Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SEM1P1
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr5:81892449-81892885  UCSC
Coordinates (T2T) chr5:82377074-82377510  UCSC
Coordinates (hg19) chr5:81188268-81188704  UCSC
Strand +
Parental Sequence NM_006304.2
Parental seq. overlap 398 bp
Parental seq. overlap (%) 82.4%
Genomic Region Intergenic
Retrocopy Summary SEM1P1, located on chr5:81892449-81892885, is a retrocopy of the parental gene SEM1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SEM1
Full Name SEM1 26S proteasome subunit
Also known as C7orf76|DSS1|ECD|PSMD15|SHFD1|SHFM1|SHSF1|Shfdg1
Coordinate chr7:96484175-96709846
Strand -
Gene summary The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SEM1P1
Bonobo Pan paniscus SEM1P1
Gorilla Gorilla gorilla SEM1P1
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SEM1P1
GTTTTCTGCTGATCTGGGAGGTGTTGGGCGCAGACAGTCGAGATGTCAGAGAAAAAGCAGCCGGTAGACTTAGGTTTCTTAGAGGAAGATGACGAGTTTGAAAAGTTCCCTGCCGAAGACTGGGCTGACTTAGATGCAGATGAACATGCACATGTCTGGGAGGATAATTGGGATGATGACAATGTAGAGGATGACTTCTCTAATCAGTTACGTGATGTTCTTTCTGTTTTATCATAGAGCTGAACTAGAGAAACATGGTTATAAGATGGAGACTTCATAGCGTCCAGAAGAAGTGTTGAAGTAACCTAAACTTGACCTGCTTAATACATTCTAGGACAGAGAACCCAGGATGGGACACTAAAAAAATAAGTTTATTTCATTATCTGCTTGGATTTATTTGTGTTTTTGTAACACAAAAAATAAATGTTTTGATATAA
>NM_006304.2
AGTGACGGTGGCGTTTCCTTGAGGAAGAGTGAGGGTTCCAACTTTTCTGCTTATCTGGGAGGTGTTGGGCGCGGACAGTCGAGATGTCAGAGAAAAAGCAGCCGGTAGACTTAGGTCTGTTAGAGGAAGACGACGAGTTTGAAGAGTTCCCTGCCGAAGACTGGGCTGGCTTAGATGAAGATGAAGATGCACATGTCTGGGAGGATAATTGGGATGATGACAATGTAGAGGATGACTTCTCTAATCAGTTACGAGCTGAACTAGAGAAACATGGTTATAAGATGGAGACTTCATAGCATCCAGAAGAAGTGTTGAAGTAACCTAAACTTGACCTGCTTAATACATTCTAGGGCAGAGAACCCAGGATGGGACACTAAAAAAATGTGTTTATTTCATTATCTGCTTGGATTTATTTGTGTTTTTGTAACACAAAAAATAAATGTTTTGATATAATCTTG

Publications

PMID - Link Title