RCPedia: Rtcs

Summary

Retrocopy Name	TBL1XR1P1	Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr6:127658608-127659906 UCSC
Coordinates (T2T)	chr6:128847539-128848837 UCSC
Coordinates (hg19)	chr6:127979753-127981051 UCSC
Strand	-
Parental Sequence	NM_001374327.1
Parental seq. overlap	834 bp
Parental seq. overlap (%)	10.3%
Genomic Region	Intergenic
Retrocopy Summary	TBL1XR1P1, located on chr6:127658608-127659906, is a retrocopy of the parental gene TBL1XR1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	TBL1XR1
Full Name	TBL1X/Y related 1
Also known as	C21\|DC42\|IRA1\|MRD41\|TBLR1
Coordinate	chr3:177019344-177197482
Strand	-
Gene summary	This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	TBL1XR1P1
Bonobo	Pan paniscus	TBL1XR1P1
Gorilla	Gorilla gorilla	TBL1XR1P1
Orangutan	Pongo abelii	Without Homology
Gibbon	Nomascus leucogenys	Without Homology
Green monkey	Chlorocebus sabaeus	Without Homology
Crab-eating macaque	Macaca fascicularis	Without Homology
Rhesus	Macaca mulatta	Without Homology
Baboon	Papio anubis	Without Homology
Golden snub-nosed monkey	Rhinopithecus roxellana	Without Homology
Marmoset	Callithrix jacchus	Without Homology
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>TBL1XR1P1
CAGAAAGAAATATATACATACAATGTATATAAACAAAATTGCACCCTGAAGATGACAGTTTTGTCACAGCTTGTGAATTCTGTTCACCAAGTGCTGGAATCTAATCTACTGTGCCCCTAAAATAGCATTTAGAAGTTTTGGATATGAAAAACAGAAGAGAGAAAAATACACATTATAAAAGCAGAACATACATGTACCAGTTTTTGGATACCACCTGACAGCCTCGTTTCTCCCCTTTGAATCCGCAGACACCAAGGATTATATTCTTTTTTCCCTTCAGTAGTGAGCAGTTTGTATGTACAGAGAAAATGGACACAAAAACTTGCAGTGGTAGTTTGTTCTTGCTTTAAAATTTTGTTTTTGGTTTAGATTATGGGTGCATGAAGTAAGGGAATGAATCAGTTTCTTGTTTATATTTTTTCAGCTTTTAAACAACAAAAAATTCTTTAAAATATTTTAATGCATTCTTTTGAAGAGGTAGATGTTTGGTACATTTTATGGCTCCCAGAGCACATATTCAATTGGTGCATGTTGTGGAAGGGAGAATTGGAAATTAAATGAAAACATGACTTTGGTCATGTCAGTCTGTAAGACACATCCATAAAAGGTGTATTAAGCCTGTGTACAGTGTAGCTTTCAGTCCTGATGGCCGGTATCTGGCCAGCAATTCTTTTGACAAATGTGTACACATCTGGAACACACAGACAGGTGCTCTAGTTCACACTGTAGGGGAACAGATGGAATTTTTGAAGTTTGCTGGAATGCCGCAGGAGACAAAGTTGGAGCCAGTGCATCAGATGGTTCAGTTTGTGTATTAGACTTTCGGAAATAGCGCTACTAGTTGGAAGCCATGGACCAACTATGAATGTGTACATAGCCAAAATGACTGTCCCTGACCCACGTACTGCTATAGTCCCACTTGAACCATGGCCAGTCGACTACAGCCAAATCTAAAAGAAATATAg

>NM_001374327.1
