Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SEPTIN7P10
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:119126314-119128425  UCSC
Coordinates (T2T) chr5:119647097-119649208  UCSC
Coordinates (hg19) chr5:118462009-118464120  UCSC
Strand -
Parental Sequence XM_017012860.1
Parental seq. overlap 1247 bp
Parental seq. overlap (%) 45.6%
Genomic Region Intragenic (DMXL1)
Retrocopy Summary SEPTIN7P10, located on chr5:119126314-119128425, is a retrocopy of the parental gene SEPTIN7. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SEPTIN7
Full Name septin 7
Also known as CDC10|CDC3|NBLA02942|SEPT7|SEPT7A
Coordinate chr7:35800986-35915763
Strand +
Gene summary This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. [provided by RefSeq, Jul 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SEPT7P1
Bonobo Pan paniscus SEPTIN7P1
Gorilla Gorilla gorilla SEPTIN7P3
Orangutan Pongo abelii SEPT7P1
Gibbon Nomascus leucogenys SEPTIN7P3
Green monkey Chlorocebus sabaeus SEPT7P4
Crab-eating macaque Macaca fascicularis SEPT7P2
Rhesus Macaca mulatta SEPTIN7P2
Baboon Papio anubis SEPTIN7P2
Golden snub-nosed monkey Rhinopithecus roxellana SEPTIN7P1
Marmoset Callithrix jacchus SEPTIN7P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SEPTIN7P10
GGATAAAGGACTGTTTACCACTTGCTGTGGTAGCCAATAATACTACCATTGAAGTTAATGGCAAGAGAGTCAGAGGAAGGCAGTATCCTAAGGGTGTTGCTGATGTTGAATATGGTGAGCACTGTAATTTTACAATTCTAAGGAGTATCTTGATAGGAACACACATACAAGACTTGAAAGATGTTCCTGATAATGCCCATTACGAAAACCACAGAAGCAGAAAAATGGCACCTGACTTACAATGGAGTTGAAAACAACAAGAATAAAGGGCAGCTTACTAAGAGCCCTCTGGCACAAATGGAAGAGGAAAGAAGACAGCATGTAGCTAAAATGAAGAAGATGGGGACAAAGATGAAGCAGGCGTTCAAGATGAAGGTCAAAAAAAAAAAAGTTCAAAAACTGAAGGACTCTGAAACTGAGCTCCAACGGTGCCAAGAGCAAAAAGGAATTTAAGCACAGCACAAAGAATTAGAGGAAAAACGTCACCAGTTTGAGAATGAAAAAGCAAACTGAGAAGCTCAACTCAACAACATATTTTAGAACAGAACTCTTCAAGACCCCTGGAAAAGAACAATAGAAAGTGAAGATCTTTCAAAATCTCTATTGACCACCAGTTATGCATTAGTTGCCAACGCCAGCTTGGACATCAGTGTTAGATGAATCTGTCTAATCAATCTTCACCAGTTTTGTCTATAATGATGGATTTTAACAGCAGGACAAAAATTTTTTTTGTTATTGTTATTTACAGAGATTACGATGCTTGAATTGTCCACGGTGTTGGGCACTTAGAAAGTAACAGCTCTAAGTACACTTCCTACATTTTCTTTTTTGTCTTTTATTGAATAGATATCCCCAATTTAATGCAAGAGAATATTTTATTGTTATACAGTCATGTCCTGGTGGTATGACTGTTGAGAGGATATTCCAAAATAAAAGGATGCTGCAAGGTTTTCAATGAGGATAAATTGCTATGACGCAAACTTTTTTGATAATTATAATATAAACGTTCCATTCAATGCAGCACATACAATAATGCATTACCAGACTAAGTAAAATTCTGTGAGTAATTCGGTAAGTTTAAAGTTGAACTAAAATTCTATCCTGGACAACCAGCTATCACCCTGCTGCTGAGGAGAGAAGCATCAACAGCAGCATGGTAGCTCAACGGAAGAACCCTGAAGTCTACGTGGGATTTTCCAGTCTCCCAAATCAAATATCCAGAAAATCAGTGAAGAGAGGGTTGGAATTCATACTTATGGCAGTGGGGAAATCTGGATTCAGAAACTTTACATTAATCAACTCATTATTCTTCACTCTGTATTCTCCAGAGTATCCAGATTCTTCTCACAGAATTAAAAAGACCGTGCAGGTGGAACTATGCAAAGTTTTAATCAAAGAAGGTGGTGTTCAGTTGCTGCTCACAAGAGTTGATATCCCATGATTTAGACTTGCAATGGGTAATAGTAATTGTTGGTTACTGACTACACTGATAGTAAATTGAGGACCACCTAAATGGAGAATCATGATAAAACAGATGTCAGATGCCTCATAACAGGGTGCAGGGTTGTTTATACTTCATTTCTCCTTCAGGACATGGACTTAAACCATTTGATACTAAGTTTATGAAGCTTTTGCTTGAAAAAGTGAATATCATTCCCACTTATTGCCAAAGCAGACATGCTGATACCAGAGAAATGCCAATAGTTTAAAAACAGATAATGAAAGAAATCTAAGAACATAAAATTAAATATATGAATTTCCAAAAACACATGATGAAGAAAATAAACTTGTTAAAAAGATAAAGGACTg
