Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name AP4S1P1
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr6:89059409-89063108  UCSC
Coordinates (T2T) chr6:90268074-90271764  UCSC
Coordinates (hg19) chr6:89769128-89772827  UCSC
Strand +
Parental Sequence NM_001128126.3
Parental seq. overlap 1618 bp
Parental seq. overlap (%) 39.7%
Genomic Region Intergenic
Retrocopy Summary AP4S1P1, located on chr6:89059409-89063108, is a retrocopy of the parental gene AP4S1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name AP4S1
Full Name adaptor related protein complex 4 subunit sigma 1
Also known as AP47B|CLA20|CLAPS4|CPSQ6|SPG52
Coordinate chr14:31025106-31096450
Strand +
Gene summary This gene encodes a member of the adaptor complexes small subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is the small subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Mutations in this gene are associated with spastic quadriplegic cerebral palsy-6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Dec 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes AP4S1P1
Bonobo Pan paniscus AP4S1P1
Gorilla Gorilla gorilla AP4S1P1
Orangutan Pongo abelii AP4S1P1
Gibbon Nomascus leucogenys AP4S1P1
Green monkey Chlorocebus sabaeus AP4S1P1
Rhesus Macaca mulatta AP4S1P1
Baboon Papio anubis AP4S1P1
Crab-eating macaque Macaca fascicularis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>AP4S1P1
TACTAAAAGCCAAAATGGCTGCCCCGAGGAAGCGCGCACCGCGTAGCTAGTGAAGGTTGGGGAGCAAGCTTCTGCGGGAAAGAGGGAGGGGTTCTCCAGGAAAAGCCGTTGAGAGGACCATCACACCCCAAGCAGCACAGGTTCCAGTTACAGCCATCCTTTGTCATAAGTCATAACTTTTGAACTATATTTGGAAAAATACTGGCCAAGAAAGAAAAAATGATAAAATTTTTCCTCATGGTGAATAAACAAGGGCAGACTCGACTTTTTAAGTACTATGAACATGTGGATATTAATAAGCATACACTTCTGGAAACAGAAGTCATAAAGAGCTGTCTCTCCTCGATCCAATGAACAATGCTCTTTCATTGAATTATAAGGATTTTAAGCTGATATATCGGCAGTATGCATCTCTCTTCGTTGTGGTTGGAGTTAATGACACTGAGAACAAGATGGCTATTTATGAATTCATTCATAACTTTGTGGAAGTTTTAGATGAGTATTTCAGCTGAGTAAGTGAATTAGATATAATGTTTAATTTGGATAAAGTACACACAATTTTGGATGAGATGGTGTTAAATGGCTACATTGTGGAAACTAACAGGGCAAGAATTCTTGCCCCTCTACTAATTCTTGATAAGATGTCAGAAAGCTGAAAGGAAGTCTCTTCCAGACAACATGGATTTATCAGAAATGCGAGTACCATGGAATACATCTCAACATCTGTAACCCAGAAGAATATGGAAGACCACAATTACAAAATGGGGTATCCTTCCAAAGACATTATAAATAGGCATTTTCCACAGTTCCTAAAAATACAACAAAACTGTACTTTAAAATATGTACAAAAGAAAAAAATTTTTTTAAACTGAGAGCGAAGTTTTACTTTCTAATTGTAAACATATCTTTCCTACTTCTTTAAATTCTGTTGAGCACCTAAGGAACCCTTCTTGGTCTGTGCTGCTTTTTGCAAATTGAATTCAGGAATAGCAGGATGGTAGTGGGAAGAAAGTATGGCAGTTTTCTGTCAGCCAATGAAGTTTTAAAATTTAAACACAAGGCATTTTGAGTAACGTTGTTTTCTGAAGGCTGTCATGTTGTACTACAACCTTGAACCTTGTGGGCCTAGCTTTAAAAGCTTTGTAATGTGGGGCTCTTTTATAACGTGTACCTAACAAAGATTGCAGAGTTAAATTTTATTTGCCAGTTTGTAAAAGCCTTTGATATTCATTTTAAGGGCACTTAGTAATTACAATGCCATTATGTAATTAACTCTATAGAGAACATTACTTCCAAATAATGGATGGTCAGACATTAAGAGAGCCCCAGAGAGTCCCTACAGCTATCCTTTATGTCCCCTTTTTATGCCACATTTTAAAGGGTTTGCTTATTACCAAGCTTACTGTTAATGAAATTTAGTTCAAAGTTTAAAAGTAGAATGCAaaaaaaaaaaaGTAAATATCTCCCATCTCAAAAAAAAAAAAAAAAGTAGAGTGCAAGAAAATGTCTCTGTACAGGTAGGCGTGAAATGAATCCTTCTCTTCCTGCCTTTTACTCCTTTAACCCCGTCTCCTGCAATGTCTTGAAGTAAATTACTGTCATTACAGAAGAGCAACACACTGCATCCCCCCAAAACCTTTCTATATGCTTTTGCTACCCAGTTAACAGAAGAATATACAGAACTATCTTAGGCGAAAATATGTAcA
>NM_001128126.3
ACTAAAAGCCAAAATGGCTGCCCCGAGGAGGCCCGCACCGCGTAGCCAGTGAAGGTTGGGGAGCAAGCTTATGCGGGAAAGAGGGAGGGGGACTCCAGGAAAAGCCGTTGAGAGGACCATCACAACCTGAGCAGCACAGGTTCCAGTTACAGCCATCCCTTGTCATAACTTTTGAACTGTATTTGGAAAAATACTGGCCAGGAAAGAAAAATGATAAAATTTTTCCTCATGGTGAATAAACAAGGGCAGACTCGACTTTCTAAGTACTATGAACATGTGGATATTAATAAGCGTACACTTCTGGAAACAGAAGTCATAAAGAGCTGTCTCTCTCGATCCAATGAACAATGCTCTTTCATTGAATATAAGGATTTTAAGCTGATATATCGGCAGTATGCAGCTCTCTTCATTGTGGTTGGAGTTAATGACACTGAGAACGAGATGGCTATTTATGAATTCATTCATAACTTTGTGGAAGTTTTAGATGAGTATTTCAGCCGAGTGAGTGAATTAGATATAATGTTTAATTTGGATAAAGTACACATCATTTTGGATGAGATGGTGTTAAATGGCTGCATTGTGGAAACTAACAGGGCAAGAATTCTTGCCCCTCTACTAATTCTTGATAAGATGTCAGAAAGCTGAAAGGAAGTCTCTTCGAGACAATATGGATTTATCAGAAATGCGAGTACCGTGGAATACATCTCAACATGTTAACCCAGAAGAATCTGGAAGACCACAATTACAAAATGGGGTATCCTTCCAAAGACATTATAAATAGGCATTTTCCACAGTTCCTAAAAAGAAAACACAACTGTACTTTAAAATATGTACAAAGAAAAAAATTTCTTTAAACTGAGAGAGAAGTTTTATTTTCTAATTGTAAACATATCTGTCGCACTTTAAATTCTGTTGAGCACCTAAGGAACCCTTCTTGGTCTATGCTTCTTTTGCAAATTGAATTCAGGAATAGCAGGATGGTAGTGGGAAGAAAGTATGGCAGTTTTCCGTCAGCCAATAAAGTTTTAAAATTTAAACACAAGGCATTTTGAGTAACGCTGTTTTCTGAAAGCTAtttttttttttttgagacggagtctagtctagctgtgtcacctggcacattctcggctcactgcaacctccacttccggggttcaagcgattctcctgcctcagcctccgagctgggactacaggcatgcaccaccacacctggctaatttttgtatttttagtagagacagggtttcaccatgttggccaggctgtctcaaactcctgacctcaggtgatctgcctgcctcagcctcccagaacgctgggattacagatgagccacagtgcctgacTTCTGAAGGCTGTCTTATTCCTTTAAAAGGCTTAGTAAAATTAACTTTTTAAGAGGtgtttttttgtttgtttttttgttttgttttttaagacggagtcttgctctgtcacccaagctggagtgcagtggtgtgatctcagctcactgcaacctccacctctgggtttaagcaattctcctgcctcagcctcctgagtagctgcgactacaggcatgtagtccccaggagactgagctgtgattacagatgtgagccaccatgccctgcccggttttatgtaaagcccagctaatttttgtatttttagtagagatagggtttcaccatgttggccaggctgttcttgaactcctgacctcaagtgatccacctgcttcagcctcccaaagtgctgggattacaagcatgagccaccatgcccagccAAGAGGTGttttttgtttgtttgtttttaagagaagcaggtcttgctgtgttgtccaggctggactgcagtggcttttcacaagcatgatcATGTTGTACTACAACCTTGAACCTTCCTGGCCTGGCTCTAAAAGCTTTGTAATGTGGGGCTggtgcagtgcctcacacctgtaacccctgcactttgggaggctgaggaaggaggatcgcttgaggccagaaattcaagaccagcctgggcaacatagacctcatctctacaaaaaatgcaaaaatcagccgggtgtggtggcacatacctgtagtctcaactactcgggagtctgaggcagaagatttcttgagcccaggagttcgagtctgcagtgagctatgatcgtgtcactgcactccagcctgggtgacagagtgaaaccctgtctcaaaaataaaaaaGTccgagtgcggtggctcaggcctgtaatcccaacattttggggggccaagccaggaggattggttgagcccattagttcaagaccagcctgggcaacacagcaagaccatatctctacaaaaaataaataggtgtgatggctcatgcctgtaatcctagtactttgggaggccgaggcaggcagatcacttgaggtcaggagtttgaaaccagcctggccaacatggcaaaaccttgtctctactaaaaatacaaaaagttagccaggcatggtggcaagcacctctaatctcagctactcaggaggctgaggcagtagaattgcttgaacccgggaggcagaggttgcagtgagccgagatcatgccactgcactccagcctgggcgacagagtgagaccctgtctctaaaaataagtaaataactaattaaaaagttagccagctgtggtggtgagcacctgtactcctaactactcaagaggctgagatgggagaattgatcaagcctaggagtttgaggctgcagtgaactatgatcacaacactgtactccaacctgggtaatggagtgaggccctgcctcaaaaacacaaaaacaaaacaaaaaaaCTTTTATAACATGTACCTAACAAAGATGCAGAGTTAAATTTTATTTGCCAGTTTGTAAAAGCCTTTGATACTCATTTTAAGGGCACTTAGTAATTACAATGCCATTATGTAATTAACTCTATAGAGAACATTACTTTCAAATAATGGATGGTCAGACATTAAGACAGCCCCAGAGAGCCCCTACAGCTATCCTTTATCCCGttttttgtttgttttttggagacagcatctccgtctcctaggctggagtgcagtggtgtgatcatgcctcactacagcctgtacctcctgggctcaggtgctcctcccacctcagcctcctgagtaactgggaccacaggtgcgcaccccctccacccagctaatttttgtattttgttgtagagatagggtttcactatgttgcccagactggtctcgaattcctgcagtcacatgatccatctgccttcgccttccaaagtgttgggattacaggcctgagccactgtgcccagtcTTTTTATGCCACATTTTAAAAGGTTTGCTTATTAATAAGCTTACTGTTAATGAAATTTAGTTCAAAGTTTAAAAGTAGAATGCAgccaggcatggtggcttacgcctataatcccagcactttgggacgccaaggtgggtagatcatttgaggtcaggagttcaagaccagcttggccaacatggtgagaccctgtctctactaaaactacgaaaaattagccgggcatggtggcacgcgcctataatcccaactacttgggaggctgtggtaggaggatcacttgaacccaggagacagaggttgcagtgagttgagatcgagattgtgccactgcactccagcctgggcacagagtgagattccgtctcaaaaaaaaaaaaaaaaaaaaaaGTAGAAAGCAAGAAAGTGTCTCTGTACAGGTAGGCATGAAATGAATCCTTCTCTTCCTCCCCTTTACTCCTTTAACCCCTTCTCCTGCAATGTCTTGAAGTAAATTACTGTCATTACAGAAGAGCAATGCACTGCATCCCCCCAAAACCTTTCTATATGCTTTTGCTACCCCGTTAACAGAAGAATATACAGAACTGTCTTAGGCGAAAGTATGTAcagtagtccctctcttatccactgtttcgcattctgtggtttgtgttactcatggtcaactgaggtcccaaaatattaaacagaaaattccagaaataaacaatgtataagttttaaactgca

Publications

PMID - Link Title