Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name GJA1P1
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:109049584-109052656  UCSC
Coordinates (T2T) chr5:109553029-109556101  UCSC
Coordinates (hg19) chr5:108385285-108388357  UCSC
Strand -
Parental Sequence NM_000165.5
Parental seq. overlap 2967 bp
Parental seq. overlap (%) 95.6%
Genomic Region Intragenic (FER)
Retrocopy Summary GJA1P1, located on chr5:109049584-109052656, is a retrocopy of the parental gene GJA1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GJA1
Full Name gap junction protein alpha 1
Also known as AVSD3|CMDR|CX43|EKVP|EKVP3|GJAL|HLHS1|HSS|ODDD|PPKCA
Coordinate chr6:121435646-121449727
Strand +
Gene summary This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes GJA1P1
Bonobo Pan paniscus GJA1P1
Gorilla Gorilla gorilla GJA1P1
Orangutan Pongo abelii GJA1P1
Gibbon Nomascus leucogenys GJA1P1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>GJA1P1
AGCTTTTACGAGGTATCAGCACTTTTCTTTCATTGGGGGAAGGTGTGAGGAAAGTAACAAACAGCAGCGGAGTTTTAAACTTTAAATAGACAGGTCTGAGTGCCTGAATTTGCCTTTTCATTTTACTTCATCCTCCAAGGAGTTCAATCACCTGGCGTGACTTCACTTCTTTTAAGCAAAAGAGTGGTGCCCAGGCAACATGCGTGACTGGAGCACTTTAGGCAAACTCCTTGACAAGGTTCAAGCCTACTTAACTGCTGGAGGGAAGGTGTGGCTGTCAGTACTTTTCATTTTCCAAATCCTGCTGCTGAAGACAGTGGTTGAGTCAGCCTGGGGAGATGAGCAGTCTGCCTTTCGTTGTAACACTCAGCAACCTGGTTGTGAAAATGTCTGCTATGACAAGTCTTTCCCAATCTCTCATGTGCGCTTCTGGGTCCTGCAGATCATATTTGTGTCTGTACCCATACTCTTGTACCTGGCTCATGTGTTCTATGTGATGCAAAAGGAAGAGAAACTGAACAAGAAAGAGGAGGAACTCAAGGTTGCCCAAACTGATGGTGTCAATGTGGAGATGCACTTGAAGCAGATTGAGATAAAGAAGTTCAAGTATGGTATTGAAGAGCATGGTAAGGTGAAAATGCAAGGGGGGTTGCTGCGAACCTACATCATCAGTATCCTCTTCAAGTCTATCTTTGAGGTGACCTTGCTGATCCAGTGGTACATCTATGGATTCAGCTTGAGTGCTGTTCACACTTGCAAAAGAGATCCCTGCCCACATCAGGTGGACTGCTTCCTCTCTTGCCCCATGGAGAAAACCATCTTCATCATCTTCATGCTGGTGGTGTCCTTGGTGTCCCTGGCCTTGAATATCATTGAACTCTTCTACGTTTTCTTCAAGGGCGTTAAGGATTGGGTTAAGGGAAAGAGCGACCCTTACCATGCGACCACTGGCCCGCTGAGCCCCGCCAAAGACTGTGGGTCTCAAAAATATGCTTATTTCAATGGCTGCTCCTCACCAACTGCTCCCCTCTCGCCTATGTCTCTTCCTGGGTACAAGCTGGTTAATGGCGACAGAAACAATTCTTCTTGCCGCAATTACGACAAGCAAGCAAGTGAGCAAAACTGGGCTAATTACAGTGCAGAACAAAATCGAATGGGGCAGGCGGGAAGCACCATCTCTAACTCCCACGCACAGCCTTTTGATTTCCCCGATGATAACCAGAATTCTAAAAAACTAGCTGCTGGACATGAACTACAGCCACTAGCCATTGTGGACCAGCAACCTTCAAGCAGAGCCAGCAGTCGTGCCAGCAGCAGGCCTCAGCCTGATGACCTGGAGATCTAGATACAGGCTTGAAAGTATCAAGATTCCTCTCACTTGTGGAGAAGAAAAAAGGTGCTGTAGAAAGTGCACCAGGTGTTAATTTTGATCCGGTGGAGGTGGTATTCAACAGTCTTATTCATGAGGCTTAGAAAACACAAAGACATTAGAATACCTAGGTTCACTGGGGGTGTATGGGGTAGATGGGTGGAGAGGGAGGGGATAAGAGAGGTGCATATTGGTATTTAAAGTAGTGGATTCAAAAAACTTAGATTATAAATAAGAGTTCCATTACATGATACATAGATTAGGGCTTTTTCTCCCAGCAAACACCCCTAAGAATGGTTCTGGGTATGTGAATGAGTGGGTGGTAATTGTGGCTAAATATTTTTGTTTTACCAAGAAACTGAAATAATTCTGGCCAGGAATAAATACTTCCTGAACATCTTAGGTCTTTTCAACAAGAAAAAGACAGAGGATTGTCCTTAAGTCCCTGCTAAAACATTCCATTGTTAAAATTTGCACTTTGAAGGTTAGCTTTCTAGGCCTGACCCTCCAGGTGTCAATGGACTTGTGCTACTATATTTTTTTATTCTTGGTATCAGTTTAAAATTCAGACAAGGCCCACAGAATAAGATTTTCCATGCATTTGAAAATCTCAGCATTATACATATATTTTTTCCATCCACTTGCACCATATCATTACCATCACTTTTTCATCATTCCTCAGCTACTACTCACATTCATTTAATGGTTTCTGTAAACATTTTTAAGACAGTTGGGATGTCACTTAACATTTTTTTTCTTTTGAGCTAGAGTCAGGGAATCAAGCCATGCTTAATATTTAACAGTCACTTGTATGTGTGTGGAAGTTTGTTTTGTTTGTCATGTATTGGTACAAGCAGATACAGTACAAACTCACAAACACAGATTTGAAAATAATGCACATACAGTGTTCAAATTTGAACCTTTCTCATGGATTTTTGTGGTGTGGGCCAATACGGTGTTTACATTATATAATTCCTGCTGTGGCAAGTAAAACACACTTTTTTTTTTCTCCTAAAATGTTTTTCCCCGTGTATCCTATTACGGATACTAGTTTTGTTAATTATGATTCTTTATTTTCTCTCTTTTTTTTAGGATATAGCAGTAATGCTATTACTGAAATGAATTTCCTTTCTCTGAAATGTAATCACTGATGCTTGAATGACAGAATTTTAGTACTGTAAACAGGCTTTAGTCATTAATGTGAGAGACTTAGAAAAAATGCTTAGAGTGGAGTGGACTATTAAACGTGCCTAAATGAATTTTGCAGTAACTGGTATTCTTGGGTTTGCCCTACTTAATACACAGTAATTCAGAACTTGTATTCTGAGTTTAACAGTCTTTTGGAGTGACCAGCAACTTTGATGTTTGCACTAAGATTTCATTTGGAATGCAAGAGAGGTTGAAAGAGGATTCAGTAGTACACATATAACTAATTTATTTGAACTATATGCTGAAGACATCTACCAGTTTCTCCAAATGCCTTTTTTAAAACTCATCACAGACGACTGGTGAAAATGCTGAGTATGACACTTTTCTACTTGCATGTCAGCTACATAAACAGTTTTGTACAATGAAAATTACTAATTTGTTTGACATTCCATGTTAAACTATGGTCATGTTCAGCTTCACTGCATGTAATGTAGACCTTGTCCATCAGATCATGTGTTCTGGAGAGTGTTCTTTATTCAATAGTTTTAATTTAGC
>NM_000165.5
AAAAGCTTTTACGAGGTATCAGCACTTTTCTTTCATTAGGGGGAAGGCGTGAGGAAAGTACCAAACAGCAGCGGAGTTTTAAACTTTAAATAGACAGGTCTGAGTGCCTGAACTTGCCTTTTCATTTTACTTCATCCTCCAAGGAGTTCAATCACTTGGCGTGACTTCACTACTTTTAAGCAAAAGAGTGGTGCCCAGGCAACATGGGTGACTGGAGCGCCTTAGGCAAACTCCTTGACAAGGTTCAAGCCTACTCAACTGCTGGAGGGAAGGTGTGGCTGTCAGTACTTTTCATTTTCCGAATCCTGCTGCTGGGGACAGCGGTTGAGTCAGCCTGGGGAGATGAGCAGTCTGCCTTTCGTTGTAACACTCAGCAACCTGGTTGTGAAAATGTCTGCTATGACAAGTCTTTCCCAATCTCTCATGTGCGCTTCTGGGTCCTGCAGATCATATTTGTGTCTGTACCCACACTCTTGTACCTGGCTCATGTGTTCTATGTGATGCGAAAGGAAGAGAAACTGAACAAGAAAGAGGAAGAACTCAAGGTTGCCCAAACTGATGGTGTCAATGTGGACATGCACTTGAAGCAGATTGAGATAAAGAAGTTCAAGTACGGTATTGAAGAGCATGGTAAGGTGAAAATGCGAGGGGGGTTGCTGCGAACCTACATCATCAGTATCCTCTTCAAGTCTATCTTTGAGGTGGCCTTCTTGCTGATCCAGTGGTACATCTATGGATTCAGCTTGAGTGCTGTTTACACTTGCAAAAGAGATCCCTGCCCACATCAGGTGGACTGTTTCCTCTCTCGCCCCACGGAGAAAACCATCTTCATCATCTTCATGCTGGTGGTGTCCTTGGTGTCCCTGGCCTTGAATATCATTGAACTCTTCTATGTTTTCTTCAAGGGCGTTAAGGATCGGGTTAAGGGAAAGAGCGACCCTTACCATGCGACCAGTGGTGCGCTGAGCCCTGCCAAAGACTGTGGGTCTCAAAAATATGCTTATTTCAATGGCTGCTCCTCACCAACCGCTCCCCTCTCGCCTATGTCTCCTCCTGGGTACAAGCTGGTTACTGGCGACAGAAACAATTCTTCTTGCCGCAATTACAACAAGCAAGCAAGTGAGCAAAACTGGGCTAATTACAGTGCAGAACAAAATCGAATGGGGCAGGCGGGAAGCACCATCTCTAACTCCCATGCACAGCCTTTTGATTTCCCCGATGATAACCAGAATTCTAAAAAACTAGCTGCTGGACATGAATTACAGCCACTAGCCATTGTGGACCAGCGACCTTCAAGCAGAGCCAGCAGTCGTGCCAGCAGCAGACCTCGGCCTGATGACCTGGAGATCTAGATACAGGCTTGAAAGCATCAAGATTCCACTCAATTGTGGAGAAGAAAAAAGGTGCTGTAGAAAGTGCACCAGGTGTTAATTTTGATCCGGTGGAGGTGGTACTCAACAGCCTTATTCATGAGGCTTAGAAAACACAAAGACATTAGAATACCTAGGTTCACTGGGGGTGTATGGGGTAGATGGGTGGAGAGGGAGGGGATAAGAGAGGTGCATGTTGGTATTTAAAGTAGTGGATTCAAAGAACTTAGATTATAAATAAGAGTTCCATTAGGTGATACATAGATAAGGGCTTTTTCTCCCCGCAAACACCCCTAAGAATGGTTCTGTGTATGTGAATGAGCGGGTGGTAATTGTGGCTAAATATTTTTGTTTTACCAAGAAACTGAAATAATTCTGGCCAGGAATAAATACTTCCTGAACATCTTAGGTCTTTTCAACAAGAAAAAGACAGAGGATTGTCCTTAAGTCCCTGCTAAAACATTCCATTGTTAAAATTTGCACTTTGAAGGTAAGCTTTCTAGGCCTGACCCTCCAGGTGTCAATGGACTTGTGCTACTATATTTTTTTATTCTTGGTATCAGTTTAAAATTCAGACAAGGCCCACAGAATAAGATTTTCCATGCATTTGCAAATACGTATATTCTTTTTCCATCCACTTGCACAATATCATTACCATCACTTTTTCATCATTCCTCAGCTACTACTCACATTCATTTAATGGTTTCTGTAAACATTTTTAAGACAGTTGGGATGTCACTTAACATTTTTTTTTTGAGCTAAAGTCAGGGAATCAAGCCATGCTTAATATTTAACAATCACTTATATGTGTGTCGAAGAGTTTGTTTTGTTTGTCATGTATTGGTACAAGCAGATACAGTATAAACTCACAAACACAGATTTGAAAATAATGCACATATGGTGTTCAAATTTGAACCTTTCTCATGGATTTTTGTGGTGTGGGCCAATATGGTGTTTACATTATATAATTCCTGCTGTGGCAAGTAAAGCACACTTTTTTTTTCTCCTAAAATGTTTTTCCCTGTGTATCCTATTATGGATACTGGTTTTGTTAATTATGATTCTTTATTTTCTCTCCTTTTTTTAGGATATAGCAGTAATGCTATTACTGAAATGAATTTCCTTTTTCTGAAATGTAATCATTGATGCTTGAATGATAGAATTTTAGTACTGTAAACAGGCTTTAGTCATTAATGTGAGAGACTTAGAAAAAATGCTTAGAGTGGACTATTAAATGTGCCTAAATGAATTTTGCAGTAACTGGTATTCTTGGGTTTTCCTACTTAATACACAGTAATTCAGAACTTGTATTCTATTATGAGTTTAGCAGTCTTTTGGAGTGACCAGCAACTTTGATGTTTGCACTAAGATTTTATTTGGAATGCAAGAGAGGTTGAAAGAGGATTCAGTAGTACACATACAACTAATTTATTTGAACTATATGTTGAAGACATCTACCAGTTTCTCCAAATGCCTTTTTTAAAACTCATCACAGAAGATTGGTGAAAATGCTGAGTATGACACTTTTCTTCTTGCATGCATGTCAGCTACATAAACAGTTTTGTACAATGAAAATTACTAATTTGTTTGACATTCCATGTTAAACTACGGTCATGTTCAGCTTCATTGCATGTAATGTAGACCTAGTCCATCAGATCATGTGTTCTGGAGAGTGTTCTTTATTCAATAAAGTTTTAATTTAGTATAAACATA

Publications

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