Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MRPL42P2
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:16171648-16172154  UCSC
Coordinates (T2T) chr6:16044237-16044743  UCSC
Coordinates (hg19) chr6:16171879-16172385  UCSC
Strand +
Parental Sequence NM_172177.5
Parental seq. overlap 433 bp
Parental seq. overlap (%) 2.8%
Genomic Region Intergenic
Retrocopy Summary MRPL42P2, located on chr6:16171648-16172154, is a retrocopy of the parental gene MRPL42. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MRPL42
Full Name mitochondrial ribosomal protein L42
Also known as HSPC204|L31MT|L42MT|MRP-L31|MRP-L42|MRP-S32|MRPL31|MRPS32|PTD007|RPML31|S32MT
Coordinate chr12:93467514-93516214
Strand +
Gene summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein identified as belonging to both the 28S and the 39S subunits. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 4q, 6p, 6q, 7p, and 15q. [provided by RefSeq, May 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MRPL42P4
Bonobo Pan paniscus MRPL42P4
Gorilla Gorilla gorilla MRPL42P4
Orangutan Pongo abelii MRPL42P4
Gibbon Nomascus leucogenys MRPL42P4
Green monkey Chlorocebus sabaeus MRPL42P4
Crab-eating macaque Macaca fascicularis MRPL42P3
Rhesus Macaca mulatta MRPL42P3
Baboon Papio anubis MRPL42P4
Golden snub-nosed monkey Rhinopithecus roxellana MRPL42P4
Marmoset Callithrix jacchus MRPL42P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MRPL42P2
GTCTTGAAACATTTATTTCCAATGCAAAATGGAGCTTTATACTGTGTGTGTTATAAATCTATGTATTCTTCTCTACCTGATGACTATAATTGCAAAACAGAGCTTGCTGTGACTTCCAATGGCAGGAAGTGAGCCTGCTACCACTCTCCTGTGGACATTCCCTATGAATACACAAAACCCATCCTTCAACCACATCCTGGGCACAATAATGAAGAAATACAAGATCAAGTGCTGAAAACCAGATTGGAAGAAAAAGGTGAACACCTTGAGCAAAGACCCATGATAGAACAACTTAGCAAAATGTTCTTTAGTATTACACGCTGTTGGTATTCTCATGGACAGTATTAAAGATGTTGCAAGAAACTAGATCTTCTAAAAGGCAGATGACTGAGGTACTCGGGGGAATCAAAGAGAAATGTTCTTCATTTGCCATTTGAGAAAATGCAATCCGGGGTGTTCACTAACATGTTATATAGTAAAGTCAGAATAATGAATGTCTTTTCATAT
>NM_172177.5
ATTGAAACAAGATGGCGGGTTCGTGGTGAGAAGCCGTCAAGCAGGAGTAGAAATTGGTATGCTTAGAAGCAGATTCTAAAAGCAGTTTCTCTTCAGAACATCTTTTTTCATACCACTTGATAAGCATCTTGAAACACCATGGCTGTAGCTGCAGTAAAATGGGTGATGTCAAAGAGAACTATCTTGAAACATTTATTTCCAGTCCAAAATGGAGCTTTATATTGTGTTTGTCATAAATCTACGTATTCTCCTCTACCAGATGACTATAATTGCAACGTAGAGCTTGCTCTGACTTCTGATGGCAGGACAATAGTATGCTACCACCCTTCTGTGGACATTCCATATGAACACACAAAACCTATCCCTCGGCCAGATCCTGTGCATAATAATGAAGAAACACATGATCAAGTGCTGAAAACCAGATTGGAAGAAAAAGTTGAACACCTTGAGGAAGGACCTATGATAGAACAACTTAGCAAAATGTTCTTTACTACTAAGCACCGTTGGTATCCTCATGGACGGTATCACAGATGTCGTAAGAATCTGAATCCTCCAAAAGACAGATGATGCGGAGGTTCCTGGGGGAATCAAAGAGAAATGTGCCTCATTTGCCATTTGAGAAAATGCAGTCTGGTGTATTCAGTAATATATAGTAAAGTAATAATGATAAAATATCTTTTCATATATTAGAATGTGTACTTTTATATAAAGTAATTCTGGATTTGACATTCTCATTTAGAGAAACctattttcttttttctttttctattttagtgtttcatttATGTGCGGTCTCCAATTTAGgacttttccatagtgccaaagccatacatattcagtagaacatcaataaattacatcagaaattcaacactttattataaaacgggcttcgtgttagataattttgctaaacagtaggctactgtaagtgttctgagcatatttaagacaggctagcattttcaatttacaatattttcaactgatagtaggtttattgggatgtaaccctatgataagttgagaaacatctCTTTTTGTGTGTCTACTGTGATTTAAGTATTTTTAATCATCAGCCAAGCATTGTTAGTAGTATAAATATGATTAATAAAAATGTGCATGGCTTTCCTGAAGGAGATTTTTTAATTGCCTTTGAGAATAAACTCATAAGGTCTACCAAGAAAATAAATGTTATGATGTTTCAGTTGGCTTCTAGGAAATAATTAAATTAGTGATATTTTAATCAGGTTTTACTATCtgctaggccccttccatcaattcttattaaattctcaaaataatcctttgaaaagggagtataattacattttacagtgactcgaaccttacccaaacaagtgggagagccaggagccaaactatcaggctccaaagcttttttttagtgcatcacaatgACAAAGGGGTGGTTTTCTTTCACCCAAGAATGTGCTTTCCTGGAAATTTTTCTAGATAGAATATTATGTAATTTGTTTTGAAGGTTTTTTTTCCTGACTGTCTTAAAGATTATGCTAGCTTTAGAACACATGCAAACAGCTGCAGCTCTGTGATTAAAATGTTAAGGTCACTAGAATAGTGTTAGGAAAATGTTAATAGATAATTCTGCTGCCTCTATTAGCTTATGTATGATCCTTAATAGCATTGCTTCCCCTTCAGTTTCTATTTAGGAGGTGAAGAATCTTTTAATAAGGTAGAAAGTTGCTTTATTTAAATTTGTACTGTAGAATGTTTGTGATACAGTATTTGTAAAATTGATATGAAAAATAATTTCTCAAAGTCTATTGTTTGATCTAGTTATTTTAATAAAGGAACTCTAGAAGTTTCAAGTGGCCAGTGAAGTGTGAGGAATAGAGAGTAAAGGAAATAATTAATAATGGTGACCCTCTGTTAAGTGGTTTACTTTTTCCATTAATATAAATTTCATTTGGAAAGATTAAAAAAACAAGTTTGATTGAACTTGATAAATCAGAAATATTTACCAGCTTTGTCGATGGTGTATTCTTGAAAAATGTTTGGTTTTCTTTCAGGTTGACTTATATCCAAAATTCTACAAATTCTTAGCTATGTTATAAATGTAGAAAGAAGTGAAAAATCAAAATATGATTATGAAGATTTTCTTCTCTTCCGAGTACAAAGCTCTGCTAAATAAGGATTTACCCAAGATGCCCACATCCACATACTTATGTGTCAGTGCTTTGGAGAATTAACTTTGACTTTATTCTACTGGAAGTATAGATTAACACTGTGCTTTCTGGGATTTTGCTTTTCATGGGTTGCTGATTTTTAATTTTGCTAAATAAGCACATAGTCCGTGATCACCAGCATCACCTGCCCTCTGTTCCTCCCCCGTCCCCCAGGGATAAGAACCTGTTATCCACCATCAGTAACATTTTATGAAAGATCTACTTATTTGTCTGTTTTGCAGACATTTTAAAATTCGTAAAGTGggatgcttctttaatttaaatacatttagcttcatgaaaaactcactacacagttcttgttCAAGCATTATTGGGAAACCACCAGAGGGCACTCTCACCCAGGGCTTAATTTGAACATCTCGCCCAAAAGTGACTTTTAAAAGCACTTAATTAGCAGAGAATTTGGATGTTCATTAGTTGAGAATGACTAGTAGAATAAATGGTAATAGTGAAATTAAGTGCTGGAATATTCTGAGTAGACCAATAGCAAAAACTGAtttttttttttttttaaagaaaaggtcttgctgtgtcgcccaggatggagtgcagtggcacaatcacattgcactgcaacctcaatatcctgggctcaagcaatcctcccaccgcagcctcccgaattgctgagactacacatgtgtgctaccatgcctggctaattgttttaattttttttatagagacggggtttcgccatgttgcccaggctggtcttgaactcctgggctcaaagcgatccacccaccttggcctccaaaagtatgggattacaggtgtgagccactgtgcccagccTTATTTTTTTTTTTTAagataatattgttaacattttgtatttctctgcataaatatatttcaaaaataaaaatagagctcataatatatgctgttttgtaatgcttttttcacttaataggaattttttccgtatcattaagtactctgatttaatgggtgcatattattctataatctggcttgtcataatttaattaactccctgctgttagacaaaatcattgtttctgttccatcttgtgaataatgctgttattaacatcctggtggattattaccattttctttttttattttttttttaAATTTATTTCTTCTTTTTTTTTTCTTATAATCTCATCAGAAGCTGGCAAGATCATTACTGTTTTCTTAGATTTGTTTCTGTAAGTGCAATCGTTGAATCACCATGTCCGGCATCCATGTTTATGTACATTTTTAAAGTCAGTGGTTTAAACTGTATACTTTTTGGGttttggagatggaggtttgctctgcccaagctggaatgcaatggcgcgatcttggctcactgcagcctccacctcccgggttcaagtgattctcctgcctcagcctccttaagtagttgggattacaagtgtgcaccaccatactcaggtaattttgcatttttagtagagacagggtttcaccatgttggtcaggctggtctcgaactcctgacctcaagtgtccacacaccttggcctcccaaagtgctgggtgggattataggtgtgagcctccatgcctggccTAAACTGCATACTCCTAACATCAGTATATAGAAATATTTTCTCTTTAGTTCTATTAAAATTTTAAAAAATCTTTATCAATTTAGTAGGCAAAGACTGGAAAATGTTTTAATTTGATCAGCCACTTTAATGTATGTCTCATTTCAAAGCATATAAAGTATACAAGTTTCAGGTCCTAGCTTAAACCTATAAGAGGCCTTATTATGGGCTTATTTCCTTTGCAGCCCTTTACCATAATGTGTTTCTTCTACCTCCCCTGCACAACATTGTTTATATGCCCCCTAAAATGTAACTTCTTTAGATTCTGTTGTTACGTGCAACActgtatatctctccatagcacttaatcagagtttgtaattaggcatctttttgtgtgattatttggtaaatgtccatatcccctactagcctataagctccatgacttctaggtaccctgtctgactacgtgtatcactgtttctaccgcctaacattgcctagcacatTCATTGCTTCACAGGCATCTGAATATGGTTTTATAAAATACATTGCTCTAGTGcacaggattttaagctaaggatttcatgaatgggatttggggtaggggcatctatgaaattcctgaaattgtgtagaattttgagaatatgtgttttcctggggatagagtatgtagtttctcagcaACTCATTACAGTCTGTCACATCATGCCCTAATTCTACTTGCCTGTAGCTAAACACCTAATAACATTAGAACTGAAATGATAGTGATATGCAAGATAGCACGTGTGGTTTCCACATATTCTAAGAGGCATCTTCAATTAGATTCCAAAAATTTTTAAGAAAAAAAGATATAATGTGCCATCATTTTGGATGGTTCTGGGCACTTCAGGTAAACCCTTACTCAAAGAATACTTTTTCAGTTTCAATGTGTATTTTTAAAATTTCCAGAAGATGAGTTGAATATCAGCCCACAAACACTGGTAGTAAGCAAACTATTTTATTTGCTAAAGGCATAAATAAATGTCTCCTTTGCTTTTAGGCAAAGGGAATGCTTCTTCAGATTTTTTTTTTTCCCCAGAAGTTCAAAATAACTTGCTCATAGTCTTCCCAAAATAATTTTCAAACATTCTAACACCAAAGAAAGATACTCCCAATTGAGCTCAGCCATCAGCCTCCTACTATTTTTTAATGTGCTGTTTAACCTTGTGAATGTGAGAATATTTTGAATGCACTGGGAAGGAATACTCAGGAACAATATGTAATGTGCTTTCTAGTTTTGCACAAAGGCATTCATTTTGATTTAGTAACAACCTCATACTTACATAGCATATCCTTCTGCAGAAATGCTTCACAGCCATGACTGCTTGAATTCTTGTCATGTTGCTTGTAAATGAGCTCCTGTTTTTAGATGGAGAAATGGAGGCAGAGTCTCACAATTACATGTGAGAATAGCAAGTAGAACCTTATGATTACTTCTGAGTCttttttttttttttttttttgagatggagtttcacttttgtcacccaggctggagtgcagtacagtggccagtggcatgatctcagcccactgcaacctccgcctcataggctcaagcaattctcctgcctcagcctcccgagtagctgggattatgagcgtgcaccagcatgcctggctgattttttgtattttcagtagagatggggtttcaccacgttggccaggctggtcttgaactcctgacctcaggtgatctgcccaccttggccccccaaaatactgggattacaagggtgagccactgtgcccagccTCTTCTGAGTCTTCAATTCAGCAAGAATGTCTCttttttttttttttttttttttgggacagagtcttgctcttgttgccttggctggagtgtagtggcacattctcagctcactgcaacctccacctcccgggttcaagcgattctcctgcctcagcttcccaagtagctgggactataggcatgcaacaccatgtccggctaattttttgtatttagtagagatggggtttctccatgttggtcaggctggtctcaaactcctgacctcaggtgatccacctgctttcgcctcctgaagtgctgggattacaggcatgagccaccacgcccggccAAGAATGTCTTTTCTTTATAATGTTGTCTCTAAGCATGTAATCTTTTCGGCAAATTTTATTAAGCACCTATAGAGTTCAAGCCACTGTGGGTTCAAAGATAGCCCTCATTCCTGATTGACAAAGTATCTTGCTATGACCATCCCTTCTTTCCCCTCTAGTCAAAATTAGTCTCTTCTTCACTCATAATGCAAAGTACATTGGATTACTATTATGCCACTTACTTGAATAATTGTCTTGATGAGTAATATATGTAGTCAGTAACATGGTTAAGTGTGGCAATTTGGATTGATCCCATTGGACTTTTCAATTGCTGCATCCAGGTGTAATTACCATAAGAGcatagaagatagaatcgtaaagctgaaagacatcttaaagatgatttttggggactgatttggaaacagatccaaagacactaattgacttgcccaagatcacagattgtggcagaacCAACCAATGTCTTTTTTAAACATTAAGGACATCTTATATGTATATTTATGCATATACATACTGATGAAATGTGCCTTTAGCAATAGATGTGTCCAGTGATGTACTAATGAAGATTTAACAACTGGTTCTAACTTGTAATGTTTGCCAGTTTCCATGACTGGGTCTTACAAGTTGTTGTGCACTGACTCCATCATTCCACTGGATGTGCCCCTGAAATCATATATTTACTACTAAAACCATTAGATTGTTTCCTTGTTCCAGTTATGCATTCAGAGACACTCCACCTTATTTTCTGATTACATTTGCAGGGAGAAATAACTCCTTACTTGtcagtttcagccttcacttttagtttctttttcTTTTCCTTTTTCCAACCCAGTATACCTTAGAAACTTTCAGTTTCTTTTAAGGATTTAATAACTTGCTTATAAGTGTTTAAAATGACTTAATGGGTTCTATCTTTTAAGGGAACTTTGGATGAATCCTTGAAtatcagttatctattgccaattaacaaatcaccccaaagctcattggcttaaaacaacaatctttcattagtttgcgttcttccaggtaattcttatagtctggatccagctcagcttatcttggctggacttgcccatgcagctgaggtcactagttgggttgttgaggctggctagtcctagatggtgtcactcatatgtctggtattgagtgactgtcacctggggcattagggggactgtgtctctcatcatccagcaagctaggcctggattcttcacatggctttaggatttcaagagtatgagattggggctgggcatgatgactcacacctgtaatcccagcactttgggaggccaaggttgggggatttcttgagcccaggagttcaagaccagcctgggcaacatagtgagagcccatctgtaaaaaaaaaaattttttgagatggagtttcgcccttgttgcccaggctggagtgcaatggcgcaatctcagcccaccagaacctttgcctcttgggttcaagcgattctcctgcctcagtctcctgagtagctgagattacaggcatgagccaccacgcccagctaattttgtatttttagtagagatgggtttctccgtgttggtcaggctggtcttgaattccccacctcaggtgatctgcctgcctcagcctcccaaagtgctgggattacaggtgtgagccaccacgcctggtcttctacaaaaaaattttaaaaaattagctgggggtggggagggtggggtggtgctgcatgcctgtagtcccagctatttgggaggctgagatgggaggattgcttgagcccatgagattgaggctgtagtgagccatgattgtgccactgcactctaggctgggcaacagaacaagcacctgtatcaaaacaaacaaaaaagtgcaagattggaagcttcgaggcttcttgaggcctagtctcagaactggcacaatatcacttcataaggctatctcagattcaagggagtaagaggagagatgctacctattaaaaggagaagcagcaaaTACTATGGCCATTCTCTTCACAATAGTTGTCACCAAAACGTAATCGATTTGTTTATGGGTTTACATTGTCATGTCTCCACAGGACAATGCACATGGTATGTTTGTCAGAACCCAGTTGGAGTTTTGTTTCCCAGCATCCAAAGGAAATCCCTAACTTTCATTTTTTCTTCCCGTAAGCAGCCCCGAACACTTACTTATAAGCCATCTCTACCTGAATTAGCAATCATGGATAAGCTCAATAACTGATCATTTCCTTATCAGTTTAAACCATATATATTTTAACACTGTCTCTTTTTCACACACACTAGTTAGCTAAGAATGAGCTGGGGggctgggcgtggtagttcacacctgtaatcccagcactttaggaggcggaggtgggcggatcacttgaggtcaggagtttgagaccagcctagctaacatggtgaaaccccgtctctactaaaaatgcaaaaattagctgggtgtggtggcaggcatctgtaatcctagctactcaggaggctgaggcaggagaatcccttgaacccaggaggcagaggttgcagtgggccaagatcacaccactgcactccagtctgggtgataaaacgagattccgtctcaaaaaaaaaaaaaaaactgccaaaacgctttttgcaaagtggttgtaccattttatattctcaccaccatgaatgaaagttccaattgctatattcttgccctcatttgataatatttttagttttagccattctaatggatatatagtaataatttgatggttttaatttgcatttctctgatgatcaataacattaagttttgattcaggtacttgttgggcactcatatctttggtgaaatatctgttcaaatcatttgctctttttttTTTCTTAGCACTTAAAAAAGACTTTTTgccaggcacagtggcacatgcctgtagacctagctactcaggaggctaagacaggaggatcacttgagtccagaagttctgggttgtagtgagctatgtcaatcaggtgtttgcactaagttcagcataaatgtagtgacctcctgggtcactgggacccagagttgcctaaggagcgtcagaagtggagcaggtcaaaactcctgtgctgatcagtagtgggatcacacctgtgaatagccactgcactgcagcctgggcaacatagtgagatcctcatctcctgaaaaaaaaaaaaaactttagtttttaaaagtagttttaggttctgagcaaaattgagaggagggtacagaaataacttatatatcctcagtgctcccctcccccatgcctccctcatcaccatcccccagcagagtggcacattggttacaattgataaacctacactgacacatcattatcacccaaagcctattgtttccattagggttcactcttggtgctgtacaatctatgggtttgaacaaaggtacaatgacatgtatccatctttatagtcatgcagagtctacactgtcctaaaaacccttggctctgcctcttcgtcgtgtcctccccactgacccccggctaccactggtcttttcactgtctccgtaagtttttcctttttcagaacgccatatagttggaatcataaagtatatatagccttttcacattggtttctttcactggataatatgcatttgtttcctctatgtcttttcacagtttgatagctcatttctttttagcatcgagtaatactccattgtctgggtgtacaacagtttatccattcacctgctgaaggacatcttggttgattgcttccaagttttggcaattatgaataaaattgctatagatatccatgtgtaggtttttgtgtccatttaagctttcaactcctttgggtaaataccaaagagcacaattgttggattgaatgctaagagaatgtttcgttttgtaaaaaaccaccaaactgtcctacagagaggctgtaccattttgcattcccaccagcagtgaataagggttcctattgctcaacatccctgtcagcacttggtgttagtgttctgaattttggccattctaaaaggtgtgtagtggtgtctcacttgttttgtgtttttctctgctcagacagctcatccacatcacatttattttaatttgcatttccctgataatatgtgatatggaacatctatttactcattattttttcttcttatgattgaagttataatatttctttaaatattttggataaatcttttgtcagatatatgcactggaaatattttTATGGGGGACCAGTGTTAAGATTAGATCTGTTTAAAGAGAAAGGAGAGAAAGTTTCAGGCAGGGAATGCAATCGATGTGAAGGTTTGGGGTaatttgtttcatttatctttaacaccatgttatggatggcaaaataacttcactggctttttttatcaagaaaagacttaccttttctgaatgcaacagtattagtaaacctaatggtgacaataaaagcgattctgaataaatgaaaaccaatagattgttctagttttactcataaatataattcttcatatactgagttcagttttttagccataaatgaagacatgggaaaaccataacatgttatttgctgagaagttctggcaaatgaagcaataaaataatcaaaactaaatcaacatttaaatacagaacataaagagataaatccaaaaccagaagatctctttgaaagaaaaacctaagtaattaaaaaactgaaagcacagatattcattatttcacaaataaacgttaatgctttttagacatctttaagcaactttagattgctaaaactaaaaaatgcaattaagacaataatcttatatatagacaataattgtcttaataataatcagcatcaaagattcttagaaatgttgggagactgtgtggcaaagaaagtacttcaattaccagttaccaacacacaacaatttgaaatatccaggaagatcaacccatagaacaaagaaagctaataaattaccttttcttgcaattggtttgatgtaccattaatatatagatattactaatatggcaattagtttatatgctatttgaatatgatagtaatatgaaggaagattctcttttttccacttcattgccaacaaacagctaactctaaacaacagtaaagtgtggaataaattactttgttaattaatgtggtttgaagctttgtaggaatccaattggatggatagcagcagtggtaagagaacattccggaataattacctaaattaaggagcttgccctagaatgtaaatcaacctactatatctttttatttgaaaaagtcttggtagaaaaagcatatcaactgaactgtacagtgtgttcagtgacttagtaaagaacataacttgtgtaaaggctaatgcaataagtttgagattgttctctttatgtaatagtttggaaaacaaacaactgtgattacatttagagatatgatgattatctagagggaaagttctgttgagcatatttgaacatttaattattgctgcaagaagccagtttggtcccagctttataaagatatacattgggctgggtgcggtggctcatgcctgtaatcccagcactttgggaggccgaggcaggcggatcacctgaggtcagaggttcgagaccagcctggccaacatggtgaaaccccatctctactaaaaatacaaaaattagctgggcgtggtggcacacacctgtattccttgctactcgggaggctaaggcaggagaatcgcttgaacccaggaagcagaggttgcagtgagccaagattgtgccactgcacaccagcctggataaaaagagtgaaactctgcctcaaaataaaataataaaatgaaataaagatataaattggccagctagagttacctgaagttactatcttcaattatctgaagacagttctgatagcttcagaattctttcatacaaggcaggaatgcaacttgttttttaatggcagataaaatcaaagagcaaaagcaaaaggtagaagcttgaaagaccagagttgctacagattgttattacatgttccataatttaacaattgtcattgaagttggtgattgtcttgatattgcacatctgtaagaagtaatcaaactattgtgaatttgatagaatgctttaagttttattttccaacaaaagaatgtctacatacggcaaattcatagatctggaatccatttatgtcatcaaaagaggatttaaatttaattgtaagcttatatgatacattgttctaactggcaactaatgaaggattaaaaatgaattttgaaaataccacaccacttgcttcattttggataaaagttaaaagtgaatattctgagtatgctgaaattagtttaaaaacttttttttcccattccgaccattatccctttgtaaatctggtttcatcttatgaataatattttttaaaaaccatggaaacagtttagatatacatcaatccatgaaagtagtagtattgtcaatctaccctggattacatattttaacgagaaagaaaccagctcatttgtgacatttagaattttttttttttttttttttttttgagagagagggtctcattcattttattgcccaggctggagtgcagtggtgcaatcgtagctcactgtaaccttgaacttctgggctcaagcaatcctctcacctcagcctgcagctggagcttcaggtgtctgccatcacgcctggcaaatttattttttgtagagaccaagtctccttgtgttacccaggttggtatcaaactcctggtctcaagtgatcctcccatctcggcccccacaagtgttgagatgacaggtgtgagccaccttgcttgacctaaaaacttttgaatattaatatgcattgtgtttattcaaagtatatctaatggtctaataaacagaatcactacttcaattataatcttcagttataattgaagaatgacaaaaagttgagttatagaaattatattaatcttaaattcacattttcagtgaaagtttttaaataattttttctctttccgttttatgtgtgttccaattctatttattgaaatttaattttatatccattaacataattaaaaattggggcttttaaaaaatgtttttcattctactaatttcattttataatttataaaagtactagaccacaatggattaaagaactatcctttcatcacagatagttCAATGACTCCTGtttttttttagaccgagtcttgctctgtcaccccagctggagtgcagtggtgtgatcttggctcactgcaacctccgtctcccaggttcaagcaagtctcctgcctcagccttccgagtagctgggactacaggtgcccaccaccacacccggctaatttttgtatttttagtagagacggggtttcaccatgttggtcaggctggtcttgaactcctgacctcatgatctgcctgcctcggcctcccaaagtgctaggattacaggcgtgagccaccatgcccagccAACTCCTGTTTTATAGTGTACTTTCTGGAATAttattcagctttctcttgaattcttttagtaactaggagttcactacgtttccatggacctaactccaataatgattggacagttttCTCCCTCTGCTTTTTCTTTCtttctttcttttttttttttttttttttgagatggcgtctcctctgtcaatctcggttcattgcaacctccacctcccaagctcaagcgattcttgtgcctcagcctcctgagtagctgggattacaggcacccaccaccacacctggctaatttttttttttggtagagacagggtttcaccatgttgaccaggctggtcttgaactcccgacctcaggtgatctggctgccttggcctcccaaagtgctgacattacaggcatgagccactgcacctggccattattggacagttttaatggaaagtgtttccttatattgagtggaaatcagtctgcttatggtttataatcctcagacttgattctccccctgaatctatatgaaataaatttactcctatttgaaaatatttgtcatattccttcttatttttctttaagctttattttttcttattatccatatgacatgtttccagaactctcccttatcctgattgtcctcctttagacacatgcttttaatgatatatttcttaaaatgtattacccaggacaacatatttttttttactgtggacagtatacttttacgaatggtgccaataatgcattacattttttagcagtcatgtcatcctcttgatttgcattgagTCATCATTTCTTAAGAGGGAATCAGGATATCAAAATAGTCTCCAAACTCAGCTGATTCCTTCTGCAGATACACTCTCCACCCTTCTTGATTCCTTTTCGGGAGAAAAGAAAAAAGTTTATTTTCATTGCTAACCTCACTGATTTTTAATTTTACCATTTAAATGTTAGTAACAGCTGGTAATGTAACCAAAGAAGATTTTTGGCAGGGGATGATGCATTCAGAGCCTtcactctggctacagggagaccatggaggatgggctggaacggaagcacgatggactcctgggcacaccgttaagtgactgatggagtcattcagctgacaaatgataatggcctggattaaggaaggagaagaggggaccaagaaatgccagagatacataggaagtaaaaattaataggccttgGCAACTAttttttttttttttttttgagacagagacttgctgtgttgcccaggctggagtgcagtggggtgatctcggctcactgcaacctctgcctcctggattcaagcaattttcgtgcctcaacctcctgagtagctgggactacaggtgtgcatcaccattcccaggtaatttttgtatttttagtatagatggagtttcgccattctggccaggctggtctcgagctcctgacctcaagtgattcgcccgcgtcggcctcccaaagggctgggattacagacatcagccactgcacctggGTTGGCAACTAATTTACACGGAATGGCAGAGAGTGATTAATGAAAAAGCGGGgagaaaagctgctcttgacatctgaaagctgacttggcattcacagctaggctatgttattttcctattgggcataagtctcacagaataccaacattaaacaagatgactctgaaaccttaataaagtgagaaaaaacaagtccactttgtaattttgtctaagcacaggcaaaaagagggtcatggtgccatccagaaaataccaaaaatcaccctctctcagctaaaatgagcaactgctactttaccagtgacagctttgtcccagctctagtctgccttccctatagagaagatgtattgagataatcatgaaattctccttctttctgatagtatccaatctggagcaaacccgtttccttagaccctctcccaatcccaaattctatactaggttcttctaaacactctcatactgagacaccccatggttccctatgttgtgtgttcttctttgctgcaatgagtaataaactcaacttgtttaacta

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