GAACCGTTTGGCTCTTTCCCTTAGTAACAGCTTTTACCTTCTGCCTCAATTCCTCTCCCCGCTCGCGCCCTTCCCCCGCGCGCCGCCTCCCCCCGCCGCCGGCCGCGTGCGCCCCCGCCCCTCCCCCCGCGGCGGGAGCACCTCCGCTCGCCACCTGGGGACCCGCGCCGCGCTCCCCGCCCCCGCCCGCCCGGCGCCCATCCCCCGCGCCCTCCGCTCGCTGGGGTTATAATTGCCTCTCACCCCCCGGAGGGGTTATTTTGGGGGTGGTTggaggcggtggcggcggcggcgAGGAGGGGAATTTCCTTGTGCCTCCATTCCCGGGAGGGGGGAGCGGCGTTGGAGGCCACCGTTTCCAGGGTTATATCCTGTGTTGTGACCTCATGGTTTAAGTGGGAATAAAGATGAGTATAAGCAGTGATGAGGTCAACTTCTTGGTATATAGATACTTGCAAGAGTCAGGATTTTCTCATTCAGCATTTACCTTTGGTATAGAAAGCCATATCAGTCAGTCCAATATAAATGGTGCCCTCGTCCCACCCGCTGCATTGATTTCTATCATCCAGAAAGGTCTACAGTATGTAGAAGCAGAAGTTAGTATTAATGAGGATGGTACCTTGTTTGATGGTCGACCAATAGAGTCTCTGTCCCTGATAGATGCCGTAATGCCTGATGTAGTACAAACAAGACAACAAGCTTATAGAGATAAGCTTgcacagcaacaggcagcagctgctgcagctgccgcagctgcagccagcCAACAAGGATCTGCAAAAAATGGAGAAAACACAGCAAATGGGGAGGAGAATGGAGCACATACTATAGCAAATAATCATACTGATATGATGGAAGTGGATGGGGATGTTGAAATCCCTCCTAATAAAGCTGTTGTGTTGCGGGGCCATGAATCTGAAGTTTTTATCTGTGCCTGGAACCCTGTTAGTGATCTCCTAGCATCAGGGTCTGGAGACTCAACAGCAAGAATATGGAATCTTAGTGAGAACAGCACCAGTGGCTCTACACAGTTAGTACTTAGACATTGTATACGAGAAGGAGGGCAAGATGTTCCAAGCAACAAGGATGTCACATCTCTAGATTGGAATAGTGAAGGTACACTTCTAGCAACTGGTTCCTATGATGGGTTTGCCAGAATATGGACTAAAGATGGTAACCTTGCTAGCACCTTAGGGCAGCATAAAGGCCCTATATTTGCATTAAAATGGAATAAGAAAGGAAATTTCATCCTAAGTGCTGGAGTAGACAAGACTACAATTATTTGGGACGCACATACTGGTGAAGCCAAGCAACAGTTTCCTTTTCATTCAGCACCAGCATTGGATGTTGATTGGCAGAGCAACAACACCTTTGCTTCTTGTAGTACAGATATGTGCATTCATGTCTGTAAATTAGGACAAGACAGACCTATTAAAACATTCCAAGGACATACGAATGAAGTAAATGCTATCAAATGGGACCCAACTGGCAATCTCTTGGCCTCCTGTTCTGACGACATGACTTTAAAGATATGGAGTATGAAACAAGACAATTGTGTCCATGATTTGCAAGCACATAATAAAGAAATTTATACTATCAAATGGAGTCCAACAGGACCAGGGACTAATAATCCAAATGCCAACCTTATGTTAGCAAGTGCATCCTTTGATTCTACTGTTAGGTTATGGGATGTAGACCGAGGGATATGCATCCATACCTTGACAAAACACCAAGAGCCTGTGTACAGTGTAGCTTTCAGTCCTGATGGCAGGTATCTGGCAAGTGGTTCTTTTGACAAATGTGTACACATCTGGAACACGCAGACAGGTGCTCTAGTTCACAGCTATAGGGGAACAGGTGGAATATTTGAAGTTTGCTGGAATGCAGCAGGAGACAAAGTTGGAGCCAGTGCATCAGATGGTTCAGTTTGTGTATTAGACCTTCGGAAATAGCGCTACTAGTTGGAAGCCATGGACCGACTATGAATGTGTACATAGCCAAAATGACTGTCCCTGACCCATGTACTGCTATAGTCCCACTTGAACCATGGCCAGTCCACTACAGCCAAATCTAAAAGAAATATATACATACAGTGTATATAAACAAAATTGCACCCTGAAGATGACAGAGTTTTGTCACAGCTTGTGAATTCTGTTCACCAAGTGCTGGAATCTAATCTGCTGTGCCCCTAAAATAGCATTTAGAAGTTTTGGATATGAAAAACAGAAGAGAGAAAAATATACATTATAAAAGCAGAACATACATGTACCAGTTTTTGGATACTAAATGACAGCCTTGTTTCTCCCCTTTGAATCAGCAGACACCATGGATTATATTCTTTTTTTCCCTTCAGTAGTGAGCAGTTTGTATGTACAGAGAAAATGGACTTACAAAAACTTGCAGCAGTAGTTTGTTCTTGCTTTAAAATTTCGTTTTTGGTTTAGATTATGGATGCATGAAGTAAGGGAGTGAATCAGTTTCTTGTTTATATTTTTTTCACCTTTTAAACAAAAAATTCTTTAAAATATTTTAATGCATTCTTTTGAAGAGGTAGATGTTTGGTACATTTTATGGCTCCCAGAGCATATATTCAGTTGGTGCATGTTGTGGAAGGGGGAATTGGAAATTAAATGAAAACCTATGACTTTGGTCATGTCAATCTGTAAGACACATCAGTAAAAGGGTATTATGCTCTGTTGGttttgtttttttgttttgctttttttttttttttttcttttttgttttttgGTGATGTGGCTTAAATGCAATAGTTTCTTTTTTGGGACATATTTCTGCCAATTAAAGACTAGAAGGGCACAACTTTTTTTTTAATTACCATAGAGAAGATACATTAAAAAAAATCTTCTGATGTTTTGTAGCCATAACTAAATTATGGTAAAAATGTGCACTATTGTGAAAAGGAGCAACGTAgttttgggttttttgttgtttgtttgttttgctttgttttttAAGAGATTAAAATGTTTCTGGATAAGGATTAGCTTCTCGAAGTGTCCATCATTCTGTGTAGAAGCTTAAATATGTAATGTAACCAAACTCCAGTATTAAAAATCTCTCATGTTGTTTTCTTTATACAAAGCAAGATAACGGCATATAACACTGCCATTACATGGCAAAATGTTTGCTACCTTAGTTTAAAAAACAATCTCAAACAAAAGACTTGCTTCAAGGTGTTTTTAAATAGCAGTGATTCAGAATTTTTTTTAATGAAAGTATAATTGCACTAACCTTCTTCCTGCTGCTCTGATTCTGCATTTGTGGTACTTGTGACTACGTTTTTTCAAATATAGATAGATTTAAGCTGCTAATTTTTTTTTTTTTAGTAATCACTACTATATCATGTCTTTTACTCTGTTTATAATATCAAGTATTTTCTTAAAGATATAGATATTAAACCTTGTGCTCATGCAACTTAGAGTAACATATACAGACAAATGATTGCATGAGGCCATGTTTATATGTGTGACTAATAAGGCTTGTCATGATTAACATAATCCAGGTATGTCATTTCTGAAGAGAATAGTCATCAAATTTATATCTCGAAGATTTTAATTAAGGAATTGCTTATTGTTGAGCTTAGCAAATTAATAACACTATTTCTGTCACTAATTATTTTGAGGCCTTTTAGTACTAAAATTTTAACCTGTGTTCTAAGTAGAAACTGATTTAACCCAAGTAATGCAGCTTTGATTGATTTCAGCATTCGTTGCTTTGCTATTTTTACAAAACAGCATTGATTGAAGCAAGTCTTGGTTTTACTAAGGTAGGGTAGCATTTGCTATTGGTAAAGAGAATAAATACACTTAATTTCACAATACATTGTTATATGTACCCCAGTTGTTGTTAGTGGGGACTATGATACTGTAATAATATTTTTAAAAATTTACATCAAGAGAGGCAGTCATTCACGATGGTTTTGTGCCAGCTCTTTTTAGGGTTTTGGATCACATTAGAGATATTTAGAACATATTACCCTGTGACTTACGTAGGAAACCTAATATGCTGAGTATCTGGCACTTGAATTCCTGCTTTTATTGCTGGAGGTCCACATCTGTGGTTGACCTCTGTTATTGTTTaaaaaaaataaataaaaattaaaaaaaTCTGTGCAATAATTTTAAAATGTGCTCCCAGGAATAGACACAAATGTTTTGAGTATCTTTTAAGCTGCATTTTCCTTTAGTGATGCATTTGTCAATTGCACTGAATTTAAATCTGAAAGTCAGAGGTGATTATTGATAGTACTTTTGTATTTTGATATGGACAGTTTATTCATTTGCATACAGTTATTGACTTTTTCCCAGCTGATTAAAAGATAGTCAAGAAATTCTGCAATATAGCTGCCAAAATAGACAGCTACATTTTTATGATATTGTCATCttttctgttttttttttcttttttttctttAGCTATTTTACTTAAGCATAATAGCCACAATAGGACATATAAAAGATTATAAATACAGAGCTTTATTATCCTGACGTCTTGGGTCTTTTAAGTATATACTTTTCTGAAAGGTATCCATTTTGTAGGCTTGGGTTCttcatgagcatacgattgtttatttttgctgctgttctcaacatcatcattgcctgctgatgtgccacgatgcTGCTCCAATAGACAGCAATAAGATTGTCTCTAATTTGAGCAGTAACATGATTGCAAGAGACCAAGTTTCACAGCTTGTAAAGTTCTGTATTTGGGATTCTTGCTTATTTTTCCGCCTGTGTTTTTCTGAGAACTTATTCCTGATGATCAATTGAATCCAGTAGTTTTTCTATGCTATTTGTTGTTGTATAAGCTACTGTAAGAAACTTATCATAAGGAAAAATAGAAAGGAAAACTTGAATCAATACTCATTGATTAAAATGGAATAAAGAAAGAGCAGCTGCCACTTTTAAACAACATAAAGGAATATCTTTTTTTGTCTCCGTGTAGGAAATCCCATAAGTTCTTATATTTGTTCCAGTTCCCATTTCCTGCCATTGACCAGATAACATCATTGACTTTCAAATGACTTTTAGAAGTGATAACTCTTAATTTCCTAATAGATACTAGATTGTATTGAATTCTGTTTTAATTATTCTCTAGGTAAGTATGTTTTAGGATTAAATACCTTTTACAGATACTGAAAGTGCCTCCTTTTGTGGTGTAAAAAACAAATTATGGTGCAAAAAGTAATCACTAGATTGAAATACATGAAGGTTTTTTGCTTTTTGACATACGAAAATGTCAAGAGAAAGGCCAAAGATTTGTACTTTTTCACTTACAAAGCACTCCTTTTTCCCTTAAACTTCTTTCTGTCAAATTAGATTTAATGAGAGAGTACTATTTTTAAGGAGCTATCTGTTTATGTAGAATGATTTTGTTAAGAGTAATGTAAACTATTATTGAGTAGAGGCCTAAAGAGGACTGTGCATTTTTGCTATTTAAAGGAATCACAAATGATCATACTTAAGTGAGCAAAAATGACAAGTTTTACTAGCTAAGTAGAGAAATAAATCTCAAATGCAGCGCTACAATTTTCATTATCTTAAGTACATTGTACATTTCTACAGAACCTGTGATTATTCTCGCATGATAAGGATGGTACTTGCATATGGTGAATTACTACTGTTGACAGTTTCCGCAGAAATCCTATTTCAGTGGACCAACATTGTGGCATGGCAGCAAATGCCAACATTTTGTGGAATAGCAGCAAATCTACAAGAGACCCTGGTTGGTTTTTCGTTTTGTTTTCTTTGTTTTTTCCCCCTTCTCCTGAATCAGCAGGGATGGAAGGAGGGTAGGGAAGTTATGAATTACTCCTTCCAGTAGTAGCTCTGAAGTGTCACATTTAATATCAGTTTTTTTTAAACATGATTCTAGTTAAATGTAGAAGAGAGAAGAAAGAGGAAGTGTTCACTTTTTTAATACACTGATTTAGAAATTTGATGTCTTATATCAGTAGTTCTGAGGTATTGATAGCTTGCTTTATTTCTGCCTTTACGTTGACAGTGTTGAAGCAGGGTGAATAACTAGGGCATATATTTTTTTTTTTTTTGTAAGCTGTTTCATGATGTTTTCTTTGGAATTTCCGGATAAGTTCAGGAAAACATTCTGCATGTTGTATCTAGTCTGATGTACTTATCCATCTCATTACAAACAAAAACACACAGACTGCATTTGTAGCTCTGTAATCCTTGAATACGGAAGTAAATTTTCTTCTTTCCTGACTTTGACATTGTAGCTATACTGTTTCCATTTTTGTTTTTACAAATCCTTTGGGTCTAATTCTGTGAGCCTACCTATAGCACTGGATTAAAATGTCTGCATCATTTCTTTAGTTATCCAGTTAACTTTAAAACTGTTGTAAAAGTGTAAACCAGCCCATGACAGGTTTTTGTACATGTTAAAGAACTTCATTGTTCAGTTTTCATGATTATTGTGTAAGGAAGACTGATGTAGATGTTCTGTGCTGTCCTGGACCATGTTAATTACACTTACGACGTATTTTAGTTCCACATCACAATGATTTGTCCCCAGTGACCCTTTTATCCTTTCTAGGCACATttcttgttgttgttgttgttgCAGTTCCCCTTTGCATTGTATTGCTTTGACAACTGTAATTTGAATCAGATCTGAAAGAGGTCCAGAATAAAATATATTTTGATATTATGTTGGCTGTGTACATATATAAAACCTTTGATGTCTATGTAGTTTATATAGACTATTTACTAGTCAGGTAAAGAGAGAGGGATGGTATTTCTTGTTTACAGTTTGTTTACATTTTAATTGCTTTTACTTCTCCAGTGTTCTATTGTAGAATAAACCTTTTTTTCCAAGTTAGCCTTCATAACCTATAACACATTCATTCTCTCCCATACTGGTGTTACTGATTAATAACTGCCATCAGAACCCAAACCACTGTTTTTCATAAACGTATTGTTTCCCAAGATATATACTTTAAGCCCATAATAAAATTACAAATTTTACTATTTTTATTACTTCTTGCAGGAGATAAGATTTTTTTAAATGAAGgggttatttactatttttattaaagtataatagagcatctaatcagctaagggattgtaattTTTAATTCTTTTGAAAAATAAATATTGTATTTAAAAGACGTTATTTCACAGAAGCTGAAAAAGAGACCTTAGATAACATTTGTTTGGTTAGCCACACGGTTGAGCACAAAACAATGTGTAGATGTGTTGAAGATTAGGGCAGGAGGCTCAACTTCTCGGTGACCTTTTTTTGCTTCACAACAAGCCAATTATAGTTGAATCATTTTCTCTCTTAGCTAGTTGTTACTACAAACTTTATAAGAAAAACAACTAGACACCTTCTAGTTTTAATTAATACCAACTCCTTTAGAGTTAGAGACTTTTTAAAAAGAATCATTGAGCATAttttcttttttttttttttAAGAATTTACACTCTCTAGGTCTTCTATTTTTCCTGTTTATTTCCTTAAACAGAAATAAATTCAAGCATAGTTTTATGTTTTATTAGAAATAAGCCACTGCAGTTGCTAGAACTGACATGCTTTCATTTTCAAGGGGTTAACTTTTATTGCATGGCATAGATTATTAGTAATATCCTGCATTGTATACTTTTCCAAAAAGGGTTGGACTCCTAAGGATTAGAATCCTTATAAGCTTGAGGGAAAGCTGAAACTAATTTGAACAGTAATAGAAGGGATTATTTTTAATTTCATAGTTAACACTTTACAATGGATTAGATTTATTACCTAGTATAATCCGTAGCAGATCAGATCAAAGTTTACTGTTTTACCAATATATTCATTTGAAAAAATACAGTGGAGGAAAAGACACTTTAGATGGTAGTTTTATGGTGCTTTTCTCTGCTGTACCAAAGTGCTTTGTCATCAATGAAATGTTAACCCTATGCTACTTTTTCTGCATGCTTCTTAAATGTCATCTTAATGCTTAATTGTCCTAACTTGTAATATTTTTGTATTAAATTTTTTTAGGAGTTCCTTGTAATTTCTTTACAATTTAAAATATATTAAACACAAAGTGTTTAGTAAAGTACAGAAGACAATTA

>NM_001374327.1 

GAACCGTTTGGCTCTTTCCCTTAGTAACAGCTTTTACCTTCTGCCTCAATTCCTCTCCCCGCTCGCGCCCTTCCCCCGCGCGCCGCCTCCCCCCGCCGCCGGCCGCGTGCGCCCCCGCCCCTCCCCCCGCGGCGGGAGCACCTCCGCTCGCCACCTGGGGACCCGCGCCGCGCTCCCCGCCCCCGCCCGCCCGGCGCCCATCCCCCGCGCCCTCCGCTCGCTGGGGTTATAATTGCCTCTCACCCCCCGGAGGGGTTATTTTGGGGGTGGTTggaggcggtggcggcggcggcgAGGAGGGGAATTTCCTTGTGCCTCCATTCCCGGGAGGGGGGAGCGGCGTTGGAGGCCACCGTTTCCAGGGTTATATCCTGTGTTGTGACCTCATGGTTTAAGTGGGAATAAAGATGAGTATAAGCAGTGATGAGGTCAACTTCTTGGTATATAGATACTTGCAAGAGTCAGGATTTTCTCATTCAGCATTTACCTTTGGTATAGAAAGCCATATCAGTCAGTCCAATATAAATGGTGCCCTCGTCCCACCCGCTGCATTGATTTCTATCATCCAGAAAGGTCTACAGTATGTAGAAGCAGAAGTTAGTATTAATGAGGATGGTACCTTGTTTGATGGTCGACCAATAGAGTCTCTGTCCCTGATAGATGCCGTAATGCCTGATGTAGTACAAACAAGACAACAAGCTTATAGAGATAAGCTTgcacagcaacaggcagcagctgctgcagctgccgcagctgcagccagcCAACAAGGATCTGCAAAAAATGGAGAAAACACAGCAAATGGGGAGGAGAATGGAGCACATACTATAGCAAATAATCATACTGATATGATGGAAGTGGATGGGGATGTTGAAATCCCTCCTAATAAAGCTGTTGTGTTGCGGGGCCATGAATCTGAAGTTTTTATCTGTGCCTGGAACCCTGTTAGTGATCTCCTAGCATCAGGGTCTGGAGACTCAACAGCAAGAATATGGAATCTTAGTGAGAACAGCACCAGTGGCTCTACACAGTTAGTACTTAGACATTGTATACGAGAAGGAGGGCAAGATGTTCCAAGCAACAAGGATGTCACATCTCTAGATTGGAATAGTGAAGGTACACTTCTAGCAACTGGTTCCTATGATGGGTTTGCCAGAATATGGACTAAAGATGGTAACCTTGCTAGCACCTTAGGGCAGCATAAAGGCCCTATATTTGCATTAAAATGGAATAAGAAAGGAAATTTCATCCTAAGTGCTGGAGTAGACAAGACTACAATTATTTGGGACGCACATACTGGTGAAGCCAAGCAACAGTTTCCTTTTCATTCAGCACCAGCATTGGATGTTGATTGGCAGAGCAACAACACCTTTGCTTCTTGTAGTACAGATATGTGCATTCATGTCTGTAAATTAGGACAAGACAGACCTATTAAAACATTCCAAGGACATACGAATGAAGTAAATGCTATCAAATGGGACCCAACTGGCAATCTCTTGGCCTCCTGTTCTGACGACATGACTTTAAAGATATGGAGTATGAAACAAGACAATTGTGTCCATGATTTGCAAGCACATAATAAAGAAATTTATACTATCAAATGGAGTCCAACAGGACCAGGGACTAATAATCCAAATGCCAACCTTATGTTAGCAAGTGCATCCTTTGATTCTACTGTTAGGTTATGGGATGTAGACCGAGGGATATGCATCCATACCTTGACAAAACACCAAGAGCCTGTGTACAGTGTAGCTTTCAGTCCTGATGGCAGGTATCTGGCAAGTGGTTCTTTTGACAAATGTGTACACATCTGGAACACGCAGACAGGTGCTCTAGTTCACAGCTATAGGGGAACAGGTGGAATATTTGAAGTTTGCTGGAATGCAGCAGGAGACAAAGTTGGAGCCAGTGCATCAGATGGTTCAGTTTGTGTATTAGACCTTCGGAAATAGCGCTACTAGTTGGAAGCCATGGACCGACTATGAATGTGTACATAGCCAAAATGACTGTCCCTGACCCATGTACTGCTATAGTCCCACTTGAACCATGGCCAGTCCACTACAGCCAAATCTAAAAGAAATATATACATACAGTGTATATAAACAAAATTGCACCCTGAAGATGACAGAGTTTTGTCACAGCTTGTGAATTCTGTTCACCAAGTGCTGGAATCTAATCTGCTGTGCCCCTAAAATAGCATTTAGAAGTTTTGGATATGAAAAACAGAAGAGAGAAAAATATACATTATAAAAGCAGAACATACATGTACCAGTTTTTGGATACTAAATGACAGCCTTGTTTCTCCCCTTTGAATCAGCAGACACCATGGATTATATTCTTTTTTTCCCTTCAGTAGTGAGCAGTTTGTATGTACAGAGAAAATGGACTTACAAAAACTTGCAGCAGTAGTTTGTTCTTGCTTTAAAATTTCGTTTTTGGTTTAGATTATGGATGCATGAAGTAAGGGAGTGAATCAGTTTCTTGTTTATATTTTTTTCACCTTTTAAACAAAAAATTCTTTAAAATATTTTAATGCATTCTTTTGAAGAGGTAGATGTTTGGTACATTTTATGGCTCCCAGAGCATATATTCAGTTGGTGCATGTTGTGGAAGGGGGAATTGGAAATTAAATGAAAACCTATGACTTTGGTCATGTCAATCTGTAAGACACATCAGTAAAAGGGTATTATGCTCTGTTGGttttgtttttttgttttgctttttttttttttttttcttttttgttttttgGTGATGTGGCTTAAATGCAATAGTTTCTTTTTTGGGACATATTTCTGCCAATTAAAGACTAGAAGGGCACAACTTTTTTTTTAATTACCATAGAGAAGATACATTAAAAAAAATCTTCTGATGTTTTGTAGCCATAACTAAATTATGGTAAAAATGTGCACTATTGTGAAAAGGAGCAACGTAgttttgggttttttgttgtttgtttgttttgctttgttttttAAGAGATTAAAATGTTTCTGGATAAGGATTAGCTTCTCGAAGTGTCCATCATTCTGTGTAGAAGCTTAAATATGTAATGTAACCAAACTCCAGTATTAAAAATCTCTCATGTTGTTTTCTTTATACAAAGCAAGATAACGGCATATAACACTGCCATTACATGGCAAAATGTTTGCTACCTTAGTTTAAAAAACAATCTCAAACAAAAGACTTGCTTCAAGGTGTTTTTAAATAGCAGTGATTCAGAATTTTTTTTAATGAAAGTATAATTGCACTAACCTTCTTCCTGCTGCTCTGATTCTGCATTTGTGGTACTTGTGACTACGTTTTTTCAAATATAGATAGATTTAAGCTGCTAATTTTTTTTTTTTTAGTAATCACTACTATATCATGTCTTTTACTCTGTTTATAATATCAAGTATTTTCTTAAAGATATAGATATTAAACCTTGTGCTCATGCAACTTAGAGTAACATATACAGACAAATGATTGCATGAGGCCATGTTTATATGTGTGACTAATAAGGCTTGTCATGATTAACATAATCCAGGTATGTCATTTCTGAAGAGAATAGTCATCAAATTTATATCTCGAAGATTTTAATTAAGGAATTGCTTATTGTTGAGCTTAGCAAATTAATAACACTATTTCTGTCACTAATTATTTTGAGGCCTTTTAGTACTAAAATTTTAACCTGTGTTCTAAGTAGAAACTGATTTAACCCAAGTAATGCAGCTTTGATTGATTTCAGCATTCGTTGCTTTGCTATTTTTACAAAACAGCATTGATTGAAGCAAGTCTTGGTTTTACTAAGGTAGGGTAGCATTTGCTATTGGTAAAGAGAATAAATACACTTAATTTCACAATACATTGTTATATGTACCCCAGTTGTTGTTAGTGGGGACTATGATACTGTAATAATATTTTTAAAAATTTACATCAAGAGAGGCAGTCATTCACGATGGTTTTGTGCCAGCTCTTTTTAGGGTTTTGGATCACATTAGAGATATTTAGAACATATTACCCTGTGACTTACGTAGGAAACCTAATATGCTGAGTATCTGGCACTTGAATTCCTGCTTTTATTGCTGGAGGTCCACATCTGTGGTTGACCTCTGTTATTGTTTaaaaaaaataaataaaaattaaaaaaaTCTGTGCAATAATTTTAAAATGTGCTCCCAGGAATAGACACAAATGTTTTGAGTATCTTTTAAGCTGCATTTTCCTTTAGTGATGCATTTGTCAATTGCACTGAATTTAAATCTGAAAGTCAGAGGTGATTATTGATAGTACTTTTGTATTTTGATATGGACAGTTTATTCATTTGCATACAGTTATTGACTTTTTCCCAGCTGATTAAAAGATAGTCAAGAAATTCTGCAATATAGCTGCCAAAATAGACAGCTACATTTTTATGATATTGTCATCttttctgttttttttttcttttttttctttAGCTATTTTACTTAAGCATAATAGCCACAATAGGACATATAAAAGATTATAAATACAGAGCTTTATTATCCTGACGTCTTGGGTCTTTTAAGTATATACTTTTCTGAAAGGTATCCATTTTGTAGGCTTGGGTTCttcatgagcatacgattgtttatttttgctgctgttctcaacatcatcattgcctgctgatgtgccacgatgcTGCTCCAATAGACAGCAATAAGATTGTCTCTAATTTGAGCAGTAACATGATTGCAAGAGACCAAGTTTCACAGCTTGTAAAGTTCTGTATTTGGGATTCTTGCTTATTTTTCCGCCTGTGTTTTTCTGAGAACTTATTCCTGATGATCAATTGAATCCAGTAGTTTTTCTATGCTATTTGTTGTTGTATAAGCTACTGTAAGAAACTTATCATAAGGAAAAATAGAAAGGAAAACTTGAATCAATACTCATTGATTAAAATGGAATAAAGAAAGAGCAGCTGCCACTTTTAAACAACATAAAGGAATATCTTTTTTTGTCTCCGTGTAGGAAATCCCATAAGTTCTTATATTTGTTCCAGTTCCCATTTCCTGCCATTGACCAGATAACATCATTGACTTTCAAATGACTTTTAGAAGTGATAACTCTTAATTTCCTAATAGATACTAGATTGTATTGAATTCTGTTTTAATTATTCTCTAGGTAAGTATGTTTTAGGATTAAATACCTTTTACAGATACTGAAAGTGCCTCCTTTTGTGGTGTAAAAAACAAATTATGGTGCAAAAAGTAATCACTAGATTGAAATACATGAAGGTTTTTTGCTTTTTGACATACGAAAATGTCAAGAGAAAGGCCAAAGATTTGTACTTTTTCACTTACAAAGCACTCCTTTTTCCCTTAAACTTCTTTCTGTCAAATTAGATTTAATGAGAGAGTACTATTTTTAAGGAGCTATCTGTTTATGTAGAATGATTTTGTTAAGAGTAATGTAAACTATTATTGAGTAGAGGCCTAAAGAGGACTGTGCATTTTTGCTATTTAAAGGAATCACAAATGATCATACTTAAGTGAGCAAAAATGACAAGTTTTACTAGCTAAGTAGAGAAATAAATCTCAAATGCAGCGCTACAATTTTCATTATCTTAAGTACATTGTACATTTCTACAGAACCTGTGATTATTCTCGCATGATAAGGATGGTACTTGCATATGGTGAATTACTACTGTTGACAGTTTCCGCAGAAATCCTATTTCAGTGGACCAACATTGTGGCATGGCAGCAAATGCCAACATTTTGTGGAATAGCAGCAAATCTACAAGAGACCCTGGTTGGTTTTTCGTTTTGTTTTCTTTGTTTTTTCCCCCTTCTCCTGAATCAGCAGGGATGGAAGGAGGGTAGGGAAGTTATGAATTACTCCTTCCAGTAGTAGCTCTGAAGTGTCACATTTAATATCAGTTTTTTTTAAACATGATTCTAGTTAAATGTAGAAGAGAGAAGAAAGAGGAAGTGTTCACTTTTTTAATACACTGATTTAGAAATTTGATGTCTTATATCAGTAGTTCTGAGGTATTGATAGCTTGCTTTATTTCTGCCTTTACGTTGACAGTGTTGAAGCAGGGTGAATAACTAGGGCATATATTTTTTTTTTTTTTGTAAGCTGTTTCATGATGTTTTCTTTGGAATTTCCGGATAAGTTCAGGAAAACATTCTGCATGTTGTATCTAGTCTGATGTACTTATCCATCTCATTACAAACAAAAACACACAGACTGCATTTGTAGCTCTGTAATCCTTGAATACGGAAGTAAATTTTCTTCTTTCCTGACTTTGACATTGTAGCTATACTGTTTCCATTTTTGTTTTTACAAATCCTTTGGGTCTAATTCTGTGAGCCTACCTATAGCACTGGATTAAAATGTCTGCATCATTTCTTTAGTTATCCAGTTAACTTTAAAACTGTTGTAAAAGTGTAAACCAGCCCATGACAGGTTTTTGTACATGTTAAAGAACTTCATTGTTCAGTTTTCATGATTATTGTGTAAGGAAGACTGATGTAGATGTTCTGTGCTGTCCTGGACCATGTTAATTACACTTACGACGTATTTTAGTTCCACATCACAATGATTTGTCCCCAGTGACCCTTTTATCCTTTCTAGGCACATttcttgttgttgttgttgttgCAGTTCCCCTTTGCATTGTATTGCTTTGACAACTGTAATTTGAATCAGATCTGAAAGAGGTCCAGAATAAAATATATTTTGATATTATGTTGGCTGTGTACATATATAAAACCTTTGATGTCTATGTAGTTTATATAGACTATTTACTAGTCAGGTAAAGAGAGAGGGATGGTATTTCTTGTTTACAGTTTGTTTACATTTTAATTGCTTTTACTTCTCCAGTGTTCTATTGTAGAATAAACCTTTTTTTCCAAGTTAGCCTTCATAACCTATAACACATTCATTCTCTCCCATACTGGTGTTACTGATTAATAACTGCCATCAGAACCCAAACCACTGTTTTTCATAAACGTATTGTTTCCCAAGATATATACTTTAAGCCCATAATAAAATTACAAATTTTACTATTTTTATTACTTCTTGCAGGAGATAAGATTTTTTTAAATGAAGgggttatttactatttttattaaagtataatagagcatctaatcagctaagggattgtaattTTTAATTCTTTTGAAAAATAAATATTGTATTTAAAAGACGTTATTTCACAGAAGCTGAAAAAGAGACCTTAGATAACATTTGTTTGGTTAGCCACACGGTTGAGCACAAAACAATGTGTAGATGTGTTGAAGATTAGGGCAGGAGGCTCAACTTCTCGGTGACCTTTTTTTGCTTCACAACAAGCCAATTATAGTTGAATCATTTTCTCTCTTAGCTAGTTGTTACTACAAACTTTATAAGAAAAACAACTAGACACCTTCTAGTTTTAATTAATACCAACTCCTTTAGAGTTAGAGACTTTTTAAAAAGAATCATTGAGCATAttttcttttttttttttttAAGAATTTACACTCTCTAGGTCTTCTATTTTTCCTGTTTATTTCCTTAAACAGAAATAAATTCAAGCATAGTTTTATGTTTTATTAGAAATAAGCCACTGCAGTTGCTAGAACTGACATGCTTTCATTTTCAAGGGGTTAACTTTTATTGCATGGCATAGATTATTAGTAATATCCTGCATTGTATACTTTTCCAAAAAGGGTTGGACTCCTAAGGATTAGAATCCTTATAAGCTTGAGGGAAAGCTGAAACTAATTTGAACAGTAATAGAAGGGATTATTTTTAATTTCATAGTTAACACTTTACAATGGATTAGATTTATTACCTAGTATAATCCGTAGCAGATCAGATCAAAGTTTACTGTTTTACCAATATATTCATTTGAAAAAATACAGTGGAGGAAAAGACACTTTAGATGGTAGTTTTATGGTGCTTTTCTCTGCTGTACCAAAGTGCTTTGTCATCAATGAAATGTTAACCCTATGCTACTTTTTCTGCATGCTTCTTAAATGTCATCTTAATGCTTAATTGTCCTAACTTGTAATATTTTTGTATTAAATTTTTTTAGGAGTTCCTTGTAATTTCTTTACAATTTAAAATATATTAAACACAAAGTGTTTAGTAAAGTACAGAAGACAATTA

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