Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CRYZP1
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr7:103087844-103089673  UCSC
Coordinates (T2T) chr7:104402965-104404794  UCSC
Coordinates (hg19) chr7:102728291-102730120  UCSC
Strand -
Parental Sequence NM_001889.4
Parental seq. overlap 1546 bp
Parental seq. overlap (%) 79.4%
Genomic Region Intragenic (ARMC10)
Retrocopy Summary CRYZP1, located on chr7:103087844-103089673, is a retrocopy of the parental gene CRYZ. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CRYZ
Full Name crystallin zeta
Also known as -
Coordinate chr1:74705470-74733115
Strand -
Gene summary Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CRYZP2
Bonobo Pan paniscus CRYZP2
Gorilla Gorilla gorilla CRYZP2
Orangutan Pongo abelii CRYZP2
Gibbon Nomascus leucogenys CRYZP1
Green monkey Chlorocebus sabaeus CRYZP2
Crab-eating macaque Macaca fascicularis CRYZP1
Rhesus Macaca mulatta CRYZP1
Baboon Papio anubis CRYZP1
Golden snub-nosed monkey Rhinopithecus roxellana CRYZP1
Marmoset Callithrix jacchus CRYZP2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CRYZP1
GTGGAATATGAAGGAGCCCTTGCAGATTTTGATTCCCACTCTAGAGCTTTTATCTAGATGACCATGGCAACTGAACAAAAGCTGGTGAGAGCTGTTAGAGTGTTTGAATTTGGTAGACCAGAAGTCCTGAAACTCAGTCAGATGTTGCAGTACCAGTTCCAAAAGACCATTAGTTGTAATCAAGGTTCATGCGTGTGGTGTCAACCCCATGGAGACATACATTTACTCTGGTATTTATAATAGAAAACCACCTTATTCTATGCTCAGATGTAACTGGGGTAACGGAAGCTGTTGGAGGGAATGCATCTACTTTCAAGAAAAGTGACAGTTTTCACTACCGGCACAATCTCTGGGAGCAGATTACGCTGTTTACAAACTGCCTGAAAAACTGGACTTTAAACAAAATGCTGCCATTGGTATCCCATATCTTACTGCATATCGAGCTCTGATTCACAGTGTCTGTATGAAAGCTGGAGAGTGTTCTGGTTCATGGGGCTAGTGGAGGAGCTGCAGTAGCAACATGCCAAATTGCTAGAGTTTATGTCTTAAAGGTTTTGGGCACAGTTGGTACTGAGGGACAAAAAGACTTTTGCAAAATGGAGCCCACAAAGTGTTTAATTACAAAGAAGTTAACTATGTTGATAAAATTAAGAAATGTGTGATAAGAAAGGAATTGATGTGATTATTGAAATAATAGCTAATATAAATCTTAGTAAATATGCGAATTGTTTGTCATATGGAAGATAAGTAATAGGTGTTGGCAACAGTGGTACCATTGAAATAAACCCATGGGACACTATGGCAAAAGAGTCTAGTAAAATTGTCGTTACTCTATTTTCCTCAACCAAGGAGGAATCTCAGCAATTTGCAGCAGCCTGTCAAGCTGGAATGGAAATTGGTTGGCTGAAACCTGTAATAAGTTCTCACTATATGTTGGAGAGGTGGCCCAGGCTCATGAAAATATCTCTCACGGCAATGGGGCTACTGTAAAAATGATTCTTCTCTTTTGATGATTAATTCTTTCATGGATTTCAGAGGTTGTCTTTTGCCCAGTTTTACTTACACAATCTTTTGTTTAATTAACATTCATTTGATCCAGTGAGTTTCTTATGGGAAAAAAGTAAGATTTTTCTTTGGAGAACTAAGCAAGTAGAGTAAAATTTATTTTATGGCTGGCAATATTTTTTTTTACCTTCTATTTCAAATCAGGAAATCTTCATAGTACAAAATAGCATGCTAGTGGTCTTCTGGCATTGGAGTGCATTCCAGAAATTCTTAACTGATACTTGATTAATTCTATACCTTTGATTAAAACATGCTAATTCAAAATAAGCGTTCTCAATTTCCAAGGACTTCCAATCCTACTTACTTTCATAAAGGTTCTTTAGTCTCTGATTAGCCATAACTGTATTGGACTCTAAAGATTTTCTGGACTAAAAAAAGACCCCTATTCCAAACTAATCTCATCTGGATCTATACGTCTTGTGGAAGGGCAAGAACACATAATTTCCAGGGCACTTTGCTAGTTTTCCAATATTTCTCCAAATATTAGAATATCCACTTCATTGGATATTCTAATTGATTGTCAATGACCCCATATATTCTGTGAGGACAGCAGCCTTATCTTTGGTATGACACTTGGTACATAGCCTCCAAACTGGTAATACTTCTTGACTGATCAGATTTTCAAAGTAGATTTAGAGTTACCTGTTTGTGTGATGGGGGTCATATATTTTTATTGAAATTAATAAGCTCACCAATTTGATACATTAAGAATGGTCTGCTTTTGCTTCATAGCATAGTAATCTGTAATTCTGTAGAAAATTAAAT
>NM_001889.4
GTGGAGCCTGCAAAAGTTGGAGAAGGTGTGGCAGTCCTCATTTCTGTGGAATCTGAAGAAGCCCACGCAGATTTTAATTCCCACTCTAGATTCTGTATCTAGATCACCATGGCGACTGGACAGAAGTTGATGAGAGCTGTTAGAGTTTTTGAATTTGGTGGGCCAGAAGTCCTGAAATTGCGATCAGATATTGCAGTACCGATTCCAAAAGACCATCAGGTTCTAATCAAGGTCCATGCATGTGGTGTCAACCCCGTGGAGACATACATTCGCTCTGGTACTTATAGTAGAAAACCACTCTTACCCTATACTCCTGGCTCAGATGTGGCTGGGGTGATAGAAGCTGTTGGAGATAATGCATCTGCTTTCAAGAAAGGTGACAGAGTTTTCACTAGCAGCACGATCTCTGGGGGTTATGCAGAGTATGCTCTTGCAGCAGACCACACTGTTTACAAACTACCTGAAAAACTGGACTTTAAACAAGGAGCTGCCATCGGCATTCCATATTTTACTGCTTATCGAGCTCTGATCCACAGTGCCTGTGTGAAAGCTGGAGAGAGTGTTCTGGTTCATGGGGCAAGTGGAGGAGTTGGATTAGCAGCATGCCAAATTGCTAGAGCTTATGGCTTAAAGATTTTGGGCACTGCTGGTACTGAGGAAGGACAAAAGATTGTTTTGCAAAATGGAGCCCATGAAGTGTTCAATCACAGAGAAGTGAATTACATTGATAAAATTAAGAAGTATGTTGGTGAGAAAGGAATTGATATAATTATTGAAATGTTAGCTAATGTAAATCTTAGTAAAGACTTGAGTCTTCTGTCACATGGAGGACGAGTGATAGTTGTTGGCAGCAGAGGTACTATTGAAATAAACCCACGAGACACCATGGCAAAGGAGTCGAGTATAATTGGAGTTACTCTCTTTTCCTCAACCAAGGAGGAATTTCAGCAATATGCAGCAGCCCTTCAAGCTGGAATGGAAATTGGCTGGTTGAAACCTGTGATAGGTTCTCAATATCCATTGGAGAAGGTGGCCGAGGCTCATGAAAATATCATTCATGGTAGTGGGGCTACTGGAAAAATGATTCTTCTCTTATGATGATTAATTCTTTCATGGATTTCCTATGTAATTAGAGGTACTGTCTTTCCCCCAGTTGTACTTACCCTATCTTTTCTTTAATTAACATTCGATTCCATGAGCTTCTTATGTGAAAAAATAAGATTTTTCTTTAGAGAGCAGAAGCAGAAGAGTAAAATTTATTGTATAGCTAGCAATATTTTTTTATGCCATCTGTCTCAAATCAAAGAGTCATCATAGTAGGAAATAACATGTTAGTTGTCATTTGGCATGAGTGTGCATTCCAGTAATTCTTAATTGATATTTGATTAATTCCATACCTTTGATTAAAACATGCTAGTTCAAAATAAGACTGCTCAGTTTCCAAGGGTTTTCAAGCCTACTTACCTTTATAAAGGTTCTCTAGTCTCTGATTAGCCATGACTGTATTGGACTTTGAACATTTTCTGAACTAAAAACCTCTATTCTAAACTAATCTCATTTGGATGTGTAAGTCTTTTGTAAAGGCAAGAATAAATAATATCCAGGACAATTTATTAGTTTTCTCAGTATTTTCCCAAATATTAGAATATTTACTTCATTATTGGTTGGCTGCCAATGACCCCATATGTTCTGTGAGAATAGTAGCTTTATCTTTGATATAATACATAGTCTCCAAATAGGTAATACTTCGCAATTGATTAGATTTTCAGAGTAGATTTAGAGTTATCTGTTTTTCTGGTGAGGGTCAAATATTTTTGTTAATTAAGCTCACAAATTTGATAAATTAAGAATTATCTGCATTTGTCTCGTAACATAATAATGTGTAATAAAGTCTATAGAAAATTAAAA

Publications

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