Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NUP50P4
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr22). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:74849239-74849530  UCSC
Coordinates (T2T) chr6:76026291-76026582  UCSC
Coordinates (hg19) chr6:75558955-75559246  UCSC
Strand -
Parental Sequence NM_007172.4
Parental seq. overlap 236 bp
Parental seq. overlap (%) 4.6%
Genomic Region Intergenic
Retrocopy Summary NUP50P4, located on chr6:74849239-74849530, is a retrocopy of the parental gene NUP50. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NUP50
Full Name nucleoporin 50
Also known as NPAP60|NPAP60L
Coordinate chr22:45163925-45188017
Strand +
Gene summary The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NUP50P3
Bonobo Pan paniscus NUP50P3
Orangutan Pongo abelii NUP50P2
Gibbon Nomascus leucogenys NUP50P2
Golden snub-nosed monkey Rhinopithecus roxellana HSPD1P9
Gorilla Gorilla gorilla Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NUP50P4
ACCATTTTCCAATAAAACATTGCAGAGTCAAGCAAAAGGTGGCAGTAATGAATGTAAAGATGGAGACAAAGGAAGAGAATGATGAGCCAACTAGAGTAATAGTTACTGAAGTAAAAGCAGAACTTTTTATTCTGAAGAGTATAATTTTTTTTACAAGAAAGATGACAAGTTTAAAGAGAAGGATGTAGGTACCCTTTTCTTAAAATCTGTAGCAAATCAGAAGCACAGCTTTTACTAGGAGCAGACACCAATTTAGGCAATGTACTGCTGAATATTCTGATTCCACCCAATT
>NM_007172.4
GCCGGCGCGCTTGCGCAGTAGCTGAACGCGGGCGTTTCTTTCCTCCCTTTTTTTCGAATTGGTTTTGGGGGTAGATTCGAGTTACAAAATGGCCGCCCGGAGCGTGTTCGGCGCGGTTCCCCCAGCTGTCTCTGGCTGAACCGGCGCTCTCGCCTCCCTGCCGAACACAGCGTGAGGAGCCCCCCCAGGGATATGGTGTTTGAGTCTCTGGGCTTGCCGAGCACTAAGTCCTCTGAGTTCCGCAGCGCAGCACCGGAAGCGGCCGAGCGCGCTCAGCCCGGCGACCCCTGCGGGCTCCAGACCCCTGCGCCGCTGCGCCCCGGGTTTCGCCGCAACCAAGACCCAGCGAGTGCAGCGGCGGCCGCCGAGGAGGTTCGAAAACATGGCCAAAAGAAATGCCGAGAAGGAACTGACAGATAGGAATTGGGATCAAGAAGATGAAGCTGAAGAGGTGGGAACATTCTCCATGGCCAGTGAGGAAGTCTTGAAGAATAGAGCCATAAAGAAAGCAAAGCGCAGAAATGTTGGATTTGAATCTGACACTGGAGGAGCCTTTAAAGGTTTTAAAGGTTTGGTGGTACCTTCTGGAGGAGGACGCTTTTCTGGATTTGGTAGTGGCGCTGGAGGGAAGCCTTTGGAAGGACTGTCGAATGGAAACAACATAACCAGTGCCCCTCCCTTCGCCAGTGCAAAGGCAGCGGCAGATCCCAAGGTAGCCTTTGGTTCTCTTGCTGCAAATGGCCCTACCACCTTGGTTGATAAAGTTTCAAATCCCAAAACTAATGGGGACAGTCAGCAGCCCTCCTCCTCTGGCCTTGCTTCCAGTAAAGCTTGTGTCGGAAATGCCTATCACAAGCAGTTGGCCGCCTTGAACTGCTCCGTGCGGGATTGGATAGTGAAGCACGTGAATACAAACCCCCTCTGTGATCTGACACCTATCTTTAAAGACTATGAGAAATATTTAGCAAACATTGAACAGCAACACGGGAACAGTGGCAGGAATTCTGAAAGTGAATCTAACAAAGTGGCAGCTGAAACACAGTCTCCTTCCCTTTTTGGCTCAACAAAATTACAGCAAGAGTCAACGTTTTTGTTTCATGGCAACAAAACTGAAGATACACCTGACAAGAAGATGGAGGTGGCATCTGAAAAGAAAACGGACCCATCATCACTAGGAGCGACAAGTGCCTCATTTAATTTCGGCAAGAAAGTTGATAGCTCTGTTTTGGGCTCATTAAGCTCTGTCCCCCTGACTGGATTTTCTTTCTCCCCTGGAAACTCCAGTTTATTTGGCAAAGATACTACCCAGAGTAAACCAGTCTCTTCACCATTTCCCACTAAACCATTGGAGGGCCAAGCAGAAGGTGACAGTGGTGAATGCAAAGGTGGAGATGAAGAAGAGAATGATGAGCCACCCAAAGTAGTAGTTACCGAAGTAAAAGAAGAAGATGCTTTTTACTCCAAAAAGTGTAAACTGTTTTACAAGAAAGACAATGAGTTTAAAGAGAAAGGCATAGGTACTCTGCATTTAAAACCTACAGCAAATCAGAAGACACAGCTTTTGGTGCGGGCAGACACCAATTTAGGCAACATATTGCTGAACGTTCTGATTCCACCCAATATGCCATGTACGCGAACAGGGAAGAATAACGTTCTTATCGTCTGTGTTCCAAATCCACCAATTGACGAGAAGAATGCCACCATGCCAGTCACCATGTTGATTCGGGTAAAAACCAGCGAGGATGCAGACGAGTTGCACAAAATTTTACTGGAGAAAAAGGATGCCTGAACACGCAAAGTCGGCTGCAGAATTATTGCCAAGTTGCTGCTGCTTCCACCGCCCCTTAAAGTTAGTCAGTTTTTCTTCTCTTCTTTGACATTCTAAGAACTTATAGATAACTTAAAACTTTTGTGAGGAAGATTAATGTGGCCAATAAAACCTTTAAATGTTAAGTGTCAAGAAACTGCACTCTCCCTTCTTAAGAACTGCCTAAAGTGTAAAATACATTTGAATGCAATTTTTGGAAGATTTTTTAATGTTCGTTTATTAAACTAACCCTAAGTGATTTCTTCAAGGACTGCAATCAGGGTATCAATTTGCTTTCCCAAAGGCTCTTCCAACCCGTGGGTTTTGGGGTCCACCGCCACCACGAGAGAGGCTTTTGAACAGGTGCCTGGCTGTGTTCAGAAGGAAGCTGGCCTGTGTGCTTCTCTCCGGTGGGCTCAGCCGACGTGTGAGACTTGTTCTGTTACCAAATGAACCGGGCTGCCACGCTGTGACAGGCGTTTGTCCTCTGCTTTATTTTTACTTTGAAGCTCAAATGCGAGTACTAAGTGTTCACCTCAGCGTTCGAATCATTGGCCTGTAACCCTGTGGGCTGCTTCACGAGAATTCAGGACCTGCATTTTCATTCTAAAAAGAAATGAACAGCTTGTGAAGGAGTTTTTTGGCTTCATAGTTTCTATTCATGAGGTAGTGTTACTTCTTTATCCCCCTAAAGACAAAATGAAGATAAAGGGGGATTGCCAGGAATGGGTTTAAAAGCACAAATGTGGTAGCTTATCATCTACACCATGGAGAGTGAACCCTTACGAAATGAAAGTCAAATGAGACCATCCGAGAAAAAGATGCGCATAGGCATTTGTACCATGATCAACCCCACGCACATGAAAACTGTGACCAAGTGACGTGCCTGGGAGCTTTGACACACGAGCCGTGTGAATTCACTAGGAAACATGTAATAAAGTCATGGAAGAGAAAATCGTGTGTAAACTTTGCCTTTAACTTTAGACCGCAGTATATTATAATACATTTGATATCTGAAATATCTTTACTTTTTTAAGAGTAAGATTCCATATGTCTGTCTGGAAGGGAGCCATGGTTATTCACACGAATATCCCTGTCACTTCTCCAGAGGTGTCAGGTAACTAACACGAGCATTCTTTGAAGACTCTGGGCACATGAATGATACACAGAATTGAATGTTTAAATTTCCACTGAGTCCTCATGAATCATTTGAGACTAGTACCAGCTGATCTTGTGTACAGGCTCAGGGTCAGTGCCCAAGGGCTCCCGCGTGTGTGTTCTGATCTTCAGTGCGTAGCACATTCTCCATTTAGAAAAGAGTGGTCAGAATAATTGTGGACGGTACAGTGGCTTTTTAAAACTACAGTCTTTAGGTGTAAGGTTTGGCGCCGGGAGCAATTTTATGATCAAATATGATGAACTCCTAAGTCACTGAGGTGTGATTGGGCCAATGTTGGCATGAGGTTCTTGCTCTACTTCCAGTGTTTTGATTCCACTGGGAGAATTTGGCCTAGTGTGTGGCTTTGGATGAATCCGTGTAGAGAGAGGTGAGCTTGTCCTGTTACAGATGCTGTCAGACATAGCGATAGTAGGCACCTAGGGAGGAAGTGGCCGTTAGTTTTACACTGACTTTTTAAGAATGGAGAATGCACGTGGGTTTCTGTTGCGGATGATTCATAGTAAGCAAGCGGTTGATGCTGTTAATACCGGCCCCACCCGATTGACATTAAGTTTATTCAGCTTTTAAAAAGATGAAGAACTAAGGGGAACAAATTTAAGTTTGTTGCAACTTAGCCACACATGCTTCCCTGGTACCAGCTGGAATCAGCAGCTCACAGGCATCTTCAGGACACTTCAGTGTATATGACACAGTACTTTGTTAGCGTCTGCGTGTGTATGGAAAGTTGACAAAAAATGGCATGAAAAGATCATGATTGGATTTTCTTTTAAACCTGCCCTTCTGTAAAAAATAGTTTATATATTTTTAAATTAGTAGGTATGTGTGGCTTCCTTTTTTCCTAACATTCCCAGCAAATTTTTGCTGCTAAGACTATCACTGTTAAAGTGAAAATTACAGGGAAAAATGTGATGAATATACCGTAACTCAAAATGTGATATTTTCTTAAAATCACTCTTTTATGCTTTAGGAACTGGTTGGTCTCCACTTTGATTATTAGTGTAAAGAGCCTGAGTATACGTGGATTTCATTGTAAAATTTAACTCCTTGTCTTTTACTTGGGGCACGGGGCCCCTGGAGGGCTTCCCTACTTTCCCCACTATGTTAACAGGTAATTCTGATTTATGCGTTTAGTTTGACTTATTTTTAACAAAATATTAGAAGTTATGCTTTAAAATGTTTAATGTGGACTGAAATTTTCATCTTTTGTTTGAGAATCTATGAAGTGTATCATATACGTGGCCTAAAGCAAGGTGTGTATTTTGTTATTCTGAAATTGTTTTGCATCTGGACAAATACTAAATATCCCAGTGGCCtttttttttttttttttAAAACCTGTGTATCCATCTCATCCTTTTGCGCATTCCTAGTAAGCAAAAAAATTTGTTATGCCATCTTCATTATTCGAATTACAGACTGAAAAAATATGGCCAGTTTTTAAAGAAGTTTAGATTATGTTTTCCATGGAAGGACAAGTCTGACTGTTCATAGGCTGATTTTCTTTAAGAGGATTATTCTGTTTTACAATTTCAATTCTAGATCACATTTTATATATGCTGCATGCCAAAAAAAAAAAAAAGAGAAAACTGCCTTTTCTGGTGTGGAGGGGAAGAAAAACTAATATTCTACCTTACTAGTAGAGTTCAAAACAAGTTTTCACTGAGAGCCTTTTCAGTAAAAGTTAAACAAGTTTGTTTTTTGAGCATTTGTCAGTTATTCTATTTCAGAAGAGTCAAAATTCAAGCACGATACATTTTGAAGGCTTTGCAAACTCCTAAACCCCTGATGAGTCCTCTCATTCTGGAAGTGGGAATTTGAGTAGATACTGATTTGTCCCGTAGTATGGCAGATGACAGGGAGGTCTTTTCCAAGCAGGCACTCAGAACACAGGTCACCGTATGTTCTCAGCCAGTAACAATCATACTGAGGACGAAGGACTCTCCGTTTGATGCAGACACAATTGTAATGGAGATGTAAAACTTCTTAGCAATCAGATGGATAAATTGTTTGCTTTTTACTTTAAATAGGAAATTGTTTTCTAAAACTAAAATACTTGAATTGTCAGACAATATAATCTCAGCTTGTATTAGTTTTTGAATGCTCCCATCGAGGAAGTGTAACAATCCATGAAATGTGAATAAATGAAAAGTAAACAAAATCCCAA

Publications

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