Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HNRNPH1P3
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:55837982-55840064  UCSC
Coordinates (T2T) chr5:56666273-56668354  UCSC
Coordinates (hg19) chr5:55133810-55135892  UCSC
Strand -
Parental Sequence NM_001364247.2_2
Parental seq. overlap 1894 bp
Parental seq. overlap (%) 87.6%
Genomic Region Intergenic
Retrocopy Summary HNRNPH1P3, located on chr5:55837982-55840064, is a retrocopy of the parental gene HNRNPH1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HNRNPH1
Full Name heterogeneous nuclear ribonucleoprotein H1
Also known as HNRPH|HNRPH1|NEDCDS|hnRNPH
Coordinate chr5:179614178-179634784
Strand -
Gene summary This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HNRNPH1P1
Bonobo Pan paniscus HNRNPH1P2
Gorilla Gorilla gorilla HNRNPH1P4
Orangutan Pongo abelii HNRNPH1P2
Gibbon Nomascus leucogenys HNRNPH1P2
Green monkey Chlorocebus sabaeus HNRNPH1P1
Crab-eating macaque Macaca fascicularis HNRNPH1P1
Rhesus Macaca mulatta HNRNPH1P2
Baboon Papio anubis HNRNPH1P1
Golden snub-nosed monkey Rhinopithecus roxellana HNRNPH1P1
Marmoset Callithrix jacchus HNRNPH1P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HNRNPH1P3
GTGTCTGGTCTGTTTTGACACCAGACCAGGTAAGAGACAATGATGTTGGGCACCAAAGGTGGCGAGGGGTTTATGTTGAAGGTCCACGGCTTGCCCTGGTCTTGCTTGGCCGATGAAGTGCAGCGTTTCTTCTGACTGCAAAATTCAAAATAAGGCTCAAGGTATTCGTTTCATCTACAACAGAGAAGGCAGGCTGGGTGACAAGGCTTTTGTTGAACTTGAATCAGAAAATGAAGTCAAATTGGCCCTGAAAAAGGACAGAGAAACTATGGGACACAGTTTTGTTGAAGCATTCAAGTCAAACAACGTTGAAATGGATTGGGTGTTGAAGCATACCGGTCGAAATAGTCCTGACACGGCCAATGATGGCTTTGTACAGCTTAGAGGACTTCCCTTTGAATGCAGCAAGGAAGAAATTGTTCAGTTCTTCTCAGGGTTGGAAATCGTGCCAAATCGGATAACATTGCCAGTGGACTCCAGGGGAGGAGTATAGGGGAGGTCTTCGTGCAGTTTGCTTCGCAGAAAATAACCGAAAAGGCTCTAAAGAAACACAAGGAAAGAATAGGGCACAGGTATATTGAAATCTTTAAAAGCAGCAGGGCTGAAGTTGGAACTCACTACAATCCACCATAAAAGCTTATGGCCATGCGGCGGCCAGGTCCCATGACAGACCTGGTTCTGGCAGAGGTTTTAACAGCATTGGCAGAGGAGCTGGCTTTCAGAGGATGAGGCATGGTGCTTATGGTGGAGGATATGGAGCCTGTGACAATTATAATGGCTATGGCTATGGATTTGGGTCAGATAGATTTGGAAGAGACCTCAATTATTGTTTTTCAGGAATGTCTGATCACAAATATGGGGATGGTGGCTCTACCTTCCAGAGCACAACAGGACACTGTATATACGTGTGGATTACCTTACAGAGCTACTGAGAATGACATTTGTAATTTTTTTGACTGCTCAATGCTGTGAGGGTACACATTGAAATTGGTCCTGATGGCAGAGTAACTGGTGAAGCAGATGTTGAGTTTGCAACTCATGAAGATGCTGTGGCAGCTATGTCAAAAGACAAAGCAAATATGCAACACAGCTATGTAGAACCCTTCTTGAATTGTGCAGCAGGAGCCAGCGGTACTGCTTACGGTAGCCAAATGATGGGGGGCATGGGCTTGTCAATCCAGTCCAGTTATGGTGGCCCAGCCAGCCCGCAGCTGAGTGGTGGTTATGGAGGTGGCTATGGTGGCCACAGCAGCATGAGTGGATTTGACCAAGTTTTACAGGAAAACTCATGTGATTTTCAATCAGACATTGCATAGGTAGCCAAGGAGCAATGAACAGCAGCTACTACAGTAATGGAAGCTGTGCATCTATAGGTGTGAATGGAATGGGAGGGATGTCTACCATGTCCAGTATGAGTGGTGGATGGGGAATATAATTGATCACTGACCCTTGCTCAATTTTTTTTTTAAGAAAAACCCAAAACTTCAGTTTAACAGTTTCTGCAATACAAACTTATGATTTATGCTTACTCTCTAAGTAGAAATCAGGATTGTTATGAAGACTTAAGGCTCAGTATTTTTTAACACAATACTCATCTAGGATGTAACACTGAAGTTGAGTAAACTATAACTGTTAAACAAGTTCCAGCTTTGCTCAAGTTAGTTATATTATAGGATGTTCTTAAGCAGTAAGTGTATTGAGGTAAAAGGAGTTGAATTATGTTCACTGTTGCCCTTTGCTACATTACATTGAACACTGTGTAGATGCATGCTGAAAGACATGGGTTTTTTTGTTGTAAAACTCAATATAGGAGCTGTGTCTGTCTACAATTAAAGTGAAACATTTTGGCTTCTTTGTTAATTCTAGTTTTATTTAATAACCTGTAAGGCACATAAGTTTAAGTTTTGTTTTTTTTTAAGTTAATGGGAAAAATTTGAGATGCAATACCAATACTTTAGGATTTTGGTCTTGATGTTTGTATGAGATTCTGAGGCCTTGATTTAAGTCTTCCATTGTACTGTGATTTCCTTTTACGTATATTGAGCTAAGTAAAACTTGTCAAATAAATCCTCATTTTTAAAAA
>NM_001364247.2_2
CATTTCGTCTTAGCCACGCAGAAGTCGCGTGTCTAGTTTGTTTCGACGCCGGACCGCGTAAGAGACGATGATGTTGGGCACGGAAGGTGGAGAGGGATTCGTGGTGAAGGTCCGGGGCTTGCCCTGGTCTTGCTCGGCCGATGAAGTGCAGAGGTTTTTTTCTGACTGCAAAATTCAAAATGGGGCTCAAGGTATTCGTTTCATCTACACCAGAGAAGGCAGACCAAGTGGCGAGGCTTTTGTTGAACTTGAATCAGAAGATGAAGTCAAATTGGCCCTGAAAAAAGACAGAGAAACTATGGGACACAGATATGTTGAAGTATTCAAGTCAAACAACGTTGAAATGGATTGGGTGTTGAAGCATACTGGTCCAAATAGTCCTGACACGGCCAATGATGGCTTTGTACGGCTTAGAGGACTTCCCTTTGGATGTAGCAAGGAAGAAATTGTTCAGTTCTTCTCAGGGTTGGAAATCGTGCCAAATGGGATAACATTGCCGGTGGACTTCCAGGGGAGGAGTACGGGGGAGGCCTTCGTGCAGTTTGCTTCACAGGAAATAGCTGAAAAGGCTCTAAAGAAACACAAGGAAAGAATAGGGCACAGGTATATTGAAATCTTTAAGAGCAGTAGAGCTGAAGTTAGAACTCATTATGATCCACCACGAAAGCTTATGGCCATGCAGCGGCCAGGTCCTTATGACAGACCTGGGGCTGGTAGAGGGTATAACAGCATTGGCAGAGGAGCTGGCTTTGAGAGGATGAGGCGTGGTGCTTATGGTGGAGGCTATGGAGGCTATGATGATTACAATGGCTATAATGATGGCTATGGATTTGGGTCAGATAGATTTGGAAGAGACCTCAATTACTGTTTTTCAGGAATGTCTGATCACAGATACGGGGATGGTGGCTCTACTTTCCAGAGCACAACAGGACACTGTGTACACATGCGGGGATTACCTTACAGAGCTACTGAGAATGACATTTATAATTTTTTTTCACCGCTCAACCCTGTGAGAGTACACATTGAAATTGGTCCTGATGGCAGAGTAACTGGTGAAGCAGATGTCGAGTTCGCAACTCATGAAGATGCTGTGGCAGCTATGTCAAAAGACAAAGCAAATATGCAACACAGATATGTAGAACTCTTCTTGAATTCTACAGCAGGAGCAAGCGGTGGTGCTTATGGTAGCCAAATGATGGGAGGCATGGGCTTGTCAAACCAGTCCAGCTACGGGGGCCCAGCCAGCCAGCAGCTGAGTGGGGGTTACGGAGGCGGCTACGGTGGCCAGAGCAGCATGAGTGGATACGACCAAGTTTTACAGGAAAACTCCAGTGATTTTCAATCAAACATTGCATAGGTAACCAAGGAGCAGTGAACAGCAGCTACTACAGTAGTGGAAGCCGTGCATCTATGGGCGTGAACGGAATGGGAGGGTTGTCTAGCATGTCCAGTATGAGTGGTGGATGGGGAATGTAATTGATCGATCCTGATCACTGACTCTTGGTCAACCttttttttttttttttttttttctttAAGAAAACTTCAGTTTAACAGTTTCTGCAATACAAGCTTGTGATTTATGCTTACTCTAAGTGGAAATCAGGATTGTTATGAAGACTTAAGGCCCAGTATTTTTGAATACAATACTCATCTAGGATGTAACAGTGAAGCTGAGTAAACTATAACTGTTAAACTTAAGTTCCAGCTTTTCTCAAGTTAGTTATAGGATGTACTTAAGCAGTAAGCGTATTTAGGTAAAAGCAGTTGAATTATGTTAAATGTTGCCCTTTGCCACGTTAAATTGAACACTGTTTTGGATGCATGTTGAAAGACATGCTTTTATTTTTTTGTAAAACAATATAGGAGCTGTGTCTACTATTAAAAGTGAAACATTTTGGCATGTTTGTTAATTCTAGTTTCATTTAATAACCTGTAAGGCACGTAAGTTTAAGCTTTTTTTTTTTTTAAGTTAATGGGAAAAATTTGAGACGCAATACCAATACTTAGGATTTTGGTCTTGGTGTTTGTATGAAATTCTGAGGCCTTGATTTAAATCTTTCATTGTATTGTGATTTCCTTTTAGGTATATTGCGCTAAGTGAAACTTGTCAAATAAATCCTCCTTTTAAAAACtgca

Publications

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