Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPS15AP18
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:179933790-179934170  UCSC
Coordinates (T2T) chr5:180488788-180489168  UCSC
Coordinates (hg19) chr5:179360790-179361170  UCSC
Strand -
Parental Sequence NM_001019.5
Parental seq. overlap 329 bp
Parental seq. overlap (%) 14.9%
Genomic Region Intragenic (RNF130)
Retrocopy Summary RPS15AP18, located on chr5:179933790-179934170, is a retrocopy of the parental gene RPS15A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPS15A
Full Name ribosomal protein S15a
Also known as DBA20|S15a
Coordinate chr16:18781295-18790334
Strand -
Gene summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RPS15AP17
Bonobo Pan paniscus RPS15AP17
Gorilla Gorilla gorilla RPS15AP16
Orangutan Pongo abelii LOC112133765P2
Gibbon Nomascus leucogenys RPS15AP6
Green monkey Chlorocebus sabaeus LOC103228971P30
Crab-eating macaque Macaca fascicularis RPS15AP18
Rhesus Macaca mulatta RPS15AP19
Golden snub-nosed monkey Rhinopithecus roxellana RPS15AP6
Marmoset Callithrix jacchus RPS15AP6
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPS15AP18
TGCTCTCAAGAGCATCCACAATGTCTAAAGGAGAGGCAAACACCAGGTTCTTATTAGGCCGTGCTTCAAAGTCGTCTTCCGGTTTCTAACTGCGGTGATGAAGCATGATTCCACTGGCAAATCTGAAATCTGATCGTCACAGAGCTGGGAACACTGTTGTGAGCTTCACAGGCAGGTTAAACAAGTGTGCCATAATCAGCCCCAACTTGGAGGTGCAGCTCAAAGATCTAGAAAAAATGGCAGAACAGTCTGCTCCCATTCTGACAGTTTGGATTCATTTTACTAACAACCTCAGCTGGCAACATGGACCATGAAGAAGCAAGACAAAAACACACAGGAGGGAAAATCCTGGGATTCTTTATCTAGTGATGTAATACATAC
>NM_001019.5
CTCTTTCCGCCATCTTTCCGCGCCGGTGAGTAGCACTCTCTGAGAGCTCCAATTTCATCCGTCTGCCATCGGCGCCATCCTGCAATCTAAGCCACAATGGTGCGCATGAATGTCCTGGCAGATGCTCTCAAGAGTATCAACAATGCCGAAAAGAGAGGCAAACGCCAGGTGCTTATTAGGCCGTGCTCCAAAGTCATCGTCCGGTTTCTCACTGTGATGATGAAGCATGGTTACATTGGCGAATTTGAAATCATTGATGACCACAGAGCTGGGAAAATTGTTGTGAACCTCACAGGCAGGCTAAACAAGTGTGGGGTGATCAGCCCCAGATTTGACGTGCAACTCAAAGACCTGGAAAAATGGCAGAATAATCTGCTTCCATCCCGCCAGTTTGGTTTCATTGTACTGACAACCTCAGCTGGCATCATGGACCATGAAGAAGCAAGACGAAAACACACAGGAGGGAAAATCCTGGGATTCTTTTTCTAGGGATGTAATACATATATTTACAAATAAAATGCCTCATGGACTCTGGTGCTTCCACTTGGTCGTTTTGAGCCTTTACAGCAGTGTAGCCACAGCTTCTGCGGCAGCATGCAGTTGCTTCGTTTATCGGTGAATGCGATTCCCTGAAGTGACTAATACAGCCAAGGGAAAAAGTTCTTATGAAACCAGTATGCCTAAGAAACAGTCACCCCTGCTGTCTGCCAAAACCAGGTATTTGACACTAAATATTTTAGTTGTATTTCAGtttttttttttttttttcttttttggagacagagtctgactctattgctcaggctggagtgcagtggcgcgatcttggcccactgcaacctccacctcccgggttcaagtgattgtcctgtctcagccgcctgagtaactgggattacaagtgtgtgtcgccacatccggctaatttttatattttagtagagacagggtttcgccatgttgcccaggctggtcttgagttctgggcctcaagtgatcagcctacctcggcctcccgaagtgctgggattacagccacgagccattacacctggccTATATTTCAGTATTTTCTATTAGTTTTTGATGAATTTGTTTTGCCTGGCTAGGATTATTCTGTAGATAGGATTTTAGATCTGGCTTTTGTCACTGACTGCTGTAATAAATACTTGCTAGGAAtttttttttttttttttttttttttaagacaaagtcgctctgtcacacaggctggagtgcagtggcatgatcttggctcactgcacctccgcttcccagattcaagtagttctcgtgcctcagcctcctgagtagctgggattacaggtgtgtgccaccatgtctggctgatttttgtatttttagtagaggtggggtttcaccatgttggccaggctggtctcgaactcctgatctcaagtgatctgcctgccttggtctcccaaagtgctgggattacaggtgtgaccaccacgccctgccTTAAGAATTGTTCCAAGAGAATCTGGTGCCACTTGCAGGTGCCCATTGAAGTGCAATGGGCACTGTTGATCACTGAGGAGGTAGTGGGTGCTGACCCGGTGCTGGGGCCTGTCCCCTAGTCTCTGCTTTGCCCTTGGCTAGCTAGGTGGTGTGCCAAGTGGGGAGAGAAGCTACCTTATTAAGGGGCATGGATCAGCTTCCTGAAAGGAGGGCCTGCCTCTGTAAGATATGGGAAGTCGCTGAGAATGTTACAGAACGGCCCTAGAGATGGGGCAGATAACGGCCCCCATTTGTGAGAAGTGAGTTGGGAGGCATGTTTGGGGCCTCTGATGTTTGGGAGGCTGTGGGTAATTAACATGAGTTTTGGGGTCCAGCAGCAGAATTCAGGTTTCCTCTTccactcagtaacctcagcatccgtatctgtaatgggaatgatacaaaacctatccccaagttgagggaaaaatgagattgtgtaaagcgcacttggcacatgacagtcacaAGCATGGGGACAGTGAGTCCAGAAGGATTTTCTTATGCCAGCattgtaagccctaggatcacagggctctggcttgtttaaccatcgtgtctctggtccctagcctgcaaacctggtgtgtagggatgcctcagtcgcttacatgttgattgagtgaatCGTCGGTTTCTTTCTGGACACTGACTTCAAAAATAAAATAGGATATGAAAATGG

Publications

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