Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name UBE2NP2
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:172379004-172380519  UCSC
Coordinates (T2T) chr4:175726952-175728470  UCSC
Coordinates (hg19) chr4:173300155-173301670  UCSC
Strand -
Parental Sequence NM_003348.4
Parental seq. overlap 784 bp
Parental seq. overlap (%) 15.1%
Genomic Region Intragenic (GALNTL6)
Retrocopy Summary UBE2NP2, located on chr4:172379004-172380519, is a retrocopy of the parental gene UBE2N. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name UBE2N
Full Name ubiquitin conjugating enzyme E2 N
Also known as HEL-S-71|UBC13|UBCHBEN|UBCHBEN; UBC13|UbcH-ben|UbcH13
Coordinate chr12:93405684-93441947
Strand -
Gene summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes UBE2NP1
Bonobo Pan paniscus UBE2NP1
Gorilla Gorilla gorilla UBE2NP1
Orangutan Pongo abelii UBE2NP1
Gibbon Nomascus leucogenys UBE2NP1
Green monkey Chlorocebus sabaeus UBE2NP3
Crab-eating macaque Macaca fascicularis UBE2NP1
Rhesus Macaca mulatta UBE2NP1
Baboon Papio anubis UBE2NP1
Marmoset Callithrix jacchus LOC100390645P2
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>UBE2NP2
TAACCTGTTCTTTAGAATATGTTCCCTAGCCAAGTCTAACTTTATTTAGATGCTGTAGATGGACAAGCTTGATTGTTTGAACCAGAATGGGAACATTAAACAAACATCACAGCTCTCAATAATAACACTGTGACTTTGCTGTCAAGTATAGATTCTCCCCTTCAGAAAAAGCTTGTGACCATTTTGTATGGCTTGTCTGGAAACTTCTGTAAGTCTTATGTTTTAGTAAAATGTTTTTTGTTATATTTCAGGGGGGAGGTAGTTTTATTTTAATTTATGAGCTCCTTTCCCACCTTTTTTTGGTGATCTAATTGCATTGATTAAAAGCAGCTAACCCGGAGACCAGAGACCCAACTCAGGACCTGACAAGATGGCTGGGCTGCCCAGCAGGATCGTCAAGGAAACCCAGCTTTTGCTGGCAGAACCAGTTCCTGGCCTCAAAGCAGAACCATATGAGAGCAACATCCATTATTTTCATGTGGTCATTGCCAGTCCCTGGGATTCCCACTGTGAGGGAGGGACTTTTAAACTTGGACTATTTCTTCCAGAAGAATACCCAATGGCAGCCCCTAAAGTGCGTTTTATGACCAAAATTTGTCATCCTAATGTAGACAAGTTGGGGAGAATACGTTAAGATATTTTGAAAGGTAAGTGGTCCCCAGCCCTGCAGATCCGCACAGTTCTGCTACGGATCCAGGCCTTGTTAAGTGCTCCAAATCCAGATGATCCATTAGCAAATGATGCAGAGGAGCAGTGGAAACACCAACGAAGCCCAAGCCATATAAACAGCTAGAGCAGGGACTAGGCTATATGCCATGAATAATATTTAAATTGATCCGATCATCAAGTATGCATCACTTCTCCTGTTCTGCCAAGACTTCTTTCTTTTGGTTTACATTTAATGGACAAGGTCTTAGAAACACTACAGAATAAAAGCCCAGACTTCTTCAGTCCTTTGGTGATTAAATGCACATTAGCAAATCTATGTTTTGTTCTGATTCACTGTCAAAAAGTATGAGCAGAGGCTAGAAGTATCGTCTGGACTGTTGGGAAACGTTTAAAAGCAGTGGCCCCTCTCTGCTTTTATTCATTTCCCCAAGCCTGGTTTAAGTGTAAAGCACTGTGAATGAAGGTAGTTGTCAGGTTAGCTCCAGGGGCGTGGGTGTt
>NM_003348.4
