Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ITGAEP1
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:38002955-38003127  UCSC
Coordinates (T2T) chr6:37827702-37827874  UCSC
Coordinates (hg19) chr6:37970731-37970903  UCSC
Strand -
Parental Sequence NM_002208.5
Parental seq. overlap 151 bp
Parental seq. overlap (%) 4%
Genomic Region Intragenic (ZFAND3)
Retrocopy Summary ITGAEP1, located on chr6:38002955-38003127, is a retrocopy of the parental gene ITGAE. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ITGAE
Full Name integrin subunit alpha E
Also known as CD103|HUMINAE
Coordinate chr17:3714628-3803766
Strand -
Gene summary Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ITGAEP1
Bonobo Pan paniscus ITGAEP1
Gibbon Nomascus leucogenys ITGAEP1
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ITGAEP1
CTTTCAACAAATCTCTATATGAGGGGCTGAATATAGAGAACCAACGAACTAAGATCATTGTCATCTTCCTGAAAGATGAGAAGTAACATTCTTTGCCTACCATCATTGGAGGCAACGTTGATGGCCTTCTGGTTTTGATAATTATAGTCATTCTGTCCAAGTGTGGCATTTTC
>NM_002208.5
GCACTCGCCTCGGCTCCCACACAGCCGCCTCTGCTCCAGCAAGGATGTGGCTCTTCCACACTCTGCTCTGCATAGCCAGCCTGGCCCTGCTGGCCGCTTTCAATGTGGATGTGGCCCGGCCCTGGCTCACGCCCAAGGGAGGTGCCCCTTTCGTGCTCAGCTCCCTTCTGCACCAAGACCCCAGCACCAACCAGACCTGGCTCCTGGTCACCAGCCCCAGAACCAAGAGGACACCAGGGCCCCTCCATCGATGTTCCCTTGTCCAGGATGAAATCCTTTGCCATCCTGTAGAGCATGTCCCCATCCCCAAGGGGAGGCACCGGGGAGTGACCGTTGTCCGGAGCCACCACGGTGTTTTGATATGCATTCAAGTGCTGGTCCGGCGGCCTCACAGCCTCAGCTCAGAACTCACAGGCACCTGTAGCCTCCTGGGCCCTGACCTCCGTCCCCAGGCTCAGGCCAACTTCTTCGACCTTGAAAATCTCCTGGATCCAGATGCACGTGTGGACACTGGAGACTGCTACAGCAACAAAGAAGGCGGTGGAGAAGACGATGTGAACACAGCCAGGCAGCGCCGGGCTCTggagaaggaggaggaggaagacaaggaggaggaggaagacgaggaggaggaggaAGCTGGCACCGAGATTGCCATCATCCTGGATGGCTCAGGAAGCATTGATCCCCCAGACTTTCAGAGAGCCAAAGACTTCATCTCCAACATGATGAGGAACTTCTATGAAAAGTGTTTTGAGTGCAACTTTGCCTTGGTGCAGTATGGAGGAGTGATCCAGACTGAGTTTGACCTTCGGGACAGCCAGGATGTGATGGCCTCCCTCGCCAGAGTCCAGAACATCACTCAAGTGGGGAGTGTCACCAAGACTGCCTCAGCCATGCAACACGTCTTAGACAGCATCTTCACCTCAAGCCACGGCTCCAGGAGAAAGGCATCCAAGGTCATGGTGGTGCTCACCGATGGTGGCATATTCGAGGACCCCCTCAACCTTACGACAGTCATCAACTCCCCCAAAATGCAGGGTGTTGAGCGCTTTGCCATTGGGGTGGGAGAAGAATTTAAGAGTGCTAGGACTGCGAGGGAACTGAACCTGATCGCCTCAGACCCGGATGAGACCCATGCTTTCAAGGTGACCAACTACATGGCGCTGGATGGGCTGCTGAGCAAACTGCGGTACAACATCATCAGCATGGAAGGCACGGTTGGAGACGCCCTTCACTACCAGCTGGCACAGATTGGCTTCAGTGCTCAGATCCTGGATGAGCGGCAGGTGCTGCTCGGCGCCGTCGGGGCCTTTGACTGGTCCGGAGGGGCGTTGCTCTACGACACACGCAGCCGCCGGGGCCGCTTCCTGAACCAGACAgcggcggcggcggcagacgcggaggctgcgCAGTACAGCTACCTGGGTTACGCTGTGGCCGTGCTGCACAAGACCTGCAGCCTCTCCTACATCGCGGGGGCTCCACGGTACAAACATCATGGGGCCGTGTTTGAGCTCCAGAAGGAGGGCAGAGAGGCCAGCTTCCTGCCAGTGCTGGAGGGAGAGCAGATGGGGTCCTATTTTGGCTCTGAGCTGTGCCCTGTGGACATTGACATGGATGGAAGCACGGACTTCTTGCTGGTGGCTGCTCCATTTTACCACGTTCATGGAGAAGAAGGCAGAGTCTACGTGTACCGTCTCAGCGAGCAGGATGGTTCTTTCTCCTTGGCACGCATACTGAGTGGGCACCCCGGGTTCACCAATGCCCGCTTTGGCTTTGCCATGGCGGCTATGGGGGATCTCAGTCAGGATAAGCTCACAGATGTGGCCATCGGGGCCCCCCTGGAAGGTTTTGGGGCAGATGATGGTGCCAGCTTCGGCAGTGTGTATATCTACAATGGACACTGGGACGGCCTCTCCGCCAGCCCCTCGCAGCGGATCAGAGCCTCCACGGTGGCCCCAGGACTCCAGTACTTCGGCATGTCCATGGCTGGTGGCTTTGATATTAGTGGCGACGGCCTTGCCGACATCACCGTGGGCACTCTGGGCCAGGCGGTTGTGTTCCGCTCCCGGCCTGTGGTTCGCCTGAAGGTCTCCATGGCCTTCACCCCCAGCGCACTGCCCATCGGCTTCAACGGCGTCGTGAATGTCCGTTTATGTTTTGAAATCAGCTCTGTAACCACAGCCTCTGAGTCAGGCCTCCGCGAGGCACTTCTCAACTTCACGCTGGATGTGGATGTGGGGAAGCAGAGGAGACGGCTGCAGTGTTCAGACGTAAGAAGCTGTCTGGGCTGCCTGAGGGAGTGGAGCAGCGGATCCCAGCTTTGTGAGGACCTCCTGCTCATGCCCACAGAGGGAGAGCTCTGTGAGGAGGACTGCTTCTCCAATGCCAGTGTCAAAGTCAGCTACCAGCTCCAGACCCCTGAGGGACAGACGGACCATCCCCAGCCCATCCTGGACCGCTACACTGAGCCCTTTGCCATCTTCCAGCTGCCCTATGAGAAGGCCTGCAAGAATAAGCTGTTTTGTGTCGCAGAATTACAGTTGGCCACCACCGTCTCTCAGCAGGAGTTGGTGGTGGGTCTCACAAAGGAGCTGACCCTGAACATTAACCTAACTAACTCCGGGGAAGATTCCTACATGACAAGCATGGCCTTGAATTACCCCAGAAACCTGCAGTTGAAGAGGATGCAAAAGCCTCCCTCTCCAAACATTCAGTGTGATGACCCTCAGCCGGTTGCTTCTGTCCTGATCATGAACTGCAGGATTGGTCACCCCGTCCTCAAGAGGTCATCTGCTCATGTTTCAGTCGTTTGGCAGCTAGAGGAGAATGCCTTTCCAAACAGGACAGCAGACATCACTGTGACTGTCACCAATTCCAATGAAAGACGGTCTTTGGCCAACGAGACCCACACCCTTCAATTCAGGCATGGCTTCGTTGCAGTTCTGTCCAAACCATCCATAATGTACGTGAACACAGGCCAGGGGCTTTCTCACCACAAAGAATTCCTCTTCCATGTACATGGGGAGAACCTCTTTGGAGCAGAATACCAGTTGCAAATTTGCGTCCCAACCAAATTACGAGGTCTCCAGGTTGTAGCAGTGAAGAAGCTGACGAGGACTCAGGCCTCCACGGTGTGCACCTGGAGTCAGGAGCGCGCTTGTGCGTACAGTTCGGTTCAGCATGTGGAAGAATGGCATTCAGTGAGCTGTGTCATCGCTTCAGATAAAGAAAATGTCACCGTGGCTGCAGAGATCTCCTGGGATCACTCTGAGGAGTTACTAAAAGATGTAACTGAACTGCAGATCCTTGGTGAAATATCTTTCAACAAATCTCTATATGAGGGACTGAATGCAGAGAACCACAGAACTAAGATCACTGTCGTCTTCCTGAAAGATGAGAAGTACCATTCTTTGCCTATCATCATTAAAGGCAGCGTTGGTGGACTTCTGGTGTTGATCGTGATTCTGGTCATCCTGTTCAAGTGTGGCTTTTTTAAAAGAAAATATCAACAACTGAACTTGGAGAGCATCAGGAAGGCCCAGCTGAAATCAGAGAATCTGCTCGAAGAAGAGAATTAGGACCTGCTATCCACTGGGAGAGGCTATCAGCCAGTCCTGGGACTTGGAGACCCAGCATCCTTTGCATTACTTTTTCCTTCAGGATGATCTAGAGCAGCATGGAGCTGTTGGTAGAATATTAGTTTTTAACCATACATTGTCCCAAAAGTGTCTGTGCATTGTGCAAAAAGTAAACTTAGGAAACATTTGGTATTAAATAAATTTACACTTTTCTTTGCA

Publications

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