RCPedia: Rtcs

Summary

Retrocopy Name	ZNF66P6	Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr4:442083-442239 UCSC
Coordinates (T2T)	chr4:435477-435633 UCSC
Coordinates (hg19)	chr4:435872-436028 UCSC
Strand	-
Parental Sequence	NM_001355197.2
Parental seq. overlap	131 bp
Parental seq. overlap (%)	2.9%
Genomic Region	Intragenic (ZNF721)
Retrocopy Summary	ZNF66P6, located on chr4:442083-442239, is a retrocopy of the parental gene ZNF66. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	ZNF66
Full Name	zinc finger protein 66
Also known as	ZNF66P
Coordinate	chr19:20776304-20809995
Strand	+
Gene summary	Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	LOC100611724P2
Gorilla	Gorilla gorilla	LOC109024078P5
Orangutan	Pongo abelii	LOC100451404P7
Golden snub-nosed monkey	Rhinopithecus roxellana	LOC104671910P1
Mouse	Mus musculus	Gm17768P1
Rabbit	Oryctolagus cuniculus	LOC100340194P2
Cow	Bos taurus	SMIM20P5
Sheep	Ovis aries	LOC114118023P1
Tasmanian Devil	Sarcophilus harrisii	LOC100917187P4
Opossum	Monodelphis domestica	LOC100015925P17
Bonobo	Pan paniscus	Without Homology
Gibbon	Nomascus leucogenys	Without Homology
Green monkey	Chlorocebus sabaeus	Without Homology
Crab-eating macaque	Macaca fascicularis	Without Homology
Rhesus	Macaca mulatta	Without Homology
Baboon	Papio anubis	Without Homology
Marmoset	Callithrix jacchus	Without Homology
Mouse lemur	Microcebus murinus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Pig	Sus scrofa	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>ZNF66P6
ATAAGAAAATTCATACTGGAGATAAACTCTACAAATGTAAAGAATGTGGGAAAGTGTTTAAACAGTCCTCACACCTGAATAGACATGAGAAAATTCATACTGGAAAGAAACCCTACAAATGTAAGGAATGTGGCAAAGTCATTACGTCATCCTCAAG

