Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TRIP4P1
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Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr15). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:139660028-139661727  UCSC
Coordinates (T2T) chr6:140843808-140845507  UCSC
Coordinates (hg19) chr6:139981165-139982864  UCSC
Strand +
Parental Sequence NM_001321924.2
Parental seq. overlap 1484 bp
Parental seq. overlap (%) 70.4%
Genomic Region Intergenic
Retrocopy Summary TRIP4P1, located on chr6:139660028-139661727, is a retrocopy of the parental gene TRIP4. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TRIP4
Full Name thyroid hormone receptor interactor 4
Also known as ASC-1|ASC1|HsT17391|MDCDC|SMABF1|ZC2HC5
Coordinate chr15:64387836-64455303
Strand +
Gene summary This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TRIP4P1
Bonobo Pan paniscus TRIP4P1
Gorilla Gorilla gorilla TRIP4P1
Orangutan Pongo abelii TRIP4P1
Gibbon Nomascus leucogenys TRIP4P1
Green monkey Chlorocebus sabaeus TRIP4P1
Crab-eating macaque Macaca fascicularis TRIP4P1
Rhesus Macaca mulatta TRIP4P1
Baboon Papio anubis TRIP4P1
Golden snub-nosed monkey Rhinopithecus roxellana TRIP4P1
Marmoset Callithrix jacchus TRIP4P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