>XM_017012860.1
CAGTGCGAGATCCGCTGCTGCTGAGGAGAGGAGCGTCAACAGCAGCACCATGGTAGCTAAGAACCTTGAAGGCTATGTGGGATTTGCCAATCTCCCAAATCAAGTATACAGAAAATCGGTGAAGAGAGGTTTTGAATTCACGCTTATGGTAGTGGaggtgatgtttcaccatgttgcccgtggctaatcttgaactcctgggctcaagcgatccatccgccttggcctcccaaagtgctaggattacagGTGAATCTGGATTGGGAAAGTCGACATTAATCAACTCATTATTCCTCACAGATTTGTATTCTCCAGAGTATCCAGGTCCTTCTCATAGAATTAAAAAGACTGTACAGGTGGAACAATCCAAAGTTTTAATCAAAGAAGGTGGTGTTCAGTTGCTGCTCACAATAGTTGATACCCCAGGATTTGGAGATGCAGTGGATAATAGTAATTGCTGGCAGCCTGTTATCGACTACATTGATAGTAAATTTGAGGACTACCTAAATGCAGAATCACGAGTGAACAGACGTCAGATGCCTGATAACAGGGTGCAGTGTTGTTTATACTTCATTGCTCCTTCAGGACATGGACTTAAACCATTGGATATTGAGTTTATGAAGCGTTTGCATGAAAAAGTGAATATCATCCCACTTATTGCCAAAGCAGACACACTCACACCAGAGGAATGCCAACAGTTTAAAAAACAGATAATGAAAGAAATCCAAGAACATAAAATTAAAATATACGAATTTCCAGAAACAGATGATGAAGAAGAAAATAAACTTGTTAAAAAGATAAAGGACCGTTTACCTCTTGCTGTGGTAGGTAGTAATACTATCATTGAAGTTAATGGCAAAAGGGTCAGAGGAAGGCAGTATCCTTGGGGTGTTGCTGAAGTTGAAAATGGTGAACATTGTGATTTTACAATCCTAAGAAATATGTTGATAAGAACACACATGCAGGACTTGAAAGATGTTACTAATAATGTCCACTATGAGAACTACAGAAGCAGAAAACTTGCAGCTGTGACTTATAATGGAGTTGATAACAACAAGAATAAAGGGCAGCTGACTAAGAGCCCTCTGGCACAAATGGAAGAAGAAAGAAGGGAGCATGTAGCTAAAATGAAGAagatggagatggagatggagcaggtgtttgagatgaagGTCAAAGAAAAAGTTCAAAAACTGAAGGACTCTGAAGCTGAGCTCCAGCGGCGCCATGAGCAAATGAAAAAGAATTTGGAAGCACAGCACAAAGAATTGGAGGAAAAACGTCGTCAGTTCGAGGATGAGAAAGCAAACTGGGAAGCTCAACAACGTATTTTAGAACAACAGAACTCTTCAAGAACCTTGGAAAAGAACAAGAAGAAAGGGAAGATCTTTTAAACTCTCTATTGACCACCAGTTAACGTATTAGTTGCCAATATGCCAGCTTGGACATCAGTGTTTGTTGGATCCGTTTGACCAATTTGCACCAGTTTTATCCATAATGATGGATTTAACAGCATGACAAAAATTATTTTTTTTTTTGTTCTTGATGGAGATTAAGATGCCTTGAATTGTCTAGGGTGTTCTGTACTTAGAAAGTAAGAGCTCTAAGTACCTTTCCTACATTTTCTTTTTTTATTAAACAGATATCTTCAGTTTAATGCAAGAGAACATTTTACTGTTGTACAATCATGTTCTGGTGGTTTGATTGTTTACAGGATATTCCAAAATAAAAGGACTCTGGAAGATTTTCATTGAGGATAAATTGCCATAATATGATGCAAACTGTGCTTCTCTATGATAATTACAATACAAAGGTTCCATTCAGTGCAGCATATACAATAATGTAATTTAGTCTAACACAGTTGACCCTATTTTTTGACACTTCCATTGTTTAAAAATACACATGGAAAAAAAAAAAACCCTATATGCTTACTGTGCACCTAGAGCTTTTTTATAACAACGTCTTTTTGTTTGTTTGTTTTGGATTCTTTAAATATATATTATTCTCATTTAGTGCCCTCTTTAGCCAGAATCTCATTACTGCTTCATTTTTGTAATAACATTTAATTTAGATATTTTCCATATATTGGCACTGCTAAAATAGAATATAGCATCTTTCATATGGTAGGAACCAACAAGGAAACTTTCCTTTAACTCCCTTTTTACACTTTATGGTAAGTAGCAGGGGGGGAAATGCATTTATAGATCATTTCTAGGCAAAATTGTGAAGCTAATGACCAACCTGTTTCTACCTATATGCAGTCTCTTTATTTTACTAGAAATGGGAATCATGGCCTCTTGAAGAGAAAAAAGTCACCATTCTGCATTTAGCTGTATTCATATATTGCATTTCTGTATTTTTTGTTTGTATTGTAAAAAATTCACATAATAAACGATGTTGTGATGTAA

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