>NM_001355197.2
GTCTCTCCCTGCAGCTGGAGCTCCAGGTCGTCTGTTCACTGCTCTCTGTCTTCTTCTCCTAGAGGCCCAGCCTCTGTGGCCCTGTGTCCTGCAGGTATTGGGAGATCCACAGCTAAGACGCCAGGACCCCCTGGAAGCCTAGAAATGGGGCCATTGCAATTTAGAGATGTGGCCATAGAATTCTCTCTGGAGGAGTGGCATTGCCTGGACATGGCACAGCGGAATTTATATAGGGATGTGATGTTAGAGAACTACAGAAACCTGGTCTTTCTTGGTATTGTTGTCTCAAAGCCAGACCTCATCACCCATCTGGAGCAAGGAAAAAAACCTTCGACTATGCAGAGACATGAGATGGTAGCCAACCCCTCAGTTTTGTGTTCTCATTTTAACCAAGACCTTTGGCCAGAGCAGAGCATAAAAGATTCTTTCCAAAAACTGATACTGAGAAGACATAAAAAATGTGGACATGATAATTTGCAGTTAAAAAAAGGCTGTGAAAGTGTGGATAAGTGTAAAGTGCACAAAAGAGGTTATAATGGACTTAACCAATGTTTGACAACTACCCAAAGCAAAATGTTTCAATGTGATAAACATGGGAAAGTCTTTCATCAATTTTCAAATACAAACAGACATAAGATAAGACATACTGGAAAAAACCCTTTCAAATTTACAGAATGTGGCAAAGCTTTTAACCGGTCCTCAACCCTTACTACACATAAGAAAATTCATACTGGAGAGAAACCCTATAAATGTATAGAATGTGGCAAAGCCTTCAACCGGTCCTCACACCTTACTACACATAAGATAATTCATACTGGAGAGAAACGGTACAAATGTGAAGACTGTGGCAAAGCCTTTAACCGCTCCTCTAACCTTACTACACATAAGAAAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAGGCCTTTAAGCGCTCCTCTATCCTTACTACACATAAGAGAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGTTTTTAAGTACCTTTCTTCCCTTTCTACACATAAGATAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGTAAAGCCTTCAACTGGTCCTCACACCTTACTACACATAAGAGAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGGCTTTAAGTACTCCTCTACCCTTACTAAACATAAAATAATCCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGTGAAGCCTTTAAGTACTCCTGTTCCCTTACTGCACATAAGATAATTCATACTGGAAAGAAACCTTACAAATGTGAAGAATGTGGCAAAGTGTTTAAGCACTCCTCTCCCCTTTCTAAACATAAGAGAATTCATGCTGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCCTTCAGTCGGTCCTCTATTCTTACTACACATAAGATAATTCACACTGGAGAGAAACCCTACGAATGTGAAGACTGTGGCAAAGCCTTTAACCGCTCCTCTAACCTTACTAAACACAAGAAAATTCATACTGGAGAGAAGCCTTACAAATGTGAAGAATGTGGCAAGGCCTTTAAGTGCTCCTCTATTCTTACTACACATAAGAGAATTCATACTGCAGATAAACCCTACAAATGTGAAGAATGTGGCAAAGACTTTAAGTACTCCTCTACCCTTACTAGACATAAGAAAATTCATACTGGAGGGAAACCACACAAGTGCAATAAATGTGGCAAAGCCTTTATTTCATCCTCAAACCTTAGTAGACATGAGATAATTCATATGGGAGGGAATCCCTACAAATGTGAAAATGTGGCAAAGCCTTAGACACTCCTCTACCCTTACTAGACATAAGATAATTCATACTGGAGAGAAACCCTATGAGTTTGATGAATGTGGGAAAGACTTTAACCAGCTATCAACTTTTACTAAATATGAGAATTTATGGAACACAAACACTACAAATATAAAGAATGTGACAAAGCTTTTAGGAAGTTCTCAACCCTTATTACACATAATTCATACTGGATAGAAACCCTACACCTGTGAAGAATGTGGCATAGCCTATAACAATTTTCAATCAAttctttttttttttttgagatgaagtttcatgcttgtcacccaagctggaatacaatgtgatgatctcggatcactgaaacctctgcctcccgggttcaagccattttcctgcctcagcttgtctagtagatgagattatggggggtggagccaagatggctgaataggtacagctcctgtctacagctcccagcctgagtgacgcagaagatgggtgatttctgcatttccgtctgatgtaccaggttcatctcactagggggtgccagacagtggctgcaggacagtggatgcagtgcactgtgcatgagccgaagcagggcgaggcattgcctcactcacgaagcgcaaggagtcagggagttccctttcctagtcaaagaaaggggtgacagatggcacctggaaaatcgggtcactcccaccctaatactgcgcaattccaatgggcttaaaaaatggcacaccagattatatcctgcacctggctcagagggtcctatgcccatggagtctcactgattgctagcacagcagtctgagatcaaactgcaaggcagcagcgaggctgggggaggagtgcctgccattgcccaggcttgcttaggtaaagcagctgggaagctagaactgggtggagcccaccacagctcaaggaggcctgcctgcctctgtaggctccacctctgggggcagggcacagacaaaaagacagcagtaacctctgcagacttaaacgtccctgtctgacagctttgaagagagtagtggttctcccagcacgcagctggagatctgagaacgggcagactgcctcctcaagtgggtctctgacccccgagcagcctaactgggaggcaccccccagtaggggcagactgacacttcacacggctgggtactcctcacacaaaacttccagaggaccgatcaggcagcagcatttgcggttcatgaaaatccgctgttctacagccactgatgctgatacccaggcaaacagtgtctggagtggacctctagcaaattccaacagacctgcagctgagggtcctgtctgttagaaggaaaactaacaaacagaaaggacatccacaccaaaaacccatctgtacatcaccatcatcaaagaccaaaagtagataaaaccacaaagatggggaaaaaacagagcagaaaaactgaaaagtctaaaaagcagagcacctctcctccaaaggaatgcagttccccaccagcaacagaacaaagctggatggagaatgactttgatgagttgagagaagaaggcttcagacgatcaaactactccgagctacaggaggaaattcaaaccaaaggcaaagaagttaaaaactttgaaaaaaaattagacgaatgtataactagaataaccaatgcagagaaatgcttaaaggacctgatggagctgaaagccaaggatcaagaactatgtgaagaatgcagaagcctcaggagccaatgcgatcaactggaagaaagggtatcagtgatggaagatgaaatgaatgaaatgaagtgagaagggaagtttagagaaaaaaaattaaaaagaaacaaacaaagtctccaagaaatatgggactatgtgaaaagaccaaatctacctctgattggtgtacctgaaagtgagggggaaaatggaaccaacttggaaaacactctgcaggatattatccaggagaacttccccaatctagcaaggcaggccgacattcagattcaggaaatacagagaacgccacaaagatactccttgagaagagcaactccaagacacataattgtcagattcaccaaagttgaaatgaaggaaaaaatgttaagggcagccagagagaaaggtcgggttacccacaaagggaagcccatcagactcacagctgacctcttggcagaaactctataagccagaagagagtgggggccaatattcaacattcttaaagaaaagaattttcaacccagaatttcatatccagccaaactaagcttcataagtgaaggagaaataaaatactttacagacaagcaaatgctgagagattttgtcaccaccaggcctgccctaaaagagctcctgaaggaagcactaaacatggaaaggaacaactgataccagccgctgcaaaatcatgccaaaatgtaaagaccatcgagactaggaagaaactgcatgaactaacgagcaaaataaccagctaacatcataatgacaggatcaaattctcacataacaatattagctttaaatgtaaatgggctaaatgctccaattaaaagacacagacaggcaaattggataaagagtcaagacccatcagtgtgctgtattcaggaaacccatctcacgtgcagagacacacataggctcaaaataaaaggatggaggaagatctacgaag

