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	TRIM38
Full Name	tripartite motif containing 38
Also known as	RNF15\|RORET
Coordinate	chr6:25962723-25991231
Strand	+
Gene summary	This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	TRIM38P1
Bonobo	Pan paniscus	TRIM38P1
Gorilla	Gorilla gorilla	TRIM38P1
Orangutan	Pongo abelii	TRIM38P1
Gibbon	Nomascus leucogenys	TRIM38P1
Green monkey	Chlorocebus sabaeus	TRIM38P1
Crab-eating macaque	Macaca fascicularis	TRIM38P1
Rhesus	Macaca mulatta	TRIM38P1
Baboon	Papio anubis	TRIM38P1
Golden snub-nosed monkey	Rhinopithecus roxellana	TRIM38P1
Marmoset	Callithrix jacchus	TRIM38P1
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>TRIM38P1
CTCCACCTGTTCTGTGAAGACAAGGGGCAGCTCATCTGCTGGCACTGTGAGCGGGCACCGCAGCACAAAGGGCACACCACAGCTCTTGTTGAAGACGTATGCCAGGGCTACAAGGAAAAGCTCCAGAAAGCTGTGACAAAATTGAGGCAACTTGAAGAGGAGTGCACAGAGCAGAAGGTGTTCACAGCAATGCACATAACTAAATGGACATCACTGCATGAATTTAGACAGCAATAATGGAAATTGCAATTTTATATCTCCTCATGAGAAGACACAAATTCAGAGACAAAAAAATCGTTTGACTTTAAGAATCTCCAGAGTTTCCTACATGAGGAGAAGAAGTCTTATCCCTGGAGACAGGAGAAGGAAGAACGATAGACTCTGAATAGACTGAGGGACCATGGGACCAGTCTGGGGCTGAATTCAAGAGCCACATGCTGGAACTGGAGGAAAAATGTCGGGGCTCAGCCCAAAAATTGCTGCAGAATGTGAATGATACTGTGGGCAGGAGTTGGACTGTGAAGCTGGAAACATCAGAGGCCTTCTCCTTAGAGCTTCATACTATGTGCAACATTTTTGAGCTTTATTTCCTGTAATGTGAAGAAAATGTTAAGGAGCCATCAgTCAACATGACTCTGGATCCAGATACAGCTCATAGTGAACTAATTCTGTATGAGGATTGGAGAAAAGTGACTTGTGGATATCCCCAGGACCATCACAGCACTTCTTCCAGGAGATTTAGTGCCTTCCCCTGTGTCCTGGGTTGTGAGGGCTTCACCTCTCAGGAAGATGCTCCTTCAAAATGGATGCTGGAAAACGAACCAGGTGGGATTTAGGAGTTTGTATGGCAATATGCAGAGGTGCACTGACATGAAGCAAGAGCCTCAGTCTGGATTCTGGAACCTCGGACTATGCCAAAAGAAAGGCTATGTAGCCCTTACATCTCCCTTAACTTCCCTTCATATGTGTGAGCAGCCCTTGGTTGTGGGAGTGTTTCTGGACTCTGAGGCTGGAGTTGTATCCTTTTACAACATGAGTACTGGCTACCACATCTTCACCTTCCCAAAGGCTTCCTTCTCTGATACTATCCGGCCCTATTTCCAGGTTTATCAATATTCTCCTTTGTTCCTGCCTCCCCCAGATGGTTAAGGAAAAGAGCAAAGTCTCATTGGTTTAACCATCACAGAGAATATAATGTAAATCCCATAAGGGC

>NM_006355.5
GTTAACTTCCTGACCCAGGAAGTGGCAGCAACAGAGGGGACTAGCAGCGAATATACTTTACACCAAATCTCAGAAGATTCAGAACTTAGATGAGTGGGGCCCAGGACAGGAACCCTGGAGCCTTGGAAGGAGGGGAGCCCCATCTCCCCAGAAGAGCAGTGACCCCAGCAGAGAGGGGCCTGGTGTATCACTGGAGGAAATAGCCTGCCAAGGAATACACGTCTTCAGAAGAAATTCTGTGTGGCTTCAAGAGACTGATCAAATTGTGAGAGGAAAACAGCCTACCCGgtcctcttttcttcaatacaaaatgagataataggggttggaaggaaaaCCTTCAAGACCTATGGAAGTCAGTTGCAGCCAGCTCATCACATAGAGGTGCAGGTGAGGTGTATTTTCATCACGGTGGAAAATTCTGGCTGCTTCATCTCCATCTCTAGAGCCAATATTGGAGCTTTTCAATAAAAGCTATGGCCTCAACCACCAGCACCAAGAAGATGATGGAGGAAGCCACCTGCTCCATCTGCCTGAGCCTGATGACGAACCCAGTAAGCATCAACTGTGGACACAGCTACTGCCACTTGTGTATAACAGACTTCTTTAAAAACCCAAGCCAAAAGCAACTGAGGCAGGAGACATTCTGCTGTCCCCAGTGTCGGGCTCCATTTCATATGGATAGCCTCCGACCCAACAAGCAGCTGGGAAGCCTCATTGAAGCCCTCAAAGAGACGGATCAAGAAATGTCATGTGAGGAACACGGAGAGCAGTTCCACCTGTTCTGCGAAGACGAGGGGCAGCTCATCTGCTGGCGCTGTGAGCGGGCACCACAGCACAAAGGGCACACCACAGCTCTTGTTGAAGACGTATGCCAGGGCTACAAGGAAAAGCTCCAGAAAGCTGTGACAAAACTGAAGCAACTTGAAGACAGATGTACGGAGCAGAAGCTGTCCACAGCAATGCGAATAACTAAATGGAAAGAGAAGGTACAGATTCAGAGACAAAAAATCCGGTCTGACTTTAAGAATCTCCAGTGTTTCCTACATGAGGAAGAGAAGTCTTATCTCTGGAGGCTGGAGAAAGAAGAACAACAGACTCTGAGTAGACTGAGGGACTATGAGGCTGGTCTGGGGCTGAAGAGCAATGAACTCAAGAGCCACATCCTGGAACTGGAGGAAAAATGTCAGGGCTCAGCCCAGAAATTGCTGCAGAATGTGAATGACACTTTGAGCAGGAGTTGGGCTGTGAAGCTGGAAACATCAGAGGCTGTCTCCTTGGAACTTCATACTATGTGCAATGTTTCCAAGCTTTACTTCGATGTGAAGAAAATGTTAAGGAGTCATCAAGTTAGTGTGACTCTGGATCCAGATACAGCTCATCACGAACTAATTCTCTCTGAGGATCGGAGACAAGTGACTCGTGGATACACCCAGGAGAATCAGGACACATCTTCCAGGAGATTTACTGCCTTCCCCTGTGTCTTGGGTTGTGAAGGCTTCACCTCAGGAAGACGTTACTTTGAAGTGGATGTTGGCGAAGGAACCGGATGGGATTTAGGAGTTTGTATGGAAAATGTGCAGAGGGGCACTGGCATGAAGCAAGAGCCTCAGTCTGGATTCTGGACCCTCAGGCTGTGCAAAAAGAAAGGCTATGTAGCACTTACTTCTCCCCCAACTTCCCTTCATCTGCATGAGCAGCCCCTGCTTGTGGGAATTTTTCTGGACTATGAGGCCGGAGTTGTATCCTTTTATAACGGGAATACTGGCTGCCACATCTTTACTTTCCCGAAGGCTTCCTTCTCTGATACTCTCCGGCCCTATTTCCAGGTTTATCAATATTCTCCTTTGTTTCTGCCTCCCCCAGGTGACTAAGGAAAAGAGCAGAAGCTCCTTGGTTTAACCAGCACAGAGAAAATaatataaatcccataagggcagacgtttggtctgttttcttcgctgtcatttccttagtagttagactagtgctgagattttagtggatatataattgatttatgttgaatatatggaCTTAGCAACTAAAAATACCACAGATGGTTAACCTGGACTGGGGCAAAGCAAGATAATAGTGATGATCGTATGTTGCTGTCTCCATCCGTCTTTAATGGGTCAGGGCTTTGATTTCCAAGGGTCTTCAGGTGATGAGTAGGGGTACCCACAAGTCAGAAGGTCTGCGTTCTCCTAGTTTGTTTGCTGCCATTTGAACTCATGTAGGGAATGAAAGAAAGCTGCAATTATCCGCCAACTGCATTTaaaacaaaacaaaacagaaaaatcaaaataaCATTGACTCTTCCAACCACTGACATGTTGTTTAATAATCTAAGCGGCAGTCCTGGAGGCTACCAGACTTACTGAGTTCTACCTGAGAAACAGCCAAGCAAAGTGTGAGAGAAGGGTTAAGACTGGCTTACAATGAGATGCTTCAAATGAAAAGGGAATTATGAGTAAAATTGAACTTTGATGGGGGATTCAGTTCTGGAAAAGAATTTGGTATTTTCCAGTCTGCTAGGACCAATTACCTTGAAATATTTTAAAATCTCAGTAAATAGTTATTGCTGAAATGGCTGTTGGCAGTTCTTATTATGATTCAGAGAAGAGCAAATAGACCTTAACTTCATTTTGAAAAAGACCAAATTACCATACCCGAGTGAGTAATGACAGGACTACAACTAAAACATAAACAACATTAATGATGACCATAAAAAGTCACAAAATTGCTAAATGTTATAATTTAGAGTTGACATAAAAATTGATggccaggcatggtggctcacgcctgtaatcccagaactatgtgaggctgaggcaggtggatcacttgaggtcaggagttcaacaccagcctggccaacatggtgaaaccctgtctctactaaaaatacaaaaattagccgggcatggtggtaggggcctgtaacccagctactcgtgaggccaaggcaggagaattgcttgagcctgcagcagctgcagtaagccaagatcatgcTGTGCCTCAAGGAAAAAAAAAATTAATGTTTACTGATATTTGTTGAAGTCCTACAACATCACCTCTGAGAATAGGAGAAATGAAGCAACAGTTGTGTCTAGATGTCAGAGGCATGGCTGGGCCTCCATCTCTGCCTAAGGGAGATATAAAAGAGTTCAAACTATTGCCCATGTTCCCCAGGGTCAGAAGTTCTAATTATGATGATAGAGGCTGGGTTGTAAGTAGTAAGtgaagggtagcagaatatgccatctttggcataagaagtattttgagttgaagacaattgagaaaaaaaatagattaaaaacaaacaaacacctctgccctctccctatttgcctaaaagcaggatatgaaattgtgaaggtgtcttcttactcggggaagaacaaaagttagtcaccagagactttagactcttatcagcctggacatagcaccagagaagtctttttttttaaaaaaaaaaaaaaaaaaagggaaagaaaaagttgccttcccacaatttactgcactagaaactcaaagtccttttcgtcttccttgtcacttaaaaaatgtattcttttcttaaaatgctatataagcccaagttctaaatcctcttttgagtattcatctcagtactcccctgtgtttgtacaatgcacatgctttgtttctgtcttgtcaatctgtcttttgttagtctacttgatagggccacagatggagaacctaagatgaatagaaaaaaaagatttttctccccaacaGAAGGATTATCGCCAGTTGCACTTGTTCTATATACCCGTAGTCTCGGTATGCTGACCCAGACTTGGGTAATAGGACCCAGTGGGTAACCGAGGAACCCCACCTTTGTGCAGGATCAGTGAAGATGTAATCTGGATATTCATAAGCTCTTCTCTACCTCTTGGCATCCCACAGTCCTGTGTTAATGTAAGTGTGGTCTTCCCCAGAAAGGGGAGGCCTCCCTAACATTGTTAAAGCCTAGCATATGCtgcttagaggaaattctatatccctaagcacttagattgctgaataagaaagaatgataataaaataaacaattaaataaaagttttaaaaaatgaataaaataaacctgtggaaactataaggaaggccagaagaaatataaaattggagattaatTGGGGTGCAGGAAAGTTATGGAAAGAATATAAGTCCTGCTAGATAAATCATTAGCTATTTTAATAAAGAAtacagaagaaaataggaacaaaagaatatatactggaataattttgagagtaatttgaagaattagatgcaaataaatttgaaaacctttaaaaagaaaccaatggcctaactgacccaagaagggaaagaaaatctaaacagactgataaATACAAAATGAAATTCAGACACTTACAGAGCAgccaggcatggtggctcacacctgtaatcctgtcactttgggaggctgagatgggaggatcacttgaggctaggagtttgagactagcctgggcaaggctcccatctctaaaagaaaagaaattagctgggcatggtggcatgtgccttagtttcagctactcaggaggctgagacgaggattgcttgagcctaggagggcaaggctgcagtgagccatggtcatgccactgaattccagcctaagtgacagagcaagaccttgtctcaaaaaaaaaaaaaaaaaaaGTTACAGAGCTCCAACTAAATAATGTGGGGAACAAAAGAAAAAAGAAGATGATTTTATGGCTGATTTTTTTTTTAAGGAAAAGCAATTCAtgtacccttgaagattagattaagttctataaaatagcccaaaatgacagtggctgaaacaagtttatttctctcccatttaaagcaagtctagatgtggaagtctgggaagcccagaaaatccaggtcttgtttgtgtatggaaactccagaaaatcacagattccttccagccacccctcaattacccctgggatccaagagagccactaaagttccagccatcatactcacaacccaagttgtaggatggaaaaaaggacacaaaagtagggtgaagagcatgtgtgcaacagctctcttttactctagtgtcctaaaacctatcataaaacctttggcttgccttgcattagccagaatttagtacatggccacacttaagaagtcagaaagattagctttttttccagggtagttggctgaaaatcaggagttctcatattaaaaaacagagaagggacatcgaatagatgaccaacaatctccttcacaCTCATACTATTTAAACTGTCCTAGTCAATGACCAAAAAAGAAAAGCCTACAAACTCATTGATATAAAAGCTTAACAAAGGTACTCCCCGCCCCCCGCCCGCCACACACCATCCCCAAAAGGAAATTTCTAATCCAATTAACAgtcttaggttgggctgctgaaacaaaataccacagcctgagtgacttaaacaacgacaatttatctctcactgttctgaggtctgagttgattctttgtgaaggccctttcctagcttgcagatggctaccttcctgctatgtcttcacatggcaaagagagagctagctttctggtcttttcttataagggaccagtcccatcatgcccatcatgaagactcgatctgctaggatctcaactaaacctaactatcacccaaagagcccacctccaaagaccatcacattgaatgtgagagtttctacatatgcattgtgggaaacacaaacatttacttcaACTGTAACTATTGAAGCAAAAATGTCcccccaccatagacatccagcaccacagtagtacatttattacaattgaacttacattgacacgtcattatcaacgaaagtctgtaatttacattagggtttattcttggtgttgtgctttctatgggttttgacaaatgtataatgtcatgtattcaccattatagtatcacagaagtttcactgccctaaaaatcctgtgttctgccttttcaacacttcctgtcacccaatttctatcaactaatcttttgactgtgtccatagttactgtcttttctagagtgtcatacagttgtgaagcaggaagcaggagtgaactccggaggcagggactttactccggaccagattgaagactagccgaaacagggacgaggttaaagcacctctccataagacacgcccaccagcgccatgtcagtttttcgttgccatggcaacaacaggacattatcgacttctttcctctgtacctactccgaagttaccactctttttctagaaatttctgcataatcccccttaacatgcacttaactaaaagcaggtatattactgcagaactgcccctgagctgctactctgggcacattacttatgggttagccctgctcagcaaggagcagtacctgttctgctgttgtacactgctgcttcagtaaaagttgctaacaccaccacttcacccttgaattcttcccgggctaagccctaatttttggcttgcttgccctgcatcagttggagtcatatagtatgcagtcttttcaggttggctttttagtaacatacatttaagtttccttcatgtgttttcatggcttgatcgtttcttttctttttctttttcttttttcttttctttctttttttttttttttttgagacagaggagtcttgctctgttgcccaggctgaagtgcagtggcactggctcactgcaacctccatctcccaggttcaaacgattctcatatctcagcctcccgagtagctgggattacaggctcacgccactatgcccggctaattggggttttcccatgttgaccaggctggtctcaaactcctggcctcaagcaatccacccacttcggcctcccaaagtgaatgcatttctttttaactctaaataacattccattattcagaagtaccacagttatccacttacctactgaaagacatcttgtttccaagttttggataaattatgaataaagctgctataaacatctatgtgcaggtttttgtgtggagataagttttcaattcctttggataaatactaaggagtgtgattggtgaatcttatggtaaaagtatggttacttttgtaagaaaccaccaaactgtcttccaaagtgattgcacattttgcattctcaccagtaatgaacaagttactattgctacatatctttgcaacctttggtgctgacagtgttctaaattttggtcattctactaggtatgcagtggtatctacttgttttaatttgcagttccctaatgacatgatgtcaagcatcttttcatatgcatacttgcatctgtgtatcttctttggtgaacagatgttcaggtcattggcctgctttaaatcaggttattttcttactgttgagttttaagtattctttgtatattctaaaaatattgttcttcatcagatctgtcttttgcaaacattacctgccaatgtgtggcttttcttcaacacttctttgtaaatttgcaagtcctttgagaaaagaaatgcacccaaagtattaatttggcaatctcatatcacgagagtactctaaagctaaataaattacagtttttcaaattttgaattaattgatctttgctattgttagcaaggtcttgtattcttttttttttttttttttttttttaatagagacgggtcttgctacagtgcccaggctggtctcgaactccaggcctaaaatgatcctcctgccttggccttccaaagtactgggattacaggcataagtcaccacgctcagccatctggtattctttagcaactgtttggtaacttaatctttcactttttgaaaacaaaaaatagtttttttctcatagttttctaacaaaatcttcataactgaaataatttctctttatcacctcttcttataaatatggttttctttttttaaataaaaatttaagacattttataactggccaaatttactagcttagatactattagatagtcaatattttttgttggatatttgatttttatttcaggcaactaatatctattcatttttgcactgttggaagaaaattactgatcaaattcactatgtatttgcagaaaatggctttcaatattgtctactttatcatcctttttttttTTttctttcttcctttttagatacagggtctcactatgttgcccaggctggtctccaacttctgggctcaaacaatcctccctccttggccttccaaagggttggATATGTTTTATCTacagttttgttgttttgttctgctacaggatatttgcaattgccatttatcatgaaattcatgacataccttcttccactctcctttttatctttattgttctggttataggactagctttgcatctctactcaattctgtatcagtagtatgctttcattttaaattttaagtttgtccatatgtatattgacacagggtcttgctctgttgcccagactggagtgcagtggcaagatcagggctcactgcagccttgactgcctaggctcaagtcatcctcccacctcagcctccagaatggctgggactacaggcacgcaccaccacacatggctcatttttttgtattgagacagggtttctccatgttgcccaggctggtcttgaactactgggctcaagcaatcctcccaccttagcctcccaaagtgttgggattacaggcttgagccaccatgcctcgcttctacacttatttttaattctaaaataatttataataataaatattaacaattagatttaattactgataaatattaaatgttaaataggttttattaaataattaaataaaaatgaaaataatcagtatttcaatttaattactaattataattcacagttatccttgtaactcctaatgtctatataaaagatttttatattttttaattcttaaaattttattatttatttCACACCAGGCCATCACTGTGATACATTTTTTAAAACACATTAAATTATCACCAGAAAAGTGCTGTGATGGAAAATATAAATTGAAATACCTTTTCTGGTTAGGAGAGTAATTCTGTTTTTCTGATAGAGAATAGAAGAGTCCTTCAGGCCCCTCCAAACTGTCATATTCCGGGCATCGGGTGTCCCCATCCTCACTTCAGTCCACAGGCAGGGTCCTCAGTCTTCAGCGCTCCTTCTCTTTCCCCTttgtcttgtgtctccttgggtctcttttctccaagacctaaactccctgaggacaggactattttttacatcttgatgtcactcctgagcacttgCTTTAATGTGTTGGACACTGGGTCCATTAAAGATTGTATGTGAAATTATAAAA

>NM_006355.5 

GTTAACTTCCTGACCCAGGAAGTGGCAGCAACAGAGGGGACTAGCAGCGAATATACTTTACACCAAATCTCAGAAGATTCAGAACTTAGATGAGTGGGGCCCAGGACAGGAACCCTGGAGCCTTGGAAGGAGGGGAGCCCCATCTCCCCAGAAGAGCAGTGACCCCAGCAGAGAGGGGCCTGGTGTATCACTGGAGGAAATAGCCTGCCAAGGAATACACGTCTTCAGAAGAAATTCTGTGTGGCTTCAAGAGACTGATCAAATTGTGAGAGGAAAACAGCCTACCCGgtcctcttttcttcaatacaaaatgagataataggggttggaaggaaaaCCTTCAAGACCTATGGAAGTCAGTTGCAGCCAGCTCATCACATAGAGGTGCAGGTGAGGTGTATTTTCATCACGGTGGAAAATTCTGGCTGCTTCATCTCCATCTCTAGAGCCAATATTGGAGCTTTTCAATAAAAGCTATGGCCTCAACCACCAGCACCAAGAAGATGATGGAGGAAGCCACCTGCTCCATCTGCCTGAGCCTGATGACGAACCCAGTAAGCATCAACTGTGGACACAGCTACTGCCACTTGTGTATAACAGACTTCTTTAAAAACCCAAGCCAAAAGCAACTGAGGCAGGAGACATTCTGCTGTCCCCAGTGTCGGGCTCCATTTCATATGGATAGCCTCCGACCCAACAAGCAGCTGGGAAGCCTCATTGAAGCCCTCAAAGAGACGGATCAAGAAATGTCATGTGAGGAACACGGAGAGCAGTTCCACCTGTTCTGCGAAGACGAGGGGCAGCTCATCTGCTGGCGCTGTGAGCGGGCACCACAGCACAAAGGGCACACCACAGCTCTTGTTGAAGACGTATGCCAGGGCTACAAGGAAAAGCTCCAGAAAGCTGTGACAAAACTGAAGCAACTTGAAGACAGATGTACGGAGCAGAAGCTGTCCACAGCAATGCGAATAACTAAATGGAAAGAGAAGGTACAGATTCAGAGACAAAAAATCCGGTCTGACTTTAAGAATCTCCAGTGTTTCCTACATGAGGAAGAGAAGTCTTATCTCTGGAGGCTGGAGAAAGAAGAACAACAGACTCTGAGTAGACTGAGGGACTATGAGGCTGGTCTGGGGCTGAAGAGCAATGAACTCAAGAGCCACATCCTGGAACTGGAGGAAAAATGTCAGGGCTCAGCCCAGAAATTGCTGCAGAATGTGAATGACACTTTGAGCAGGAGTTGGGCTGTGAAGCTGGAAACATCAGAGGCTGTCTCCTTGGAACTTCATACTATGTGCAATGTTTCCAAGCTTTACTTCGATGTGAAGAAAATGTTAAGGAGTCATCAAGTTAGTGTGACTCTGGATCCAGATACAGCTCATCACGAACTAATTCTCTCTGAGGATCGGAGACAAGTGACTCGTGGATACACCCAGGAGAATCAGGACACATCTTCCAGGAGATTTACTGCCTTCCCCTGTGTCTTGGGTTGTGAAGGCTTCACCTCAGGAAGACGTTACTTTGAAGTGGATGTTGGCGAAGGAACCGGATGGGATTTAGGAGTTTGTATGGAAAATGTGCAGAGGGGCACTGGCATGAAGCAAGAGCCTCAGTCTGGATTCTGGACCCTCAGGCTGTGCAAAAAGAAAGGCTATGTAGCACTTACTTCTCCCCCAACTTCCCTTCATCTGCATGAGCAGCCCCTGCTTGTGGGAATTTTTCTGGACTATGAGGCCGGAGTTGTATCCTTTTATAACGGGAATACTGGCTGCCACATCTTTACTTTCCCGAAGGCTTCCTTCTCTGATACTCTCCGGCCCTATTTCCAGGTTTATCAATATTCTCCTTTGTTTCTGCCTCCCCCAGGTGACTAAGGAAAAGAGCAGAAGCTCCTTGGTTTAACCAGCACAGAGAAAATaatataaatcccataagggcagacgtttggtctgttttcttcgctgtcatttccttagtagttagactagtgctgagattttagtggatatataattgatttatgttgaatatatggaCTTAGCAACTAAAAATACCACAGATGGTTAACCTGGACTGGGGCAAAGCAAGATAATAGTGATGATCGTATGTTGCTGTCTCCATCCGTCTTTAATGGGTCAGGGCTTTGATTTCCAAGGGTCTTCAGGTGATGAGTAGGGGTACCCACAAGTCAGAAGGTCTGCGTTCTCCTAGTTTGTTTGCTGCCATTTGAACTCATGTAGGGAATGAAAGAAAGCTGCAATTATCCGCCAACTGCATTTaaaacaaaacaaaacagaaaaatcaaaataaCATTGACTCTTCCAACCACTGACATGTTGTTTAATAATCTAAGCGGCAGTCCTGGAGGCTACCAGACTTACTGAGTTCTACCTGAGAAACAGCCAAGCAAAGTGTGAGAGAAGGGTTAAGACTGGCTTACAATGAGATGCTTCAAATGAAAAGGGAATTATGAGTAAAATTGAACTTTGATGGGGGATTCAGTTCTGGAAAAGAATTTGGTATTTTCCAGTCTGCTAGGACCAATTACCTTGAAATATTTTAAAATCTCAGTAAATAGTTATTGCTGAAATGGCTGTTGGCAGTTCTTATTATGATTCAGAGAAGAGCAAATAGACCTTAACTTCATTTTGAAAAAGACCAAATTACCATACCCGAGTGAGTAATGACAGGACTACAACTAAAACATAAACAACATTAATGATGACCATAAAAAGTCACAAAATTGCTAAATGTTATAATTTAGAGTTGACATAAAAATTGATggccaggcatggtggctcacgcctgtaatcccagaactatgtgaggctgaggcaggtggatcacttgaggtcaggagttcaacaccagcctggccaacatggtgaaaccctgtctctactaaaaatacaaaaattagccgggcatggtggtaggggcctgtaacccagctactcgtgaggccaaggcaggagaattgcttgagcctgcagcagctgcagtaagccaagatcatgcTGTGCCTCAAGGAAAAAAAAAATTAATGTTTACTGATATTTGTTGAAGTCCTACAACATCACCTCTGAGAATAGGAGAAATGAAGCAACAGTTGTGTCTAGATGTCAGAGGCATGGCTGGGCCTCCATCTCTGCCTAAGGGAGATATAAAAGAGTTCAAACTATTGCCCATGTTCCCCAGGGTCAGAAGTTCTAATTATGATGATAGAGGCTGGGTTGTAAGTAGTAAGtgaagggtagcagaatatgccatctttggcataagaagtattttgagttgaagacaattgagaaaaaaaatagattaaaaacaaacaaacacctctgccctctccctatttgcctaaaagcaggatatgaaattgtgaaggtgtcttcttactcggggaagaacaaaagttagtcaccagagactttagactcttatcagcctggacatagcaccagagaagtctttttttttaaaaaaaaaaaaaaaaaaagggaaagaaaaagttgccttcccacaatttactgcactagaaactcaaagtccttttcgtcttccttgtcacttaaaaaatgtattcttttcttaaaatgctatataagcccaagttctaaatcctcttttgagtattcatctcagtactcccctgtgtttgtacaatgcacatgctttgtttctgtcttgtcaatctgtcttttgttagtctacttgatagggccacagatggagaacctaagatgaatagaaaaaaaagatttttctccccaacaGAAGGATTATCGCCAGTTGCACTTGTTCTATATACCCGTAGTCTCGGTATGCTGACCCAGACTTGGGTAATAGGACCCAGTGGGTAACCGAGGAACCCCACCTTTGTGCAGGATCAGTGAAGATGTAATCTGGATATTCATAAGCTCTTCTCTACCTCTTGGCATCCCACAGTCCTGTGTTAATGTAAGTGTGGTCTTCCCCAGAAAGGGGAGGCCTCCCTAACATTGTTAAAGCCTAGCATATGCtgcttagaggaaattctatatccctaagcacttagattgctgaataagaaagaatgataataaaataaacaattaaataaaagttttaaaaaatgaataaaataaacctgtggaaactataaggaaggccagaagaaatataaaattggagattaatTGGGGTGCAGGAAAGTTATGGAAAGAATATAAGTCCTGCTAGATAAATCATTAGCTATTTTAATAAAGAAtacagaagaaaataggaacaaaagaatatatactggaataattttgagagtaatttgaagaattagatgcaaataaatttgaaaacctttaaaaagaaaccaatggcctaactgacccaagaagggaaagaaaatctaaacagactgataaATACAAAATGAAATTCAGACACTTACAGAGCAgccaggcatggtggctcacacctgtaatcctgtcactttgggaggctgagatgggaggatcacttgaggctaggagtttgagactagcctgggcaaggctcccatctctaaaagaaaagaaattagctgggcatggtggcatgtgccttagtttcagctactcaggaggctgagacgaggattgcttgagcctaggagggcaaggctgcagtgagccatggtcatgccactgaattccagcctaagtgacagagcaagaccttgtctcaaaaaaaaaaaaaaaaaaaGTTACAGAGCTCCAACTAAATAATGTGGGGAACAAAAGAAAAAAGAAGATGATTTTATGGCTGATTTTTTTTTTAAGGAAAAGCAATTCAtgtacccttgaagattagattaagttctataaaatagcccaaaatgacagtggctgaaacaagtttatttctctcccatttaaagcaagtctagatgtggaagtctgggaagcccagaaaatccaggtcttgtttgtgtatggaaactccagaaaatcacagattccttccagccacccctcaattacccctgggatccaagagagccactaaagttccagccatcatactcacaacccaagttgtaggatggaaaaaaggacacaaaagtagggtgaagagcatgtgtgcaacagctctcttttactctagtgtcctaaaacctatcataaaacctttggcttgccttgcattagccagaatttagtacatggccacacttaagaagtcagaaagattagctttttttccagggtagttggctgaaaatcaggagttctcatattaaaaaacagagaagggacatcgaatagatgaccaacaatctccttcacaCTCATACTATTTAAACTGTCCTAGTCAATGACCAAAAAAGAAAAGCCTACAAACTCATTGATATAAAAGCTTAACAAAGGTACTCCCCGCCCCCCGCCCGCCACACACCATCCCCAAAAGGAAATTTCTAATCCAATTAACAgtcttaggttgggctgctgaaacaaaataccacagcctgagtgacttaaacaacgacaatttatctctcactgttctgaggtctgagttgattctttgtgaaggccctttcctagcttgcagatggctaccttcctgctatgtcttcacatggcaaagagagagctagctttctggtcttttcttataagggaccagtcccatcatgcccatcatgaagactcgatctgctaggatctcaactaaacctaactatcacccaaagagcccacctccaaagaccatcacattgaatgtgagagtttctacatatgcattgtgggaaacacaaacatttacttcaACTGTAACTATTGAAGCAAAAATGTCcccccaccatagacatccagcaccacagtagtacatttattacaattgaacttacattgacacgtcattatcaacgaaagtctgtaatttacattagggtttattcttggtgttgtgctttctatgggttttgacaaatgtataatgtcatgtattcaccattatagtatcacagaagtttcactgccctaaaaatcctgtgttctgccttttcaacacttcctgtcacccaatttctatcaactaatcttttgactgtgtccatagttactgtcttttctagagtgtcatacagttgtgaagcaggaagcaggagtgaactccggaggcagggactttactccggaccagattgaagactagccgaaacagggacgaggttaaagcacctctccataagacacgcccaccagcgccatgtcagtttttcgttgccatggcaacaacaggacattatcgacttctttcctctgtacctactccgaagttaccactctttttctagaaatttctgcataatcccccttaacatgcacttaactaaaagcaggtatattactgcagaactgcccctgagctgctactctgggcacattacttatgggttagccctgctcagcaaggagcagtacctgttctgctgttgtacactgctgcttcagtaaaagttgctaacaccaccacttcacccttgaattcttcccgggctaagccctaatttttggcttgcttgccctgcatcagttggagtcatatagtatgcagtcttttcaggttggctttttagtaacatacatttaagtttccttcatgtgttttcatggcttgatcgtttcttttctttttctttttcttttttcttttctttctttttttttttttttttgagacagaggagtcttgctctgttgcccaggctgaagtgcagtggcactggctcactgcaacctccatctcccaggttcaaacgattctcatatctcagcctcccgagtagctgggattacaggctcacgccactatgcccggctaattggggttttcccatgttgaccaggctggtctcaaactcctggcctcaagcaatccacccacttcggcctcccaaagtgaatgcatttctttttaactctaaataacattccattattcagaagtaccacagttatccacttacctactgaaagacatcttgtttccaagttttggataaattatgaataaagctgctataaacatctatgtgcaggtttttgtgtggagataagttttcaattcctttggataaatactaaggagtgtgattggtgaatcttatggtaaaagtatggttacttttgtaagaaaccaccaaactgtcttccaaagtgattgcacattttgcattctcaccagtaatgaacaagttactattgctacatatctttgcaacctttggtgctgacagtgttctaaattttggtcattctactaggtatgcagtggtatctacttgttttaatttgcagttccctaatgacatgatgtcaagcatcttttcatatgcatacttgcatctgtgtatcttctttggtgaacagatgttcaggtcattggcctgctttaaatcaggttattttcttactgttgagttttaagtattctttgtatattctaaaaatattgttcttcatcagatctgtcttttgcaaacattacctgccaatgtgtggcttttcttcaacacttctttgtaaatttgcaagtcctttgagaaaagaaatgcacccaaagtattaatttggcaatctcatatcacgagagtactctaaagctaaataaattacagtttttcaaattttgaattaattgatctttgctattgttagcaaggtcttgtattcttttttttttttttttttttttttaatagagacgggtcttgctacagtgcccaggctggtctcgaactccaggcctaaaatgatcctcctgccttggccttccaaagtactgggattacaggcataagtcaccacgctcagccatctggtattctttagcaactgtttggtaacttaatctttcactttttgaaaacaaaaaatagtttttttctcatagttttctaacaaaatcttcataactgaaataatttctctttatcacctcttcttataaatatggttttctttttttaaataaaaatttaagacattttataactggccaaatttactagcttagatactattagatagtcaatattttttgttggatatttgatttttatttcaggcaactaatatctattcatttttgcactgttggaagaaaattactgatcaaattcactatgtatttgcagaaaatggctttcaatattgtctactttatcatcctttttttttTTttctttcttcctttttagatacagggtctcactatgttgcccaggctggtctccaacttctgggctcaaacaatcctccctccttggccttccaaagggttggATATGTTTTATCTacagttttgttgttttgttctgctacaggatatttgcaattgccatttatcatgaaattcatgacataccttcttccactctcctttttatctttattgttctggttataggactagctttgcatctctactcaattctgtatcagtagtatgctttcattttaaattttaagtttgtccatatgtatattgacacagggtcttgctctgttgcccagactggagtgcagtggcaagatcagggctcactgcagccttgactgcctaggctcaagtcatcctcccacctcagcctccagaatggctgggactacaggcacgcaccaccacacatggctcatttttttgtattgagacagggtttctccatgttgcccaggctggtcttgaactactgggctcaagcaatcctcccaccttagcctcccaaagtgttgggattacaggcttgagccaccatgcctcgcttctacacttatttttaattctaaaataatttataataataaatattaacaattagatttaattactgataaatattaaatgttaaataggttttattaaataattaaataaaaatgaaaataatcagtatttcaatttaattactaattataattcacagttatccttgtaactcctaatgtctatataaaagatttttatattttttaattcttaaaattttattatttatttCACACCAGGCCATCACTGTGATACATTTTTTAAAACACATTAAATTATCACCAGAAAAGTGCTGTGATGGAAAATATAAATTGAAATACCTTTTCTGGTTAGGAGAGTAATTCTGTTTTTCTGATAGAGAATAGAAGAGTCCTTCAGGCCCCTCCAAACTGTCATATTCCGGGCATCGGGTGTCCCCATCCTCACTTCAGTCCACAGGCAGGGTCCTCAGTCTTCAGCGCTCCTTCTCTTTCCCCTttgtcttgtgtctccttgggtctcttttctccaagacctaaactccctgaggacaggactattttttacatcttgatgtcactcctgagcacttgCTTTAATGTGTTGGACACTGGGTCCATTAAAGATTGTATGTGAAATTATAAAA

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