Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name FTMT
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:121852163-121852599  UCSC
Coordinates (T2T) chr5:122369030-122369466  UCSC
Coordinates (hg19) chr5:121187858-121188294  UCSC
Strand +
Parental Sequence NM_002032.3
Parental seq. overlap 351 bp
Parental seq. overlap (%) 29.2%
Genomic Region Intergenic
Retrocopy Summary FTMT, located on chr5:121852163-121852599, is a retrocopy of the parental gene FTH1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name FTH1
Full Name ferritin heavy chain 1
Also known as FHC|FTH|FTHL6|HFE5|PIG15|PLIF
Coordinate chr11:61964285-61967634
Strand -
Gene summary This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes FTH1P11
Bonobo Pan paniscus FTH1P11
Gorilla Gorilla gorilla FTH1P11
Orangutan Pongo abelii FTH1P10
Gibbon Nomascus leucogenys FTH1P3
Green monkey Chlorocebus sabaeus FTH1P13
Crab-eating macaque Macaca fascicularis FTH1P7
Rhesus Macaca mulatta FTH1P7
Baboon Papio anubis FTH1P4
Golden snub-nosed monkey Rhinopithecus roxellana FTH1P6
Marmoset Callithrix jacchus FTH1P6
Mouse lemur Microcebus murinus FTH1P5
Rat Rattus norvegicus Fth1P6
Chinese hamster Cricetulus griseus Fth1_1P1
Cow Bos taurus FTH1P4
Dolphin Tursiops truncatus FTH1P6
Dog Canis familiaris LOC102152958P1
Panda Ailuropoda melanoleuca FTH1P2
Cat Felis catus FTH1P1
Sloth Choloepus didactylus FTH1P75
Mouse Mus musculus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Sheep Ovis aries Without Homology
Horse Equus caballus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>FTMT
GGGTGCGCCAGAACTTCCACCCCGACTCCGAGGCTGCCATCAACCGCCAGATCAACCTCGAGCTCTATGCGTCCTACGTGTACTTGTCCATGGCCTATTACTTCTCCCGGGATGACGTGGCCTTGAACAACTTCTCCAGGTATTTCCTTCACCAGTCCCGGGAGGAGACCGAGCACGCGGAGAAGCTGATGAGGCTGCAGAACCAGCGAGGAGGCCGGATCCGCCTGCAGGACATCAAGAAGCCGGAACAGGACGACTGGGAAAGCGGGCTGCATGCCATGGAGTGTGCTCTACTCTTGGAAAAGAACGTGAACCAGTCGTTGCTGGAATTGCACGCTCTAGCCTCAGATAAAGGTGACCCCCATTTGTGCGATTTCCTGGAAACCTACTACCTGAATGAGCAGGTGAAGTCTATCAAAGAACTAGGTGACCACGTG
>NM_002032.3
GCCAGACGTTCTTCGCCGAGAGTCGTCGGGGTTTCCTGCTTCAACAGTGCTTGGACGGAACCCGGCGCTCGTTCCCCACCCCGGCCGGCCGCCCATAGCCAGCCCTCCGTCACCTCTTCACCGCACCCTCGGACTGCCCCAAGgcccccgccgccgctccagcgccgcgcagccaccgccgccgccgccgccTCTCCTTAGTCGCCGCCATGACGACCGCGTCCACCTCGCAGGTGCGCCAGAACTACCACCAGGACTCAGAGGCCGCCATCAACCGCCAGATCAACCTGGAGCTCTACGCCTCCTACGTTTACCTGTCCATGTCTTACTACTTTGACCGCGATGATGTGGCTTTGAAGAACTTTGCCAAATACTTTCTTCACCAATCTCATGAGGAGAGGGAACATGCTGAGAAACTGATGAAGCTGCAGAACCAACGAGGTGGCCGAATCTTCCTTCAGGATATCAAGAAACCAGACTGTGATGACTGGGAGAGCGGGCTGAATGCAATGGAGTGTGCATTACATTTGGAAAAAAATGTGAATCAGTCACTACTGGAACTGCACAAACTGGCCACTGACAAAAATGACCCCCATTTGTGTGACTTCATTGAGACACATTACCTGAATGAGCAGGTGAAAGCCATCAAAGAATTGGGTGACCACGTGACCAACTTGCGCAAGATGGGAGCGCCCGAATCTGGCTTGGCGGAATATCTCTTTGACAAGCACACCCTGGGAGACAGTGATAATGAAAGCTAAGCCTCGGGCTAATTTCCCCATAGCCGTGGGGTGACTTCCCTGGTCACCAAGGCAGTGCATGCATGTTGGGGTTTCCTTTACCTTTTCTATAAGTTGTACCAAAACATCCACTTAAGTTCTTTGATTTGTACCATTCCTTCAAATAAAGAAATTTGGTACCCAGGTGTTGTCTTTGAGGTCTTGGGATGAATCAGAAATCTATCCAGGCTATCTTCCAGATTCCTTAAGTGCCGTTGTTCAGTTCTAATCACACTAATCAAAAAGAAACGAGTATTTGTATTTATTAAACTCATTAGTTTGGGCAGTATACTAAGGTGTGGCTGTCTTGGATTCAGATAGAACTAAGGGTTCCCGACTCTGAATCCAGAGTCTGAGTTAAATGTTTCCAATGGTTCAGTCTAGCTTTCACAGTTTTTATGAATAAAAGGCATTAAAGGCTGAA

Publications

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