Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name LAMTOR3P2
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:119132131-119132917  UCSC
Coordinates (T2T) chr5:119652913-119653699  UCSC
Coordinates (hg19) chr5:118467826-118468612  UCSC
Strand -
Parental Sequence NM_021970.4
Parental seq. overlap 387 bp
Parental seq. overlap (%) 9.2%
Genomic Region Intragenic (DMXL1)
Retrocopy Summary LAMTOR3P2, located on chr5:119132131-119132917, is a retrocopy of the parental gene LAMTOR3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name LAMTOR3
Full Name late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Also known as MAP2K1IP1|MAPBP|MAPKSP1|MP1|PRO0633|Ragulator3
Coordinate chr4:99878336-99894546
Strand -
Gene summary This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes LAMTOR3P1
Bonobo Pan paniscus LAMTOR3P1
Gorilla Gorilla gorilla LAMTOR3P1
Orangutan Pongo abelii LAMTOR3P1
Gibbon Nomascus leucogenys LAMTOR3P1
Green monkey Chlorocebus sabaeus LAMTOR3P3
Crab-eating macaque Macaca fascicularis LAMTOR3P1
Rhesus Macaca mulatta LAMTOR3P1
Baboon Papio anubis LAMTOR3P1
Golden snub-nosed monkey Rhinopithecus roxellana LAMTOR3P1
Marmoset Callithrix jacchus LAMTOR3P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>LAMTOR3P2
AAGTTATGTAACTTTCTTAATCTGACAGTGGTATATGCACCTTATCTTCATTATAACAACACAAAATCAATCCAGCAATCTATAGATGACAATAATACTTTTATTAAACATGTGCTCAAGAAAGGGGCCTCTTTCGCCACCTTATAATAATAAAGAGCCTATAGACATAATTTATAGCCAGATCAATTGTCACATATTCTAGTGTAGAGCCTTTTCTTATTTAGTGAGATCTGGGGATATCACCAGAATGGTTCAATCTATCACAGCCAATGATAATGCTCCAGAGCATACTTTGAGATCTAGTTTCTTATCTACTTTTGCCCTTGCACAGATGAAAGGAGAAAACTTGGACTTTCAAAAAATAAAAGTATCATTTGTTACCATAACACCTACCAAGTAGTTCAAATTAATCGTTTACCTTTGGTGGTGAGTTTCATAGCCAGCAGCAATGCCAATATAGGACTAATTGTCAACCCAGAAAAGGGACTTGCTCCAt
>NM_021970.4
ATGAATCATGTGACGGTGGCTTGAGGAGGAACCTGTCTTTAAAGCTGTCCCTGAAGTGACAGCGGAGAGAACCAGGCAGCCCAGAAACCCCAGGCGTGGAGATTGATCCTGCGAGAGAAGGGGGTTCATCATGGCGGATGACCTAAAGCGATTCTTGTATAAAAAGTTACCAAGTGTTGAAGGGCTCCATGCCATTGTTGTGTCAGATAGAGATGGAGTACCTGTTATTAAAGTGGCAAATGACAATGCTCCAGAGCATGCTTTGCGACCTGGTTTCTTATCCACTTTTGCCCTTGCAACAGACCAAGGAAGCAAACTTGGACTTTCCAAAAATAAAAGTATCATCTGTTACTATAACACCTACCAGGTGGTTCAATTTAATCGTTTACCTTTGGTGGTGAGTTTCATAGCCAGCAGCAGTGCCAATACAGGACTAATTGTCAGCCTAGAAAAGGAACTTGCTCCATTGTTTGAAGAACTGAGACAAGTTGTGGAAGTTTCTTAATCTGACAGTGGTTTCAGTGTGTACCTTATCTTCATTATAACAACACAATATCAATCCAGCAATCTTTAGACTACAATAATACTTTTATCCATGTGCTCAAGAAAGGGCCCCTTTTTCCAACTTATACTAAAGAGCTAGCATATAGATGTAATTTATAGATAGATCAGTTGCTATATTTTCTGGTGTAGGGTCTTTCTTATTTAGTGAGATCTAGGGATACCACAGAAATGGTTCAGTCTATCACAGCTCCCATGGAGTTAGTCTGGTCACCAGATATGGATGAGAGATTCTATTCAGTGGATCAGAATCAAACTGGTACATTGATCCACTTGAGCCGTTAAGTGCTGCCAATTGTACAATATGCCCAGGCTTGCAGAATAAAGCCAACTTTTTATTGTGAATAATAATAAGGACATATTTTTCTTCAGATTATGTTTTATTTCTTTGCATTGAGTGAGGAACATAAAATGGCTTGGTAAAAGTAATAAAATCAGTACAATCACTAACTTTCCTTTGTACATATTATTTTGCAGTATAGATGAATATTACTAATCAGTTTGATTATTCTCAGAGGGTGCTGCTCTTTAATGAAAATGAAAATTATAGCTAATGTTTTTTCCTCAAACTCTGCTTTCTGTAACCAATCAGTGTTTTAATGTTTGTGTGTTCTTCATAAAATTTAAATACAATTCGTTATTCTGTTTCCAATGTTAGTATGTATGTAAACATGATAGTACAGCCATTTTTTTCATATGTGAGTAAAAATAAAATAGTATTTTTAAAAATATAGTTTGAGCACTGTATAGGTCCTTTTTTTGTTCAGACTTTTTCCAAAAATCTAAACATAATTAATATACTCTTTCAGCCACATGAATAAATAATGAGTGTTTCTTGTAGGTATTGGTTTGGAGATTGTTTTACGGTAGTATGAACTGTTAACTGGAAAAGAAACCTgagattgcagtcagccaagattgtgccactgcaccccagcctgggcaacagagactccgtctcaaaaacaaaaaagaaaagaaaCCAAGAAACCTCAGGCATGAACCTAATTTAATCTCCATGAAAGAGGTACTACAGTTCTAGAATATACCCTTTATGTTCAGGAATGCAGTCTATCATTCAGAGTTAATTTCTTTCTAGGCTCTTTGACAATCAGTTTTTCCCTGGATCAGTTCAGTACATATGCATTGAGCACCTGTGTGCCAGTCAGCCGAGCTATCAcattgcacaattctaagaagcaccattcatgtctcatcatatttctatgctctgggagttgcctttcacatagaatatgtgtgattgttatccctagaattgtgcagtgAGGCAATTGGCTAGGTGCTGTGCTGCtttttctttctttctttttttttttaagagacagagtcttgctgtgttgcccagtctggagtgcagtggtggcatgatcttgcctcactgtaacctctgcctcctgggttcaagctgttctcatgccccattctcccttgtagctgggattacaggcttacaccatcgcacttggcaaatttgtgtatttttagtagagacaggaattcaccatgttggccaggctggtcttgaactcctgacttaaagtgatccacctgctttggcctcccaaaatgctaggattataggtgtgagccactgcaccgggccATGTGCTACTTtttcttccttccatccttcctcccttcttcAGTGTAAATATGAGATTAATTTGTGATACCTTACTTTAAAGAACTTAGAGTTCAGTAAAGGAAGCAGGTATAGAaagtgctatgataaagctatacataggatggtatagaaccacagactaggggcacttaaaatgggcAAGAAAATAGCCTTTGTAAATAAAATAGAGGCAAGAGATATAATGCTTTACCTGCAAAGAGCTATAAATAcagccatgtaccatataatgatgtttcagttagtgaaggaccacatacgagggtggtcagaacagcaggctataccatatagcctaggtgtgtagtaggctataccatatagcctaggtgtgtagtagtaggctataccatatagcctaggtgtgtagtagtaggcgataccatatagcctaggtgtgtagtagtaggctataccatatagcctaggtgtatagtagtaggctataccatatagcctaggtgtgtagtaggctataccatatagcctaggtatgtagtagtaggctataccatatagcctaggtgtgtagtagtaggctataccatctggggttcctgtcagtacagtatgatgttcacataatgatgaaatcacctaacaaagcatgtctcgaaatgtatccacattgttacgtaacacatgactgTAGTTAATTGTTACAATTGAAATACTAGATGTACTCATTGAAATCCAGAATTCCCATTATCTGGATtatttaatatcgttcaggaaatttttgccagtgcaatggtgcatgaaacaatgtcttttagaaatgaggtggccagatttctatttgcagataataattgtatatctaaaaatccTAGAAAAAGAAATGATAACAAATGGAGCTACTTAACCTTTACATGTTGAATGCTGCCACTGTTAAAATTTCTGAGGGGGTATAATAGATAAACTATCCCATAGTTCATCTGGAAAAATAAGGTGGTGAAAATTGCTAAGAAATTTTTGAAAGGGTAATGTAAACCTAGATTAACTGTTTTTGAAAGGTAGTACAGAACTGAATGCACAACTAGATATCAATGGTATGTACTCACCCAGAAAAAAGACTTCAGTACATACATGTGAGGGCTTAAAACATTGTTATAAAGACGGGATCACAATGGGAAAAGGATTATTCAATAAgtagggcaggcattctctatgcctgctagggaagtgtgacttgttatactctttatgtacagcaattggcagtctgtgaaacttttaaattcatatacataaccttttgccctgcaattccacttctagaaatttatcctaccaaacaaagcacatagatgtgcaaaagtatgtatttacaagtatattctttgcaacttggtaatgtcaaagaattggaagcaacctaaatatctgccataggtaggataaccatatgctttggctttttgaacactaccagtttatacctgctgttcttggataattattaatagtgctttcattctcaatgtctcactttagataataaattacaGAGGATTGGTGAAACTAATTTGCCCAATGGaaaaaggaatgaagaagtgctttaggtactgagatgaaaagatctctaaggcataataatgtttattgagaaaagcatggtgtcaaactgtatggcatgctacaattgatgtataagaagaaaaaatgtgtatgtattcctatttgtttgtatatggtagactgtctctgaagacatatatggaagaacctgatcacattggtagtctccaaggagcagaactagatacctgggggataaggatcccaggagtgagccttttcattgtaaacttcattgtactttgagtttttaacTGTTCAAAAATAATAAAATTAGAAATAAAATATTTCAACAAACAATAAAATGGGATATTTGGGGAAGAAAGTTGTCtcagggctctccaaagaagcagaa

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