Related Sequence

>TRIP4P1
ACAGTGCTTCCAAAAAGATGAAACTTTACATGGGCAGAAATCAAGGGACCAGCTAAAGCTGGGTAGGAGGAAAGGGAGAGATAGAGAGGAAGTTCCCGTATTTGCTGAACCTGACACAGCTGCAGAGGTAAAACATCTTTTGATTTGCCCAAGGCACGAGAGAACAGCAACTCCTTTAAGAAGAAGACAAAGTTTGTCAATTTACACACAAGAGAGGGACCCACAGGCCTGCAGTCTGCTCCCCAGTTGCCACCCTTGTGTTTGCCTGGGCCAGAAGCACAAGCTCATCAATAGCTGTCTGATCTGTGGGCCTGTTGTTTGTGAACAAGAGGGCTCCAATCCTTGCTTATTCTGTGTGACAACCATATGTACTATGAAGAACAGGATATTTTACAGCATAACTCAAATGAGAGCCAGAAACTGCTAAAGAAGCTCATGCCATTGATGGAGAATTCTGGAAAGGTGGACAACTCTGCCAAGGACTTTCTATGTCATCGAGAATTTCAAATTATGTCTGGTCTGGAGAAGGATATCAAGCACAAAGACAGGCTGTTAGAGTTGGATAGAGCTAGTTTTCAAAGGACCCAAGTTATTGATGATCAGATTTTTTGCCAGTGATTCTAACCAGTGGTTGTCCAAACTTGAGTGGGAAACGAAATGAGAAGTGAGAAGAAGAGCTGAGAGAACTTCGACATGCCTCTGTACTCTCTAAGAAGGTCACCATTGACTTTACAGCAGGAAGATCCTGGAAGAAGAAAATCCATTAGCAGAATATCACAGCAGACTAGATGAGACAATACAGGCCATTGCTAAGGAAACCTTGAACTAGACACTGATCACATTTGATATATCTCCTGAAGAACCTTTGGAAGTTCTGGTAAATCTCAGCACATACGAGTCCCCTCCCCAGTGGGTTGACCACACAGGTGCAGCCTCACAGAAGAAGGCTTTCCATTCAGCAGGATTGGGACTAGAATTCAACTCATTTCGGTACCTCTTGTGAATCCAGGATCAAGACTTTCAGGGAGGTTGGACAGTGGCTCATGTCTCTCTATACATCAGCCCTGGGTTTCTCAGCTTGTTAGAGGGATTAGAAAATGATGGAGTACAGATCCTGGTACATCTGCCACAGAGGACAACTTTGGATAGTAGTCATAGCCAAAACCTCCCTCTGCCTTCAAAAAGTCTCAGAACTCCGGGCTACATATCATCTTCTTCATAGAAAAGATGTGGAATTCCCCAGTGACTATCCATCAGGTTGTTTTTTGGGCTGTCTGGACCTAATTGCTTGTTTCAGAGGCAATTTAAGGAGCAGTTTCCAGACATCAGCTAAGAATCACGTTCTCCACTTGTTTTCATCTGCAAAAGTCCTGAGGAAATGGTTGTGAAGTTTCCTATTAAAGGAAATAAAAAAATCTGGAAACTGGATTCCAAGATCCATTAAGGAGCAAAGAAGAGGTAAATGAAGCAGAATAAAGCTTTCTGACTCAGGAGAAAATAAACCATACAGCACAGTGGAGTTTGGTACACTAAAATTGCCATCCACTAGGTTTTTGGAATTGAAGCAGTAGAAATCTAAAGGCTTGGCATCGGGCTTGAATCTCTCAGAATTTAAACTCTTACCAAAATCTGTATATTTTTCTTAAGGAGTAGGATTCTTACTTATGTAGTGGCTCAAAATCTTTGAATACATTATTTA
>NM_001321924.2
GCAGCTCAGCTGGTTCCGGCTGGGGAAGATGGCGGTGGCTGGGGCGGTGTCCGGGGAGCCGCTGGTGCACTGGTGCACCCAGCAGTTGCGGAAGACTTTCGGCCTGGATGTCAGCGAGGAGATCATTCAGTGAGAACAGTTCGGGTCCAAGCGGGGAAGGAGCTCTGGGATGTGCACTGCCTGAGCGAACCGGGAAGCGGGGAGGACTGAAAAGTACGTTTTGTCAATTGAGAGTGCTGAAGAGATACGAGAATATGTTACTGATCTCCTCCAGGGAAATGAAGGCAAAAAAGGTCAATTCATAGAAGAACTTATAACCAAATGGCAAAAGAATGATCAGGAGTTGATTTCGGATCCTTTGCAGCAGTGCTTCAAAAAAGATGAAATTTTAGATGGGCAGAAATCAGGCGACCATCTAAAGCGGGGTAGGAAGAAAGGGAGAAACAGACAGGAAGTTCCTGCATTTACTGAACCTGACACGACTGCAGAGGTTAAAACACCTTTTGATTTGGCCAAGGCACAAGAGAACAGCAACTCCGTAAAGAAGAAGACAAAGTTTGTCAATTTATACACAAGAGAGGGACAGGACAGGCTTGCAGTCCTGCTCCCTGGTCGTCACCCTTGTGATTGCCTGGGCCAGAAGCACAAGCTCATCAATAACTGTCTGATCTGTGGGCGCATTGTCTGTGAACAAGAAGGCTCAGGCCCTTGCTTATTCTGTGGCACTCTGGTGTGTACTCATGAGGAACAAGATATTTTACAGCGTGACTCAAACAAGAGCCAGAAACTGCTAAAGAAACTCATGTCAGGAGTGGAGAATTCTGGAAAGGTGGACATCTCTACCAAGGACCTTCTTCCTCATCAAGAATTGCGAATTAAGTCTGGTCTGGAGAAGGCTATCAAGCATAAAGACAAACTGTTAGAGTTTGACAGAACTAGTATTCGAAGGACCCAAGTCATTGATGATGAGTCAGATTACTTTGCCAGTGATTCTAACCAATGGTTGTCCAAACTTGAGCGGGAAACCTTGCAGAAGCGAGAGGAGGAGCTGAGAGAACTTCGACACGCCTCTCGACTTTCTAAGAAGGTCACCATTGACTTTGCAGGAAGGAAGATCCTGGAAGAAGAAAATTCACTAGCAGAGTATCATAGCAGACTAGATGAGACAATACAGGCCATTGCCAATGGAACCTTGAACCAGCCACTGACCAAATTGGATAGATCTTCTGAAGAGCCTTTGGGAGTTCTGGTAAATCCCAACATGTACCAGTCCCCTCCCCAGTGGGTTGACCACACAGGTGCAGCCTCACAGAAGAAGGCTTTCCGTTCTTCAGGATTTGGACTAGAGTTCAACTCATTTCAGCACCAGTTGCGAATCCAGGATCAAGAATTTCAGGAAGGCTTTGATGGTGGCTGGTGCCTCTCTGTACATCAGCCCTGGGCTTCTCTGCTTGTCAGAGGGATTAAAAGGGTGGAGGGCAGATCCTGGTACACCCCCCACAGAGGACGACTTTGGATAGCAGCCACAGCTAAAAAACCCTCCCCTCAAGAAGTCTCAGAACTCCAGGCTACATATCGTCTTCTTCGTGGGAAAGATGTGGAATTTCCTAATGACTATCCGTCAGGTTGTCTTCTGGGCTGTGTGGACCTAATTGACTGCTTGTCCCAGAAGCAATTTAAGGAGCAGTTTCCAGACATCAGTCAAGAGTCTGATTCTCCATTTGTTTTCATCTGCAAAAATCCTCAGGAAATGGTTGTGAAGTTTCCTATTAAAGGAAATCCAAAAATCTGGAAATTGGATTCCAAGATCCATCAAGGAGCAAAGAAGGGGTTAATGAAGCAGAATAAAGCTGTCTGACCCAGGAGAAAAGGAACTATACAGCATAGTGGAGTTTTGTGTACTAAAATTGCTATCTACTGGTCCTTTGGAATTGAAGTAGTAGAAACCTAAAGGCTTGGCGTCAGGCTTGAATATCTCAGAACTTAAACTCTTACCAAAATCTGTATATTTTTCTTAAGGAGTGGGATTCCTACTTTATGTAATGGGGTCGAAATCTTTGAACACATTATTTATAAAAACCTGTTTAAAAATTCTAA

Publications

PMID - Link Title
No publications available for this retrocopy