>NM_001355197.2 

GTCTCTCCCTGCAGCTGGAGCTCCAGGTCGTCTGTTCACTGCTCTCTGTCTTCTTCTCCTAGAGGCCCAGCCTCTGTGGCCCTGTGTCCTGCAGGTATTGGGAGATCCACAGCTAAGACGCCAGGACCCCCTGGAAGCCTAGAAATGGGGCCATTGCAATTTAGAGATGTGGCCATAGAATTCTCTCTGGAGGAGTGGCATTGCCTGGACATGGCACAGCGGAATTTATATAGGGATGTGATGTTAGAGAACTACAGAAACCTGGTCTTTCTTGGTATTGTTGTCTCAAAGCCAGACCTCATCACCCATCTGGAGCAAGGAAAAAAACCTTCGACTATGCAGAGACATGAGATGGTAGCCAACCCCTCAGTTTTGTGTTCTCATTTTAACCAAGACCTTTGGCCAGAGCAGAGCATAAAAGATTCTTTCCAAAAACTGATACTGAGAAGACATAAAAAATGTGGACATGATAATTTGCAGTTAAAAAAAGGCTGTGAAAGTGTGGATAAGTGTAAAGTGCACAAAAGAGGTTATAATGGACTTAACCAATGTTTGACAACTACCCAAAGCAAAATGTTTCAATGTGATAAACATGGGAAAGTCTTTCATCAATTTTCAAATACAAACAGACATAAGATAAGACATACTGGAAAAAACCCTTTCAAATTTACAGAATGTGGCAAAGCTTTTAACCGGTCCTCAACCCTTACTACACATAAGAAAATTCATACTGGAGAGAAACCCTATAAATGTATAGAATGTGGCAAAGCCTTCAACCGGTCCTCACACCTTACTACACATAAGATAATTCATACTGGAGAGAAACGGTACAAATGTGAAGACTGTGGCAAAGCCTTTAACCGCTCCTCTAACCTTACTACACATAAGAAAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAGGCCTTTAAGCGCTCCTCTATCCTTACTACACATAAGAGAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGTTTTTAAGTACCTTTCTTCCCTTTCTACACATAAGATAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGTAAAGCCTTCAACTGGTCCTCACACCTTACTACACATAAGAGAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGGCTTTAAGTACTCCTCTACCCTTACTAAACATAAAATAATCCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGTGAAGCCTTTAAGTACTCCTGTTCCCTTACTGCACATAAGATAATTCATACTGGAAAGAAACCTTACAAATGTGAAGAATGTGGCAAAGTGTTTAAGCACTCCTCTCCCCTTTCTAAACATAAGAGAATTCATGCTGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCCTTCAGTCGGTCCTCTATTCTTACTACACATAAGATAATTCACACTGGAGAGAAACCCTACGAATGTGAAGACTGTGGCAAAGCCTTTAACCGCTCCTCTAACCTTACTAAACACAAGAAAATTCATACTGGAGAGAAGCCTTACAAATGTGAAGAATGTGGCAAGGCCTTTAAGTGCTCCTCTATTCTTACTACACATAAGAGAATTCATACTGCAGATAAACCCTACAAATGTGAAGAATGTGGCAAAGACTTTAAGTACTCCTCTACCCTTACTAGACATAAGAAAATTCATACTGGAGGGAAACCACACAAGTGCAATAAATGTGGCAAAGCCTTTATTTCATCCTCAAACCTTAGTAGACATGAGATAATTCATATGGGAGGGAATCCCTACAAATGTGAAAATGTGGCAAAGCCTTAGACACTCCTCTACCCTTACTAGACATAAGATAATTCATACTGGAGAGAAACCCTATGAGTTTGATGAATGTGGGAAAGACTTTAACCAGCTATCAACTTTTACTAAATATGAGAATTTATGGAACACAAACACTACAAATATAAAGAATGTGACAAAGCTTTTAGGAAGTTCTCAACCCTTATTACACATAATTCATACTGGATAGAAACCCTACACCTGTGAAGAATGTGGCATAGCCTATAACAATTTTCAATCAAttctttttttttttttgagatgaagtttcatgcttgtcacccaagctggaatacaatgtgatgatctcggatcactgaaacctctgcctcccgggttcaagccattttcctgcctcagcttgtctagtagatgagattatggggggtggagccaagatggctgaataggtacagctcctgtctacagctcccagcctgagtgacgcagaagatgggtgatttctgcatttccgtctgatgtaccaggttcatctcactagggggtgccagacagtggctgcaggacagtggatgcagtgcactgtgcatgagccgaagcagggcgaggcattgcctcactcacgaagcgcaaggagtcagggagttccctttcctagtcaaagaaaggggtgacagatggcacctggaaaatcgggtcactcccaccctaatactgcgcaattccaatgggcttaaaaaatggcacaccagattatatcctgcacctggctcagagggtcctatgcccatggagtctcactgattgctagcacagcagtctgagatcaaactgcaaggcagcagcgaggctgggggaggagtgcctgccattgcccaggcttgcttaggtaaagcagctgggaagctagaactgggtggagcccaccacagctcaaggaggcctgcctgcctctgtaggctccacctctgggggcagggcacagacaaaaagacagcagtaacctctgcagacttaaacgtccctgtctgacagctttgaagagagtagtggttctcccagcacgcagctggagatctgagaacgggcagactgcctcctcaagtgggtctctgacccccgagcagcctaactgggaggcaccccccagtaggggcagactgacacttcacacggctgggtactcctcacacaaaacttccagaggaccgatcaggcagcagcatttgcggttcatgaaaatccgctgttctacagccactgatgctgatacccaggcaaacagtgtctggagtggacctctagcaaattccaacagacctgcagctgagggtcctgtctgttagaaggaaaactaacaaacagaaaggacatccacaccaaaaacccatctgtacatcaccatcatcaaagaccaaaagtagataaaaccacaaagatggggaaaaaacagagcagaaaaactgaaaagtctaaaaagcagagcacctctcctccaaaggaatgcagttccccaccagcaacagaacaaagctggatggagaatgactttgatgagttgagagaagaaggcttcagacgatcaaactactccgagctacaggaggaaattcaaaccaaaggcaaagaagttaaaaactttgaaaaaaaattagacgaatgtataactagaataaccaatgcagagaaatgcttaaaggacctgatggagctgaaagccaaggatcaagaactatgtgaagaatgcagaagcctcaggagccaatgcgatcaactggaagaaagggtatcagtgatggaagatgaaatgaatgaaatgaagtgagaagggaagtttagagaaaaaaaattaaaaagaaacaaacaaagtctccaagaaatatgggactatgtgaaaagaccaaatctacctctgattggtgtacctgaaagtgagggggaaaatggaaccaacttggaaaacactctgcaggatattatccaggagaacttccccaatctagcaaggcaggccgacattcagattcaggaaatacagagaacgccacaaagatactccttgagaagagcaactccaagacacataattgtcagattcaccaaagttgaaatgaaggaaaaaatgttaagggcagccagagagaaaggtcgggttacccacaaagggaagcccatcagactcacagctgacctcttggcagaaactctataagccagaagagagtgggggccaatattcaacattcttaaagaaaagaattttcaacccagaatttcatatccagccaaactaagcttcataagtgaaggagaaataaaatactttacagacaagcaaatgctgagagattttgtcaccaccaggcctgccctaaaagagctcctgaaggaagcactaaacatggaaaggaacaactgataccagccgctgcaaaatcatgccaaaatgtaaagaccatcgagactaggaagaaactgcatgaactaacgagcaaaataaccagctaacatcataatgacaggatcaaattctcacataacaatattagctttaaatgtaaatgggctaaatgctccaattaaaagacacagacaggcaaattggataaagagtcaagacccatcagtgtgctgtattcaggaaacccatctcacgtgcagagacacacataggctcaaaataaaaggatggaggaagatctacgaag

Publications

PMID - Link	Title