Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SSXP10
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:118589033-118590175  UCSC
Coordinates (hg19) chr6:118910196-118911338  UCSC
Strand +
Parental Sequence NM_005635.4
Parental seq. overlap 947 bp
Parental seq. overlap (%) 76.6%
Genomic Region Intragenic (CEP85L)
Retrocopy Summary SSXP10, located on chr6:118589033-118590175, is a retrocopy of the parental gene SSX1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SSX1
Full Name SSX family member 1
Also known as CT5.1|SSRC
Coordinate chrX:48255392-48267444
Strand +
Gene summary The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX2 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SSX1P1
Bonobo Pan paniscus SSX2BP1
Gorilla Gorilla gorilla LOC101153153P1
Orangutan Pongo abelii LOC100440684P1
Gibbon Nomascus leucogenys LOC100587351P1
Rhesus Macaca mulatta LOC106995770P1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SSXP10
GCTGCTTCGTCTCCGAGGTCAGACTGCTCCCAATGCCATGAACGGAGACAGCACCTTTGCAAAGAGACCCAGGGATGATGCTCAGATATCAGAGAAGAAACACAAGGCCTTCAATGATATTGCCAGATACTTATCTAATAAAGAGTGGGGAAAGCTGAAAAACTCAGAGAAAATCACCTATGTGTATATGAAGAGAAACTATGAGACCATGACTAAACTAGGTCTCTAGGCCACCCTCCCAACTTTCATGTACAATAAATGGGCTGCAGAATTCCAGGGGAATGATTCTGATATAGACTAAAACTGCAGGAATCAGGATGAATATCCTCAGATGGCTTTCGGCATGCTACAAGGGAACTTTCCAAAGATGATGCCCAAGAAGCCAGCAGAGGAAGGAAATGATTTGAAGGGAGTGCCAGAAACATCTGGCTCACAAAACAATGGGAAACAGCTGTGTCCCCTGGGAAAAGAAAGTACCTCTGAGAAGACTAACAAGACATCTAGACCCAAGAAAAGGGGGAACACGTCTGGACCCACGGACTGCGAGAGAGAAAGTATCTAGTGATTTATGAAGAGATCAGAAACCCTGAGGAAGATGACAAATAACTCCCCTCAGGGATAGGATGCAAGCCCATGATGAGAAGCAGAAACTGGTGACCTTCTATGAACATGGGCATGGCTGCGAACCCCTCATCATCAGGTGTATAGCAAGTGAAAGCAGGAGTTCACGACAGTGAAAAGTTGAGCGTCATTTTTCTTACAGTGTGCCAAGAGTTAGATATTAGCATTTTCATTGTATTTTCTTACAGTGTGCCATCCTGTTAGATATTTGCATTTTTGTTGATGAATGAGACATAGTTAATGCATATTTCTGTTTGTGTATCCATGCACCTACCTCAGAAAACAAGTATTGTCAGGTATTCTCTGCATAGAACAGCACTACCCTCCTCTCTCCCCAGATGTGACTATTGAGGCCAGTTCTGGGTGTTTCAGATTTTTTTTCTCTGCATTTcGTGGAATACCACTATAAATATCTCCATCTGCTTTTCCCCATCGCTAATGAGTCCTGGTCAAGCCCCCCTCACTCTGTTTCCTGTTCAACATGCACTCCC
>NM_005635.4
ACCACTGCTGCCGACCTCGCAACCACTGCTTTGTCTCTGAAGTGAGACTGCTCCTGGTGCCATGAACGGAGACGACACCTTTGCAAAGAGACCCAGGGATGATGCTAAAGCATCAGAGAAGAGAAGCAAGGCCTTTGATGATATTGCCACATACTTCTCTAAGAAAGAGTGGAAAAAGATGAAATACTCGGAGAAAATCAGCTATGTGTATATGAAGAGAAACTATAAGGCCATGACTAAACTAGGTTTCAAAGTCACCCTCCCACCTTTCATGTGTAATAAACAGGCCACAGACTTCCAGGGGAATGATTTTGATAATGACCATAACCGCAGGATTCAGGTTGAACATCCTCAGATGACTTTCGGCAGGCTCCACAGAATCATCCCGAAGATCATGCCCAAGAAGCCAGCAGAGGACGAAAATGATTCGAAGGGAGTGTCAGAAGCATCTGGCCCACAAAACGATGGGAAACAACTGCACCCCCCAGGAAAAGCAAATATTTCTGAGAAGATTAATAAGAGATCTGGACCCAAAAGGGGGAAACATGCCTGGACCCACAGACTGCGTGAGAGAAAGCAGCTGGTGATTTATGAAGAGATCAGTGACCCTGAGGAAGATGACGAGTAACTCCCCTGGGGGATACGACACATGCCCTTGATGAGAAGCAGAACGTGGTGACCTTTCACGAACATGGGCATGGCTGCGGCTCCCTCGTCATCAGGTGCATAGCAAGTGAAAGCAAGTGTTCACAACGGTGAAACTTGAGCGTCATTTTTCTTAGTGTGCCAAGAGTTCGATGTTAGTGTTTCCATTGTATTTTCTTACAGTGTGCCATTCTGTTAGATACTATCCTTATAATTGATGAGCAAGACATACTGAATGCATATTTCGGTTTGTGTATCCATGCACCTACGTCAGAAAACAAGTATTGTCAGGTATTCTCTCCATAGAACAGCACTATCCTCATctctccccagatgtgactactgagggcagttctgagtgtttaatttcagactttttcctctgcatttacacacacacacacacacacacgcacacacacacacCAAGTACCAGTATAAGCATCTCCCATCTGCTTTTCCCATTGCCATGCGTCCTGGTCAAGCCCCCCTCACTCTGTTTCCTGTTCAGCATGTACTCCCCTCATCCGATTCCCCTGTATCAGTCACTGACAGTTAATAAACCTTTGCAAACGTTC

Publications

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