ACTCGTGCGTgaggcgagaggagccggagacgagaccagaGGCCGAACTCGGGTTCTGACAAGATGGCCGGGCTGCCCCGCAGGATCATCAAGGAAACCCAGCGTTTGCTGGCAGAACCAGTTCCTGGCATCAAAGCCGAACCAGATGAGAGCAACGCCCGTTATTTTCATGTGGTCATTGCTGGCCCTCAGGATTCCCCCTTTGAGGGAGGGACTTTTAAACTTGAACTATTCCTTCCAGAAGAATACCCAATGGCAGCCCCTAAAGTACGTTTCATGACCAAAATTTATCATCCTAATGTAGACAAGTTGGGAAGAATATGTTTAGATATTTTGAAAGATAAGTGGTCCCCAGCACTGCAGATCCGCACAGTTCTGCTATCGATCCAGGCCTTGTTAAGTGCTCCCAATCCAGATGATCCATTAGCAAATGATGTAGCGGAGCAGTGGAAGACCAACGAAGCCCAAGCCATAGAAACAGCTAGAGCATGGACTAGGCTATATGCCATGAATAATATTTAAATTGATACGATCATCAAGTGTGCATCACTTCTCCTGTTCTGCCAAGACTTCCTCCTCTTTGTTTGCATTTAATGGACACAGTCTTAGAAACATTACAGAATAAAAAAGCCCAGACATCTTCAGTCCTTTGGTGATTAAATGCACATTAGCAAATCTATGTCTTGTCCTGATTCACTGTCATAAAGCATGAGCAGAGGCTAGAAGTATCATCTGGATTGTTGTGAAACGTTTAAAAGCAGTGGCCCCTCCCTGCTTTTATTCATTTCCCCCATCCTGGTTTAAGTATAAAGCACTGTGAATGAAGGTAGTTGTCAGGTTAGCTGCAGGGGTGTGGGTGTttttattttattttattttattttattttTGAGGGGGGAGGTAGTTTAATTTTATGGGCTCCTTTCCCCCTTTTTTGGTGATCTAATTGCATTGGTTAAAAGCAGCTAACCAGGTCTTTAGAATATGCTCTAGCCAAGTCTAACTTTATTTAGACGCTGTAGATGGACAAGCTTGATTGTTGGAACCAAAATGGGAACATTAAACAAACATCACAGCCCTCACTAATAACATTGCTGTCAAGTGTAGATTCCCCCCTTCAAAAAAAGCTTGTGACCATTTTGTATGGCTTGTCTGGAAACTTCTGTAAATCTTATGTTTTAGTAAAATATTTTTTGTTATTCTACTTTGCCTTTGTACAGTTTATTTTACTGTGTTTATTTCATTTTCCCAATTTGACAATCGTATTTTAAAATTGAAACTGATGGAACATTCTTTCTTGGTCTTCACCATCTGACAAATTGAATGGCAAGAGGTGGATTTTGCCAGTTTCTTTTCACTGATGCAGATTTGTGTTAAGATAGTACTGAATGGAGTATTTATAAACTGGCCCTGAGCATGCATAAAGCATCAGTATCTGACCTTTTTTTAACCTTCTAGGAATTTGAAATAAATGTGTTTGTGTTGTCTGATTAGATGATCATTGGTGTCTTGCCACAATGTTTAAAAATTACTGTACAGGAAAGTCACAGCAAAGATAGCAGTTGTGACTGACATGTAGGACTTTCACAGTTGTGCCACATTTTTGCCTAAAATTTGGGTTATGACATTTTTCTTGGTTCTTATCTGAAAATTTCATCTGTAACCTTTCATGTGTGTTAAGAAACACTGATCTGATCATTTGGGATTTGCTGAGGCATTTGTGAGTCTTCCTTATAAACCTGATGAGCAGATCTCAACTATCTAGCTTGTGTGTCATCAGAAAGGTTTATCCCTTTGAGAGTATCAAGTCCTCAGTTAATGATTCTTGCTTTCATCCCTCCAGTATTTGCTGTGGGAGCTCGTTTTATTCTTTAATTTGGAATTCAGTAATTTTTCTTCTTTATTGACGAATTCCTCCCCTCACAAAACTGTTCTTTCCCACCTCTCTCCATATCTAATTCCTGATTCTTGTTATTTTTAAGTCATAAATGTAGCCAGTCATAAATACATAAATGTTAACCTTCGGGTTGCAACCTTGTCTCTTGCAGTTTAAGGTAATGGATATTGTAGCCCATTTGAATTTTCTTCACTCTTATTCTCGTAATTCTGGAGTTTCTTCAGATTGTGGTGTATTTTATTGTGCTCCTATGTAAGATGAAGAATTAACTATTAAAATTACATTTTCAACATACAAAAGCTTTTGATGACTGGTAACTGGTATCCTTCCAAATAAATGCATTGCTTGGTAACAAATGTTAGCTTAATTCAGAATGAAATAGTTAACAACCCTAATATTGTAAAATTTGAAAACTGATAGCAGCTGTCATTTATAACAATTCTTGGGCTGTTTAAAGGGTACATTTGACTATAGCTAAGGAAATTGAATCTCACTTTAAAAATGAACCACACAAAACTTCAAGAAACGAAATAGAAATCAACATTTACTGCCCGTAATATTGCTCATGGTTATAGCTAGTATCACATAGTGATTTACAAACCATGAAATTCCAGATTTAAATCTGTTGCACTACAAAAATGTCTAAATGATGTCTGCTAAATTTGTGAGTTATAGAAGTACAGAAATAAGTCATTTTCATTTCAAATGCAGTGAATTTCTAATTTCATGGTATCATATTTTTTTCCTTTGCAGTTTTGGTAAGACTCCCCCATTACTTTGCTAAGACTTGCTTTCTCAACCAGTGGGATGAAACGAGTGCCAGTGTGTTGACTGAGCCTTCTTAGGACTTAAGGGGCTCTGGGAGAGGCCAAGGCAGCAGTTGAAAACTGCAGCTTCacctggcctttgggcctgttttccctggcccacacagtgtggctggttaaaacattctgaatttgatgccaacatttttaaaaattgggagatttgcatgaaaatccagaattcgggtaacttttgaatgatctgaagatctggcaacagtagacctgacccacctttgtgcacgggacttaactgagaggatctgagtagcagacaccctaagagcatgtcattgtcttctcaccagttactctccagttggctagagtcccctccgagcacacctgctagtccttcccccttgtaagcctttgactttgtaatccctgGGCTAAAGGAAACACATTATTCAACAAAAGTGTTTCATGTTTGCCCACTAGTTGTTGGGGATGATTAGGTGGTGAGTGAATGGCATGGGGCTTTCCTTTGGGGACCATATACTCTAATGGGGAAGGGGGACAGACAAATAGTTGTAACTCTGTCATGGAAAAGAGAAGTAACTTGGACAGACTTTTGGATTCAGGCCAgatgaacatctccaggcagagggaacagcagcatctgcaaagtcctgggagagaagaaaagaatctgAACATTAAGTGGCTTCCTGAAAATCGACTGCCCAggccgggcacagtggctcatgcctgtaatcccagcactttaggaggccaaggcaggaggatcacttgagtccaggagtttgtgaccagcctggctaacatagtgggacccagtctttatttaaaagaaaaTTGCCCGTTAAGAGGCTTTTCTAAAATCTTGAGGTGTTGATAGGAGCTTTATGTTTTTTGACTTGATTGTTGTAGTCTACTTCGCTGCGATTTGCTTCTGCTCTAGTTATCCTTCATCCTCTCAAAGGCTGTCTAGCAAGATCTTAGGTCTAAAGTAAagtcatctcttggtatttgtcgggaactggttctaggacttcctttggatatccaaattcgcagatgctcaagtctctggaataaaatgatgttgtatatgcatacaatctacacaaatcctcccgcttatgttaatatttagattacttataatacctattataatgtaagtgctatgtaaatagttacactattgtttaaggaataatgacaaaaatatacatgttgactacagacacaatgttttttggaatattttgtctggttgtttgaatccacggaagtggaacccatggatatggagggccaactATATAGAACCTTACTCTAGACCAAGAATGTACTTGTAAAACAATTTCAAAGAAGCACTTAAAAATAAGATTAAATACAAACCAACAGATAAAAGTCACAGGTGCTATGGTTGTTTGATGGAGAATGGGGAAGGAAATCTGTCCTAAAAGACATTATAAACACAGTGACCTAAGTGGAACTAAATTGGATCGAGGAAATGATAGGAATAGGCCTCATTTTTCTGTTGAATGGTTCAGGAACCttttttttttttttttttttttttttttttggctgctctagccactttctagctctgtagtttaggctggagtgctgtggcatgatcttggctcactgcaggttctgcctcccgcgttcaagcgattctcctgcctcagcctcctgaggagctgggactacagacacctgccaccacacctggctaattttttgtatttttagtagagacggggtttcaccatgttgggccaggatggtctccatctcctgacctcgtgatctgcccgcctcggcctcccaaagtgctgggattacaggcgtgagccaccgtgcccagccCTGCCACATCTTTTTTGTTAGTTGCAGTAGCAATACAACCTTATCTAGAAAAGCTGGCCAAAAAAGAAAATACCATGATAATAGGGTACCTAATTTATTGCTTTATTTAAGAAAAATGTAATATTTCATTCGAATAAGTACTTTTGGGCTGGGATGATATTTCATTTAGCTACTTGGCATGCCACCCATCTTAGGGAATTATATGAGGGTTTATACTTTAAATAACATAAAAAGCAAAACATGCTGAATGTAATAATTTGAGAGAAGTGTAAATAATAAAAATCTGTCATCTACCACCTGGA

Publications

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